CN102166258A - Preparation method of slow-release micropill with mulberry leaf extract - Google Patents
Preparation method of slow-release micropill with mulberry leaf extract Download PDFInfo
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- CN102166258A CN102166258A CN2010105576832A CN201010557683A CN102166258A CN 102166258 A CN102166258 A CN 102166258A CN 2010105576832 A CN2010105576832 A CN 2010105576832A CN 201010557683 A CN201010557683 A CN 201010557683A CN 102166258 A CN102166258 A CN 102166258A
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- folium mori
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- mori extract
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Abstract
The invention discloses a preparation method of a slow-release micropill with mulberry leaf extract, which comprises the following steps: (1) proportionally and evenly mixing a filler, a binder and a lubricant to prepare a smooth spherical blank pill core of 20-30 meshes; (2) preparing the mulberry leaf extract and a high molecular material binder into a mixed solution, and coating the mixed solution at the outer layer of the blank pill core to prepare a quick-release micropill; and (3) dissolving a retarder, a hole former and a plasticizer with a coating solvent, and then, spraying at the outer layer of the quick-release micropill to prepare the slow-release micropill. The weight increment of the slow-release micropill is controlled to be 5-25%. The slow-release micropill prepared by the invention can be effectively controlled to be released in a certain period of time, the effective blood concentration can be maintained for 24 hours, and no burst-release phenomenon occurs, thereby greatly enhancing the effect of the mulberry leaf extract on a human body. The method disclosed by the invention is simple to operate and is easy to realize industrialized production.
Description
Technical field
The present invention relates to the medicine food technical field, be specifically related to a kind of preparation method of Folium Mori extract slow-release micro-pill.
Background technology
The wild buttocks doctor of Japan scientist has carried out reaching the research in 20 years to Folium Mori, that wherein human body is played a role is a kind of magical composition-DNJ that contains in the Folium Mori, and per 20 kilograms of Folium Mori could extract 1 gram DNJ, and are also more precious than gold, so it has the title of nature " diamond " again!
DNJ full name 1-deoxynojirimycin can see that under ultramicroscope DNJ divides in structure very similar to glucose, only " oxygen " on strand of glucose is changed into " nitrogen ".This just distinctive molecular structure, allow DNJ can effectively control food is converted into blood glucose in small intestinal speed and quantity, make the rising of blood sugar for human body become gentler, more steady, thereby effectively solved the islets of langerhans problem that over-burden, the islets of langerhans Reduction of Students' Study Load become a reality! DNJ is with its unique effects, rapid fashionable Japan! Countless diabeticss are by taking DNJ, and islet function has recovered more than 70%! 100% patient reduces insulin dosage, part patient even thoroughly broken away from medicine! Complication rate is more and more lower especially!
Shortcomings such as at present, be subjected to consumers in general's approval deeply about the product of Folium Mori extract, these products are common tablet and capsule substantially, and these dosage forms cause blood concentration fluctuation big, and the drug action time is short, and bioavailability is low.
Summary of the invention
The objective of the invention is provides a kind of Folium Mori extract slow-release micro-pill in order to overcome shortcoming and defect of the prior art.This slow-release micro-pill can be kept effective blood drug level in vivo in 24 hours, thereby can 24 hours glucose level control.
A kind of Folium Mori extract slow-release micro-pill, make with following method:
(1) with filler and binding agent, be 20-30 purpose granule with comminutor granulation and pill-rolling to particle diameter, pill-rolling limit, limit adds lubricant, and oven dry makes smooth circular celphere; The mass ratio of described filler, binding agent and lubricant is 3-8: 2-4: 1-3;
(2) Folium Mori extract is added polymeric adhesive material, add water or ethanol water again and make first kind of mixed liquor; The mass ratio of described Folium Mori extract, polymeric adhesive material and water or ethanol water is 2-4: 1-3: 8-20;
(3) described celphere is placed on the fluid bed, make the temperature of ball core be controlled at 25 ℃-50 ℃, the skin that described first kind of mixed liquor is coated on described celphere is made the micropill that has release layer;
(4) blocker, porogen, plasticizer are added water or ethanol water and be mixed with second kind of mixed liquor; The mass ratio of described blocker, porogen, plasticizer and water or ethanol water is 1-10: 2-4: 1-3: 10-25;
(5) the described micropill that has release layer is placed on the fluid bed, make the temperature of the micropill that has release layer be controlled at 25 ℃-45 ℃, second kind of mixed liquor is sprayed on the described micropill, and the weight ratio of making celphere, release layer, slow release layer is the Folium Mori extract slow-release micro-pill of 2-6: 3-8: 1-4.
Described filler is that dextrin, starch, microcrystalline Cellulose and lactose are at least a.
Described binding agent is that sucrose, methylcellulose, carboxymethyl cellulose are at least a.
Described lubricant is that Pulvis Talci, stearic acid, magnesium stearate and colloidal silica are at least a.
Described polymeric adhesive material is hydroxypropyl emthylcellulose or polyvinylpyrrolidone.
Described blocker is ethyl cellulose or acrylic resin.
Described porogen is carboxymethyl cellulose, lactose or Polyethylene Glycol.
Described plasticizer is diethyl phthalate, triethyl citrate or dibutyl sebacate.
The weight ratio of described celphere, release layer, slow release layer is 3: 5: 2.
Advantage of the present invention is:
The slow-release micro-pill of the present invention's preparation can effectively be controlled medicine and discharge in the regular hour, keeps 24 hours effective blood drug concentration, does not have the prominent phenomenon of releasing and takes place, thereby strengthened the effect of Folium Mori extract to human body greatly.Method of the present invention is simple to operate, easily realizes suitability for industrialized production.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of preparation method of Folium Mori extract slow-release micro-pill comprises the steps:
(1) get 100 gram starch and 100 gram microcrystalline Cellulose mix homogeneously, add 70 gram sucrose, the use comminutor is granulated and pill-rolling to required order is counted the 20-30 order, and pill-rolling limit, limit adds 30 and restrains Pulvis Talci, and oven dry makes slick celphere.
(2) 300 gram Folium Mori extracts and 200 gram polyvinylpyrrolidones are joined in the 2L water, made into uniform solution in ultrasonic 20 minutes, on fluid bed, 40 ℃ of the temperature of maintenance celphere evenly are sprayed at the celphere skin with this solution, make fast release micropill.
(3) 120 gram ethyl celluloses, 40 gram carboxymethyl celluloses and 40 gram diethyl phthalates are joined in the 0.5L water, made into uniform solution in ultrasonic 20 minutes, on fluid bed, 40 ℃ of the temperature of maintenance fast release micropill, this solution evenly is sprayed at the fast release micropill skin, makes slow-release micro-pill.
We find that by the release in vitro simulation test its release profiles is obvious with this product, and when 4h, release is 20%; During 8h, release is more than 50%; During 12h, release is 75%; During 16h, release is 80%; During 20h, release is 88%; During 24h, release is 92%.
Annotate: the present invention's concrete technical scheme required for protection is not limited to the concrete combination of the expressed technical scheme of the foregoing description.
Claims (9)
1. Folium Mori extract slow-release micro-pill is characterized in that making with following method:
(1) with filler and binding agent, be 20-30 purpose granule with comminutor granulation and pill-rolling to particle diameter, pill-rolling limit, limit adds lubricant, and oven dry makes smooth circular celphere; The mass ratio of described filler, binding agent and lubricant is 3-8: 2-4: 1-3;
(2) Folium Mori extract is added polymeric adhesive material, add water or ethanol water again and make first kind of mixed liquor; The mass ratio of described Folium Mori extract, polymeric adhesive material and water or ethanol water is 2-4: 1-3: 8-20;
(3) described celphere is placed on the fluid bed, make the temperature of ball core be controlled at 25 ℃-50 ℃, the skin that described first kind of mixed liquor is coated on described celphere is made the micropill that has release layer;
(4) blocker, porogen, plasticizer are added water or ethanol water and be mixed with second kind of mixed liquor; The mass ratio of described blocker, porogen, plasticizer and water or ethanol water is 1-10: 2-4: 1-3: 10-25;
(5) the described micropill that has release layer is placed on the fluid bed, make the temperature of the micropill that has release layer be controlled at 25 ℃-45 ℃, second kind of mixed liquor is sprayed on the described micropill, and the weight ratio of making celphere, release layer, slow release layer is the Folium Mori extract slow-release micro-pill of 2-6: 3-8: 1-4.
2. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described filler is that dextrin, starch, microcrystalline Cellulose and lactose are at least a.
3. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described binding agent is that sucrose, methylcellulose, carboxymethyl cellulose are at least a.
4. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described lubricant is that Pulvis Talci, stearic acid, magnesium stearate and colloidal silica are at least a.
5. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described polymeric adhesive material is hydroxypropyl emthylcellulose or polyvinylpyrrolidone.
6. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described blocker is ethyl cellulose or acrylic resin.
7. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described porogen is carboxymethyl cellulose, lactose or Polyethylene Glycol.
8. a kind of Folium Mori extract slow-release micro-pill according to claim 1 is characterized in that described plasticizer is diethyl phthalate, triethyl citrate or dibutyl sebacate.
9. a kind of Folium Mori extract slow-release micro-pill according to claim 1, the weight ratio that it is characterized in that described celphere, release layer, slow release layer is 3: 5: 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105576832A CN102166258A (en) | 2010-11-23 | 2010-11-23 | Preparation method of slow-release micropill with mulberry leaf extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105576832A CN102166258A (en) | 2010-11-23 | 2010-11-23 | Preparation method of slow-release micropill with mulberry leaf extract |
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| CN102166258A true CN102166258A (en) | 2011-08-31 |
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| CN2010105576832A Pending CN102166258A (en) | 2010-11-23 | 2010-11-23 | Preparation method of slow-release micropill with mulberry leaf extract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281271A (en) * | 2016-04-12 | 2017-10-24 | 长沙三友医药科技有限公司 | A kind of DNJ sustained release preparation and preparation method thereof |
| CN107789391A (en) * | 2016-08-30 | 2018-03-13 | 长沙三友医药科技有限公司 | A kind of Mulberry plant extract slow-release preparation and its preparation method and application |
| CN113855642A (en) * | 2021-11-25 | 2021-12-31 | 中合泰克(南京)生物科技有限公司 | Blood sugar reducing sustained release tablet and preparation method thereof |
-
2010
- 2010-11-23 CN CN2010105576832A patent/CN102166258A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281271A (en) * | 2016-04-12 | 2017-10-24 | 长沙三友医药科技有限公司 | A kind of DNJ sustained release preparation and preparation method thereof |
| CN107789391A (en) * | 2016-08-30 | 2018-03-13 | 长沙三友医药科技有限公司 | A kind of Mulberry plant extract slow-release preparation and its preparation method and application |
| CN113855642A (en) * | 2021-11-25 | 2021-12-31 | 中合泰克(南京)生物科技有限公司 | Blood sugar reducing sustained release tablet and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20110831 |