CN102160858B - Edible film and manufacturing method thereof - Google Patents
Edible film and manufacturing method thereof Download PDFInfo
- Publication number
- CN102160858B CN102160858B CN201110042920.6A CN201110042920A CN102160858B CN 102160858 B CN102160858 B CN 102160858B CN 201110042920 A CN201110042920 A CN 201110042920A CN 102160858 B CN102160858 B CN 102160858B
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- CN
- China
- Prior art keywords
- solution
- polyethylene glycol
- sugar
- edible film
- polyvinyl alcohol
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
Abstract
The invention relates to a method for manufacturing edible films. The edible film is used for biologically active substances of oral administration, particularly drugs. The method comprises the following steps: (a) polyethylene glycol and sugar are dissolved in water; (b) glycerol is added and mixed with the polyethylene glycol-sugar solution; (c) polyvinyl alcohol particles are dissolved in water; (d) once polyvinyl alcohol solution is uniform, the polyethylene glycol-sugar-glycerol solution is added to the polyvinyl alcohol solution and the components are mixed together; (e) the rice starch is stirred into the above solution; (f) the obtained solution is heated to at least 70 DEG C, preferably heated to 80 - 85 DEG C during the stirring process; (g) the obtained solution is cooled to below 45 DEG C. The invention also relates to an edible film, which comprises the following components: about 12-15 wt % of rice starch, preferably 13-14 wt %, especially 13.4 wt %; about 8-11 wt% of polyethylene glycol, preferably 9-10 wt %, especially 9.5 wt %; about 8 -12 wt % of polyvinyl alcohol, preferably 9-11 wt %, especially 10 wt %; about 5-8 wt % of glycerol, preferably 6-7 wt %, especially 6.8 wt %; about 4-7 wt % of sugar, preferably 5-6 wt % , especially 5.4 wt %.
Description
Technical field
The present invention relates to a kind of edible film for oral bioactive substance, particularly medicine, the invention still further relates to the method for making this edible film.
Background technology
Edible film is for example for providing food additive taking exact dose as food processing enterprises, as food coloring, flavouring agent, ferment and cold drink batching.These food additive, and are joined in food by direct quantitative dispensing to edible film together with edible film.This edible film can be dissolved in water conventionally completely within one minute.
Except above-mentioned application target, edible film also can be used for exact dose oral bioactive substance, particularly medicine recently.This is also application of the present invention., effective medical components is applied on an edible film for this reason, and covers upper the second film when needed.By the edible film that is equipped with bioactive substance being put into mouth and resting on there until edible film dissolves, receive described effective ingredient.
Up to now, normally tablet or capsule of oral drugs.But, for reaching the medical effect of hope, need to carry out effective ingredient described in rationing with high precision, wherein a lot of effective ingredient often only need to add the minimum amount of several micrograms.
On the other hand, for convenience of people's to be treated operation, tablet or capsule have certain minimum dimension or minimum mass conventionally.Correspondingly, effectively medical components will mix quite a large amount of filleies or binding agent to produce tablet or capsule.These materials are necessary for human body and effectively medical components institute is compatible, thus sizable cost factor when its production and supply are also patent medicine production.In addition, also need effective medical components and supplementary element or binding agent fully to mix, this needs expensive machine.Finally, successfully treating often hope for one only needs oral than the few effective ingredient unit of amount of effective ingredient contained in a slice tablet or capsule.But tablet described in cut almost can not realize want and even necessary precision where necessary.
Alternatively, oral drugs can be also liquid form (" drops "), but this form has the application limitation of himself, and are not suitable for all patients.
Under this background, also having occurred for the previous period can be as the edible film in this area of effective medical components carrier material.Because effective medical components can be applied on the surface of this edible film in the mode distributing the most subtly, therefore can carry out the effective medical components of rationing with minimum amount and very high precision.So the unit are of edible film with regard to the utmost point accurately corresponding to the effective given dose of medical components.The example of this class edible film for example can be with reference to US 2004/0136923A1 and EP 1306071B1.
Summary of the invention
The object of the invention is, the manufacture method of another kind of edible film is provided, this edible film is for oral bioactive substance, and application target provides a kind of use edible film that described manufacture method is made for this reason.
Described object realizes by having the method for feature of claim 1 and the edible film with the feature of claim 14.In claim 2 to 13, provide the favourable design of the method; The suitable improvement project of edible film of the present invention has been described in claim 15.
,, first by soluble in water to Polyethylene Glycol and sugar and then glycerol is sneaked in formed polyvinyl alcohol-sugar solution for making the method for the edible film of oral bioactive substance of the present invention.During this period, before or after, granule of polyvinyl alcohol is dissolved in water.Once poly-vinyl alcohol solution is even, just Polyethylene Glycol-sugar-glycerite is joined in poly-vinyl alcohol solution, these components are mixed.Next in formed solution, stir/be in harmonious proportion into rice starch.The solution forming is thus heated to at least 70 DEG C in the situation that stirring, is preferably heated to 80～85 DEG C, be preferably noted that described solution does not heat here and exceed 85 DEG C.Finally mixture is cooled to 45 DEG C following or be cooled to and can form edible film, then just can continue further to have processed.
The weight rate of the edible film component that used is in the methods of the invention preferably as follows:
Rice starch: the preferred 13-14% of about 12-15% especially 13.4%
Polyethylene Glycol: the preferred 9-10% of about 8-11% especially 9.5%
Polyvinyl alcohol: the preferred 9-11% of about 8-12% especially 10%
Glycerol: the preferred 6-7% of about 5-8% especially 6.8%
Sugar: the preferred 5-6% of about 4-7% especially 5.4%
Water: the preferred 50-60% of about 40-70% especially 55%.
Correspondingly, edible film of the present invention comprises the component as follows with following relative weight ratio:
Rice starch: the preferred 13-14% of about 12-15% especially 13.4%
Polyethylene Glycol: the preferred 9-10% of about 8-11% especially 9.5%
Polyvinyl alcohol: the preferred 9-11% of about 8-12% especially 10%
Glycerol: the preferred 6-7% of about 5-8% especially 6.8%
Sugar: the preferred 5-6% of about 4-7% especially 5.4%.
At this, the moisture of edible film of the present invention depends on drying condition, and can change.The thickness of edible film of the present invention is preferably between approximately 60 microns to approximately 100 microns.
In a kind of preferred version of the inventive method, adopt following methods by soluble in water to Polyethylene Glycol and sugar: first water (approximately 1/3rd of preferred institute's water consumption altogether) to be called in Polyethylene Glycol, just add sugar after dissolving completely and dissolve etc. all Polyethylene Glycol, wherein sugar should be Powdered aptly.
According to another excellent scheme of the inventive method, in the following ways that granule of polyvinyl alcohol is soluble in water: in the situation that stirring, granule of polyvinyl alcohol all to be put into water, and be particularly heated to about 50 DEG C, so that dissolve very fast.Here preferably use approximately 2/3rds of institute's water consumption altogether.
According to another preferred version of the inventive method, Polyethylene Glycol-sugar-glycerite mixes by stirring and carry out under vacuum environment with poly-vinyl alcohol solution, avoids thus producing bubble.
In another preferred version of the inventive method, rice starch is stirred in solution bit by bit.This preferably at room temperature carries out, to prevent rice starch caking.
According to another preferred version of the inventive method, be stirred into after rice starch agitating solution at least 10 minutes, preferably approximately 15 minutes, to guarantee abundant mixing.Here also preferably make solution keep at room temperature.
Ensuing formed solution is heated to at least 70 DEG C, preferably preferably under homogenizer auxiliary, carries out to the process of 80 DEG C, wherein carry out where necessary active cooling, exceed 85 DEG C to prevent that solution is warmed up to.
According to another preferred version of the inventive method, filter being heated to the solution fie screen generating after preferred approximately 80 DEG C, to remove the fritter that may exist, these fritters may be by not having consoluet rice starch to form.
Then, biological active matter mass-energy just adds and is processed into edible film after edible film solution is cooled to the highest 45 DEG C, or after making edible film, bioactive substance is applied on this edible film.After this, edible film is preferably coated and particularly approximately 8 DEG C and cooling preservation in the situation that relative air humidity is approximately 30% particularly.
Detailed description of the invention
Embodiment:
Batching:
Rice starch 13.4% 80.5g
Polyethylene Glycol (PEG) 9.5% 56.7g
Polyvinyl alcohol (Mowiol) 10% 60g
Glycerol 6.8% 40.5g
Sugar (powder) 5.4% 32.1g
Water 55% 330g
100% 600g altogether
Make flow process:
1. first, granule of polyvinyl alcohol is dissolved in about 2/3rds water.To in the situation that stirring, all granule of polyvinyl alcohol be put into water immediately for this reason.In order to dissolve quickly, perhaps to heat slightly (to approximately 50 DEG C).
2. Polyethylene Glycol and sugar are dissolved in 1/3rd remaining water.Weigh Polyethylene Glycol for this reason, add water, and constantly stir, until this polymer all dissolves.
3. and then add the sugar (being Powdered) of aequum, make equally its dissolving.
4. glycerol is added in described solution, described each component is mixed.
5. once poly-vinyl alcohol solution is even, just add Polyethylene Glycol-sugar-glycerite, all these are mixed with each other well.In this step, advantageously, under vacuum environment, stir, can avoid producing thus bubble.
6. adding before rice starch, solution entirety should drop to room temperature, this be because otherwise starch can lump.
7. rice starch will be stirred in described polymer solution bit by bit well.
8. then advantageously, at room temperature stir whole solution 15 minutes, fully to mix.
9. last, in the situation that stirring, described mixture is heated to 80 DEG C, wherein work by homogenizer during this period.But said solution should not be heated to and exceed 85 DEG C (may from external refrigeration).
10. ready-made edible film solution also should filter with fie screen, to remove fritter (undissolved starch).
11. adding before effective medical components, and edible film solution should at least be cooled to 45 DEG C.Just effective ingredient can be added afterwards.
12. at this moment edible film solution just can be used for being coated with.In the situation of airtight and cooling (8 DEG C, air humidity 30%), can preserve about one week.
The 13. coat thickness that can reach are between 60 to 100 μ m.
Claims (22)
1. for making a method for edible film, this edible film is for oral bioactive substance, and the method comprises the following steps:
(a) by soluble in water to Polyethylene Glycol and sugar,
(b) glycerol is added and is mixed in Polyethylene Glycol-sugar solution,
It is (c) granule of polyvinyl alcohol is soluble in water,
(d) once poly-vinyl alcohol solution is even, just Polyethylene Glycol-sugar-glycerite added and is mixed in poly-vinyl alcohol solution, and making each component mix homogeneously,
(e) rice starch is stirred in described solution,
(f) in the situation that stirring, formed solution is heated to at least 70 DEG C,
(g) this solution is cooled to below 45 DEG C,
Wherein, described component is used following weight rate:
Rice starch: 12-15%,
Polyethylene Glycol: 8-11%,
Polyvinyl alcohol: 8-12%,
Glycerol: 5-8%,
Sugar: 4-7%,
Water: 40-70%,
All components content percent sum is 100%.
2. method according to claim 1, is characterized in that, this bioactive substance is medicine.
3. method according to claim 1, is characterized in that, in step (f), formed solution is heated to 80～85 DEG C.
4. according to the method in any one of claims 1 to 3, it is characterized in that, described component is used following weight rate:
Rice starch: 13-14%
Polyethylene Glycol: 9-10%
Polyvinyl alcohol: 9-11%
Glycerol: 6-7%
Sugar: 5-6%
Water: 50-60%,
All components content percent sum is 100%.
5. method according to claim 4, is characterized in that, described component is used following weight rate:
Rice starch: 13.4%,
Polyethylene Glycol: 9.5%,
Polyvinyl alcohol: 10%,
Glycerol: 6.8%,
Sugar: 5.4%,
Water: 55%.
6. according to the method in any one of claims 1 to 3, it is characterized in that, in step (a), water is called in Polyethylene Glycol, after Polyethylene Glycol all dissolves, just add and dissolve sugar.
7. method according to claim 6, is characterized in that, 1/3rd water is used for dissolving Polyethylene Glycol.
8. according to the method in any one of claims 1 to 3, it is characterized in that, in step (c), granule of polyvinyl alcohol is all put into water in the situation that stirring, and be heated to 50 DEG C.
9. method according to claim 8, is characterized in that, described granule of polyvinyl alcohol is dissolved in 2/3rds water.
10. according to the method in any one of claims 1 to 3, it is characterized in that, in step (d), each component by stirring and mix under vacuum.
11. according to the method in any one of claims 1 to 3, it is characterized in that, in step (e), rice starch is stirred in solution bit by bit, and wherein this solution remains on room temperature.
12. according to the method in any one of claims 1 to 3, it is characterized in that, and between step (e) and step (f), the solution that stirring forms at least 10 minutes.
13. methods according to claim 12, is characterized in that, between step (e) and step (f), and the solution that stirring forms 15 minutes.
14. according to the method in any one of claims 1 to 3, it is characterized in that, adopts homogenizer to carry out work in step (f).
15. according to the method in any one of claims 1 to 3, it is characterized in that, after step (f), formed solution filtered.
16. according to the method in any one of claims 1 to 3, it is characterized in that, after completing steps (g), bioactive substance is applied in the solution forming when cooling.
17. methods according to claim 16, is characterized in that, are equipped with the described solution of bioactive substance coated and in the situation that being cooled, at 8 DEG C and preserve in the situation that relative air humidity is 30%.
18. 1 kinds of edible films, this edible film is used for oral bioactive substance, it is characterized in that, and described edible film comprises the following component with following relative weight ratio:
Rice starch: 12-15%,
Polyethylene Glycol: 8-11%,
Polyvinyl alcohol: 8-12%,
Glycerol: 5-8%,
Sugar: 4-7%,
Wherein said edible film is made by the method for any one in claim 1 to 17.
19. edible films according to claim 18, is characterized in that, described bioactive substance is medicine.
20. edible films according to claim 18, is characterized in that, described edible film comprises the following component with following relative weight ratio:
Rice starch: 13-14%
Polyethylene Glycol: 9-10%,
Polyvinyl alcohol: 9-11%,
Glycerol: 6-7%,
Sugar: 5-6%.
21. edible films according to claim 18, is characterized in that, described edible film comprises the following component with following relative weight ratio:
Rice starch: 13.4%,
Polyethylene Glycol: 9.5%,
Polyvinyl alcohol: 10%,
Glycerol: 6.8%,
Sugar: 5.4%.
22. according to claim 18 to the edible film described in any one in 21, it is characterized in that, the film thickness of described edible film is between 60 μ m to 100 μ m.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010009071.9 | 2010-02-23 | ||
| DE102010009071A DE102010009071A1 (en) | 2010-02-23 | 2010-02-23 | Preparing edible film useful for oral bioactivator, involves dissolving polyethylene glycol and sugar in water, and adding and mixing glycerol with polyethylene glycol-sugar solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102160858A CN102160858A (en) | 2011-08-24 |
| CN102160858B true CN102160858B (en) | 2014-07-30 |
Family
ID=44462484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110042920.6A Active CN102160858B (en) | 2010-02-23 | 2011-02-23 | Edible film and manufacturing method thereof |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN102160858B (en) |
| DE (1) | DE102010009071A1 (en) |
| HK (1) | HK1157248A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2866592T3 (en) | 2012-06-28 | 2017-01-31 | Optimags Dr Zimmermann Gmbh | Method for producing a film formulation for an edible film, and the use thereof |
| CN105962377B (en) * | 2016-05-06 | 2019-03-19 | 华侨大学 | A kind of preparation method carrying high-activity probiotics edible film |
| US10058531B1 (en) | 2017-06-01 | 2018-08-28 | Spartak LLC | Dosage delivery film |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1687204A (en) * | 2005-03-31 | 2005-10-26 | 方墉 | Total biodegradable film and preparation method |
| WO2007118280A1 (en) * | 2006-04-18 | 2007-10-25 | Plantic Technologies Limited | Polymeric films |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962715B2 (en) | 2001-10-24 | 2005-11-08 | Hewlett-Packard Development Company, L.P. | Method and dosage form for dispensing a bioactive substance |
| JP2006515598A (en) | 2002-11-14 | 2006-06-01 | イノゼン・インコーポレイテッド | Edible film to reduce cough or pharyngitis related symptoms |
-
2010
- 2010-02-23 DE DE102010009071A patent/DE102010009071A1/en active Pending
-
2011
- 2011-02-23 CN CN201110042920.6A patent/CN102160858B/en active Active
- 2011-11-03 HK HK11111877.2A patent/HK1157248A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1687204A (en) * | 2005-03-31 | 2005-10-26 | 方墉 | Total biodegradable film and preparation method |
| WO2007118280A1 (en) * | 2006-04-18 | 2007-10-25 | Plantic Technologies Limited | Polymeric films |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102160858A (en) | 2011-08-24 |
| DE102010009071A1 (en) | 2011-10-06 |
| HK1157248A1 (en) | 2012-06-29 |
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