CN102172323B - Self-assembly nano-medicament bi-stable quantum wire array and preparation method thereof - Google Patents
Self-assembly nano-medicament bi-stable quantum wire array and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of advanced quantum information materials, in particular relating to a self-assembly nano-medicament bi-stable quantum wire array and a preparation method thereof. The self-assembly nano-medicament bi-stable quantum wire array is prepared by self-assembling an antioxidase oxygen radical antagonist, a beta-receptor agonist, a P2 receptor agonist, a benzene alkyl amine calcium antagonist and/or a purine nucleic acid monomer as well as binary, ternary, quaternary and quinary complexes of the components under interaction of inelastic electron tunneling. The quantum wire array has the advantages of regular geometric structure, controllable and adjustable dimension, inelastic electron tunneling and quantum bit electrical properties and kondo effect. The self-assembly nano-medicament bi-stable quantum wire array and the preparation method thereof are beneficial to research of innovative medicaments with a targeted disease mechanism and research of a new quantum biological information sensing material and a nano-structured magnetic random access memory (MRAM).
Description
The application is that the application number submitted on July 15th, 2005 is 200510027795.6, denomination of invention is divided an application for the Chinese invention patent application of " Nano medication self assembly bistable state quantum linear array and preparation method thereof ".
Technical field
The present invention relates to man-made polymer's molecular quantum information material field, be specifically related to a kind of Nano medication self assembly bistable state quantum linear array and preparation method thereof.
Background technology
Quantum wire is the core of development quantum calculation and ultrafast or super quick diagnostic techniques and nano-biosensing, and quantum bit is the focus of present information material research.Development is the focus of both at home and abroad modern and long-term research with the biomolecule for the information material construction elements.There are some researches show the different pyridine of fighting, isoproterenol, superoxide dismutase and adenosine triphosphate be one group of nanoscale size, possess the drug molecule network of charge transfering and target identification ability, but do not see at single molecules level the report of Nano medication bistable state quantum linear array and preparation method thereof so far as yet.
Summary of the invention
The purpose of this invention is to provide a kind of single molecules level Nano medication self assembly bistable state quantum linear array that is applicable to the clinical nanometer diagnostic tool of development and preparation method thereof.
The present invention adopts non-resilient electron tunneling interaction self assembly antioxidant reductase oxygen-derived free radicals antagonist, the beta-receptor agonist, the P2 receptor stimulating agent, phenyl alkylamide calcium antagonist monomer and/or nucleic acid and binary thereof, ternary, quaternary and five yuan of complex are made the bistable state quantum linear array of quantum bit, Kondo effect.
Described Nano medication self assembly bistable state quantum linear array component is: isoproterenol (Isoprenalini), adenosine triphosphate (adenonine triphoaphate), different rich pyridine (Verapamil), the geometric configuration of superoxide dismutase (Superoxide dismutase) and xanthine and optimization proportioning thereof.
Above-mentioned component optimum medicine concentration scope is:
Different rich pyridine (Verapamil) 20zeptoM to 0.001zeptoM,
Isoproterenol (Isoprenalini) 210zeptoM to 0.001zeptoM,
Superoxide dismutase (Superoxide dismutase) 1zeptoM to 0.001zeptoM,
Adenosine triphosphate (adenosine triphophate) 260zeptoM to 1zeptoM,
Xanthine (Xanthine) 50uM to 5mM.
The present invention utilizes non-resilient electron tunneling to interact to carry out the different pyridine of fighting of self assembly, isoproterenol, and superoxide dismutase, and/or adenosine triphosphate and xanthine, and two to pentamer Nano medication bistable state quantum linear array.This optimization MOLECULE DESIGN and self-assembling method based on the space geometry configuration not only are of value to discovering of original new drug, and are of value to the research invention of quantum information material.
Outstanding advantage of the present invention is that Nano medication is the quantum bit performance of base, and it is expressed by current-voltage curve and first derivative, electron spin, time-phase place-energy spectrum and frequency-phase place-energy spectrum; The feature identification of quantum bit performance is according to obtaining from the time-phase place-energy spectrum of Nano medication quantum wire and frequency-phase place-energy spectrum, be phase place experience nearly thousand to hundreds of or dozens of 90 degree to 180 degree electron spin processes, spin can be spent electron spin up to 906 90 degree and 302 180 in 1,000 microseconds.
The present invention adopts L16 (2) 15 and the design of L9 (3) 4 orthogonal optimum seekings, and the interaction of PCI Scanning Probe Microscopy and-4 degree low temperature self assemblies and ORINGIN work obtains quantum linear array.
Core component of the present invention is by isoproterenol (Isoprenalini), adenosine triphosphate (adennosine triphosphate), different rich pyridine (Verapamil), superoxide dismutase (Superoxidedismutase) and xanthine, press monomer, diploid, triplet, quaternary body and penton are prepared self-assembly system respectively
Wherein the unimolecule Nano medication is base with the xanthine, respectively by 1: 0: 0: 0; 0: 1: 0: 0; 0: 0: 1: 0; 0: 0: 0: 1 proportioning preparation isoproterenol, adenosine triphosphate, different rich pyridine, superoxide dismutase self-assembly system;
Wherein the diploid Nano medication is base with the xanthine, respectively by 1: 1: 0: 0; 1: 0: 1: 0; 1: 0: 0: 1; 0: 1: 0: 0; 0: 1: 0: 1; 0: 0: 1: 1 proportioning preparation isoproterenol, adenosine triphosphate, different rich pyridine, superoxide dismutase self-assembly system;
Wherein the triplet Nano medication is base with the xanthine, respectively by 1: 1: 1: 0; 1: 0: 1: 1; 1: 1: 0: 1; 0: 1: 1: 1 proportioning preparation isoproterenol, adenosine triphosphate, different rich pyridine, superoxide dismutase self-assembly system;
Wherein quaternary body Nano medication is base with the xanthine, respectively by 1: 1: 1: 1; 1: 2: 2: 2; 1: 3: 3: 3; 2: 1: 2: 3; 2: 2: 3: 1; 2: 3: 1: 2; 3: 1: 3: 2; 3: 2: 1: 3; 3: 3: 2: 1 proportioning preparation isoproterenol, adenosine triphosphate, different rich pyridine, superoxide dismutase self-assembly system.
Core component monomer of the present invention, diploid, triplet, the I-V curve of quaternary body and penton and different self-assembly systems thereof, first derivative and time-phase place-energy spectrum and frequency-phase place-energy spectrum forms the Nano medication quantum linear array of 25 group pattern data and 24 kinds of size adjustable, as: 1.4,1.6,1.8,2.0,2.5,3.0,3.5,4,5,6,7,8,10,12,14,16,20,25,30,35,40,50,60,70 nanometer line lengths.
Nano medication self assembly bistable state quantum linear array of the present invention has the geometric configuration rule, and yardstick is controllable, non-resilient electron tunneling, the variable electrology characteristic of electron spin speed.The present invention not only is of value to the original new drug development of targeting disease mechanisms, and is of value to the development of bio-compatible, the super quick quantum information sensing new material of ultra micro and nanostructured magnetic memory (MRAM) new unit.
The present invention prepares by following method and step,
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. prepare the different rich pyridine solution of hydrochloric acid
2. prepare isoprenaline solution
3. prepare superoxide dismutase physiology salt buffer
4. the physiology salt buffer for preparing adenosine triphosphate
5. get the each component solute number in the optimum concentration range respectively, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopt resistivity 8-12 Europe mother respectively. centimetre and 0.01-0.05 Europe mother. centimetre the P type and N-type silicon chip as the substrate of self assembly quantum wire, above-mentioned medicinal component is pressed L16 (2) 15 and L9 (3) 4 scheme self assemblies on silicon chip substrate, placed 96 hours for-4 ℃.
Description of drawings
Fig. 1 is that the self assembly xanthine is that the fore-telling structure chart is opened up on the Nano medication diploid quantum wire of base and the surface of thin film thereof on the N-type silicon chip.
Fig. 2 is that the self assembly xanthine reaches the ultrasonic Nano medication triplet quantum wire of 254 90 degree electron spin or 127 180 degree spin for base, quantum bit and the fore-telling structure chart is opened up on the surface of thin film on the N-type silicon chip.
Fig. 3 is that the self assembly xanthine is that the fore-telling structure chart is opened up on the non-volatile quantum bit Nano medication penton quantum wire of base and the surface of thin film thereof on the P type silicon chip.
Fig. 4 be on the P type silicon chip self assembly xanthine for the base, up to 906 90 the degree and 302 180 the degree or 151 360 the degree electron spin, optimum quantum bit Nano medication penton quantum wire and thin film thereof surfaces open up the fore-telling structure chart.
Fig. 5 is that the self assembly xanthine is opened up the fore-telling structure chart for base, quantum bit Nano medication penton quantum wire that electron spin phase place (0,90,180,360 degree) is adjustable and the surface of thin film thereof on the P type silicon chip.
Fig. 6 is that the self assembly xanthine is opened up the fore-telling structure chart for base, quantum bit Nano medication penton quantum wire that electron spin phase place (0,90,180,270 degree) is adjustable and the surface of thin film thereof on the P type silicon chip.
Fig. 7 be on the P type silicon chip self assembly xanthine for base ,+/-10V starts the Nano medication penton quantum wire of quantum bit and the fore-telling structure chart is opened up on the surface of thin film.
Fig. 8 be on the P type silicon chip self assembly xanthine for base ,+/-7,9V starts 0 degree-90 degree-180 degree respectively and 0 degree-90 degree-360 spend the Nano medication penton quantum wire of electron spin phase shift and the fore-telling structure chart is opened up on the surface of thin film.
Fig. 9 be on the P type silicon chip self assembly xanthine for base ,+/-7,8,9V starts 180 degree-90 degree respectively--360 degree and 0 degree-90 degree-360 spend the Nano medication penton quantum wire of electron spin phase shift and the fore-telling structure chart is opened up on the surface of thin film.
Figure 10 be corresponding diagram 1+/-2V starts quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum (d).
Figure 11 be corresponding diagram 2+/-9V starts 954 90 degree and 477 180 and spends electron spin, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum (d).
Figure 12 is corresponding diagram 3+/-6, and 8,9,10V starts non-volatile quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum (d).
Figure 13 is corresponding diagram 4+/-7,8,9,10V starts 180 degree-90 degree-180 degree and comes and goes electron spin, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum and frequency-phase place-energy spectrum (d).
Figure 14 is corresponding diagram 5+/-6, and 7,8,9,10V starts 0 degree-90 degree-360 degree and comes and goes electron spin, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum.
Figure 15 is corresponding diagram 6+/-8, and 9,10V starts 180 degree-90 degree-180 degree and comes and goes electron spin, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum (d).
Figure 16 be corresponding diagram 7+/-8V starts 0 degree-90 degree-180 degree and the round electron spin of 0 degree-90 degree-360 degree, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum (d) respectively.
Figure 17 is corresponding diagram 8+/-8,9,10V can start 0 degree-90 degree-180 degree and 0 degree-90 degree-360 degree come and go electron spin, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum.
Figure 18 is corresponding diagram 9+/-8,9,10V can start 0 degree-90 degree-360 degree and 180 degree-90 degree-360 degree come and go electron spin, quantum bit voltage-to-current curve (a), Kondo effect electric conductance (b), frequency-phase place-energy spectrum (c) and time-phase place-energy spectrum.
The specific embodiment
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 1: 1: 1: the best solute number of the each component in 1 ratio range, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 3) of 10nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+0.813 skin peace and-19.95 skins peace, and voltage is+/-8 volts (accompanying drawing 12a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-3.741 volts of its maximum conductance crests (seeing accompanying drawing 12b) of locating to occur 13.08854 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 0 to-1260 degree appears to the 7.2475E-12 hertz scope, the feature electron spin of 14 90 degree or 7 180 degree spins ultrasonic (spin echo) and 0.00603 electron-volt of Z-direction energy change (accompanying drawing 12c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows that occurring 0 to 1260 in 0 to the 1000 microsecond scope spends phase shift, visible Y-axis center, 513 microsecond places generation 14 90 degree feature electron spin or 7 180 degree spins ultrasonic (spin echo) and 0.00151 electron-volt of Z-direction energy change (accompanying drawing 12d) in the X-axis center; Accompanying drawing 12c and 12d disclose N (1/2 π ,-1/2 π) feature electron spin jointly and produce quantum bit.
Embodiment 2
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 1: 2: 2: the best solute number of the each component in 2 ratio ranges, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 4) of 4nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+20.71 skins peace and-27.053 skins peace, and voltage is+/-7 volts (accompanying drawing 13a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-2.376 volts of its maximum conductance crests (accompanying drawing 13b) of locating to occur 110.492 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 180 to-18180 degree appear to the 7.2475E-12 hertz scope, 99 90 degree or 33 3/2 π or 404 1/4 π feature electron spins and 0.04216 electron-volt of Z-direction energy change (accompanying drawing 13c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows and occurs 0 to 18540 degree phase shift in 0 to the 1000 microsecond scope, and 906 90 degree or 302 3/2 π or 412 1/4 π feature electron spins and 0.010541 electron-volt of Z-direction energy change (accompanying drawing 13d) take place visible Y-axis center, 513 microsecond places in the X-axis center; Accompanying drawing 13c and 13d disclose N (1/2 π, 1/4 π, 3/2 π ,-1/2 π ,-1/4 π ,-3/2 π) feature electron spin jointly and produce quantum bit.
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 1: 3: 3: the best solute number of the each component in 3 ratio ranges, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 5) of 3.5nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+1.021 skins peace and-23.998 skins peace, and voltage is+/-6 volts (accompanying drawing 14a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-1.917 volts of its maximum conductance crests (accompanying drawing 14b) of locating to occur 67.2825 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 0 to-11512 degree appears to the 7.2475E-12 hertz scope, the feature electron spin of 128 90 degree or 64 180 degree spins ultrasonic (spin echo) or 32 2 π phase shift and 0.01581 electron-volt of Z-direction energy change (accompanying drawing 14c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows and occurs 0 to 11512 degree phase shift in 0 to the 1000 microsecond scope, and the feature electron spin of 128 90 degree or 64 180 degree spins ultrasonic (spin echo) or 32 2 π phase shift and 0.00395 electron-volt of Z-direction energy change (accompanying drawing 14d) take place visible Y-axis center, 513 microsecond places in the X-axis center; Accompanying drawing 14c and 14d disclose N (1/2 π, π, 2 π ,-1/2 π ,-π ,-2 π) feature electron spin jointly and produce quantum bit.
Embodiment 4
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 2: 1: 2: the each component solute number in 3 ratio ranges, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 6) of 6nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+2.07 skins peace and-32.834 skins peace, and voltage is+/-10 volts (accompanying drawing 15a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-0.96 volt of its maximum conductance crest (accompanying drawing 15b) of locating to occur 53.2375 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 180 to-14580 degree appear to the 7.2475E-12 hertz scope, the feature electron spin of 162 90 degree or 81 180 degree spins ultrasonic (spin echo) and Z-direction energy change 9.58648E-9 electron-volts (accompanying drawing 15c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows that occurring 180 to 14940 in 0 to the 1000 microsecond scope spends phase shift, visible Y-axis center, 513 microsecond places generation 166 90 degree feature electron spin or 83 180 degree spins ultrasonic (spinecho) and 0.00298 electron-volt of Z-direction energy change (accompanying drawing 15d) in the X-axis center; Accompanying drawing 15c and 15d disclose jointly N (1/2 π, π ,-1/2 π ,-π) the feature electron spin produces quantum bit.
Embodiment 5
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 2: 2: 3: the each component solute number in 1 ratio range, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 7) of 8nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+20.723 skins peace and-27.549 skins peace, and voltage is+/-8 volts (accompanying drawing 16a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-0.223 volt of its maximum conductance crest (seeing accompanying drawing 16b) of locating to occur 55.54688 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 0 to-10800 degree appears to the 7.2475E-12 hertz scope, 120 90 degree or 40 3/2 π or 240 1/4 π feature electron spins or 60 180 degree spins ultrasonic (spinecho) and Z-direction energy changes 0 take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place.03332 electron-volt (accompanying drawing 16c); And time-phase place-energy collection of illustrative plates (TPP) shows and occurs 0 to 10800 degree phase shift in 0 to the 1000 microsecond scope, and 120 90 degree or 40 3/2 π or 240 1/4 π feature electron spins or 60 180 degree spins ultrasonic (spin echo) and 0.00833 electron-volt of Z-direction energy change (accompanying drawing 16d) take place visible Y-axis center, 513 microsecond places in the X-axis center; Accompanying drawing 16c and 16d disclose N (1/2 π, π, 3/2 π, 1/4 π ,-1/2 π ,-π ,-3/2 π ,-1/4 π) feature electron spin jointly and produce quantum bit.
Embodiment 6
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 3: 1: 3: the each component solute number in 2 ratio ranges, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 8) of 4.5nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+21.576 skins peace and-31.509 skins peace, and voltage is+/-7 volts (accompanying drawing 17a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-0.715 volt of its maximum conductance crest (accompanying drawing 17b) of locating to occur 63.5786 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 0 to-15480 degree appears to the 7.2475E-12 hertz scope, the feature electron spin of 172 90 degree or 81 180 degree spins ultrasonic (spin echo) and 0.05289 electron-volt of Z-direction energy change (seeing accompanying drawing 17c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows that occurring 0 to 15480 in 0 to the 1000 microsecond scope spends phase shift, visible Y-axis center, 513 microsecond places generation 172 90 degree feature electron spin or 81 180 degree spins ultrasonic (spin echo) and 0.01322 electron-volt of Z-direction energy change (accompanying drawing 17d) in the X-axis center; Accompanying drawing 17c and 17d disclose jointly N (1/2 π, π ,-1/2 π ,-π) the feature electron spin produces quantum bit.
Embodiment 7
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 3: 2: 1: the best solute number of the each component in 3 ratio ranges, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 8-12 Europe mother. centimetre P type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L9 (3) 4 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 9) of 50nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+5.478 skins peace and-25.614 skins peace, and voltage is+/-8 volts (accompanying drawing 18a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-1.096 volts of its maximum conductance crests (accompanying drawing 18b) of locating to occur 35.5468 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 180 to 23580 degree appear to the 7.2475E-12 hertz scope, 262 90 degree or 32 2 π feature electron spins or 64 180 degree spins ultrasonic (spin echo) and 0.01244 electron-volt of Z-direction energy change (accompanying drawing 17c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows that occurring 0 to-23220 in 180 to the 1000 microsecond scopes spends phase shift, 158 90 degree of visible Y-axis center, 513 microsecond places generation or 69 2 π feature electron spins or 78 180 degree spins ultrasonic (spin echo) and 0.00311 electron-volt of Z-direction energy change (accompanying drawing 18d) in the X-axis center; Accompanying drawing 18c and 18d disclose N (1/2 π, π, 2 π ,-1/2 π ,-π ,-2 π) feature electron spin jointly and produce quantum bit.
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 1: 2: 2: the best solute number of the each component in 1 ratio range, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 0.01-0.05 Europe mother. centimetre N-type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L16 (2) 15 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 1) of 3nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+/-34.581 skins peace, and voltage is+/-9 volts of accompanying drawing 10a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, its maximum conductance crest (seeing accompanying drawing 10b) of 140.51398 skins peace/volt namely occurs at-3.25 Fu Chu; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 0 to-19080 degree appears to the 7.2475E-12 hertz scope, the feature electron spin of 254 90 degree or 127 180 degree spins ultrasonic (spin echo) and 0.05027 electron-volt of Z-direction energy change (accompanying drawing 10c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows that occurring 0 to 19080 in 0 to the 1000 microsecond scope spends phase shift, visible Y-axis center, 513 microsecond places generation 254 90 degree feature electron spin or 127 180 degree spins ultrasonic (spin echo) and 0.0124 electron-volt of Z-direction energy change (accompanying drawing 10d) in the X-axis center; Accompanying drawing 10c and 10d disclose N (1/2 π ,-1/2 π) feature electron spin jointly and produce quantum bit.
Embodiment 9
The pharmacopeia standard of issuing by Ministry of Health of the People's Republic of China is formulated as follows medicinal liquid:
1. the different rich pyridine solution of preparation hydrochloric acid is 2.5 milligrams/5 milliliters
2. preparation contains 2 milligrams/100 milliliters isoprenaline solution
3. preparation contains 1 milligram/2 milliliters superoxide dismutase physiology salt buffers
4. preparation contains the physiology salt buffer of 20 milligrams/3.3 milliliters of adenosine triphosphate
5. got respectively 2: 1: 2: the best solute number of the each component in 2 ratio ranges, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, it is standby to put-4 ℃ of preservations.
6. adopting 0.01-0.05 Europe mother. centimetre N-type silicon chip with other Nano medication of above-mentioned pharmaceutical grade, is pressed L16 (2) 15 scheme self assemblies as the substrate of self assembly quantum wire on silicon chip substrate, places 96 hours for-4 ℃.
Visible height is the quantum linear array (accompanying drawing 2) of 16nm as a result; Current-voltage (I-V) curve display bistable state electricity characteristic height two horizontal stable current/voltages namely occur as+3.568 skins peace and-22.19 skins peace, and voltage is+/-2 volts (accompanying drawing 11a); Differential conductance collection of illustrative plates (dI/dV) discloses the quantization Kondo effect, namely at-0.874 volt of its maximum conductance crest (accompanying drawing 11b) of locating to occur 315.62 skins peace/volt; Frequency-phase place-energy collection of illustrative plates (FPP) shows+/-50000 the phase shift of 0 to 18540 degree appears to the 7.2475E-12 hertz scope, the feature electron spin of 206 90 degree or 103 180 degree spins ultrasonic (spin echo) and 0.14939 electron-volt of Z-direction energy change (accompanying drawing 11c) take place in visible Y-axis center, X-axis center 7.2475E-12 hertz place; And time-phase place-energy collection of illustrative plates (TPP) shows that occurring 0 to-18180 in 0 to the 1000 microsecond scope spends phase shift, visible Y-axis center, 513 microsecond places generation 202 90 degree feature electron spin or 101 180 degree spins ultrasonic (spin echo) and 0.01116 electron-volt of Z-direction energy change (accompanying drawing 11d) in the X-axis center; Accompanying drawing 11c and 11d disclose N (1/2 π ,-1/2 π) feature electron spin jointly and produce quantum bit.
Claims (3)
1. single molecules level Nano medication self assembly bistable state quantum linear array, it is characterized in that Nano medication bistable state quantum linear array component is interacted by non-resilient electron tunneling by xanthine and different rich pyridine, isoproterenol, superoxide dismutase and adenosine triphosphate and certain proportioning is self-assembled into penton Nano medication complex, make the bistable state quantum linear array of quantum bit, Kondo effect;
Described penton Nano medication complex adopts L16 (2) 15 and the design of L9 (3) 4 orthogonal optimum seekings and-4 degree low temperature self assemblies on P-type or N-type silicon chip substrate, and corresponding voltage-to-current curve, Kondo effect electric conductance, frequency-phase place-energy spectrum and time-phase place-energy spectrum, electron spin, the quantum bit of the surface topology geometric configuration height of described penton Nano medication complex and described surface topology obtains by the interaction of PCI Scanning Probe Microscopy and ORINGIN work;
Geometric configuration height shown in the described penton Nano medication composite surface topology diagram is respectively 3.5nm, 4.0nm, 4.5nm, 6nm, 8nm, 10nm or 50nm, described penton Nano medication complex has bistable state electricity characteristic, electron spin, quantization Kondo effect, described electron spin be ± 1/4 π N, ± 1/2 π N, ± π N, ± 3/2 π N or ± 2 π N;
Described bistable state electricity characteristic is ± 6 volts, ± 7 volts, ± 8 volts or ± height two horizontal stable electric currents appear in 10 Fu Chu :+5.478 skins peace ,-25.614 skins peace; + 21.576 skins peace ,-31.509 skins peace; + 20.723 skins peace ,-27.549 skins peace; + 2.07 skins peace ,-32.834 skins peace; + 1.021 skins peace ,-23.998 skins peace; + 20.71 skins peace ,-27.053 skins peace; Or ,+0.813 skin peace ,-19.95 skins peace;
Described quantum bit performance is expressed by current-voltage curve and first derivative, electron spin, time-phase place-energy spectrum and frequency-phase place-energy spectrum;
Described electron spin obtains from frequency-phase place-energy spectrum and time-phase place-energy spectrum;
Described ± 1/4 π N, ± 1/2 π N, ± π N, ± 3/2 π N or ± 2 π N electron spins produces quantum bit;
Described penton Nano medication complex is that xanthine is base;
Described xanthine is that different rich pyridine, isoproterenol, superoxide dismutase and the adenosine triphosphate penton of base pressed 1: 1: 1 respectively: 1; 1: 2: 2: 2; 1: 3: 3: 3; 2: 1: 2: 3; 2: 2: 3: 1; 2: 3: 1: 2; 3: 1: 3: 2; 3: 2: 1: 3 or 3: 3: 2: 1 solute was counted proportioning configuration self assembly;
Penton Nano medication complex on described P-type or the N-type silicon chip substrate is that xanthine is the isoproterenol of base, adenosine triphosphate, different rich pyridine, superoxide dismutase Nano medication complex is the geometric configuration of Nano medication quantum linear array by certain optimization proportioning self assembly, described xanthine is the isoproterenol of base, adenosine triphosphate, different rich pyridine and the geometric configuration of superoxide dismutase Nano medication composite surface topological structure and the corresponding electron spin of geometric configuration of described Nano medication composite surface topological structure, the quantum bit current-voltage curve, the Kondo effect electric conductance, frequency-phase place-energy spectrum and time-phase place-energy spectrum is optimized the proportioning self assembly in following each component drug level scope:
Different rich pyridine 0.001zeptoM to 20zeptoM,
Isoproterenol 0.001zeptoM to 210zeptoM,
Superoxide dismutase 0.001zeptoM to 1zeptoM,
Adenosine triphosphate 1zeptoM to 260zeptoM and
Xanthine 50 μ M to 5mM.
2. the described single molecules level Nano medication of claim 1 self assembly bistable state quantum linear array is used for development bio-compatible, the super quick quantum information sensing new material of ultra micro and nanostructured magnetic memory new unit.
3. the preparation method of the described a kind of single molecules level Nano medication self assembly bistable state quantum linear array of claim 1, this method comprises the steps:
(a) be formulated as follows medicinal liquid respectively:
1) the different rich pyridine solution of preparation hydrochloric acid,
2) preparation isoprenaline solution,
3) preparation superoxide dismutase physiology salt buffer,
4) the physiology salt buffer of preparation adenosine triphosphate,
5) preparation xanthine buffer;
(b) get each component solute number in the optimum concentration range respectively, after evenly mixing under the room temperature, add physiology salt buffer solution to 1 milliliter, put-4 ° of C and preserve standby;
(c) adopt the female * centimetre of P type silicon chip of the female * centimetre of N-type in 0.01-0.05 Europe or 8-12 Europe as the substrate of self-assembled nanometer medicine quantum wire, with other above-mentioned each component of pharmaceutical grade, press L16 (2) 15 and L9 (3) 4 scheme self assemblies respectively on above-mentioned silicon chip substrate ,-4 ° of C placed 96 hours;
Each component solute number in the optimum concentration range described in the step (b) is selected from following concentration range respectively:
Different rich pyridine 0.001zeptoM to 20zeptoM,
Isoproterenol 0.001zeptoM to 210zeptoM,
Superoxide dismutase 0.001zeptoM to 1zeptoM,
Adenosine triphosphate 1zeptoM to 260zeptoM and
Xanthine 50 μ M to 5mM;
L16 (2) 15 described in the step (c) and L9 (3) 4 schemes, be that basic different rich pyridine, isoproterenol, superoxide dismutase and adenosine triphosphate formed by xanthine respectively, described xanthine is that different rich pyridine, isoproterenol, superoxide dismutase and the adenosine triphosphate Nano medication complex of base pressed 1: 1: 1 respectively: 1; 1: 2: 2: 2; 1: 3: 3: 3; 2: 1: 2: 3; 2: 2: 3: 1; 2: 3: 1: 2; 3: 1: 3: 2; 3: 2: 1: 3 or 3: 3: 2: 1 proportioning preparation self-assembled nanometer medicine bistable state quantum linear array.
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