CN102128918B - Detecting test paper - Google Patents
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- CN102128918B CN102128918B CN201010542684XA CN201010542684A CN102128918B CN 102128918 B CN102128918 B CN 102128918B CN 201010542684X A CN201010542684X A CN 201010542684XA CN 201010542684 A CN201010542684 A CN 201010542684A CN 102128918 B CN102128918 B CN 102128918B
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- 238000012360 testing method Methods 0.000 title claims abstract description 65
- 239000007788 liquid Substances 0.000 claims abstract description 189
- 239000000463 material Substances 0.000 claims description 38
- 238000000926 separation method Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 230000004888 barrier function Effects 0.000 claims description 5
- 239000008280 blood Substances 0.000 abstract description 11
- 210000004369 blood Anatomy 0.000 abstract description 11
- 238000007705 chemical test Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 96
- 239000003153 chemical reaction reagent Substances 0.000 description 28
- 238000001514 detection method Methods 0.000 description 24
- 238000001035 drying Methods 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 14
- 238000010521 absorption reaction Methods 0.000 description 7
- 238000005534 hematocrit Methods 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 3
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 3
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- 229920001220 nitrocellulos Polymers 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 229920006267 polyester film Polymers 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000011152 fibreglass Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920000715 Mucilage Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
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- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a detecting test paper, in particular to a dry chemical test paper for detecting the content of the analyzed object in the blood sample. The detecting test paper comprises a sample adding layer, a reacting layer, a base plate and a liquid-locking component, wherein the sample adding layer, the reacting layer and the base plate are vertically arranged from the top to bottom; at least one side of the reacting layer is provided with the liquid-locking component; and the speed of the liquid-locking component for absorbing the liquid is less than or equal to the speed of the reacting layer for absorbing the liquid. As the liquid-locking component is capable of absorbing the redundant liquid sample, the redundant sample does not flow out of the range of the test paper, and the phenomenon of polluting the environment or the sample contacting to the detector is avoided.
Description
Technical field
The present invention relates to a kind of clinical detection technique field, especially a kind of drying chemical reagent paper that detects the blood sample Biochemical Indexes.
Background technology
At present, comprise that for detection of the method that whether has certain composition or this component content in blood liquid reagent detects and drying chemical reagent paper detects.The characteristics that drying chemical reagent paper has is easy to use, simple to operate, go out result fast.
Flow path according to the tracer liquid sample on drying chemical reagent paper, can be divided into polytype by drying chemical reagent paper, and vertically the vertical detection test paper is a kind of of drying chemical reagent paper.Vertically the vertical detection test paper comprises the carrier with reaction reagent is superimposed mutually, and top-down each reaction reagent layer of flowing through of liquid sample, finally show testing result.For example U.S. Pat 4816224 adopts the method for vertical vertical detection test paper.
Vertically the area of its reaction reagent carrier of vertical detection test paper is all less, therefore only needs less liquid sample consumption just can complete detection.Because individual difference, in the process of finger tip blood sampling, the sample size of collection is very rambunctious, and for example, occidentals's finger tip blood sampling volume tends to more than the Asian.And the reaction reagent carrier saturation degree certain to being absorbed with of liquid, when the blood sample of dropping on test paper is too much, existing dry chemical Test paper can not be processed unnecessary blood sample in time.Of the prior art vertical vertical detection test paper as shown in Figure 1, this test paper comprises: base plate 2 adheres to and is supporting responding layer 1, is coated with sample separation layer 4, fiberglass layer 3 and clathrum 5 on responding layer.After fluid drips is added to clathrum 5, vertical current, through fiberglass layer 3 and sample separation layer 4, finally arrives responding layer 1 chemical reaction occurs.If the blood sample amount added is more, when the responding layer that reaches hold-up can not absorb unnecessary sample again, these unnecessary blood samples will overflow Test paper, contaminated environment or touch the tester.Unnecessary blood also can be gathered on reaction reagent layer and form drop, not only affects the interpretation of the detecting instruments such as optics to result, pollution detection instrument that also can be serious.
Summary of the invention
The object of the present invention is to provide a kind of easy to use, and drying chemical reagent paper that can the unnecessary liquid sample of fast processing.
Drying chemical reagent paper of the present invention comprises on base plate 11 and adheres to and supporting responding layer 12, in responding layer, with respect to the opposite side of base plate, is coated with application of sample layer 13, and an adding mouth 14 is arranged on the application of sample layer.Responding layer is overlapping lock liquid parts 15 along at least one side of base plate direction, and lock liquid parts are fixed on base plate.With respect to responding layer 12 places, one detection window 16 for reading reaction result is arranged at base plate.Can also pass through the more firmly position between fixing them of bonding sheet 17 between responding layer, application of sample layer, lock liquid parts and base plate.For example, the adhesion that bonding sheet 17 is continuous also is pressed on application of sample layer, lock liquid parts and base plate, thereby makes responding layer, application of sample layer, lock liquid parts and base plate mutual alignment fix.
The speed that described lock liquid parts absorb liquid is less than or equal to the speed that responding layer absorbs liquid.When liquid sample is added to the application of sample layer, first vertically flows into responding layer and absorbed by responding layer.When the responding layer hold-up, liquid is diffused in the lock liquid parts that overlap with responding layer by the mode of horizontal effluent.The speed that absorbs liquid due to lock liquid parts is less than or equal to the absorption liquid velocity of responding layer, so when unnecessary liquid is diffused into lock liquid parts, liquid on responding layer has enough carried out relevant detection reaction, thereby does not affect the required effective dose of detection reaction.Therefore when adding excessive sample, unnecessary sample is locked the liquid parts and is absorbed, and unnecessary sample can not form drop and overflows outside test paper.
The invention has the beneficial effects as follows, lock liquid parts can absorb unnecessary liquid sample, make unnecessary sample can not flow out the test paper scope, have avoided environment and detecting instrument are polluted or touch the tester.And the liquid absorption speed of lock liquid parts is less than the liquid absorption infiltration rate of responding layer, guaranteed like this when there being unnecessary sample to be locked liquid section while absorbing, on responding layer, have enough for detection of liquid sample, guaranteed that testing result is stable, accurate.
The accompanying drawing explanation
Fig. 1 is Test paper structural representation of the prior art;
Fig. 2 is the first Test paper structural representation of the present invention;
Fig. 3 is the first Test paper decomposing schematic representation of the present invention;
Fig. 4 is the second Test paper structural representation of the present invention;
Fig. 5 is the third Test paper structural representation of the present invention;
Fig. 6 is the 4th kind of Test paper structural representation of the present invention;
Fig. 7 is the 5th kind of Test paper decomposing schematic representation of the present invention;
Fig. 8 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid component combination;
Fig. 9 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid component combination;
Figure 10 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid component combination;
Figure 11 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid component combination;
Figure 12 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid component combination.
Embodiment
Below in conjunction with concrete accompanying drawing, the present invention will be described in detail.These specific embodiments are only limited the enumerating under spirit of the present invention, do not get rid of one of ordinary skill in the art prior art and the present invention in conjunction with and other specific embodiments of producing.
As Figure 2-3, drying chemical reagent paper of the present invention comprises base plate 11, responding layer 12 and lock liquid parts 15.Responding layer 12 and lock liquid parts 15 are placed on the same side of base plate 11 and are mutually contiguous.Include detection reagent on responding layer 12, for the receiving liquid sample body, and with draw testing result after liquid sample reacts.Lock liquid parts 15 are positioned in the side of responding layer 12, for absorbing excessive liquid sample, thereby make to detect health more.One or more lock liquid parts 15 can be settled in the side of responding layer 12, when a plurality of lock liquid parts are arranged, these lock liquid parts 15 preferably are symmetrical placement or are regular polygon centered by responding layer 12, as settings such as equilateral triangle, square, regular pentagon, regular hexagons, so further improve the beneficial effect that lock liquid parts absorb excessive liquid sample.Lock liquid parts 15 can be also middle porose monoblocks, and responding layer 12 is placed in hole and by lock liquid parts 15 and surrounds (as shown in figure 12).Responding layer 12 and lock liquid parts 15 can be fixed on base plate 11 by glue, double faced adhesive tape or alternate manner, and responding layer 12 can contact side by side or overlap up and down with lock liquid parts 15, also can be intercepted and not contacted by space.Liquid sample directly is added on responding layer 12, and unnecessary liquid sample is absorbed by lock liquid parts 15.
In another embodiment, as in Figure 3-5, in responding layer 12, with respect to the opposite side of base plate 11, be coated with application of sample layer 13, the end of application of sample layer 13 can contact side by side with lock liquid parts 15 or overlap joint up and down, also can be intercepted and not contacted by space.Can also pass through bonding sheet 17 position between fixing them more firmly between responding layer 12, application of sample layer 13, lock liquid parts 15 and base plate 11.For example, the adhesion that bonding sheet 17 is continuous also is pressed on application of sample layer 13, lock liquid parts 15 and base plate 11, thereby makes responding layer 12, application of sample layer 13, lock liquid parts 15 and base plate 11 mutual alignments fix.Bonding sheet 17 is impermeable materials, and not bonded 17 place covered of application of sample layer 13 is formed with an adding mouth 14.With respect to responding layer 12 places, one detection window 16 for reading reaction result is arranged at base plate 11.
The speed that described lock liquid parts absorb liquid is less than or equal to the speed that responding layer absorbs liquid.On the one hand, responding layer is shorter to application of sample layer path than lock liquid parts to the path of application of sample layer, and the liquid sample dripped on the application of sample layer first arrives responding layer; On the other hand, the speed that the selected material of lock liquid parts absorbs liquid is less than or equal to the speed that the selected material of responding layer absorbs liquid.When liquid sample is added to the application of sample layer, first vertically flows into responding layer and absorbed by responding layer.When the responding layer hold-up, liquid is diffused in lock liquid parts by the mode of horizontal effluent.The speed that absorbs liquid due to lock liquid parts is less than or equal to the absorption liquid velocity of responding layer, so when unnecessary liquid is diffused into lock liquid parts, liquid on responding layer has enough carried out relevant detection reaction, thereby does not affect the required effective dose of detection reaction.Therefore when adding excessive sample, unnecessary sample is locked the liquid parts and is absorbed, and unnecessary sample can not form drop and overflows outside test paper.
Test paper as shown in Figure 4, at least one end of application of sample layer 13 is divided and has been covered lock liquid parts 15.It is shorter than the path that arrives lock liquid parts that liquid sample arrives the path of responding layer, because adding mouth be positioned at responding layer directly over, arriving responding layer and only have the distance of perpendicular flow, is first to diffuse laterally into lock liquid parts top and then the vertical lock liquid parts that flow into and arrive lock liquid parts.On the other hand, responding layer is selected the material identical with locking the liquid parts or is selected and makes than the stronger material of lock liquid parts absorption liquid ability of immigrants.The speed that absorbs liquid due to described lock liquid parts is less than or equal to the speed of the absorption liquid of responding layer, so, when unnecessary liquid is diffused into lock liquid parts, the amount of liquid on responding layer has enough met the consumption that detection is relevant.When adding excessive sample, unnecessary sample is locked the liquid parts and is absorbed.
In an embodiment as shown in Figure 5, between responding layer 12 and lock liquid parts 15 not liquid communicate.Liquid does not communicate and can realize by the mode that has gap or interpolation spacing block between the two.In embodiment as described in Figure 5, lock liquid parts 15 cut off with responding layer 12 use barrier blocks 18, and between them, liquid does not communicate, and barrier blocks is impermeable mucilage materials.The present invention also comprises that those skilled in the art can expect making to lock between liquid parts and responding layer other modes that liquid communication does not occur.At least one end of application of sample layer 13 is divided and has been covered lock liquid parts 15, and when adding excessive liquid, unnecessary liquid arrives lock liquid parts and is absorbed by the transverse dispersion of application of sample layer.
Test paper as shown in Figure 6, also comprise at least one sample separation layer 19 between responding layer 12 and application of sample layer 13, described sample separation layer, for the interfering material of liquid sample and detected material are separated, stops interfering material to enter responding layer and contacts with the chemical reagent on responding layer.
Lock liquid parts can also be bonded with double faced adhesive tape up and down, and its thickness is 0.1mm, and described double faced adhesive tape more firmly is combined with application of sample layer and base plate respectively for locking the liquid parts.
Lock liquid parts of the present invention 15 adopt as Fig. 2-during 6 described embodiment, selected material be can the absorption liquid sample body any material, such as filter paper, cellulose nitrate, nonwoven fabrics etc., preferred filter paper.The thickness of lock liquid parts determines according to the different structure that detects sample type and test paper, preferably contour with responding layer or be slightly less than the height of responding layer.
The material that base plate 11 of the present invention is not liquid permeable samples forms, and described material is selected from polypropylene, polystyrene, plastic sheet etc.
The selected material of application of sample layer 13 of the present invention is the material that has water wettability or did hydrophilic treatment, and it can spread and permeate the sample added fast.Described material comprises nylon, glass fibre, nonwoven fabrics, polyester film, filter paper and other suitable materials.
Barrier blocks 18 of the present invention can be the suitable materials such as heat molten type adhesive, siloxane, acrylic acid derivative, rubber, preferably the heat molten type adhesive.
Embodiment as described in Figure 7, lock liquid parts 15 are a kind of with capillary device.Described lock liquid parts 15 comprise the capillary channel 20 of an orientating reaction layer 12, when the liquid sample added is excessive, unnecessary liquid sample is drawn into rapidly in the capillary channel 20 of lock liquid parts under capillarity, thereby pin unnecessary sample, makes it not excessive.The material of the described lock liquid of the present embodiment parts 15 can be plastics etc.
A plurality of (more than two and two) responding layer 12 also can be arranged on base plate 11, can place identical or dissimilar detection reagent on each responding layer 12, in order to carry out a plurality of identical or dissimilar detections simultaneously, thereby improve detection efficiency, save testing cost.While on base plate 11, a plurality of responding layer 12 being arranged, preferably leave each other gap between these responding layers 12.The side of each responding layer 12 can at least be mounted with lock liquid parts 15.The positional alignment mode of responding layer 12 and lock liquid parts 15 please refer to Fig. 8-12, and (for simplicity, Fig. 8-12 only illustrate responding layer 12 and lock liquid parts 15, and will omit such as base plate 11 elements such as grade.Also should comprise base plate 11 and other necessary element in actual design).
As shown in Figure 8, responding layer 12 and lock liquid parts 15 are arranged in a row on base plate 11, and each responding layer 12 2 side all has lock liquid parts 15.
As shown in Figure 9, responding layer 12 and lock liquid parts 15 on base plate 11 successively compartment of terrain be arranged in a row, lock liquid parts 15 are arranged between adjacent two responding layers 12, between adjacent two lock liquid parts 15, a responding layer 12 is arranged.
As shown in figure 10, having two rows on base plate 11 locks liquid parts 15 and is sandwiched in two rows and lock one between liquid parts 15 rows responding layer 12.
As shown in figure 11, there are two strip lock liquid parts 15 that are arranged side by side on base plate 11 and be sandwiched in two row's responding layers 12 between strip lock liquid parts 15.
As shown in figure 12, there are strip lock liquid parts 15 on base plate 11, on strip lock liquid parts 15, have a round, be mounted with a responding layer 12 in each hole.
In addition, as required, upper and lower two of base plate 11 all can be provided with responding layer 12 and lock liquid parts 15, thereby can settle more responding layer 12 on base plate 11 of the same area, so that same product carries out the detection of more.
In this specification and claims book, said liquid sample comprises liquid sample and is dissolved in the sample in liquid.
A kind of drying chemical reagent paper of embodiment 1 the present invention
Dry chemical Test paper of the present invention, as shown in Figure 4, adhere to and supporting responding layer 12 on base plate 11, in responding layer, with respect to the opposite side of base plate, be coated with application of sample layer 13, and an adding mouth 14 is arranged on the application of sample layer.The two end portions of application of sample layer 13 has covered lock liquid parts 15.With respect to responding layer 12 places, detection window 16 is arranged at base plate.The adhesion that bonding sheet 17 is continuous also is pressed on application of sample layer, lock liquid parts and base plate.Base plate 11 adopts the PET material, and thickness is 0.35mm.Responding layer 12 adopts the nylon membrane material, and thickness is 0.05mm.Application of sample layer 13 adopts the glass polymeric material.Lock liquid parts 15 adopt filter paper material, and thickness is 0.4mm.Sample separation layer 19 thickness are 0.35mm.
Application of sample amount cholesterol detection on drying chemical reagent paper of the present invention that embodiment 2 is different
The whole blood solution that the preparation cholesterol concentration is 150mg/dl, wherein the hematocrit of this sample (HCT) concentration is 42%.Get respectively the above-mentioned whole blood solution of 15 μ l, 20 μ l, 30 μ l and 40 μ l, be added drop-wise on the described drying chemical reagent paper of the embodiment of the present invention 1 and detected.When the sample consumption reaches 20 μ l, the absorbance log of its responding layer test paper of the described drying chemical reagent paper of the embodiment of the present invention 1 reaches capacity.The sample consumption is considered to excessive application of sample amount while being 30/ μ l and 40 μ l.Test result shows that drying chemical reagent paper of the present invention is not subject to the impact of application of sample amount, can well absorb unnecessary sample.Testing result is stable, accurate.Testing result is in Table 1.
Table 1
The different application of sample amounts of embodiment 3 are tested by the impact of HCT concentration
Prepare respectively the whole blood solution that hematocrit (HCT) is 30%, 42%, 55%, be added drop-wise on the described drying chemical reagent paper of the embodiment of the present invention 1 and detected.The application of sample amount is respectively 15ul, 20ul, 30ul, 40ul.When the sample consumption reaches 20 μ l, the absorbance log of its responding layer test paper of the described drying chemical reagent paper of the embodiment of the present invention 1 reaches capacity.The sample consumption is considered to excessive application of sample amount while being 30 μ l and 40 μ l.Result shows, uses drying chemical reagent paper of the present invention, is not subject to the impact of hematocrit, also is not subject to the impact of application of sample amount, and testing result is stable, consistent.The results are shown in Table 2 to table 4.
Table 2
Table 3
Table 4
In order to support better claims, for later modification right claim provides foundation, the present invention's disclosed content when filing an application is supplemented as follows.
1, a kind of Test paper, comprise base plate (11) and be positioned at the responding layer (12) on base plate, it is characterized in that: at least one side in responding layer (12) includes for absorbing the lock liquid parts (15) of unnecessary liquid.
2, Test paper according to claim 1 is characterized in that: the speed that lock liquid parts (15) absorb liquid is less than or equal to the speed that responding layer (12) absorbs liquid.
3, Test paper according to claim 1 is characterized in that: respectively have one in the relative both sides of responding layer (12) for absorbing the lock liquid parts (15) of unnecessary liquid.
4, Test paper according to claim 1, it is characterized in that: Test paper also comprises the application of sample layer (13) be positioned on responding layer (12), and application of sample layer (13) contacts side by side, mutually overlaps or do not contact mutually with lock liquid parts (15).
5, Test paper according to claim 4 is characterized in that: between responding layer (12) and lock liquid parts (15), contact side by side or mutually overlap.
6, Test paper according to claim 4 is characterized in that: between responding layer (12) and lock liquid parts (15), by gap, intercepted or intercepted by fluid-tight barrier blocks (18).
7, Test paper according to claim 4 is characterized in that: also comprise at least one sample separation layer (19) between application of sample layer and responding layer.
8, Test paper according to claim 1 is characterized in that: lock liquid parts (15) have capillary channel (20) at an end of orientating reaction layer (12), and the material of described lock liquid parts (15) is material impervious to water.
9, Test paper according to claim 1, it is characterized in that: responding layer (12) is surrounded by the lock liquid parts (15) more than three or three, and these lock liquid parts (15) are the regular polygon layout centered by responding layer (12).
10, Test paper according to claim 1 is characterized in that: the size of lock liquid parts (15) is larger than responding layer (12), and there is a hole inside, and responding layer (12) is enclosed in the hole of locking the liquid parts.
11, Test paper according to claim 1 is characterized in that: the responding layer (12) more than two or two is arranged on base plate (11), and the side of each responding layer (12) is equipped with at least one lock liquid parts (15).
12, Test paper according to claim 11 is characterized in that: responding layer (12) and lock liquid parts (15) are arranged in a row on base plate (11), and each responding layer (12) two side all has lock liquid parts (15).
13, Test paper according to claim 11, it is characterized in that: responding layer (12) and the lock liquid parts (15) on base plate (11) successively compartment of terrain be arranged in a row, lock liquid parts (15) are arranged between adjacent two responding layers (12), between adjacent two lock liquid parts (15), a responding layer (12) is arranged.
14, Test paper according to claim 1 is characterized in that: have two rows on base plate (11) and lock liquid parts (15) and be sandwiched in two rows and lock one between liquid parts (15) rows responding layer (12).
15, Test paper according to claim 1 is characterized in that: have two strip lock liquid parts (15) that are arranged side by side on base plate (11) and be sandwiched in the row's responding layer (12) between two strip lock liquid parts (15).
16, Test paper according to claim 1, it is characterized in that: there are strip lock liquid parts (15) on base plate (11), have a round on strip lock liquid parts (15), be mounted with a responding layer (12) in each hole.
17, according to the described Test paper of any one of claim 1 to 16, it is characterized in that: upper and lower two all respond layer (12) and the lock liquid parts (15) of base plate (11).
18,, according to the described Test paper of any one of claim 1 to 16, it is characterized in that the material of responding layer and lock liquid parts is selected from the material that has water wettability or did hydrophilic treatment.
19,, according to the described Test paper of any one of claim 4 to 6, it is characterized in that the material of application of sample layer is selected from the material that has water wettability or did hydrophilic treatment.
20, Test paper according to claim 7, is characterized in that the material of sample separation layer is selected from the material that has water wettability or did hydrophilic treatment.
Claims (7)
1. a Test paper, comprise base plate (11) and be positioned at the responding layer (12) on base plate, it is characterized in that: at least one side in responding layer (12) includes for absorbing the lock liquid parts (15) of unnecessary liquid sample, Test paper also comprises the application of sample layer (13) be positioned on responding layer (12), application of sample layer (13) is the material that has water wettability or did hydrophilic treatment, the end of application of sample layer (13) overlaps up and down with lock liquid parts (15), between responding layer (12) and lock liquid parts (15) not liquid communicate, when liquid sample is added to application of sample layer (13), first vertically flow into responding layer (12) and absorbed by responding layer, when responding layer (12) hold-up, unnecessary liquid sample first diffuses laterally into top and then the vertical lock liquid parts (15) that flow into of lock liquid parts (15) by application of sample layer (13).
2. Test paper according to claim 1 is characterized in that: the speed that lock liquid parts (15) absorb liquid is less than or equal to the speed that responding layer (12) absorbs liquid.
3. Test paper according to claim 1, is characterized in that: respectively have one in the relative both sides of responding layer (12) for absorbing the lock liquid parts (15) of unnecessary liquid.
4. Test paper according to claim 1, is characterized in that: between responding layer (12) and lock liquid parts (15), by gap, intercepted or intercepted by fluid-tight barrier blocks (18).
5. Test paper according to claim 1, is characterized in that: also comprise at least one sample separation layer (19) between application of sample layer and responding layer.
6. Test paper according to claim 1 is characterized in that: responding layer (12) is surrounded by the lock liquid parts (15) more than three or three, and these lock liquid parts (15) are the regular polygon layout centered by responding layer (12).
7. Test paper according to claim 1 is characterized in that: the size of lock liquid parts (15) is larger than responding layer (12), and there is a hole inside, and responding layer (12) is enclosed in the hole of locking the liquid parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010542684XA CN102128918B (en) | 2010-11-11 | 2010-11-11 | Detecting test paper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010542684XA CN102128918B (en) | 2010-11-11 | 2010-11-11 | Detecting test paper |
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| Publication Number | Publication Date |
|---|---|
| CN102128918A CN102128918A (en) | 2011-07-20 |
| CN102128918B true CN102128918B (en) | 2013-12-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010542684XA Active CN102128918B (en) | 2010-11-11 | 2010-11-11 | Detecting test paper |
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| CN (1) | CN102128918B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102680672B (en) * | 2012-05-08 | 2015-02-11 | 艾康生物技术(杭州)有限公司 | Detection device |
| CN103267839B (en) * | 2013-04-28 | 2015-09-23 | 上海快灵生物科技有限公司 | Enclosed chromatographic test paper plastics cartridge |
| CN106645763B (en) * | 2017-01-03 | 2019-03-22 | 长沙中生众捷生物技术有限公司 | The Test paper of total cholesterol |
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