CN102160824A - Compression nail for experimental animal model operation of cervical spondylosis - Google Patents
Compression nail for experimental animal model operation of cervical spondylosis Download PDFInfo
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- CN102160824A CN102160824A CN 201110135780 CN201110135780A CN102160824A CN 102160824 A CN102160824 A CN 102160824A CN 201110135780 CN201110135780 CN 201110135780 CN 201110135780 A CN201110135780 A CN 201110135780A CN 102160824 A CN102160824 A CN 102160824A
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Abstract
The invention provides a compression nail for an experimental animal model operation of cervical spondylosis, belonging to the technical field of orthopedics. The compression nail is used for better simulating cervical spondylotic myelopathy caused by cervical disc herniation or ossification of posterior longitudinal ligament in an experimental animal model of cervical spondylosis. The invention adopts the following technical scheme: the compression nail provided by the invention comprises a nail cap and a nail body, wherein a filling hole is formed in the nail body; the filling hole is formed along the central axis of the nail body; one end of the filling hole is positioned at the upper part of the nail body, and the other end of the filling hole is opened at the tip of the nail body; and a filler in the filling hole is a developing biological material. The invention has the following beneficial effects: the compression nail can be used for better simulating cervical spondylotic myelopathy caused by cervical disc herniation or ossification of posterior longitudinal ligament, is simple and safe in surgical operations, has little damage to experimental animals, can not cause the rejection reaction of the animals, is suitable for various imaging examinations, has a simple structure, and is economical and practical.
Description
Technical field
The present invention relates to a kind of cervical spondylosis experimental animal model operation compressing nail, belong to the orthopaedics technical field.
Background technology
Cervical spondylosis claims cervical spine syndrome again, is a kind of illness of changing into the basis with degeneration pathology.Mainly due to cervical vertebra strain for a long time, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, causes a series of handicapped clinical syndromes.Cervical spondylotic myelopathy (CSM) is mainly due to prolapse of cervical intervertebral disc, cervical vertebral osteophyte forms, ossification of posterior longitudinal ligament, hypertrophy of ligamentum flavum, the syndrome that reason such as narrow and cervical spinal instability of cervical spinal canal causes tissues such as cervical spinal cord, blood vessel to suffer oppression, stimulate and occur.
At present, chronic spinal compression is used sacculus, peg, resin nail or epidural neoplasm analogue formation usually.Application sacculus, peg, resin nail cause the pressure thing as spinal cord, the degree of compressing is controlled, but peg and resin nail all need the above operation of secondary just can finish modelling, and the compressing that applies once more very easily causes spinal cord injury, even cause serious acute compressing; Using sacculus to implement compressing, more similarly is the compressing of having simulated a kind of soft tissue from pathology, and clinically more near capsule sexual oppressions such as hemangioma, but not the intercalated disc that the cervical vertebra regression causes is outstanding, ligamentous ossification or rigid compressing that hyperosteogeny produced.
No matter be basic research or aspect clinical diagnosis and treatment, X line, CT and MRI check that diagnosis is absolutely necessary for cervical spondylosis at present.But peg can cause serious pseudo-shadow because of it, can not check by MRI CSM is made an exhaustive study, and promptly can not use MRI and check, this is the most serious defective of peg.Though resin nail and sacculus are applicable to the MRI inspection, but can not develop under X line and CT examination, can't see the mutual relation of compressing nail or sacculus and cervical vertebra and canalis spinalis, also be very inconvenience in actual applications.Though the screw of peg and resin nail is the controlled pressure size and the degree of depth easily, in fact the way that this repeatedly operation screws in the gradual compressing of artificial manufacturing of screw is still a kind of subacute damage, and repeatedly operation also can reduce the survival rate of laboratory animal.
In general, the more approaching cervical spondylotic myelopathy that causes by prolapse of cervical intervertebral disc or ossification of posterior longitudinal ligament clinically of peg or resin nail, but its defective is respectively arranged again, can not satisfy basic research and clinically about all imaging examinations of cervical spondylotic myelopathy.Sacculus then because its compressing scope and degree are wayward, is not suitable for the modelling of cervical spondylotic myelopathy.
Summary of the invention
The technical problem to be solved in the present invention is, provides a kind of and can simulate better that the cervical spondylotic myelopathy, the operation technique that are caused by prolapse of cervical intervertebral disc or ossification of posterior longitudinal ligament are simple, safe, little to injury of laboratory animal, the rejection that can not cause animal, is applicable to that multiple imaging examination, simple in structure, economical and practical cervical spondylosis experimental animal model operation are with the compressing nail.
The technical scheme that solves the problems of the technologies described above is:
A kind of cervical spondylosis experimental animal model operation is followed closely with compressing, and it is made up of the head of a nail and nail body, and its improvements are, in the nail body filler opening is arranged, filler opening is along the central axis of nail body, and filler opening one end is on nail body top, the other end has implant development biomaterial at the most advanced and sophisticated opening of nail body in the filler opening.
Above-mentioned cervical spondylosis experimental animal model operation is the 1/3-1/2 of nail body diameter with compressing nail, the diameter of described filler opening.
Above-mentioned cervical spondylosis experimental animal model operation is followed closely with compressing, and the described head of a nail and nail body are by polymethyl methacrylate or the one-shot forming of bone cement material.
Above-mentioned cervical spondylosis experimental animal model operation is followed closely with compressing, and described implant development biomaterial can be gutta percha point, gutta-percha rod or bone cement.
Adopt the cervical spondylosis experimental animal model operation of this structure following advantage to be arranged with the compressing nail:
1. can better simulate by prolapse of cervical intervertebral disc or ossification of posterior longitudinal ligament and the cervical spondylotic myelopathy that causes.
2. simple, the safety of operation technique has been avoided repeatedly performing the operation to the operation wound of animal with to the damage once more of spinal cord.
3. after using this compressing nail, can go up the change that CSM is taken place after the long-term chronic compressing at multiple iconography (X line, CT and MRI) simultaneously studies, avoided peg can not be used for that MRI checks and the drawback of continuously connected fastener unable to walk X ray examination, significant for clinical research.
4. making material of the present invention is polymethyl methacrylate and bone cement, and histocompatibility is good, all can not cause the rejection of animal, and simple for production, economical and practical.
5. filling development biomaterial in the compressing nail body of the present invention, as gutta percha point or the gutta-percha rod of making for natural gum, root-canal filling when being used for the department of stomatology clinically and doing root canal, has certain intensity, be easy to moulding, nerve etc. is organized nontoxic, non-stimulated, histocompatibility is good, and the resistance advantage of penetrating X ray.The present invention has made full use of the above-mentioned advantage of development biomaterial, is applied to the compressing nail, is the initiative of compressing nail technology, has also improved compressing nail quality and effect greatly.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Labelling is as follows among the figure: the head of a nail 1, nail body 2, pack hole 3, implant development biomaterial 4.
The specific embodiment
Show among the figure, the present invention is made up of the head of a nail 1 and nail body 2, in the nail body 2 filler opening 3 is arranged, filler opening 3 is along the central axis of nail body 2, filler opening 3 one ends are on nail body 2 tops, the other end is at nail body 2 most advanced and sophisticated openings, and the diameter of filler opening 3 is filled with implant development biomaterial 4 for the 1/3-1/2 of nail body 2 diameters in the filler opening 3.The head of a nail 1 of the present invention and nail body 2 are by the polymethyl methacrylate materials one-shot forming, and implant development biomaterial 4 is a gutta percha point, is made by natural gum.
The size of embodiments of the invention 1 is as follows:
The length of nail body 1 is 4mm, and diameter is 3mm; The diameter of the head of a nail 2 is 5mm, and thickness is 2mm; The about 4mm of the length of filler opening 3.Be applicable to the making of Rabbit Model.
The size of embodiments of the invention 2 is as follows:
The length of nail body 1 is 5-20mm, and diameter is 4-10mm; The diameter of the head of a nail 2 is 6-20mm, and thickness is 3-5mm; The about 5-20mm of the length of filler opening 3.Be applicable to the making of sheep, dog and miniature pig or experimental rat class model.
Using method of the present invention is as follows:
The conventional anesthesia of laboratory animal, preserved skin, sterilization, drape, the capable stringer otch of 1cm is about 5cm under the 0.5cm thyroid cartilage of the other right side of trachea.Cut skin, subcutaneous, fascia, platysma, expose trachea, the esophagus of trachea and its below is pulled to a side, expose muscular tissue before the cone.The stringer passivity is separated the preceding muscular tissue of cone, and subperiosteum is peeled off, and exposes cervical vertebra C3 cone.Sting except that cortical bone before the vertebra with vascular forceps, form the opening of about a 3 * 3mm, strike off spongy bone, to vertebral body posterior bony cortex with little curet.The compressing nail of getting ready is inserted in the hole gently, cause the compressing of ventral side of spinal cord.The normal saline flushing wound resets muscle before the cone of peeling off, and sews up.Platysma and skin are sewed up in layering again, povidone iodine wiping wound, and operation finishes.
The capable X line of postoperative, CT and MRI check all can clearly observe the compressing nail.
Claims (4)
1. a cervical spondylosis experimental animal model operation is followed closely with compressing, it is made up of the head of a nail [1] and nail body [2], it is characterized in that, in the nail body [2] filler opening [3] is arranged, filler opening [3] is along the central axis of nail body [2], filler opening [3] one ends are on nail body [2] top, and the other end has implant development biomaterial [4] at the most advanced and sophisticated opening of nail body [2] in the filler opening [3].
2. cervical spondylosis experimental animal model operation according to claim 1 is followed closely with compressing, it is characterized in that: the diameter of described filler opening [3] is the 1/3-1/2 of nail body [2] diameter.
3. cervical spondylosis experimental animal model operation according to claim 1 is followed closely with compressing, it is characterized in that: the described head of a nail [1] and nail body [2] are by polymethyl methacrylate or the one-shot forming of bone cement material.
4. cervical spondylosis experimental animal model operation according to claim 1 is followed closely with compressing, and it is characterized in that: described implant development biomaterial [4] is gutta percha point, gutta-percha rod or bone cement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110135780 CN102160824A (en) | 2011-05-25 | 2011-05-25 | Compression nail for experimental animal model operation of cervical spondylosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110135780 CN102160824A (en) | 2011-05-25 | 2011-05-25 | Compression nail for experimental animal model operation of cervical spondylosis |
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| Publication Number | Publication Date |
|---|---|
| CN102160824A true CN102160824A (en) | 2011-08-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110135780 Pending CN102160824A (en) | 2011-05-25 | 2011-05-25 | Compression nail for experimental animal model operation of cervical spondylosis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2386781Y (en) * | 1999-09-14 | 2000-07-12 | 中国辐射防护研究院 | Bone screw of same bone and its tap and rotary tap |
| US6524345B1 (en) * | 1996-10-25 | 2003-02-25 | Bionx Implants Oy | Surgical implant |
| CN2691519Y (en) * | 2003-09-05 | 2005-04-13 | 中南大学湘雅医院 | Mould making apparatus for pathological model protrasion of lumbar intervertebral disci |
-
2011
- 2011-05-25 CN CN 201110135780 patent/CN102160824A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524345B1 (en) * | 1996-10-25 | 2003-02-25 | Bionx Implants Oy | Surgical implant |
| CN2386781Y (en) * | 1999-09-14 | 2000-07-12 | 中国辐射防护研究院 | Bone screw of same bone and its tap and rotary tap |
| CN2691519Y (en) * | 2003-09-05 | 2005-04-13 | 中南大学湘雅医院 | Mould making apparatus for pathological model protrasion of lumbar intervertebral disci |
Non-Patent Citations (1)
| Title |
|---|
| 《医学研究生学报》 20020630 王与荣,等 颈脊髓压迫模型的建立及意义 第220-222页 1-4 第15卷, 第03期 * |
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Application publication date: 20110824 |