CN102132995B - Oral care implement - Google Patents

Oral care implement Download PDF

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Publication number
CN102132995B
CN102132995B CN2011100666536A CN201110066653A CN102132995B CN 102132995 B CN102132995 B CN 102132995B CN 2011100666536 A CN2011100666536 A CN 2011100666536A CN 201110066653 A CN201110066653 A CN 201110066653A CN 102132995 B CN102132995 B CN 102132995B
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China
Prior art keywords
cleaning
tissue cleanser
tongue
brush
dental treatment
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Expired - Fee Related
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CN2011100666536A
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Chinese (zh)
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CN102132995A (en
Inventor
D·J·霍尔贝因
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Colgate Palmolive Co
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Colgate Palmolive Co
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Filing date
Publication date
Priority claimed from US10/601,106 external-priority patent/US20040255416A1/en
Priority claimed from US29/189,729 external-priority patent/USD517812S1/en
Priority claimed from PCT/US2003/029497 external-priority patent/WO2004026162A2/en
Priority claimed from PCT/US2003/030633 external-priority patent/WO2004028235A2/en
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of CN102132995A publication Critical patent/CN102132995A/en
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Publication of CN102132995B publication Critical patent/CN102132995B/en
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    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B9/00Arrangements of the bristles in the brush body
    • A46B9/06Arrangement of mixed bristles or tufts of bristles, e.g. wire, fibre, rubber
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B15/00Other brushes; Brushes with additional arrangements
    • A46B15/0002Arrangements for enhancing monitoring or controlling the brushing process
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B15/00Other brushes; Brushes with additional arrangements
    • A46B15/0002Arrangements for enhancing monitoring or controlling the brushing process
    • A46B15/0016Arrangements for enhancing monitoring or controlling the brushing process with enhancing means
    • A46B15/0032Arrangements for enhancing monitoring or controlling the brushing process with enhancing means with protrusion for polishing teeth
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B15/00Other brushes; Brushes with additional arrangements
    • A46B15/0055Brushes combined with other articles normally separate from the brushing process, e.g. combs, razors, mirrors
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B15/00Other brushes; Brushes with additional arrangements
    • A46B15/0055Brushes combined with other articles normally separate from the brushing process, e.g. combs, razors, mirrors
    • A46B15/0081Brushes with a scraper, e.g. tongue scraper
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/24Surgical instruments, devices or methods, e.g. tourniquets for use in the oral cavity, larynx, bronchial passages or nose; Tongue scrapers
    • A61B17/244Surgical instruments, devices or methods, e.g. tourniquets for use in the oral cavity, larynx, bronchial passages or nose; Tongue scrapers for cleaning of the tongue
    • AHUMAN NECESSITIES
    • A46BRUSHWARE
    • A46BBRUSHES
    • A46B2200/00Brushes characterized by their functions, uses or applications
    • A46B2200/10For human or animal care
    • A46B2200/1066Toothbrush for cleaning the teeth or dentures

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Brushes (AREA)
  • Cosmetics (AREA)

Abstract

An oral care implement with a handle includes a head with a tissue cleanser. The tissue cleanser may be a pad composed of an elastomeric material. The pad is disposed on the head on a surface opposite the tooth cleaning elements. The tissue cleanser may include a plurality of nubs extending for cleaning between the papillae of the tongue. The tissue cleanser may include a plurality of conically shaped nubs. A tissue cleanser can be used to reduce oral malodor problems and remove oral epithelial cells.

Description

Dental treatment
The application is that to be CN200480017113.7, denomination of invention be the application for a patent for invention of " dental treatment " (international application no: dividing an application PCT/US2004/019541) for the application number submitted on June 18th, 2004.
Technical field
The present invention relates to a kind of dental treatment that has for the cleaning device of cleaning mouthful interior soft tissue surfaces.
Background technology
According to ADA, the main cause of Healthy People halitosis is the microbe deposition on the tongue, and wherein the bacterium covering provides environment for biology and the little bits that produce halitosis.Because the papillary nature of tongue surface has produced the very large unique ecological environment that helps oral bacteria to assemble of surface area, tongue is the paradise of microbial growth.Anaerobic bacteria flora on the tongue and bacterium play very important effect for the formation of chronic bad (being commonly referred to halitosis).In general, bacteria produce volatile sulfur compounds (VSC).If accumulated enough sulphur compounds, will cause halitosis or oral malodor.
Although used in the past the tongue scraper that blade (bladed) is housed, these tongue scrapers are not enough to the effectiveness of tongue soft tissue surfaces.Wide plate shaped scraper plate arrives limited in one's ability between the tongue mastoid process of assembling bacterium and little bits.In addition, although the ability of cleaning tongue can obtain advantage,, some users do not use this blade, in default of the comfort of tongue surface.
Thereby, need to a kind ofly have the dental treatment that effective removal tongue bacteria and other little bits guarantee the tongue cleaning spare that the user is comfortable simultaneously.
Summary of the invention
The present invention relates to a kind of dental treatment with tissue cleanser that the bacterium of improving cleaning and effectively removing the oral tissue surfaces deposition and little bits are provided.
In one aspect of the invention, this tissue cleanser comprises the fritter (nub) between a plurality of tongue mastoid processes that clean tongue for soft tissue surfaces and being used in particular in the cleaning mouthful.Of the present invention another preferred aspect in, tissue cleanser comprises a plurality of conical fritters.
In another aspect of this invention, tissue cleanser is made by elastomeric material.In a preferred embodiment, tissue cleanser forms on the elastomeric pad that is installed in the dental treatment brush, in order to improve cleaning effect, be easy to manufacturing and make the user feel comfortable.
In another aspect of this invention, dental treatment comprises pedestal, to make things convenient for and easily tissue cleanser to be molded on the brush.In a preferred structure, brush has one or more for the protrusion at the molding process grappling brush of tissue cleanser.Brush can also comprise tray, in order to further limit the appearance profile of molded tissue cleanser.
In another aspect of this invention, dental treatment comprises the tissue cleanser that has for oral volatile sulfur compounds is reduced 35% device from the benchmark of measuring with rear two hours.
In another aspect of this invention, dental treatment is provided with cleaning of teeth element and tissue cleanser, so that the oral surfaces of thorough cleaning teeth, gum, tongue and cheek and lip.In preferred structure, cleaning of teeth element and tissue cleanser are supported on the opposite side that supports brush.
In another aspect of this invention, the dental treatment that comprises cleaning of teeth element and tissue cleanser is with at least one element of cleaning of teeth element and the tissue cleanser formula member that forms as one.
Description of drawings
By considering that appended accompanying drawing can more fully understand the present invention and advantage thereof with reference to subsequent descriptions, wherein identical Reference numeral represents identical feature, wherein:
Fig. 1 is the decomposition assembling view according to the dental treatment of one or more aspects of illustrative examples;
Fig. 2 is the enlarged perspective of brush of the dental treatment of Fig. 1;
Fig. 3 is the plane of dental treatment that shows Fig. 1 of tongue cleaning feature;
Fig. 4 is the partial cross section figure along the dental treatment brush of Fig. 1 of the 4-4 line of Fig. 3;
Fig. 5 is the plane of dental treatment that shows Fig. 1 of at least one cleaning of teeth structure;
Fig. 6 is the perspective view that shows the dental treatment of cleaning of teeth element example; And
Fig. 7 is the sectional view of the alternative construction of dental treatment brush.
The specific embodiment
In subsequent descriptions, will be take toothbrush as example discussion the present invention, but the present invention can adopt other dental treatment form that only comprises tissue cleanser.In addition, need be appreciated that and to use other embodiment and can carry out structural and functional modifications in the situation that does not break away from the scope of the invention.
Fig. 1-Fig. 7 shows a kind of dental treatment (for example toothbrush) 100, and it has brush holder 103 and can be used for cleaning teeth and the brush 105 of mouthful interior soft tissue (for example, tongue, the inner surface of cheek, lip or gum).Brush holder 103 is set is used for making the user catch easily and handle toothbrush, and can be formed by many difformities and structure.Although brush will be wider than the neck of brush holder usually, brush can be that the simple of brush holder extended or contraction continuously in some structure.In preferred structure, brush 105 has the first surface 106 (Fig. 5 and Fig. 6) of supports tooth cleaning element 107 and second 108 (Fig. 2 and Fig. 3) of supporting tissue cleaning device 300.First and second 106,108 opposite sides that are preferably placed at brush 105.But, tissue cleanser 300 can be installed in other places, for example the near-end 104 of brush holder 103.Tissue cleanser 300 or part cleaning device can also be positioned on the peripheral sidewall surface 101 of brush 105 or than illustrated near-end 104 to brush holder 103 and further extend.
The elastomeric material of tissue cleanser 300 can be any biocompatible elastomeric material that is applicable to oral hygiene apparatuses.For optimum reelability quality and cleaning effect are provided, the hardness property of elastomeric material is preferably between Durometer A hardness 8 to A25.As an example, a kind of preferred elastomeric material is the styrene-ethylene/butylene-styrene block copolymer (SEBS) that GLS Corp. produces.But, can use within the SEBS material of other manufacturer or the above-mentioned hardness range or other material in addition.
Tissue cleanser 300 preferred disposition have diversity to organize counterpart 303 (Fig. 1-Fig. 4), organize counterpart 303 to form with the fritter form in preferred structure.Employed among the application " fritter " general expression comprises the cylindrical projections upright from the bottom surface (not limiting the cross sectional shape of projection).In general sense, in preferred structure, the height of fritter is greater than the width of fritter bottom (measuring at length direction).But, fritter can comprise width and be slightly less than highly about equally or highly the projection of bottom width.In addition, in some cases (for example, the fritter terminad be tapered or when comprising to bottom that less projection narrows down), bottom width can be much larger than height.
Thisly organize counterpart 303 to be designed to the main source of halitosis among the obvious reduction crowd and improve health.Fritter 303 can be removed microbiologic population and other little bits of soft tissue surfaces in tongue and other mouthful.Tongue forms the bacterium covering especially easily, and the bacterium covering is known for the biology that produces halitosis and little bits provide environment.Can find this microbiologic population in the depression between the most of regional tongue mastoid process of tongue upper surface and along soft tissue surfaces in other mouthful.When cooperating with tongue surface or promoting against tongue surface, for example elastomeric tissue cleanser 300 fritters 303 are with in soft tissue cooperates the depression that arrives simultaneously the adjacent tongue mastoid process of tongue downwards gently.The elastic construction of tissue cleanser 300 can also make the natural contour motion on 301 bead cavity tissues surfaces, bottom surface (for example, user's tongue, cheek, lip and gum).In addition, soft fritter 303 can be with the mode deflection of needs, in order to cross and clean fritter along the interior soft tissue surfaces of mobile mouth.
As in Fig. 2 and Fig. 4 see that in a preferred disposition of tissue cleanser 300, fritter 303 is preferably conical.As used in this application, " conical " or " circular cone " expression comprise pure circular cone, conical butt element and other to narrow end be tapered and thus with the similar shape of circular cone, no matter these shapes whether evenly, tapering whether continuously, whether have a circular cross-section.Referring to Fig. 4, each taper shape organizes the bottom 305 of counterpart 303 greater than respective end 307.In this conical configuration, the wider cross-sectional area of bottom 305 is in order to provide effective shear strength to stand tissue cleanser 300 along the lateral movement of tongue surface or other soft tissue surfaces.Less width or the end of diameter 307 make the fritter can be inswept in tongue or other depression in the surface in conjunction with the length of conical fritter 303, so that from soft tissue surfaces cleaning microbe deposition and other little bits.In preferred structure, in use, along with applying of lateral pressure, fritter 303 can be from vertical axis deflection and bending separately.This deflection has strengthened the cleaning of comfort and soft tissue surfaces.In preferred structure, the thickness of fritter bottom or width are 0.64 millimeter and preferably from about 0.51 millimeter to about 2.00 millimeters.The end 307 of fritter is 0.127 millimeter and preferably between about 0.10 millimeter to about 0.75 millimeter, in order to most desirably sting in the depression of access customer tongue tongue mastoid process.Measure from bottom surface 301 end 307 fritter 303 length or highly be preferably 0.91 millimeter and preferably about 0.5 millimeter to about 2.5 millimeters, be preferably between 0.75 millimeter to 1.5 millimeters.Yet, can use the fritter of other size and dimension beyond the given range.
As alternative, organizing cleaning element 303 can be other shape.As an example, tissue cleanser can have for example common unsettled U.S. Patent application No.10/601,106 described grid, and this application is incorporated herein by reference.
In preferred structure, fritter 303 is arranged on the bottom surface 301 of tissue cleanser 300 with high density pattern.The interval of each fritter 303 and adjacent isles 303 is preferably between about 0.5 millimeter to about 3 millimeters; Preferred interval and is preferably between 1 millimeter to 2 millimeters between 0.7 millimeter to 2.5 millimeters.But, can use other interval.The surface density of the fritter 303 on the bottom surface 301 preferably about 100 arrives between about 600 fritters per square inch.In the more preferably structure of tissue cleanser, surface density is per square inch between 200 to 500 fritters, is preferably in per square inch between 300 to 450 fritters.In a preferred embodiment, tissue cleanser 300 comprises about 400 fritters in surface area per square inch.The surface density feature of fritter 303 is in conjunction with highly making tissue cleanser can strengthen the cleaning of soft tissue surfaces and improving comfort level.But, can use other surface density.
As seeing among Fig. 3, fritter 303 preferably is arranged in the stringer on the direction that is basically parallel to longitudinal axis a-a.In addition, fritter 303 is arranged on walking crosswise in RI, the R2 on the axis that is parallel to bottom surface 301 and is basically perpendicular to longitudinal axis a-a.In a preferred structure, on bottom surface 301, provide adjacent fritter 303 with the configuration of staggering.For example, the adjacent R1 of walking crosswise of fritter and R2 have and are not located immediately at the each other fritter 303 of back.When the first fritter is positioned at the lateral extent of the second fritter of longitudinal extension, then claim the first fritter to be located immediately at the back of the second fritter.This configuration can improve the cleaning of soft tissue surfaces by promote to remove microbiologic population and other little bits (especially removing) in the depression of the adjacent tongue mastoid process of tongue.But.Can be at random or with countless these fritters of different style configuration.
Although can use other manufacturing process, preferably form tongue cleaning spare 300 by the mode that is molded on the brush 105.Referring to Fig. 1 and Fig. 4, tissue cleanser 300 preferably is molded in the tray or container cavity 111 of face 108 of brush 105.Container cavity 111 has bottom surface 113 and from bottom surface 113 outward extending peripheral sidewalls 115.In an assembled configuration, the fritter 303 of tissue cleanser 300 exposes, in order to together use with the bottom surface of tissue cleanser 300, and this bottom surface and brush surface 114 concordant or relative depressions.But, can use other oriented approach.Equally, the bottom surface 301 of tissue cleanser can embed in the brush 105 or by other layer and be covered, and wherein, fritter 303 is outstanding by suitable opening.
As seeing among Fig. 1 and Fig. 4, face 108 preferably also comprises one or more peg members 117a-c that are arranged in the tray 111.Peg members 117 has formed the anchor point that is close to relative mould, and is mobile under injection pressure to prevent brush.Thereby tissue cleanser 300 preferably includes one or more complimentary aperture 311a-c that peg members 117a-c top is exposed.Although the center line (for example, longitudinal axis a-a) that dowel pin is shown as along brush is aimed at, dowel pin can have many different location.In addition, brush 105 preferably includes dowel pin and tray, but also can use another in the situation of neither one.
As alternative, can provide tray 111 and peg members 117a-c, so that location and fixing in advance molded tissue cleanser, although these structures are not to use this in advance molded tissue cleanser necessary.
Peg members 117a-c can adopt various shapes and length.Continuation is with reference to Fig. 1 and Fig. 4, and brush 105 comprises the peg members 117a-c that extends outwardly into peripheral sidewall 115 height from the bottom surface 113 of tray 111.Peg members 117a-c is configured as cylindrical, but peg members 117a-c can be other shape or length.Although preferably use moulding process that tissue cleanser is attached on the brush, can use viscose glue or other known approaches to form and the conjunctive tissue cleaning device.
Such as Fig. 1-shown in Figure 4, it is the pad that comprises flexible resilient material that tissue cleanser 300 is preferably formed, so that comfortable cleaning and effectively remove in tongue and other mouthful on the soft tissue surfaces even along bacterium and little bits of lip deposition.Tissue cleanser 300 also provides effective massage, stimulation and removes tongue, cheek, gum and the bacterium on lip surface, little bits and epithelial cell.
In preferred structure (Fig. 1-Fig. 6), when user of toothbrushing, tissue cleanser 300 can rub to the inner surface of cheek or lip and in the side of tongue, and thereby the various soft tissue surfaces in mouth desirable massage, stimulation and cleaning are provided.For example, in the process of brush facial tooth surfaces, the oral surfaces that is arranged on the 300 pairs of cheek of tissue cleanser on the outer surface 108 of brush 105 carries out the nature friction.Thereby, in the situation that does not need additional cleaning, obtain the cleaning effect that strengthens.In addition, some user can feel the lip-deep excitant pain of cheek, and this pain causes user's active responding, or even the enjoyment of the comfort of the tissue cleanser of soft tissue surfaces in the bead.Tissue cleanser 300 can also be extraly in frictions such as cheek, tongues, this can be used as the desirable another kind of cleaning mode the contact of generation when brushing teeth.
With reference to Fig. 5 and Fig. 6, the cleaning of teeth element 107 of brush 105 can comprise multiple cleaning of teeth element for wiping, cleaning and massage user's tooth and gum.Can use the cleaning of teeth element of any appropriate format.Use term " cleaning of teeth element " with upperseat concept, its expression has thread bristle or resilient fingers or the wall shape thing of any desirable shape.In example shown in Figure 5, vertical cleaning of teeth element 207a-c, arc cleaning of teeth element 209a-d and 211a-b that cleaning of teeth element 107 comprises the far-end cleaning of teeth element 203a-b that is arranged on brush 105 far-ends 121, peripheral cleaning of teeth element 205a-1, arranges along longitudinal axis a-a, and near-end cleaning element 213a, b.Preferably the form with brushing cluster provides cleaning of teeth element 205,207,211 and 213, however preferred form formation cleaning of teeth element 209 with elastic wall.But, can use the cleaning of teeth element of other form and type.
Fig. 7 has shown the sectional view of the alternative configurations of toothbrush head 400.The structure of brush 400 is similar to brush 105, except cleaning of teeth element 209a-d and the formation of tissue cleanser 300 monoblock types.In order to realize alternative construction, brush 400 has size suitably port or the opening 401 of customization, in order to make the elastomeric material brush of flowing through in injection moulding process.In this structure, cleaning of teeth element 209a-d and tissue cleanser 300 are formed by same resilient material.Thereby brush 400 can comprise the form as one elasticity cleaning of teeth element of formula element of at least one and tissue cleanser 300.
Can carry out various variations to above method, composition and structure without departing from the present invention, all the elements of the application (comprising above-mentioned interactional all mechanism and/or pattern) all should only be interpreted as exemplary, and limit never in any form the scope of claims.
Subsequent instance is set forth in representative with operation improving of the present invention.These examples are not construed as limiting the scope of the invention.
Example 1
Use known halitosis assessment method to measure the performance of toothbrush.Study in order to assess the performance of toothbrush that the elastomeric tissue cleanser with conical fritter is installed (for example, as discussed above the preferred structure of toothbrush 100).Tested crowd has participated in this research.Be to clean or normalization period before about 7 days test, wherein the testee brushes teeth twice with fluoride dental cream (referring to table 1) every day.Behind wash phase, require the testee before oral cavity test, not carry out any oral hygiene (brush teeth, flushing and backguy cleaning), feed and drinking-water.Extract benchmark volatile sulfur compounds (VSC) sample from each testee.In the research that is used for overnight odor control, the testee uses the toothbrush 100 that tissue cleanser 300 mentioned above is installed to utilize fluoride dental cream (referring to table 1) to brush teeth one minute.Next, the testee utilizes organizing ten seconds of counterpart cleaning tongue surface of toothbrush.The testee sleeps night and return and carry out post processing.The time point that cleans ten hours the previous day in distance extracts the VSC sample.In exemplary embodiment, and only be to brush teeth to compare, use toothbrush to make oral cavity VSC reduce 60% from the benchmark with measurement in rear ten hours.Can obtain the VSC reading by gas chromatographic analysis.
Example 2
In another research of toothbrush 100 mentioned above, be to clean or normalization period before about 7 days test, wherein the testee brushes teeth twice with fluoride dental cream (referring to table 1) every day.Require the testee before test, not carry out any oral hygiene (brush teeth, flushing and backguy cleaning), feed and drinking-water.Behind wash phase, provide testee's benchmark tongue bacteria sample by the dorsal part that utilizes disinfecting cotton swab wiping tongue.The testee uses the toothbrush that has by tissue cleanser mentioned above to utilize fluoride dental cream (referring to table 1) to brush teeth one minute.Next, the testee utilizes ten seconds of preferred structure cleaning tongue surface of organizing counterpart 300 of toothbrush 100.The cleaning tongue surface utilized cotton swab to extract the tongue bacteria sample from the tongue dorsal part after two hours.In exemplary embodiment, the use of tissue bond element more can be controlled the tongue bacteria that produces stink than only brushing teeth simply.0.8 times of colony forming unit logarithm in the logarithm of the use of tissue cleanser 300 proof tongue bacteria after tongue uses two hours reduces to surpass every milliliter.
Example 3
In another research of toothbrush mentioned above, use MTT test check to use before the toothbrush with above-mentioned tissue cleanser and afterwards from the epithelial survival ability of oral collection.The MTT test is based on the tetrazolium in the living cells that metabolic activity is arranged
Figure BSA00000454993500091
Salt MTT[3-(4,5-dimethyl-2-thiazole)-2,5-diphenyl bromination tetrazolium +++] enzyme reduction.In test tube, carry out real time reaction, and use the porous culture plate reader to measure product (being dissolved in the purple formazan in the dimethyl formamide) with colorimetric method.Advantageously, the MTT experimental accuracy is high, easy to use and be applicable to extensive chemical sensitivity tests.
Behind 7 days wash phase, the testee is not taking food in advance, is drinking water or carrying out in the situation of oral hygiene to the report of test base.The testee by utilize 9 ml sterile waters gargle 10 seconds and with mouthwash spue 10x SPBS (PBS) solution is housed the saliva rinse samples in vitro is provided.Before carrying out MTT test with freezing about 30 minutes of sample.10 seconds of tongue cleaning spare 300 cleaning tongues that the testee uses fluoride dental cream (referring to table 1) to brush teeth then to utilize preferred structure in one minute under guidance.Brush teeth and clean tongue after about 30 minutes, the testee provides rinse samples with previously described method.
Before rinse samples and rinse samples were afterwards carried out with about 3000RPM centrifugal 15 minutes.Remove the upper strata stillness of night (for example, clear liquid) and with Particles Suspension in 2.5 milliliters PBS.Make 5 seconds of sample whirling motion, add subsequently 2.5 milliliters of MTT solution.Then culture sample 2 hours in being set as 37 ℃ soft shaking bath.Behind 2 hours the cultivation stage, sample was carried out with about 3000RPM centrifugal 15 minutes.With the supernatant liquor sucking-off and add 3 milliliters of detergents (0.04N acid isopropyl alcohol), so that dissolve purple crystals.The increase that MTT transforms or reduce to quantize by the method for spectral measurement.From each sample, take out 200 microlitres and join in 96 well plates, and measure the optical density of 570 nanometers and compare with negative buffering control.In exemplary embodiment, brush teeth one minute then the using-system cleaning device mouth epithelial cells can be reduced 72% from the determined value of MTT test protocols 10 seconds.
Example 4
In another research, tested crowd passes through Halimeter TM(being the sulfide measuring instrument) provides benchmark VSC sample.Halimeter TMUse the electrochemistry voltammetric sensor that in the time being exposed to VSC (for example, sulfide and mercaptan gas), produces signal and with the precision measure sulfureted hydrogen gas concentration of parts per billion (ppb).The testee utilizes the toothbrush of the preferred structure with tissue cleanser mentioned above to brush teeth under guidance one minute.Subsequently, the tester uses above-mentioned toothbrush to knock six times at tongue surface.After the step two hour of brushing teeth, extract follow-up VSC sample from the testee.In exemplary embodiment, use the toothbrush with tissue cleanser that the VSC that measures in the implication is reduced more than 35% from the benchmark of measuring with rear two hours.
Example 5
In another research, behind wash phase, tested crowd utilizes sterilized water to gargle in order to be provided for utilizing the MTT test to carry out the baseline sample of viable epithelial cell analysis.The testee utilizes the toothbrush of the preferred structure with tissue cleanser mentioned above to brush teeth under guidance one minute.Subsequently, the tester uses above-mentioned toothbrush to knock six times at tongue surface.The rear sample of gargling that the testee is provided for analyzing.This sample is tested and analyzed to the method that utilization is discussed for example 3.In this example, use toothbrush that oral epithelial cells has been reduced about 92% from analyzed the definite benchmark of agreement by MTT.
In example mentioned above, the testee uses and is brushed teeth by the fluoride dental cream of table 1 equation expression.
Percentage by weight Composition
48.76% Two calcium phosphates
22.0063% Water
22.00% Glycerine
4.138% SO3 lauryl sodium sulfate matrix-29%
1.000% CMC sodium-7MF food grade
0.89% 105 tooth cream spices
0.76% Sodium monofluorophosphate
0.25% Tetrasodium pyrophosphate
0.20% Saccharin sodium
Table 1

Claims (6)

1. dental treatment comprises:
Shank;
Be connected to the head of described shank;
The cleaning of teeth element, its side from described head is extended;
Organize mating area, it is arranged at the opposite side of described head and/or is arranged at described shank, and the described mating area of organizing comprises a plurality of projections, is used for cleaning mouthful interior soft tissue surfaces,
Wherein, the described tissue cleanser of organizing mating area to comprise to be provided with described projection, wherein a plurality of protrusions extend from the described mating area of organizing, and protrusion has respectively free end, and described tissue cleanser has a plurality of holes that make the free end exposure of described protrusion.
2. dental treatment according to claim 1 is characterized in that, described tooth cleaning member comprises first group of arc cleaning of teeth element and second group of arc cleaning of teeth element.
3. dental treatment according to claim 2 is characterized in that, described first group of arc cleaning of teeth element and second group of arc cleaning of teeth element comprise elastomeric material, and described tissue cleanser has the Xiao A hardness between about 8-25.
4. dental treatment according to claim 1 is characterized in that, described projection comprises a plurality of fritters.
5. dental treatment according to claim 4 is characterized in that, described fritter is configured as taper shape.
6. dental treatment according to claim 1 is characterized in that, described head comprises tray, and described protrusion and tissue cleanser are positioned in the described tray.
CN2011100666536A 2003-06-20 2004-06-18 Oral care implement Expired - Fee Related CN102132995B (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US10/601,106 US20040255416A1 (en) 2003-06-20 2003-06-20 Toothbrush with tongue cleaning member
US10/601,106 2003-06-20
US10/601106 2003-06-20
US29/189,729 2003-09-10
US29/189,729 USD517812S1 (en) 2003-09-10 2003-09-10 Toothbrush
US29/189729 2003-09-10
PCT/US2003/029497 WO2004026162A2 (en) 2002-09-20 2003-09-17 Toothbrush with gripping area
USPCT/US03/29497 2003-09-17
PCT/US2003/030633 WO2004028235A2 (en) 2002-09-27 2003-09-26 Toothbrush
USPCT/US03/30633 2003-09-26

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CN2004800171137A Division CN1809301B (en) 2003-06-20 2004-06-18 Oral care implement

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CN102132995A CN102132995A (en) 2011-07-27
CN102132995B true CN102132995B (en) 2013-03-27

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CN201210307256.8A Expired - Fee Related CN102783811B (en) 2003-06-20 2004-06-18 A kind of toothbrush
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