CN102125909A - Siliconizing method of transfusionapparatus - Google Patents
Siliconizing method of transfusionapparatus Download PDFInfo
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- CN102125909A CN102125909A CN2011100266868A CN201110026686A CN102125909A CN 102125909 A CN102125909 A CN 102125909A CN 2011100266868 A CN2011100266868 A CN 2011100266868A CN 201110026686 A CN201110026686 A CN 201110026686A CN 102125909 A CN102125909 A CN 102125909A
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- silicidation
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- transfusion device
- transfusion
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Abstract
The invention relates to a processing method of the inner surface of medical equipment, in particular to a siliconizing method of a transfusion apparatus used in stem cell transfusion. The method comprises the steps of: dissolving organic silicon oil in a solvent, preparing a siliconizing reagent, uniformly coating the siliconizing reagent on the inner surface of the transfusion apparatus, then drying to ensure the solvent in the reagent is volatilized, and forming an organic silicon oil thin layer on the inner surface of the transfusion apparatus. The invention has the advantage of solving the problem of pollution to the environment because F113 is used as a solvent for processing in the prior art. Meanwhile, the invention has the remarkable advantages of providing a path for solving the problem of attachment in the stem cell transfusion process, and overcoming the defect of attachment generated in the stem cell transfusion process by the common transfusion apparatus.
Description
Technical field
The present invention relates to a kind of processing method of medicine equipment inner surface, particularly a kind of silicidation method that is used for the transfusion device of stem cell transfusion.
Background technology
The input stem cell mostly is attached cell, is detained in the pipe more, and the stem cell waste is many, can reach more than 15%.
Disposable transfusion device is indispensable infusion apparatus in medicine venous transfusion process, and clinical practice is very extensive.The transfusion device of China's hospital clinical use at present generally adopts polyvinyl chloride (PVC) resin to make.In order to make PVC become transparent and soft, add phthalic acid (diethyl) plasticizer about 40%.The purpose of silicidation is the very thin organosilicon oil reservoir of inner surface formation one deck at transfusion device, but this organosilicon oil reservoir can not directly adopt organic silicone oil to smear, but organic silicone oil is dissolved in a kind of volatile solvent, form the weak solution of organic silicone oil, and then transfusion device is immersed in a period of time in this solvent, allow transfusion device attach one deck solution, dry a period of time, after treating that solvent evaporates in the solution is intact, just the inner surface at transfusion device stays very thin one deck organic silicone oil, forms very smooth surface.Prior art generally is to adopt trifluorotrichloroethane as solvent when the weak solution of preparation organic silicone oil, and the popular name of trifluorotrichloroethane is called for short F113 Freon 113.F113 is that as the advantage of solvent it does not burn, and does not explode, and uses fool proof; It is nontoxic, good biocompatibility; It is the fine solvent of organic silicone oil, and boiling point is suitable, and is volatile, can not remain on the disposable medical instrument.Therefore, F113 has obtained extensive use in the disposable medical instrument industry.But, banned use of now by more and more countries owing to after it evaporate in the air, can produce destruction to the foul smell layer in the atmosphere.Therefore, the substitute of seeking a kind of F113 is the problem that the disposable medical instrument industry presses for solution.
Summary of the invention
Purpose of the present invention is to provide a kind of silicidation method of transfusion device, and solvent does not wherein adopt F113, can avoid the problem of environmental pollution that uses F113 to bring.
The objective of the invention is to be achieved through the following technical solutions:
The chemical analysis of medical silicone oil is a dimethyl silicone polymer, is commonly called as dimethicone. be mainly used in the silicidation of syringe or plug.Dimethicone has following characteristics: (1) high hydrophobicity; (2) good stable; (3) to plastics, rubber and skin good lubricity; (4) extremely low surface tension (21 dynes/cm) is so have excellent especially spreading property; (5) low skin irritability.
The invention provides a kind of stem cell specialty transfusion device of silicidation, described silicidation method comprises, silicidation reagent is dissolved in solvent 100 weight portions formulated by organic silicone oil 1-5 weight portion, solvent wherein is selected from HMDO, 1, a kind of in 1-two chloro-1-fluoroethanes, dichloro pentafluoropropane, the 3-pentafluorobutane.The silicidation method is: silicidation reagent is evenly spread upon the transfusion device inner surface, dry then, the solvent evaporates in the reagent is fallen, at the very thin organosilicon oil reservoir of inner surface formation one deck of transfusion device.
Described processing method generally has two kinds of methods.(1) is diluted to 1%-5% with solvent (as OS-10), adopts dipping, the method that sprays or smear; (2) directly with the spraying of pure silicon oil.
Transfusion device of the present invention the solvent that silicidation adopted be not F113, but all approaching substitute of every index with F113, under the situation of the silication quality that guarantees transfusion device, can not pollute after its volatilization, solve and used F113 in the prior art as the pollution problem of solvent to environment to environment.Simultaneously, the most outstanding advantage of the present invention is for medical industry provides a kind of problem that can solve the stem cell wall built-up, has overcome the wall built-up problem that general infusion set produces in carrying out the stem cell input process.
The specific embodiment
Embodiment 1
Taking out organic silicone oil 5 grams is dissolved in the 100 gram HMDOs, obtain silicidation reagent, above-mentioned silicidation reagent is evenly spread upon the transfusion device inner surface, oven dry then, solvent evaporates in the reagent is fallen, inner surface at transfusion device forms very thin organosilicon oil reservoir, finishes the silicidation of transfusion device.
Embodiment 2
Take out organic silicone oil 3 grams and be dissolved in 100 grams 1, in the 1-two chloro-1-fluoroethanes, obtain silicidation reagent, above-mentioned silicidation reagent is evenly spread upon the transfusion device inner surface, oven dry then, solvent evaporates in the reagent is fallen, formed very thin organosilicon oil reservoir, finish the silicidation of transfusion device at the inner surface of transfusion device.
Embodiment 3
Taking out organic silicone oil 1 gram is dissolved in the 100 gram dichloro pentafluoropropanes, obtain silicidation reagent, above-mentioned silicidation reagent is evenly spread upon the transfusion device inner surface, oven dry then, solvent evaporates in the reagent is fallen, inner surface at transfusion device forms very thin organosilicon oil reservoir, finishes the silicidation of transfusion device.
Embodiment 4
Taking out organic silicone oil 2 grams is dissolved in the 100 gram 3-pentafluorobutanes, obtain silicidation reagent, above-mentioned silicidation reagent is evenly spread upon the transfusion device inner surface, oven dry then, solvent evaporates in the reagent is fallen, inner surface at transfusion device forms very thin organosilicon oil reservoir, finishes the silicidation of transfusion device.
Claims (6)
1. the silicidation method of a transfusion device, described method comprises that organic silicone oil is dissolved in the solvent, be mixed with silicidation reagent, silicidation reagent is evenly spread upon the transfusion device inner surface, dry then, solvent evaporates in the silicidation reagent is fallen, at the very thin organosilicon oil reservoir of inner surface formation one deck of transfusion device.
2. silicidation method according to claim 1 is characterized in that described solvent is selected from HMDO, 1,1-two chloro-1-fluoroethanes, dichloro pentafluoropropane or 3-pentafluorobutane.
3. silicidation method according to claim 1 is characterized in that described solvent is selected from HMDO or 3-pentafluorobutane.
4. silicidation method according to claim 1 is characterized in that described silicidation reagent is dissolved in solvent 100 weight portions by organic silicone oil 1-5 weight portion to be mixed with.
5. silicidation method according to claim 1 is characterized in that described silicidation reagent is dissolved in solvent 100 weight portions by organic silicone oil 2.5-3 weight portion to be mixed with.
6. silicidation method according to claim 1 is characterized in that described smearing is dipping, sprays or directly smears.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100266868A CN102125909A (en) | 2011-01-21 | 2011-01-21 | Siliconizing method of transfusionapparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100266868A CN102125909A (en) | 2011-01-21 | 2011-01-21 | Siliconizing method of transfusionapparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102125909A true CN102125909A (en) | 2011-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2011100266868A Pending CN102125909A (en) | 2011-01-21 | 2011-01-21 | Siliconizing method of transfusionapparatus |
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| CN (1) | CN102125909A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106221976A (en) * | 2016-07-26 | 2016-12-14 | 温州科技职业学院 | A kind of insulin needle surface siliconization inorganic agent |
| CN107349486A (en) * | 2017-06-28 | 2017-11-17 | 安徽光大医疗科技股份有限公司 | A kind of biliquid is the same as defeated type disposable transfusion device |
| WO2018023826A1 (en) * | 2016-08-01 | 2018-02-08 | 北京臻惠康生物科技有限公司 | Infusion pump and infusion method dedicated for stem cell |
| CN108484957A (en) * | 2018-04-18 | 2018-09-04 | 山东济海医疗科技股份有限公司 | Medical grade rubber process for treating surface |
| CN110499063A (en) * | 2019-07-24 | 2019-11-26 | 张建光 | A kind of environment-friendly type Medical silicone oil diluent and its silicidation agent |
| CN113429877A (en) * | 2021-06-28 | 2021-09-24 | 山东中保康医疗器具有限公司 | Silicone oil for silicification and silicification method of puncture needle |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1904601A (en) * | 2006-08-03 | 2007-01-31 | 厦门大学 | pH micro electrode using 4-enndecyl pyrimidine as sensor carrier and its manufacturing method |
| CN1978567A (en) * | 2005-12-08 | 2007-06-13 | 上海康德莱企业发展集团有限公司 | Syringe sleeve siliconizing reagent, and its siliconizing method |
-
2011
- 2011-01-21 CN CN2011100266868A patent/CN102125909A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1978567A (en) * | 2005-12-08 | 2007-06-13 | 上海康德莱企业发展集团有限公司 | Syringe sleeve siliconizing reagent, and its siliconizing method |
| CN1904601A (en) * | 2006-08-03 | 2007-01-31 | 厦门大学 | pH micro electrode using 4-enndecyl pyrimidine as sensor carrier and its manufacturing method |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106221976A (en) * | 2016-07-26 | 2016-12-14 | 温州科技职业学院 | A kind of insulin needle surface siliconization inorganic agent |
| WO2018023826A1 (en) * | 2016-08-01 | 2018-02-08 | 北京臻惠康生物科技有限公司 | Infusion pump and infusion method dedicated for stem cell |
| CN107670145A (en) * | 2016-08-01 | 2018-02-09 | 北京臻惠康生物科技有限公司 | Infusion pump and infusion method special for stem cells |
| US11511036B2 (en) | 2016-08-01 | 2022-11-29 | BENING ZHEN HUIKANG BIOLOGICAL TECH. Co., Ltd. | Infusion pump and infusion method dedicated for stem cell |
| CN107349486A (en) * | 2017-06-28 | 2017-11-17 | 安徽光大医疗科技股份有限公司 | A kind of biliquid is the same as defeated type disposable transfusion device |
| CN108484957A (en) * | 2018-04-18 | 2018-09-04 | 山东济海医疗科技股份有限公司 | Medical grade rubber process for treating surface |
| CN110499063A (en) * | 2019-07-24 | 2019-11-26 | 张建光 | A kind of environment-friendly type Medical silicone oil diluent and its silicidation agent |
| CN113429877A (en) * | 2021-06-28 | 2021-09-24 | 山东中保康医疗器具有限公司 | Silicone oil for silicification and silicification method of puncture needle |
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Application publication date: 20110720 |