CN102138964A - Quality control method of Tongbaole chewing tablet - Google Patents
Quality control method of Tongbaole chewing tablet Download PDFInfo
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- CN102138964A CN102138964A CN2010101048921A CN201010104892A CN102138964A CN 102138964 A CN102138964 A CN 102138964A CN 2010101048921 A CN2010101048921 A CN 2010101048921A CN 201010104892 A CN201010104892 A CN 201010104892A CN 102138964 A CN102138964 A CN 102138964A
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Abstract
The invention relates to a quality control method of a Tongbaole chewing tablet, which comprises the following steps of: identifying whether components of radix astragali, codonopsis pilosula and liquorice are contained in the formula of the Tongbaole chewing tablet through thin-layer chromatography; taking ammonium glycyrrhetate as a contrast product; and measuring the content of the radix astragali in the Tongbaole chewing tablet through the thin-layer chromatography. In the invention, the quality standard of the Tongbaole chewing tablet is improved and perfected; a thin-layer identification method of the radix astragali, codonopsis pilosula and liquorice in the formula is increased; a measurement method of the content of the liquorice is formed by taking the ammonium glycyrrhetate as the contrast product and taking glycyrrhizic acid as a quantitative index; and the quality control of the medicine is improved on the basis of the revised quality standard; therefore, the qualitative and quantitative measurements of the medicine is more accurate, and the quality is easier to control.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to the detection method of Chinese medicine, the method for quality control of the precious happy chewable tablet of especially a kind of child.
Background technology
The main component and the content of virgin precious happy chewable tablet are as follows: Radix Astragali 35.3g, Poria 35.3g, Radix Codonopsis 35.3g, Rhizoma Atractylodis Macrocephalae 35.3g, Radix Glycyrrhizae 8.8g, preparation method: the above five tastes, Poria 4.4g is ground into fine powder, sieving for standby.All the other Poria and the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae decocts with water twice, and 3 hours for the first time, 2 hours for the second time.Merge decocting liquid, filter, filtrate is condensed into the clear paste that relative density is 1.20～1.30 (50～60 ℃), adds Poria fine powder and adjuvant in the clear paste, drying, and mixing is made granule, is blended into flavoring orange essence, and mixing is pressed into 1000, that is, and every heavy 0.6g.
Function with cure mainly: invigorating the spleen and benefiting QI, appetizing is kept fit.Be used for inappetence, stool does not change, spontaneous sweating, and the rare Huang of hair, yellowish complexion is thin and weak, crouches night and does not rather wait disease.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, a kind of method of quality control of virgin precious happy chewable tablet that can the qualitative detection ingredient is provided, this method has that detection means is simple, testing result characteristic of accurate more.
The objective of the invention is to be achieved through the following technical solutions:
The method of quality control of the precious happy chewable tablet of a kind of child, the step of its method is:
(1) is to product with astragaloside, adopts the astragalus root components in the virgin precious happy chewable tablet of thin layer chromatography discriminating;
(2) with the Radix Codonopsis be control medicinal material, adopt the Radix Codonopsis composition in the virgin precious happy chewable tablet of thin layer chromatography discriminating;
(3) with the Radix Glycyrrhizae be control medicinal material, adopt the licorice ingredient in the virgin precious happy chewable tablet of thin layer chromatography discriminating;
(4) with the ammonium glycyrrhizinate be reference substance, adopt the Radix Astragali content in the virgin precious happy chewable tablet of high effective liquid chromatography for measuring.
And the thin layer discrimination method of the described Radix Astragali is:
1. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize adds methanol, reflux filters, and filtrate is added on the neutral alumina post, use 40% methanol-eluted fractions, collect eluent, evaporate to dryness, residue adds water makes dissolving, with water saturated n-butyl alcohol collection, each 20ml, merge n-butyl alcohol liquid, wash with water, discard water liquid, n-butyl alcohol liquid evaporate to dryness, residue add methanol 0.5ml makes dissolving, as need testing solution;
2. the preparation of reference substance solution: other gets the astragaloside reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution;
3. thin layer condition and result: draw each 2 μ l of above-mentioned three kinds of solution, put respectively in same with silica gel g thin-layer plate on, with chloroform: methanol: lower floor's solution of water=13: 7: 2 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, it is clear to be heated to speckle colour developing at 105 ℃, respectively the test sample chromatograph is inspected under daylight and 365nm ultra-violet lamp, inspect with the corresponding position of reference substance chromatograph on whether show the speckle of same color, determine whether contain astragalus root components in the test sample.
And the method that described Radix Codonopsis thin layer is differentiated is:
1. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize adds n-butyl alcohol, and reflux filters, and filtrate is put and is concentrated into 2ml in the water-bath, as need testing solution;
2. the preparation of control medicinal material solution: get Radix Codonopsis control medicinal material 1g, shine medical material solution in pairs with legal system;
3. thin layer condition and result: other draws each 6 μ l of above-mentioned three kinds of solution, put respectively on same silica gel G plate, with n-butyl alcohol: glacial acetic acid: water=7: 1: 0.5 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, clear 105 ℃ of heating 10 minutes to speckle colour developing, inspect in the test sample chromatograph with the corresponding position of control medicinal material chromatograph on show the speckle of same color, determine in test sample, whether to contain the Radix Codonopsis composition.
And the method that described Radix Glycyrrhizae thin layer is differentiated is:
1. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize adds diethyl ether, reflux, filter, medicinal residues add methanol after waving most ether, reflux filters the filtrate evaporate to dryness, residue adds water 40ml makes dissolving, with water saturated n-butanol extraction 3 times, and each 20ml, merge n-butyl alcohol liquid, wash with water 3 times, each 20ml, n-butyl alcohol liquid evaporate to dryness, residue add methanol 2ml makes dissolving, as need testing solution;
2. the preparation of control medicinal material solution: extracting liquorice control medicinal material 1g, shine medical material solution in pairs with legal system;
3. thin layer condition and result: draw each 5 μ l of above-mentioned three kinds of solution, put respectively in same with silica gel g thin-layer plate on, with ethyl acetate: formic acid: glacial acetic acid: water=15: 1: 1: 2 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, it is clear to be heated to speckle colour developing at 105 ℃, inspect in the test sample chromatograph with the corresponding position of control medicinal material chromatograph under daylight, whether show identical orange-yellow speckle, determine in test sample, whether to contain licorice ingredient.
And the method for described Radix Astragali assay is:
1. chromatographic condition: be filler with octadecylsilane chemically bonded silica surely; Mobile phase: methanol: 0.2mol/L ammonium acetate: glacial acetic acid=62: 38: 1; Flow velocity: 1ml/min; Column temperature: 25 ℃; The detection wavelength is 250nm, and number of theoretical plate calculates by the ammonium glycyrrhizinate peak and is not less than 8000;
2. the preparation of reference substance solution: extracting liquorice acid ammonium reference substance is an amount of, and accurate the title decides, and adds methanol and makes the solution that every 1ml contains 20 μ g, promptly gets (every 1ml contains monoammonium glycyrrhizinate reference substance 0.02mg, and amounting to glycyrrhizic acid is 0.01959mg);
3. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize is got 3g, the accurate title, decide, accurate methanol, the supersound process of adding, filter, residue and filter wash with methanol 15ml gradation, and washing liquid and filtrate merge, water bath method, residue is transferred in the 10ml measuring bottle with methanol, add methanol and be diluted to scale, shake up, promptly;
4. measure and the result: accurate respectively absorption reference substance solution and need testing solution be 10 μ l respectively, inject chromatograph of liquid, measure, and calculate, that is, the precious happy chewable tablet sample of child contains Radix Glycyrrhizae in every 0.6g calculating must not be less than 0.024mg with glycyrrhizic acid.
Advantage of the present invention and good effect are:
The present invention has carried out raising, perfect to the precious happy chewable tablet quality standard of child, on the primary standard basis, has increased the thin layer discrimination method of the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae in the prescription; With the ammonium glycyrrhizinate is reference substance, is quantitative target with the glycyrrhizic acid, has formulated the content assaying method of Radix Glycyrrhizae, and revised quality standard has improved the quality control of medicine, makes the qualitative and detection by quantitative of medicine more accurate, and quality is more prone to control.
Description of drawings
Inspect chromatogram under the daylight of Fig. 1 for Radix Astragali thin layer chromatography discriminating of the present invention, be followed successively by from left to right: 1 sample 1 (lot number: 0603003), 2 samples 2 (lot number: 0603004), 3 sample 3 (lot numbers: 0603001), 4 astragaloside reference substances (middle inspection institute), 5 Radix Astragali negative samples;
Inspect chromatogram under the ultra-violet lamp (365nm) of Fig. 2 for Radix Astragali thin layer chromatography discriminating of the present invention, be followed successively by from left to right: 1 sample 1 (lot number: 0603003), 2 sample 2 (lot numbers: 0603004), 3 sample 3 (lot numbers: 0603001), 4 astragaloside reference substances (middle inspection institute), 5 Radix Astragali negative samples;
The chromatogram that Fig. 3 differentiates for Radix Astragali thin layer chromatography of the present invention, be followed successively by from left to right: 1 sample 1 (lot number: 0603003), 2 samples 2 (lot number: 0603004), 3 sample 3 (lot numbers: 0603001), 4 astragaloside reference substances (middle inspection institute), 5 Radix Astragali negative samples; The chromatogram that thin layer chromatography is differentiated is followed successively by from left to right: and 1 sample 1 (lot number: 0603003), 2 samples 2 (lot number: 0603004), 3 samples 3 (lot number: 0603001), 4 Radix Codonopsis control medicinal materials (middle inspection institute), 5 Radix Codonopsis negative samples;
Inspect chromatogram under the daylight of Fig. 4 for Radix Glycyrrhizae thin layer chromatography discriminating of the present invention, be followed successively by from left to right: 1 sample 1 (lot number: 0603003), 2 samples 2 (lot number: 0603004), 3 sample 3 (lot numbers: 0603001), 4 Radix Glycyrrhizae control medicinal materials (middle inspection institute), 5 Radix Glycyrrhizae negative samples;
Fig. 5 ammonium glycyrrhizinate reference substance solution of the present invention chromatogram;
The virgin precious happy chewable tablet sample solution chromatogram of Fig. 6 the present invention;
Fig. 7 Radix Glycyrrhizae negative sample of the present invention solution chromatogram.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
The method of quality control of the precious happy chewable tablet of a kind of child, the step of its method is:
(1) Radix Astragali thin layer is differentiated
1. the preparation of need testing solution: get 8 in virgin precious happy chewable tablet sample, porphyrize adds methanol 20ml, reflux 1 hour filters, and filtrate is added on neutral alumina post (100～200 orders, 5g, internal diameter 10～15 orders) on, with 40% methanol 100ml eluting, collect eluent, evaporate to dryness, residue add water 30ml makes dissolving, with water saturated n-butanol extraction 2 times, each 20ml merges n-butyl alcohol liquid, wash twice with water, each 20ml; Discard water liquid, n-butyl alcohol liquid evaporate to dryness, residue add methanol 0.5ml makes dissolving, as need testing solution.
2. the preparation of reference substance solution: other gets the astragaloside reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.
3. the preparation of negative sample solution: by the prescription proportioning, get other medical materials except that the Radix Astragali, prepare, make negative sample solution by 1. need testing solution preparation method again by former medicine preparation technology.
4. thin layer condition and result: according to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2005) test, draw each 2 μ l of above-mentioned three kinds of solution, put respectively in same with silica gel g thin-layer plate on, with chloroform: methanol: lower floor's solution of water=13: 7: 2 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, the speckle of apparent same color is seen Fig. 1 under the daylight; The orange-yellow speckle that shows same color under the 365nm ultra-violet lamp is seen Fig. 2, and negative noiseless.
(2) the Radix Codonopsis thin layer is differentiated
1. the preparation of need testing solution: get 8 in virgin precious happy chewable tablet sample, porphyrize adds n-butyl alcohol 20ml, and reflux 3 hours filters, and filtrate is put and is concentrated into 2ml in the water-bath, as need testing solution.
2. the preparation of control medicinal material solution: get Radix Codonopsis control medicinal material 1g, shine medical material solution in pairs with legal system.
3. the preparation of negative sample solution: by the prescription proportioning, get other medical materials except that Radix Codonopsis,, make negative sample solution by " 6.2.1 " need testing solution preparation method again by former medicine preparation technology preparation.
4. thin layer condition and result: according to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2005) test, other draws each 6 μ l of above-mentioned three kinds of solution, put respectively on same silica gel G plate, with n-butyl alcohol: glacial acetic acid: water=7: 1: 0.5 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to develop the color to speckle in 10 minutes 105 ℃ of heating.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color, and negative noiseless, the results are shown in Figure 3.
(3) the Radix Glycyrrhizae thin layer is differentiated
1. the preparation of need testing solution: get 8 in virgin precious happy chewable tablet sample, porphyrize, the 20ml that adds diethyl ether, reflux 1 hour, filter, after medicinal residues are waved most ether, add methanol 20ml, reflux 1 hour filters the filtrate evaporate to dryness, residue adds water 40ml makes dissolving, with water saturated n-butanol extraction 3 times, and each 20ml, merge n-butyl alcohol liquid, wash with water 3 times, each 20ml, n-butyl alcohol liquid evaporate to dryness, residue add methanol 2ml makes dissolving, as need testing solution.
2. the preparation of control medicinal material solution: extracting liquorice control medicinal material 1g, shine medical material solution in pairs with legal system.
3. the preparation of negative sample solution: by the prescription proportioning, get other medical materials except that Radix Glycyrrhizae,, make negative sample solution by " 6.3.1 " need testing solution preparation method again by former medicine preparation technology preparation.
4. thin layer condition and result: according to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2005) test, draw each 5 μ l of above-mentioned three kinds of solution, put respectively in same with silica gel g thin-layer plate on, with ethyl acetate: formic acid: glacial acetic acid: water=15: 1: 1: 2 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, daylight shows down identical orange-yellow speckle, and negative noiseless, the results are shown in Figure 4.
(4) Radix Astragali assay
1. chromatographic condition: be filler with octadecylsilane chemically bonded silica surely; Mobile phase: methanol: 0.2mol/L ammonium acetate: glacial acetic acid=62: 38: 1; Flow velocity: 1ml/min; Column temperature: 25 ℃; The detection wavelength is 250nm.Number of theoretical plate calculates by the ammonium glycyrrhizinate peak and is not less than 8000.
2. the preparation of reference substance solution: extracting liquorice acid ammonium reference substance is an amount of, and accurate the title decides, and adds methanol and makes the solution that every 1ml contains 20 μ g, promptly gets (every 1ml contains monoammonium glycyrrhizinate reference substance 0.02mg, and amounting to glycyrrhizic acid is 0.01959mg).
3. the preparation of need testing solution: get 20 in virgin precious happy chewable tablet sample, porphyrize is got 3g, the accurate title, decide, accurate methanol 30ml, the supersound process 40min of adding, filter, residue and filter wash with methanol 15ml gradation, and washing liquid and filtrate merge, water bath method, residue is transferred in the 10ml measuring bottle with methanol, add methanol and be diluted to scale, shake up, promptly.
4. the preparation of negative sample solution: get the medical material of respectively distinguishing the flavor of by prescription, make sample, by 3. need testing solution preparation method, make negative sample solution again by former medicine preparation technology except that Radix Glycyrrhizae.
5. measure and the result: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, calculate, that is, detect chromatogram and see Fig. 5, Fig. 6, Fig. 7, every 0.6g of this product contains Radix Glycyrrhizae with glycyrrhizic acid (C
42H
62O
16) meter, must not be less than 0.024mg, from experimental analysis: three batch sample average contents are the 0.0402mg/ sheet, by 60% conversion, every of this product contains Radix Glycyrrhizae with glycyrrhizic acid (C
42H
62O
16) meter, all be less than 0.024mg.
Claims (5)
1. the method for quality control of the precious happy chewable tablet of child, it is characterized in that: the step of its method is:
(1) is to product with astragaloside, adopts the astragalus root components in the virgin precious happy chewable tablet of thin layer chromatography discriminating;
(2) with the Radix Codonopsis be control medicinal material, adopt the Radix Codonopsis composition in the virgin precious happy chewable tablet of thin layer chromatography discriminating;
(3) with the Radix Glycyrrhizae be control medicinal material, adopt the licorice ingredient in the virgin precious happy chewable tablet of thin layer chromatography discriminating;
(4) with the ammonium glycyrrhizinate be reference substance, adopt the Radix Astragali content in the virgin precious happy chewable tablet of high effective liquid chromatography for measuring.
2. the method for quality control of the precious happy chewable tablet of child according to claim 1 is characterized in that: the thin layer discrimination method of the described Radix Astragali is:
1. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize adds methanol, reflux filters, and filtrate is added on the neutral alumina post, use 40% methanol-eluted fractions, collect eluent, evaporate to dryness, residue adds water makes dissolving, with water saturated n-butyl alcohol collection, each 20ml, merge n-butyl alcohol liquid, wash with water, discard water liquid, n-butyl alcohol liquid evaporate to dryness, residue add methanol 0.5ml makes dissolving, as need testing solution;
2. the preparation of reference substance solution: other gets the astragaloside reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution;
3. thin layer condition and result: draw each 2 μ l of above-mentioned three kinds of solution, put respectively in same with silica gel g thin-layer plate on, with chloroform: methanol: lower floor's solution of water=13: 7: 2 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, it is clear to be heated to speckle colour developing at 105 ℃, respectively the test sample chromatograph is inspected under daylight and 365nm ultra-violet lamp, inspect with the corresponding position of reference substance chromatograph on whether show the speckle of same color, determine whether contain astragalus root components in the test sample.
3. the method for quality control of the precious happy chewable tablet of child according to claim 1 is characterized in that: the method that described Radix Codonopsis thin layer is differentiated is:
1. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize adds n-butyl alcohol, and reflux filters, and filtrate is put and is concentrated into 2ml in the water-bath, as need testing solution;
2. the preparation of control medicinal material solution: get Radix Codonopsis control medicinal material 1g, shine medical material solution in pairs with legal system;
3. thin layer condition and result: other draws each 6 μ l of above-mentioned three kinds of solution, put respectively on same silica gel G plate, with n-butyl alcohol: glacial acetic acid: water=7: 1: 0.5 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, clear 105 ℃ of heating 10 minutes to speckle colour developing, inspect in the test sample chromatograph with the corresponding position of control medicinal material chromatograph on show the speckle of same color, determine in test sample, whether to contain the Radix Codonopsis composition.
4. the method for quality control of the precious happy chewable tablet of child according to claim 1 is characterized in that: the method that described Radix Glycyrrhizae thin layer is differentiated is:
1. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize adds diethyl ether, reflux, filter, medicinal residues add methanol after waving most ether, reflux filters the filtrate evaporate to dryness, residue adds water 40ml makes dissolving, with water saturated n-butanol extraction 3 times, and each 20ml, merge n-butyl alcohol liquid, wash with water 3 times, each 20ml, n-butyl alcohol liquid evaporate to dryness, residue add methanol 2ml makes dissolving, as need testing solution;
2. the preparation of control medicinal material solution: extracting liquorice control medicinal material 1g, shine medical material solution in pairs with legal system;
3. thin layer condition and result: draw each 5 μ l of above-mentioned three kinds of solution, put respectively in same with silica gel g thin-layer plate on, with ethyl acetate: formic acid: glacial acetic acid: water=15: 1: 1: 2 is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, it is clear to be heated to speckle colour developing at 105 ℃, inspect in the test sample chromatograph with the corresponding position of control medicinal material chromatograph under daylight, whether show identical orange-yellow speckle, determine in test sample, whether to contain licorice ingredient.
5. the method for quality control of the precious happy chewable tablet of child according to claim 1 is characterized in that: the method for described Radix Astragali assay is:
1. chromatographic condition: be filler with octadecylsilane chemically bonded silica surely; Mobile phase: methanol: 0.2mol/L ammonium acetate: glacial acetic acid=62: 38: 1; Flow velocity: 1ml/min; Column temperature: 25 ℃; The detection wavelength is 250nm, and number of theoretical plate calculates by the ammonium glycyrrhizinate peak and is not less than 8000;
2. the preparation of reference substance solution: extracting liquorice acid ammonium reference substance is an amount of, and accurate the title decides, and adds methanol and makes the solution that every 1ml contains 20 μ g, promptly gets (every 1ml contains monoammonium glycyrrhizinate reference substance 0.02mg, and amounting to glycyrrhizic acid is 0.01959mg);
3. the preparation of need testing solution: get virgin precious happy chewable tablet sample, porphyrize is got 3g, the accurate title, decide, accurate methanol, the supersound process of adding, filter, residue and filter wash with methanol 15ml gradation, and washing liquid and filtrate merge, water bath method, residue is transferred in the 10ml measuring bottle with methanol, add methanol and be diluted to scale, shake up, promptly;
4. measure and the result: accurate respectively absorption reference substance solution and need testing solution be 10 μ l respectively, inject chromatograph of liquid, measure, and calculate, that is, the precious happy chewable tablet sample of child contains Radix Glycyrrhizae in every 0.6g calculating must not be less than 0.024mg with glycyrrhizic acid.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102645509A (en) * | 2012-04-24 | 2012-08-22 | 西藏奇正藏药股份有限公司 | Method for detecting white vein preparation |
| CN109568496A (en) * | 2019-01-10 | 2019-04-05 | 陈浩 | The Chinese medicine composition treating the method for diabetes and using |
| CN113092620A (en) * | 2021-04-07 | 2021-07-09 | 保定冀中药业有限公司 | Licorice detection method for veterinary motherwort biochemical mixture |
| CN114965726A (en) * | 2021-11-03 | 2022-08-30 | 葵花药业集团(佳木斯)有限公司 | Chewable tablet fingerprint detection method and fingerprint thereof |
-
2010
- 2010-02-03 CN CN2010101048921A patent/CN102138964A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102645509A (en) * | 2012-04-24 | 2012-08-22 | 西藏奇正藏药股份有限公司 | Method for detecting white vein preparation |
| CN109568496A (en) * | 2019-01-10 | 2019-04-05 | 陈浩 | The Chinese medicine composition treating the method for diabetes and using |
| CN113092620A (en) * | 2021-04-07 | 2021-07-09 | 保定冀中药业有限公司 | Licorice detection method for veterinary motherwort biochemical mixture |
| CN114965726A (en) * | 2021-11-03 | 2022-08-30 | 葵花药业集团(佳木斯)有限公司 | Chewable tablet fingerprint detection method and fingerprint thereof |
| CN114965726B (en) * | 2021-11-03 | 2024-01-30 | 葵花药业集团(佳木斯)有限公司 | Fingerprint detection method and fingerprint of chewable tablet |
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Application publication date: 20110803 |