CN102126911A - Industrial method for efficiently producing lycopene crystals - Google Patents
Industrial method for efficiently producing lycopene crystals Download PDFInfo
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- CN102126911A CN102126911A CN 201010615193 CN201010615193A CN102126911A CN 102126911 A CN102126911 A CN 102126911A CN 201010615193 CN201010615193 CN 201010615193 CN 201010615193 A CN201010615193 A CN 201010615193A CN 102126911 A CN102126911 A CN 102126911A
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Abstract
The invention relates to an industrial method for purifying natural extracts, in particular to an industrial method for efficiently producing lycopene crystals. The method comprises the following steps of: (1) mixing 6-15 percent of lycopene oleoresin with a diolefine solvent in the mass ratio of 1:(3-7) and stirring the mixture to dissolve the mixture into mixed liquor; (2) standing the mixed liquor at the temperature of between 10 DEG C below zero and 20 DEG C and centrifuging the mixed liquor to obtain viscous paste; (3) mixing the viscous paste with the paraffin solvent, standing and centrifuging to obtain paste; (4) performing vacuum drying on the paste and removing solvent residues to obtain the lycopene crystals; and (5) and performing vacuum low-temperature concentration on filtrate obtained by centrifuging in the step (2) and the step (3) to obtain low-content lycopene oleoresin. The method has low environmental requirements, and an enriched high-content lycopene oleoresin component can be efficiently and continuously separated.
Description
Technical field
The present invention relates to the commercial run of natural extract purifying, particularly a kind of industrial method of High-efficient Production lycopene crystal.
Background technology
Lyeopene is celebrated because of its superior anti-oxidant function, be made into the product of various ways such as soft capsule, microcapsule, oily molten suspension, tablet, pulvis, injection, specification, be applied to medical treatment, health care market, a pyrogenicity that was subjected to domestic and international health-product market is in recent years held in both hands.
Lyeopene is difficult for being absorbed by the body originally as fat-soluble, generally need be prepared into the aqueous dispersion type product application.In the practical application, the most common with all kinds of formulation products, and to strengthen its stability by embedding.The raw material that is used to produce formulation products must use the high purity lycopene crystal, generally need content greater than 80%, enough spaces so just can be arranged in order to add all kinds of auxiliary materials and wall material, and the tomato red product that directly extracts preparation is generally the oleo-resinous of content below 15%, therefore, simple and feasible industrial method must be arranged, be used for oleo-resinous is processed into high-load lycopene crystal, satisfy market demand.
Publication number is in the patent of CN1775867A, tomato red is mixed with alcoholic solution, stirring after-filtration, drying obtain the purified lycopene product, but the tomato red filtration difficulty can only be selected the bigger filter screen in aperture, and leaving standstill filtration procedure generally needs more than 10 hours altogether, one side length consuming time, efficient is low, can not effectively tackle high content component on the other hand, and its content 19～65% can illustrate this problem.Publication number is in the patent of CN1807410A, and tomato red repeats crystallization for three times and obtains high-purity crystals, and recrystallization is the process of loss high content component, and its yield is difficult to guarantee that production efficiency is also well imagined.Publication number is in the patent of CN1687239A, and its Tc control is higher, is unfavorable for the enrichment speed and the effect of high purity Lyeopene, and has also used filtration, crystalline operation that production efficiency and yield must have one can't guarantee.Publication number is in the patent of CN1405235A, discloses a kind of technology of utilizing reverse-phase chromatography column separating purification Lyeopene, can prepare the product of 99% above purity, but needs expensive chromatographic equipment, and production efficiency is low, and output is little, is not suitable for suitability for industrialized production.
In a word, among the preparation method of high purity Lyeopene, mostly use low temperature environment, continued to use crystallization, recrystallization, filtration, exsiccant method, process is tediously long, filtration difficulty, general whole production requirements of process can only obtain tens to a few hectogram high purity lycopene crystals more than 24 hours at every turn, simultaneously because very easily oxidational losses of Lyeopene, long inevitable loss consuming time is big, and product purity and yield all are difficult to guarantee that cost and efficient aspect are difficult to ensure industrialized smooth realization.
Summary of the invention
In order to overcome the shortcoming of prior art, the invention provides a kind of industrial method of High-efficient Production lycopene crystal, it is low to environmental requirement, can make the high-content Lyeopene component of enrichment efficient, separate continuously.
The present invention solves the technical scheme that its technical problem takes: may further comprise the steps: (1), the tomato red oleo-resinous of content 6～15% is mixed with alkane solvents, the mass ratio of tomato red oleo-resinous and alkane solvents is 1: 3～and 7, stir and make it be dissolved as mixed solution; (2), mixed solution leaves standstill under-10～20 ℃ of conditions, centrifugal mixed solution obtains the thickness paste; (3), the thickness paste is mixed with alkane solvents again, leave standstill centrifugal paste; (4), with paste vacuum-drying, slough dissolvent residual, lycopene crystal; (5), with (2), centrifugal gained filtrate vacuum and low temperature of (3) step concentrates, low levels tomato red oleo-resinous.
Described alkane solvents is normal hexane, sherwood oil or No. 6 petroleum naphthas.
(2), (3) go on foot twice time of repose and are 0.5～4 hour.
Described whizzer is the supercentrifuge that has automatic discharging function, and separating factor is greater than 10000.
The lycopene crystal purity of (4) step gained is greater than 90%.
The present invention has following advantage: (1), can obtain highly purified lycopene crystal, content are greater than 90%, and tomato red oleo-resinous byproduct still can be used as the tomato red oleo-resinous of low levels and uses; (2), technology is simple, flow process is short, loss is few, cost is low; (3), the total content rate of recovery is greater than 95%, no waste discharge; (4), be easy to realize the serialization industrial production.
Embodiment
Get the tomato red oleo-resinous 100kg of content 12.9%, add sherwood oil 500kg, fully stirring and evenly mixing after leaving standstill 1 hour under 10 ℃ of conditions, uses automatic discharging formula whizzer (separating factor 1.5 ten thousand), and the continuously centrifuged mixed solution obtains thickness paste 15.3kg.Add the 50.0kg sherwood oil in the thickness paste, fully stirring and evenly mixing after leaving standstill 1 hour under 10 ℃ of conditions, uses automatic discharging formula whizzer (separating factor 1.5 ten thousand), and the continuously centrifuged mixed solution obtains paste.Paste through after the vacuum-drying, is obtained content and is 91.3% high purity lycopene crystal 10.1kg.Two times centrifugal filtrate is merged, in vacuum tightness be-0.09KPa, temperature is concentrated under 45 ℃ the condition, obtains content and be 6.1% tomato red oleo-resinous 56.4kg.Total content yield 98.15%.
Embodiment 2
Get the tomato red oleo-resinous 500kg of content 10.1%, add normal hexane 2000kg, fully stirring and evenly mixing, after leaving standstill 2.5 hours under 15 ℃ of conditions, use automatic discharging formula whizzer (separating factor 1.5 ten thousand), the continuously centrifuged mixed solution obtains thickness paste 112.1kg.In the thickness paste, add the 500.0kg normal hexane, abundant stirring and evenly mixing, after leaving standstill 2.5 hours under 15 ℃ of conditions, use automatic discharging formula whizzer (separating factor 1.5 ten thousand), the continuously centrifuged mixed solution, obtain paste, paste through after the vacuum-drying, is obtained content and be 90.7% high purity lycopene crystal 44.2kg.Two times centrifugal filtrate is merged, and vacuum tightness be-0.09KPa, and temperature is concentrated under 45 ℃ the condition, obtains content and be 4.6% tomato red oleo-resinous 187.4kg.Total content yield 96.46%.
Claims (5)
1. the industrial method of a High-efficient Production lycopene crystal, it is characterized in that: may further comprise the steps: (1), the tomato red oleo-resinous of content 6～15% is mixed with alkane solvents, the mass ratio of tomato red oleo-resinous and alkane solvents is 1: 3～and 7, stir and make it be dissolved as mixed solution; (2), mixed solution leaves standstill under-10～20 ℃ of conditions, centrifugal mixed solution obtains the thickness paste; (3), the thickness paste is mixed with alkane solvents again, leave standstill centrifugal paste; (4), with paste vacuum-drying, slough dissolvent residual, lycopene crystal; (5), with (2), centrifugal gained filtrate vacuum and low temperature of (3) step concentrates, low levels tomato red oleo-resinous.
2. the industrial method of High-efficient Production lycopene crystal according to claim 1 is characterized in that: described alkane solvents is normal hexane, sherwood oil or No. 6 petroleum naphthas.
3. the industrial method of High-efficient Production lycopene crystal according to claim 1 is characterized in that: (2), (3) go on foot twice time of repose and are 0.5～4 hour.
4. the industrial method of High-efficient Production lycopene crystal according to claim 1 is characterized in that: described whizzer is the supercentrifuge that has automatic discharging function, and separating factor is greater than 10000.
5. the industrial method of High-efficient Production lycopene crystal according to claim 1 is characterized in that: the lycopene crystal purity of (4) step gained is greater than 90%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106151933A CN102126911B (en) | 2010-12-22 | 2010-12-22 | Industrial method for efficiently producing lycopene crystals |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010106151933A CN102126911B (en) | 2010-12-22 | 2010-12-22 | Industrial method for efficiently producing lycopene crystals |
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| CN102126911A true CN102126911A (en) | 2011-07-20 |
| CN102126911B CN102126911B (en) | 2012-08-08 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526334A (en) * | 2011-12-09 | 2012-07-04 | 新疆晨曦椒业有限公司 | Industrial method for producing tomato red by using tomato peel residues |
| CN102660380A (en) * | 2012-05-29 | 2012-09-12 | 刘伯堂 | Method for extracting lycopene oil with dried tomato skin as raw material |
| CN107106625A (en) * | 2014-11-25 | 2017-08-29 | 利库德有限公司 | The biological activity tomato compositions of lycopene with decrement |
| EP3702412A4 (en) * | 2017-10-25 | 2021-07-28 | Chenguang Biotech Group Co., Ltd. | Method for preparing lycopene crystals with high purity and low harm |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176577A (en) * | 1994-10-31 | 1998-03-18 | 马克特辛姆化学工厂有限公司 | Stable lycopene concentrates and process for their preparation |
| WO1998043620A1 (en) * | 1997-04-03 | 1998-10-08 | Kemin Foods, L.C. | Process for the isolation and purification of lycopene crystals |
-
2010
- 2010-12-22 CN CN2010106151933A patent/CN102126911B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176577A (en) * | 1994-10-31 | 1998-03-18 | 马克特辛姆化学工厂有限公司 | Stable lycopene concentrates and process for their preparation |
| WO1998043620A1 (en) * | 1997-04-03 | 1998-10-08 | Kemin Foods, L.C. | Process for the isolation and purification of lycopene crystals |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526334A (en) * | 2011-12-09 | 2012-07-04 | 新疆晨曦椒业有限公司 | Industrial method for producing tomato red by using tomato peel residues |
| CN102526334B (en) * | 2011-12-09 | 2014-04-02 | 新疆晨曦椒业有限公司 | Industrial method for producing tomato red by using tomato peel residues |
| CN102660380A (en) * | 2012-05-29 | 2012-09-12 | 刘伯堂 | Method for extracting lycopene oil with dried tomato skin as raw material |
| CN107106625A (en) * | 2014-11-25 | 2017-08-29 | 利库德有限公司 | The biological activity tomato compositions of lycopene with decrement |
| EP3702412A4 (en) * | 2017-10-25 | 2021-07-28 | Chenguang Biotech Group Co., Ltd. | Method for preparing lycopene crystals with high purity and low harm |
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| Publication number | Publication date |
|---|---|
| CN102126911B (en) | 2012-08-08 |
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Application publication date: 20110720 Assignee: Xinjiang Chenxi Pepper Industry Co.,Ltd. Assignor: Chengguang Natural Pigment Group Co., Ltd. Contract record no.: 2019990000135 Denomination of invention: Industrial method for efficiently producing lycopene crystals Granted publication date: 20120808 License type: Common License Record date: 20190430 |
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