CN102172327A - Simultaneous stimulating and recording system of cross sensory channels of sight, sound and body sense - Google Patents
Simultaneous stimulating and recording system of cross sensory channels of sight, sound and body sense Download PDFInfo
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- CN102172327A CN102172327A CN 201110086107 CN201110086107A CN102172327A CN 102172327 A CN102172327 A CN 102172327A CN 201110086107 CN201110086107 CN 201110086107 CN 201110086107 A CN201110086107 A CN 201110086107A CN 102172327 A CN102172327 A CN 102172327A
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Abstract
The invention relate to a simultaneous stimulating and recording system of cross sensory channels of sight, sound and body sense, comprising a stimulus control host, an audio-visual stimulus device, an electroencephalogram (EEG) signal filter amplifier and a digital EEG signal recording device, wherein, the stimulus control host is connected with the audio-visual stimulus device; the audio-visual stimulus device is connected with the EEG signal filter amplifier through a testee; and the output end of the EEG signal filter amplifier is connected with the digital EEG signal recording device. The main technical characteristics are as follows: the audio-visual stimulus device is connected with the triggering signal input ends of two body sense stimulators and the marking signal input ends of the EEG signal filter amplifier through a marking signal distributor; and the output ends of the two body sense stimulators are connected with the EEG signal filter amplifier through a testee. By utilizing the system, the function of inducing and recording the stimulus of three sensory channels is realized in a programming manner, and the problem that the prior art can realize the united presentation of the stimulus of only two sensory channels is solved and the research field of (evoked potentials) ERPs is broadened.
Description
Technical field
The invention belongs to the biomedical signals measuring field, especially a kind ofly look, listen, sensory channel is striden in the body sense stimulates simultaneously and recording system.
Background technology
Event related potential (Event Related Potentials, ERPs) be with sensation, the closely-related class EEG signals of cognitive activities (Electroencephalogram, EEG).Nineteen sixties, Sutton etc. have proposed the notion of event related potential, the neuroelectricity physiological change that reflects the cognitive process deutocerebrum by average superimposing technique from scalp surface recording CEP, because event related potential and cognitive process have substantial connection, so be considered to the reflection of brain ' embedded ' function, also be the window that we understand brain.ERPs belongs to and brings out current potential (Evoked Potentials, EPs) a kind of, bring out current potential and be divided into auditory evoked potential (Auditory Evoked Potentials according to stimulation channels, AEPs), visual evoked potential (VisualEvoked Potentials, VEPs), somatosensory evoked potential (Somatosensory Evoked Potentials, SEPs) etc.; According to incubation period length be divided into and early bring out current potential, middle incubation period incubation period and bring out current potential, (length) incubation period in evening and bring out current potential and slow wave.According to the human brain cognitive process, be divided into two big classes: exogenous stimulation related potential relevant and relevant endogenous event related potential with cognitive function with sensation or motor function with bringing out current potential.
The stimulation of polyesthesia passages such as vision, audition and somesthesia all can induce the ERP signal under the background of spontaneous brain electricity (EEG).In recent years because the accumulation of relevant knowledge and the progress of measuring technology, the application of new technique in ERP research obtains fast development, make and stride sensory channel event related potential (CMERPs, Cross-Modal Event-Related Potentials) research and become possibility.In daily life, people have to note simultaneously multiple sensory information so that make accurate judgment in complex environment, and the ERP that single sensation path stimulates brings out pattern for the tangible limitation of initiative cognitive activities existence accurate, that stablize, analyze apace and locate the people.In order more to be close to the usual functional activity state of real cognitive environment and brain, to stride sensation path (Cross-Model) stimulation and in neuro physiology research in recent years, obtain extensive concern.CMERPs has the multi-sensory data and gathers simultaneously, and lack wave amplitude height, incubation period and especially also contain high-dimensional space distribution information, can remedying single sensory channel, to bring out ERP information single and can't integrate the limitation of other sensory informations, becomes research tendency new in the ERP research field.
CMERPs is as a kind of novel research means in Cognitive Science and the medical nerve scientific research, up to now, the sensory signal of in cognitive neuroscience and man-machine interaction research, using stimulate recording system be mostly based on look, listen, body sense stimulation and audio-visual combined stimulation separately, the scope of the CMERP research that so just limits is as needing sensory channels such as somesthesia, the pain sensation with looking, listen a sensation passage to participate in the cognition neural activity under a lot of environment; On the other hand, the SEP technology is widely applied in advanced country's neurosurgery abroad, to detect the nerve signal channel status in patient's art, to protect the neural safety of patient to greatest extent.But, prior art can only realize that vision, two kinds of sensory channels of audition stimulate associating, SEP and VEP and AEP signal combination can not be got up use, main cause is a triple channel combined stimulation system to the requirement that stimulates triggering technique than higher, be difficult to trigger simultaneously the stimulation of three passages and accurately labelling stimulate the triggered time.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of and look, listen, sensory channel is striden in the body sense stimulates simultaneously and recording system, the present invention is by making up the cover system that triggers three kinds of sensory channels stimulations simultaneously able to programme, accurately the labelling stimulation time is also adjusted the stimulus parameter of three kinds of sensory channels within the specific limits arbitrarily, realize bringing out simultaneously and writing down the function that three kinds of sensory channels stimulate, solved prior art and can only realize that two kinds of sensory channels stimulate and unite the problem that presents.
The present invention solves its technical problem and takes following technical scheme to realize:
A kind of looking, listen, sensory channel is striden in the body sense to stimulate and recording system simultaneously, comprise the stimulation main control system, the audiovisual stimulating apparatus, EEG signal filtering amplifier and digitized EEG signal recording apparatus, this stimulation main control system is connected with the audiovisual stimulating apparatus, the audiovisual stimulating apparatus is connected with EEG signal filtering amplifier by the subjects, the outfan of this EEG signal filtering amplifier is connected with digitized EEG signal recording apparatus, the audiovisual stimulating apparatus also is connected with the triggering signal input of two stage body sense stimulators and the marking signal input of EEG signal filtering amplifier by the marking signal allotter, and the outfan of two stage body sense stimulators is connected with EEG signal filtering amplifier by the subjects.
And described signal distributor is an one-to-two parallel port device, and a parallel port is connected with two stage body sense stimulators, and another parallel port is connected with EEG signal filtering amplifier.
And the parallel port that is connected with two stage body sense stimulators is 25 pin parallel ports, and the 4th pin of this 25 pin parallel port is connected with the triggering signal input of two stage body sense stimulators respectively with the 5th pin.
And described stimulation main control system comprises computer that the stimulation programs software for editing is installed and the visual stimulus display that shows the visual stimulus signal; Described audiovisual stimulating apparatus is a STIM AUDIO SYSTEM P/N1105 equipment; Described EEG signal filtering amplifier is the SynAmps amplifier; Described digitized EEG signal recording apparatus is the computer that EEG record analysis software is installed; Described somatosensory stimulator is according to Lay wound electrostimulator.
Advantage of the present invention and good effect are:
A cover is looked, is listened, three kinds of sensory channel stimulating systems of body sense by making up in the present invention, realize bringing out simultaneously and writing down the function that three kinds of sensory channels stimulate with programming mode, can adjust simultaneously the stimulus parameter that three sensory channels stimulate within the specific limits arbitrarily, having solved prior art can only realize that two kinds of sensory channels stimulate and unite the problem that presents, expanded the research field of ERPs, for three sensory channel combined stimulations provide reliable assurance in the application of cognitive neuroscience and man-machine interaction research field.
Description of drawings
Fig. 1 is a system of the present invention connection diagram;
Fig. 2 is 25 pin parallel ports and two stage body sense stimulator connection diagrams;
Fig. 3 is the system handles schematic flow sheet;
Fig. 4 is the connection diagram of application example of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing the embodiment of the invention is further described:
A kind ofly look, listen, sensory channel is striden in the body sense stimulates simultaneously and recording system, as shown in Figure 1, comprise stimulation main control system, audiovisual stimulating apparatus, marking signal allotter, two stage body sense stimulators, EEG signal filtering amplifier and digitized EEG signal recording apparatus.Stimulate main control system to be connected with the audiovisual stimulating apparatus, the marking signal outfan of audiovisual stimulating apparatus is connected respectively to two stage body sense stimulator triggering signal inputs and EEG signal filtering amplifier marking signal input by the marking signal allotter; This audiovisual stimulating apparatus is connected with the data receiver of EEG signal filtering amplifier by the subjects, the outfan of two stage body sense stimulators is connected with the data receiver of EEG signal filtering amplifier by the subjects, and the outfan of this EEG signal filtering amplifier is connected with digitized EEG signal recording apparatus.Wherein, stimulate main control system to comprise computer that stimulation programs software for editing (Stim2 software) is installed and the visual stimulus display that is used to show the visual stimulus signal; The audiovisual stimulating apparatus adopts STIM AUDIO SYSTEM P/N 1105 equipment, and EEG signal filtering amplifier adopts the SynAmps amplifier, and digitized EEG signal recording apparatus is a computer that EEG record analysis software (scan4.3) is installed; What two stage body sense stimulators employing Zhuhai City was refreshing and the armarium company limited is produced creates electrostimulator (ELECTRON-ESA) according to Lay; The marking signal allotter is an one-to-two parallel port device, a parallel port is connected with two stage body sense stimulators, another parallel port is connected with EEG signal filtering amplifier, wherein, the interface that is connected with two stage body sense stimulators is 25 pin parallel ports, and as shown in Figure 2, the 4th pin of this 25 pin and the 5th pin are connected respectively to two stage body sense stimulator triggering signal inputs, the 25th pin is an earth terminal, and the marking signal of audiovisual stimulating apparatus triggers two stage body sense stimulator work by the 4th pin and the 5th pin of 25 pin parallel ports.
Specify the work process of native system below in conjunction with application example as shown in Figure 3.To stimulate main control system, audiovisual stimulating apparatus, marking signal allotter, two stage body sense stimulators, EEG signal filtering amplifier and digitized EEG signal recording apparatus to link together in the manner described above, the subjects is sitting in the front of visual stimulus display and is with pneumatic earphone, left hand is connected with somatosensory stimulator simultaneously, carry out vision, audition and three kinds of stimulations of somesthesia, wherein every class stimulation comprises target stimulation and two kinds of forms of non-target stimulation again.Visual stimulus is presented on 17 cun CRT visual stimulus display central authorities, comprises target stimulation (filled circles, green; Diameter 3cm; Persistent period 60ms) and non-target stimulation (filled circles, red; Diameter 3cm; Persistent period 60ms); Auditory stimulus is transmitted to ears by audiovisual stimulating apparatus (STIM AUDIO SYSTEM P/N 1105) output by pneumatic earphone, comprises that the target pure tone stimulates (frequency 2kHz, 80 decibels of intensity, persistent period 60ms) and non-target pure tone stimulate (frequency 1kHz, 80 decibels of intensity, persistent period 60ms); The somesthesia stimulation is presented by the finger ring electrode that is connected to tested left index finger, comprise target stimulation (high strength: 1.5 ± 0.1mA, persistent period 1ms) and non-target stimulation (low-intensity: 1.0 ± 0.1mA, persistent period 1ms), somesthesia stimulates by two Tai Yilai wound electrostimulators (ELECTRON-ESA) generation, and vision, audition and somesthesia stimulation present simultaneously.
Native system is stimulating main control system can produce 26 incentive conditions by programming, wherein the target stimulation condition has 19, each incentive condition has 72 stimulations, the non-target stimulation condition has 7, each incentive condition has 150 stimulations, the ratio of target stimulation quantity and non-target stimulation quantity was near 1: 1, and target stimulation and non-target stimulation present at random.Stimulate test to comprise six unit, each unit finished the back subjects and took a momentary rest from producing at random between 1.5-2.5s the blanking time between incentive condition.The test request subjects makes judgement after detecting target stimulation as early as possible exactly, and presses response key with right hand forefinger, and subjects's response time, accuracy and eeg data quilt be record simultaneously.Test needs the subjects is carried out the repetition training of 200 stimulations before formally beginning, up to tested be familiar with test till.Test is finished in a sound damping darkroom.In test process, require the subjects to loosen mood, focus one's attention on, be sitting in rightly apart from the position of display 75cm, few nictation, head keeps motionless as far as possible.
The handling process of native system, as shown in Figure 4, after stimulating main frame to send the stimulation order, the audiovisual stimulating apparatus sends marking signal to two stage body sense stimulators and EEG signal filtering amplifier simultaneously, simultaneously, the audiovisual stimulating apparatus presents audiovisual to stimulate, somatosensory stimulator presents the body sense to stimulate, the subjects is upset back and brings out ERPs, the EEG signal that is produced is fed to EEG signal filtering amplifier, is sent to after EEG signal filtering amplifier amplifies the EEG signal to carry out the record analysis processing in the digitized EEG signal recording apparatus.
In order to realize 26 kinds of incentive conditions, at the output principle of audiovisual stimulating apparatus, stimulus type is set and stimulates numbering with the Stim2 of stimulation programs software for editing, to realize 26 kinds of stimulus types, see Table 1.
Utilize binary coding to trigger the 4th pin and the 5th pin output triggering signal of 25 pin parallel ports, by on two stage body sense stimulators, different stimulus parameters being set, thereby triggering out two kinds of different body senses stimulates, with difference target and non-target stimulation, the target and the non-target stimulation of uniting two other sensory channel are again formed 26 kinds of incentive conditions jointly.For a plurality of stimulations in every kind of multi-sensory incentive condition are presented simultaneously, utilize the Stim2 of stimulation programs software for editing to adjust the triggering type of audiovisual stimulating apparatus, stimulation main control system transmission triggering signal is become with sonic stimulation bring out triggering signal, again by adjusting the triggered time of sonic stimulation triggering signal, adjust the output time of audiovisual stimulating apparatus triggering signal, further adjust and trigger the time that the body sense stimulates, thereby realize that three kinds of sensory channels arrive tested sensory organ simultaneously.
It is emphasized that; embodiment of the present invention is illustrative; rather than it is determinate; therefore the present invention is not limited to the embodiment described in the specific embodiment; every other embodiments that drawn by those skilled in the art's technical scheme according to the present invention belong to the scope of protection of the invention equally.
Claims (4)
1. look for one kind, listen, sensory channel is striden in the body sense to stimulate and recording system simultaneously, comprise the stimulation main control system, the audiovisual stimulating apparatus, EEG signal filtering amplifier and digitized EEG signal recording apparatus, this stimulation main control system is connected with the audiovisual stimulating apparatus, the audiovisual stimulating apparatus is connected with EEG signal filtering amplifier by the subjects, the outfan of this EEG signal filtering amplifier is connected with digitized EEG signal recording apparatus, it is characterized in that: the audiovisual stimulating apparatus also is connected with the triggering signal input of two stage body sense stimulators and the marking signal input of EEG signal filtering amplifier by the marking signal allotter, and the outfan of two stage body sense stimulators is connected with EEG signal filtering amplifier by the subjects.
2. according to claim 1ly a kind ofly look, listen, sensory channel is striden in the body sense stimulates simultaneously and recording system, it is characterized in that: described signal distributor is an one-to-two parallel port device, a parallel port is connected with two stage body sense stimulators, and another parallel port is connected with EEG signal filtering amplifier.
3. according to claim 2ly a kind ofly look, listen, sensory channel is striden in the body sense stimulates simultaneously and recording system, it is characterized in that: the parallel port that is connected with two stage body sense stimulators is 25 pin parallel ports, and the 4th pin of this 25 pin parallel port is connected with the triggering signal input of two stage body sense stimulators respectively with the 5th pin.
4. each is describedly a kind ofly looked, listens according to claim 1 to 3, sensory channel is striden in the body sense stimulates and recording system simultaneously, and it is characterized in that: described stimulation main control system comprises computer that the stimulation programs software for editing is installed and the visual stimulus display that shows the visual stimulus signal; Described audiovisual stimulating apparatus is STIM AUDIO SYSTEM P/N 1105 equipment; Described EEG signal filtering amplifier is the SynAmps amplifier; Described digitized EEG signal recording apparatus is the computer that EEG record analysis software is installed; Described somatosensory stimulator is according to Lay wound electrostimulator.
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Cited By (8)
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| CN102793540A (en) * | 2012-06-14 | 2012-11-28 | 天津大学 | Method for optimizing audio-visual cognitive event-related potential experimental paradigm |
| CN103494608A (en) * | 2013-10-16 | 2014-01-08 | 上海谱康电子科技有限公司 | Electroencephalogram detection signal synchronization circuit and method and electroencephalogram detection system |
| CN103690165A (en) * | 2013-12-12 | 2014-04-02 | 天津大学 | Cross-inducing-mode emotion electroencephalogram recognition and modeling method |
| CN104615887A (en) * | 2015-02-05 | 2015-05-13 | 广州市润杰医疗器械有限公司 | Voice-image matching method for detecting cognitive function of child |
| CN104888331A (en) * | 2015-03-30 | 2015-09-09 | 徐志强 | Training system for treating infantile autism |
| CN107122602A (en) * | 2017-04-12 | 2017-09-01 | 海南医学院 | A kind of TMS is stimulated is presented control method and equipment with visual synchronization |
| CN110236498A (en) * | 2019-05-30 | 2019-09-17 | 北京理工大学 | A kind of more physiological signal synchronous acquisitions, data sharing and online real time processing system |
| CN112137616A (en) * | 2020-09-22 | 2020-12-29 | 天津大学 | Consciousness detection device for multi-sense brain-body combined stimulation |
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Cited By (12)
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|---|---|---|---|---|
| CN102793540A (en) * | 2012-06-14 | 2012-11-28 | 天津大学 | Method for optimizing audio-visual cognitive event-related potential experimental paradigm |
| CN103494608A (en) * | 2013-10-16 | 2014-01-08 | 上海谱康电子科技有限公司 | Electroencephalogram detection signal synchronization circuit and method and electroencephalogram detection system |
| CN103494608B (en) * | 2013-10-16 | 2015-04-15 | 上海谱康电子科技有限公司 | Electroencephalogram detection signal synchronization circuit and method and electroencephalogram detection system |
| CN103690165A (en) * | 2013-12-12 | 2014-04-02 | 天津大学 | Cross-inducing-mode emotion electroencephalogram recognition and modeling method |
| CN103690165B (en) * | 2013-12-12 | 2015-04-29 | 天津大学 | Modeling method for cross-inducing-mode emotion electroencephalogram recognition |
| CN104615887A (en) * | 2015-02-05 | 2015-05-13 | 广州市润杰医疗器械有限公司 | Voice-image matching method for detecting cognitive function of child |
| CN104888331A (en) * | 2015-03-30 | 2015-09-09 | 徐志强 | Training system for treating infantile autism |
| CN104888331B (en) * | 2015-03-30 | 2019-01-15 | 徐志强 | For treating the training system of self-closing disease |
| CN107122602A (en) * | 2017-04-12 | 2017-09-01 | 海南医学院 | A kind of TMS is stimulated is presented control method and equipment with visual synchronization |
| CN110236498A (en) * | 2019-05-30 | 2019-09-17 | 北京理工大学 | A kind of more physiological signal synchronous acquisitions, data sharing and online real time processing system |
| CN112137616A (en) * | 2020-09-22 | 2020-12-29 | 天津大学 | Consciousness detection device for multi-sense brain-body combined stimulation |
| CN112137616B (en) * | 2020-09-22 | 2022-09-02 | 天津大学 | Consciousness detection device for multi-sense brain-body combined stimulation |
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