CN102160854A - Cyclodextrin-included florfenicol quick-release water-soluble powder preparation and preparation method thereof - Google Patents
Cyclodextrin-included florfenicol quick-release water-soluble powder preparation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a cyclodextrin-included florfenicol quick-release water-soluble powder preparation and a preparation method thereof. The preparation is prepared by stirring florfenicol, cyclodextrin and water at a uniform speed and including by using an inclusion technology. The preparation can be directly dissolved in water to be taken by livestock, and has the characteristics of high medicine dissolution rate, high dissolubility, high bioavailability, good absorption and the like; and the medicine (florfenicol) is included in a carrier material, the bitterness of the florfenicol can be masked, and the intake or drinking of animals cannot be influenced by the bitterness of the medicine.
Description
Technical field
The present invention relates to a kind of florfenicol water-soluble powder preparation technique field of animal specific, florfenicol quick-releasing type water-soluble powder preparation of especially a kind of enclose cyclodextrin and preparation method thereof.
Background technology
Florfenicol (florfenicol. fluorine first inkstone mycin): the New-type wide-spectrum antibiotic that is a kind of chemosynthesis chloromycetin animal specific.Protect refined (Schering-Plough) company development by U.S.'s spirit earlier the late nineteen eighties in last century, and nineteen ninety in Japan's listing, is mainly used in culture fishery first.This medicine with its has a broad antifungal spectrum, safe and efficient, absorb and to distribute wide in good, the body and do not have the favor that characteristics such as potential induced aplastic anemia enjoy domestic and international veterinary circle.
At present, florfenicol successively in the Asia, more than 20 the national registration listing in Europe and America, China is in approval listing in 1999, is mainly used in the control of the bacterial disease of pig, chicken and fish due to the sensitive bacterial.The florfenicol antibacterial activity is better than chloromycetin and thiamphenicol, and Grain-positives such as actinobacillus pleuropneumoniae, pasteurella multocida, bronchus deteriorated blood bordetella bacilli, streptococcus, haemophilus parasuis, Salmonella, escherichia coli and negative bacteria are all had powerful killing action.This medicine uses at veterinary clinic as line antibacterials at present.But because the florfenicol dissolubility is low, be non-water-soluble powder, in animal body absorption and bioavailability are low, carry out administration in the feedstuff by sneaking into often during administration, limited giving full play to of drug effect, because the administration inconvenience, appetite is useless exhausted when the morbidity of fowl poultry, often causes unsatisfactory curative effect.
It is generally undesirable that the water miscible technology of China's florfenicol mainly contains its solubilization-aid effects such as flux method, solid dispersion method, ultra micro at present, dissolution velocity is slow, dissolution is little, be difficult to satisfy preparation and dense demand of joining use, adopt the research of inclusion technique, mainly be to rest on laboratory research at present, lack the research aspect industrialized manufacturing technique.
Cyclodextrin: the stereochemical structure of cyclodextrin is a void structure, has determined it to be suitable for the capsule material in the inclusion technique, and inclusion technique is meant that a kind of molecule is embedded in the void structure of another kind of molecule by bag, forms the technology of clathrate (inclusion compound).This clathrate is made up of host molecule (host molecule) and two kinds of component adductions of enclosed molecule (guest molecule), host molecule has bigger void structure, in being enough to enclosed molecule is contained in, forming and divide an ascus (molecule capsule).
Cyclodextrin is the product that starch forms after cyclodextrin glucosan translocase (Cyclodextrin glucanotransferase) effect that cultivation obtains with basophilia spore bacillus.Be by 6～10 D-glucose molecules with 1, the cyclic oligomer sugar compounds that becomes of 4-glycosidic bond joint face.Cyclodextrin is the white crystalline powder of water solublity, irreducibility.Commonly used have three kinds of alpha-cyclodextrins, beta-schardinger dextrin-, gamma-cyclodextrin, and respectively by 6,7,8 glucose molecules constitute.
There are dosage form characteristics single, with low content of technology in veterinary formulations at present.Oral administrations such as some insoluble drugs such as florfenicol, tilmicosin, tylosin, diclazuril can only adopt the mode of mixed feeding administration, have influenced the performance of drug effect when useless the cutting off of fowl poultry morbidity appetite greatly.Therefore, adopt bag and technology to be used for veterinary drug preparation and carry out secondary development, improve the dissolution rate in vitro and the bioavailability of medicine, has remarkable advantages in the clinical practice, especially solved insoluble drug be not suitable for the drinking water difficult problem of application of treatment Animal diseases, from the angle of veterinary drug new preparation developing, inclusion technique provides new way for the form improvement of veterinary drug.
Summary of the invention
The objective of the invention is to solve above-mentioned the deficiencies in the prior art, and provide a kind of cyclodextrin inclusion technique that utilizes to prepare florfenicol quick-releasing type preparation and preparation method, new formulation can improve dissolubility, dissolution rate and the bioavailability of florfenicol, make it reach quick-acting, purpose efficiently, possess convenient drug administration, onset is advantage rapidly.
The technical solution adopted for the present invention to solve the technical problems is: a kind of florfenicol quick-releasing type water-soluble powder preparation of enclose cyclodextrin, it is characterized in that, stir enclose by florfenicol, cyclodextrin and water average rate and make, the mass percent of described florfenicol, cyclodextrin and water is allocated as 17:50:140.
Described cyclodextrin can for alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin one of them.
A kind of method for preparing the florfenicol quick-releasing type water-soluble powder preparation of above-mentioned enclose cyclodextrin comprises the steps:
(1) inclusion reaction: adopt saturated water solution method, deployed florfenicol, cyclodextrin and water are put into stainless steel cask to stir with traveling agitator, it is 50 rev/mins that mixing speed is provided, be placed on the electric furnace after stirring or other firing equipment heats and continue to stir, heating-up temperature is since 80 degree and timing, be 45 minutes to 60 minutes heat time heating time, prepares the florfenicol cyclodextrin clathrate of liquid state;
(2) oven dry: it is even to pour the florfenicol cyclodextrin clathrate into the drip pan middle berth, put into baking oven and continue oven dry 3.5 hours, during turn-over once, bake out temperature is 105 degree, obtains pulverous florfenicol cyclodextrin clathrate;
(3) cooling;
(4) cross 60 mesh sieves: will cool off the pulverous florfenicol cyclodextrin clathrate in back and cross 60 mesh sieves;
(5) mix detection: sampling detected testing goal after sieving was carried out multiple batches of mix homogeneously with feeder suction mixer by high performance liquid chromatograph: whether the checking florfenicol can both be detected with meeting legal standard method by the content before and after the enclose;
(6) adjuvant dilution: by feeder glucose is added in the mixer as adjuvant and to be mixed together evenly with prepared florfenicol cyclodextrin clathrate, the 1.5-4 that the component of the glucose that adds is about the florfenicol cyclodextrin clathrate doubly (specifically makes semi-finished product on demand, add glucose, florfenicol content is diluted to the content of defined in the product the most at last);
(7) semi-finished product detect: sampling detects to semi-finished product with high performance liquid chromatograph;
(8) qualified semi-finished product are sealed with sealing machine with racking machine packing, packaging bag; With packing semi-finished product tinning, with tin seamer sealed cans, with canned case, with the sealing compound joint sealing and with steps such as baling press packings with finished product packing, finished product sampling reuse high performance liquid chromatograph detects qualified warehouse-in.
The invention has the beneficial effects as follows: (1); show no matter be all can produce and the product that meets the pharmacopeia regulation by experiment at the laboratory experiment or the experiment of simulation actual production technology; compared with prior art; quality improves a lot; finished product character particularly; uniformity of dosage units; granularity; aspects such as water solublity; production technology is simplified; easy to operate; production cycle shortens; compare semi-finished product does not need to pulverize with solid dispersion technology; solved because of pulverizing and produced high temperature; the situation of fusing occurs and pulverize non-uniform phenomenon; directly sieve; adopt florfenicol; the beta-schardinger dextrin-saturated solution method prepares florfenicol soluble powder; have easy and simple to handle; equipment requirements is low; small investment; cost-effective characteristics; suitability for scale production, florfenicol dissolubility have improved nearly 4 times, and florfenicol one cyclodextrin clathrate has significantly improved the water solublity of florfenicol.
(2), the florfenicol quick-releasing type water-soluble powder preparation of a kind of enclose cyclodextrin of the present invention, its host molecule beta-cyclodextrin inclusion compound enclosed molecule florfenicol, constitute florfenicol inclusion body preparation, medicine (being florfenicol) is present in the water solublity enclose carrier (being beta-schardinger dextrin-) with molecularity, can directly dissolve water administration fowl poultry drinking-water takes, has medicine dissolution rate height, dissolubility is good, the bioavailability height, characteristics such as good absorbing, medicine (florfenicol) enclose is in carrier material, also can cover the bitterness of florfenicol, avoid bitterness owing to medicine to influence animal and searched for food or drink water.
Description of drawings
Fig. 1 is the molecular structure of florfenicol among the present invention.
Fig. 2 is the molecular structure of cyclodextrin among the present invention.
Fig. 3 is florfenicol and a cyclodextrin inclusion compound principle assumption diagram among the present invention.
Fig. 4 is a process chart of the present invention.
The specific embodiment
The present invention is further described below in conjunction with drawings and Examples.
As shown in Figure 1 to Figure 3, a kind of florfenicol quick-releasing type water-soluble powder preparation of enclose cyclodextrin, it is characterized in that, stirring enclose by florfenicol, cyclodextrin and water average rate makes, the mass percent of described florfenicol, cyclodextrin and water adopts orthogonal design to determine proportioning, finally is defined as 17:50:140.
Described cyclodextrin can for alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin one of them, present embodiment has been selected beta-schardinger dextrin-for use.
A kind of method for preparing the florfenicol quick-releasing type water-soluble powder preparation of above-mentioned enclose cyclodextrin as shown in Figure 4, comprises the steps:
(1) inclusion reaction: adopt saturated water solution method, deployed florfenicol, cyclodextrin and water are put into stainless steel cask to stir with traveling agitator, it is 50 rev/mins that mixing speed is provided, be placed on the electric furnace after stirring or other firing equipment heats and continue to stir, heating-up temperature is since 80 degree and timing, be 45 minutes to 60 minutes heat time heating time, prepares the florfenicol cyclodextrin clathrate of liquid state;
(2) oven dry: it is even to pour the florfenicol cyclodextrin clathrate into the drip pan middle berth, put into baking oven and continue oven dry 3.5 hours, during turn-over once, bake out temperature is 105 degree, obtains pulverous florfenicol cyclodextrin clathrate;
(3) natural cooling;
(4) cross 60 mesh sieves: will cool off the pulverous florfenicol cyclodextrin clathrate in back and cross 60 mesh sieves, and collect with the splendid attire bucket;
(5) mix detection: sampling detected testing goal after sieving was carried out multiple batches of mix homogeneously with feeder suction mixer by high performance liquid chromatograph: whether the checking florfenicol can both be detected with meeting legal standard method by the content before and after the enclose;
(6) adjuvant dilution: by feeder glucose is added in the mixer as adjuvant and to be mixed together evenly with prepared florfenicol cyclodextrin clathrate, the component of the glucose that adds is about 1.5-4 times of florfenicol cyclodextrin clathrate, optimum is 4 times and (specifically makes semi-finished product on demand, add glucose, florfenicol content is diluted to the content of defined in the product the most at last);
(7) semi-finished product detect: sampling detects to semi-finished product with high performance liquid chromatograph, with qualified semi-finished product racking machine, sealing machine packing;
(8) qualified semi-finished product are sealed with sealing machine with racking machine packing, packaging bag; With packing semi-finished product tinning, with tin seamer sealed cans, with canned case, with the sealing compound joint sealing and with steps such as baling press packings with finished product packing, finished product sampling reuse high performance liquid chromatograph detects qualified warehouse-in.
About the florfenicol quick-releasing type water-soluble powder preparation of enclose cyclodextrin of the present invention to quality control:
1. the evaluation of physical property: microscopic method and electron-microscope scanning, UV-VIS spectrophotometry, infrared spectrophotometer, nuclear magnetic resonance method, X-ray diffraction method are identified the enclose degree and the state of florfenicol in clathrate, thus evaluation florfenicol enclose quality;
2. dissolubility and dissolution rate are identified: change the basket method and measure dissolubility and dissolution rate mensuration; Adopt high performance liquid chromatography and potentiometric determination medicament contg;
3. stability study: adopt illumination experiment, classical constant temperature method, accelerated test, reserved sample observing method to carry out stability study.
The preparation character that the present invention finally draws: should be white powder or off-white powder.
Dissolubility: by dissolution rate and solubility test, the dissolubility of preparation and dissolution rate than crude drug and fixedly other preparations such as dispersion significantly improve (P＜0.01), preparation is soluble in water during by the dissolving of actual clinical consumption.
Stability and medicament contg: clathrate does not influence medicine assay, and medicament contg should be in 98%～102% of labelled amount.Classical constant temperature method is measured its stability should be suitable with crude drug.
Preparation of the present invention is at pharmacokinetic study: compare with crude drug, require that peak time is short, peaking is high, the bioavailability height.
Preparation of the present invention by the dissolution rate of inclusion technique in 30 minutes detect be with raw material, adjuvant directly mix, solid dispersion technology all has superiority, the dissolution rate of a plurality of samples to three active ingredient in ten minutes that test is joined all can reach about 100%.
Improve about ten points, than about high five points of solid dispersion technology than former powder.
The scheme that the ratio effect is best, 15 minutes dissolution rate just can reach the former powder of 98%(and have only 81%).
High performance liquid chromatograph: be with high performance liquid chromatography material to be carried out instrument qualitative, quantitative analysis, the system of high performance liquid chromatograph is made up of several parts such as reservoir, pump, injector, chromatographic column, detector, monitors.Mobile phase in the reservoir is squeezed into system by high-pressure pump, sample solution enters mobile phase through injector, be written in the chromatographic column (immobile phase) by mobile phase, because each component in the sample solution has different partition coefficients in biphase, when in biphase, making relative motion, the assigning process of the absorption-desorbing of process repeated multiple times, each component produces bigger difference on translational speed, being separated into single component flows out in post successively, during by detector, sample concentration is converted into the signal of telecommunication and is sent to monitor, and data print with the collection of illustrative plates form analyzes contrast.
Claims (3)
1. the florfenicol quick-releasing type water-soluble powder preparation of an enclose cyclodextrin is characterized in that, stirs enclose by florfenicol, cyclodextrin and water average rate and makes, and the mass percent of described florfenicol, cyclodextrin and water is allocated as 17:50:140.
2. according to the florfenicol quick-releasing type water-soluble powder preparation of the described enclose cyclodextrin of claim 1, it is characterized in that described cyclodextrin is a beta-schardinger dextrin-.
3. according to the method for the florfenicol quick-releasing type water-soluble powder preparation of the described preparation enclose of claim 1 cyclodextrin, it is characterized in that, comprise the steps:
(1) inclusion reaction: adopt saturated water solution method, deployed florfenicol, cyclodextrin and water are put into stainless steel cask to stir with traveling agitator, mixing speed is 50 rev/mins, be placed on the electric furnace after stirring or other firing equipment heats and continue to stir, heating-up temperature is since 80 degree and timing, be 45 minutes to 60 minutes heat time heating time, prepares the florfenicol cyclodextrin clathrate of liquid state;
(2) oven dry: it is even to pour the florfenicol cyclodextrin clathrate into the drip pan middle berth, put into baking oven and continue oven dry 3.5 hours, during turn-over once, bake out temperature is 105 degree, obtains pulverous florfenicol cyclodextrin clathrate;
(3) cooling;
(4) cross 60 mesh sieves: will cool off the pulverous florfenicol cyclodextrin clathrate in back and cross 60 mesh sieves;
(5) mix to detect: sieving is carried out taking a sample behind the multiple batches of mix homogeneously with feeder suction mixer detect by high performance liquid chromatograph;
(6) adjuvant dilution: by feeder glucose is added in the mixer as adjuvant and to be mixed together evenly with prepared florfenicol cyclodextrin clathrate, the component of the glucose of adding is about 1.5-4 times of florfenicol cyclodextrin clathrate;
(7) semi-finished product detect: sampling detects to semi-finished product with high performance liquid chromatograph;
(8) semi-finished product packing, finished product packing, warehouse-in.
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| CN104706629A (en) * | 2015-04-14 | 2015-06-17 | 四川美嘉龙生物科技有限公司 | Florfenicol powder and preparation method thereof |
| CN104825400A (en) * | 2015-05-28 | 2015-08-12 | 中牧南京动物药业有限公司 | Florfenicol included controlled-release preparation and its preparing method and application |
| CN105640889A (en) * | 2014-11-11 | 2016-06-08 | 天津嘉创生物科技有限公司 | Florfenicol soluble powder and preparation method thereof |
| CN105878186A (en) * | 2014-09-12 | 2016-08-24 | 中牧实业股份有限公司黄冈动物药品厂 | Water-soluble powder of cyclodextrin clathrate of quinocetone and preparation method thereof |
| CN105902497A (en) * | 2016-06-01 | 2016-08-31 | 洛阳瑞华动物保健品有限公司 | Preparation method of water-soluble florfenicol veterinary preparation |
| CN105997966A (en) * | 2016-08-03 | 2016-10-12 | 佛山科学技术学院 | Clathrate for controlling aquatic animal bacterial diseases and preparation method thereof |
| CN106177983A (en) * | 2016-08-03 | 2016-12-07 | 佛山科学技术学院 | A kind of florfenicol beta cyclodextrin clathrate and preparation method thereof |
| CN106727334A (en) * | 2016-11-24 | 2017-05-31 | 山东滨州智源生物科技有限公司 | A kind of florfenicol water soluble pulvis and preparation method thereof |
| CN107648616A (en) * | 2017-10-27 | 2018-02-02 | 四川康四海动物药业有限公司 | A kind of Tilmicosin clathrate process |
| CN111374949A (en) * | 2018-12-29 | 2020-07-07 | 西安市昌盛动物保健品有限公司 | Preparation process of florfenicol soluble powder or solution |
| CN112641954A (en) * | 2020-12-30 | 2021-04-13 | 广东三水正大康畜牧发展有限公司 | Water-soluble florfenicol clathrate compound, simple molecular coating method thereof and prepared solid preparation |
| CN112641730A (en) * | 2021-02-19 | 2021-04-13 | 山东鲁抗舍里乐药业有限公司高新区分公司 | Preparation method of soluble florfenicol powder |
| CN112716902A (en) * | 2021-02-04 | 2021-04-30 | 广州市和生堂动物药业有限公司 | Florfenicol powder and preparation method thereof |
| CN115645376A (en) * | 2022-10-26 | 2023-01-31 | 山东德州神牛药业有限公司 | Tilmicosin efficient double-layer coated pellet and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1459282A (en) * | 2003-05-29 | 2003-12-03 | 季华 | Method for prodn. of water soluble fluorophenylnicol |
| CN101686956A (en) * | 2007-04-27 | 2010-03-31 | 谢尔英·普劳有限公司 | Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins |
| CN101966340A (en) * | 2010-10-20 | 2011-02-09 | 无锡正大畜禽有限公司 | Method for producing florfenicol soluble powder |
-
2011
- 2011-04-15 CN CN2011100949450A patent/CN102160854A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1459282A (en) * | 2003-05-29 | 2003-12-03 | 季华 | Method for prodn. of water soluble fluorophenylnicol |
| CN101686956A (en) * | 2007-04-27 | 2010-03-31 | 谢尔英·普劳有限公司 | Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins |
| CN101966340A (en) * | 2010-10-20 | 2011-02-09 | 无锡正大畜禽有限公司 | Method for producing florfenicol soluble powder |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105878186A (en) * | 2014-09-12 | 2016-08-24 | 中牧实业股份有限公司黄冈动物药品厂 | Water-soluble powder of cyclodextrin clathrate of quinocetone and preparation method thereof |
| CN105640889A (en) * | 2014-11-11 | 2016-06-08 | 天津嘉创生物科技有限公司 | Florfenicol soluble powder and preparation method thereof |
| CN104706629A (en) * | 2015-04-14 | 2015-06-17 | 四川美嘉龙生物科技有限公司 | Florfenicol powder and preparation method thereof |
| CN104825400A (en) * | 2015-05-28 | 2015-08-12 | 中牧南京动物药业有限公司 | Florfenicol included controlled-release preparation and its preparing method and application |
| CN105902497B (en) * | 2016-06-01 | 2019-06-11 | 洛阳瑞华动物保健品有限公司 | A kind of preparation method of water-solubility florfenicol veterinary drug preparation |
| CN105902497A (en) * | 2016-06-01 | 2016-08-31 | 洛阳瑞华动物保健品有限公司 | Preparation method of water-soluble florfenicol veterinary preparation |
| CN105997966A (en) * | 2016-08-03 | 2016-10-12 | 佛山科学技术学院 | Clathrate for controlling aquatic animal bacterial diseases and preparation method thereof |
| CN106177983A (en) * | 2016-08-03 | 2016-12-07 | 佛山科学技术学院 | A kind of florfenicol beta cyclodextrin clathrate and preparation method thereof |
| CN106727334A (en) * | 2016-11-24 | 2017-05-31 | 山东滨州智源生物科技有限公司 | A kind of florfenicol water soluble pulvis and preparation method thereof |
| CN107648616A (en) * | 2017-10-27 | 2018-02-02 | 四川康四海动物药业有限公司 | A kind of Tilmicosin clathrate process |
| CN111374949A (en) * | 2018-12-29 | 2020-07-07 | 西安市昌盛动物保健品有限公司 | Preparation process of florfenicol soluble powder or solution |
| CN112641954A (en) * | 2020-12-30 | 2021-04-13 | 广东三水正大康畜牧发展有限公司 | Water-soluble florfenicol clathrate compound, simple molecular coating method thereof and prepared solid preparation |
| CN112716902A (en) * | 2021-02-04 | 2021-04-30 | 广州市和生堂动物药业有限公司 | Florfenicol powder and preparation method thereof |
| CN112716902B (en) * | 2021-02-04 | 2021-10-12 | 广州市和生堂动物药业有限公司 | Florfenicol powder and preparation method thereof |
| CN112641730A (en) * | 2021-02-19 | 2021-04-13 | 山东鲁抗舍里乐药业有限公司高新区分公司 | Preparation method of soluble florfenicol powder |
| CN115645376A (en) * | 2022-10-26 | 2023-01-31 | 山东德州神牛药业有限公司 | Tilmicosin efficient double-layer coated pellet and preparation method thereof |
| CN115645376B (en) * | 2022-10-26 | 2023-10-31 | 山东德州神牛药业有限公司 | Efficient double-layer coated tilmicosin pellets and preparation method thereof |
| CN118141954A (en) * | 2024-05-09 | 2024-06-07 | 四川育强本草生物技术有限公司 | Pithecellobium soluble powder and preparation method thereof |
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Application publication date: 20110824 |