CN102125171A - Method for preparing microencapsulation envelope zinc oxide - Google Patents
Method for preparing microencapsulation envelope zinc oxide Download PDFInfo
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- CN102125171A CN102125171A CN2010100396316A CN201010039631A CN102125171A CN 102125171 A CN102125171 A CN 102125171A CN 2010100396316 A CN2010100396316 A CN 2010100396316A CN 201010039631 A CN201010039631 A CN 201010039631A CN 102125171 A CN102125171 A CN 102125171A
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- oxide powder
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Abstract
The invention relates to a method for preparing an animal feed additive, namely microencapsulation envelope zinc oxide. The microencapsulation envelope zinc oxide consists of 5 to 20 percent of starch, 5 to 10 percent of sodium carboxymethylcellulose, 50 to 80 percent of zinc oxide powder, 5 to 15 percent of stearic acid and 3 to 5 percent of resin 3#. By the method, the feed zinc oxide powder is subjected to microencapsulation envelope treatment, so that damage of gastric acid to the zinc oxide is avoided, long-term sustained release of the zinc oxide in an animal intestinal tract is realized, zinc oxide bioavailability of the animal is improved, using amount and using cost of the zinc oxide are reduced, and excrement zinc excretion and environmental pollution are reduced.
Description
Technical field
Patent of the present invention relates to a kind of preparation method who is used for the microencapsulated coating zinc oxide of animal feed level additive.
Background technology
Diarrhea of weaned piglets is the key factor that limits the level of raising pigs at present, very easily causes the mortality of piglet, has caused great loss for the breed industry.The means that solve grice diarrhoea at present are mainly uses antibiotic and zinc oxide.Along with antibiotic long-term being extensive use of, the pathogenic bacteria in the breeding environment have produced certain drug resistance, have caused antibiotic result of use to descend day by day; And feeding high dose zinc oxide (being generally 2000～3000ppm) can significantly reduce grice diarrhoea, promotes piglet growth; Therefore, in present pig starter feed, generally add the zinc oxide of high dose.According to the literature, have only the zinc oxide of high dose just to have significant anti diar rhea effect, have only the zinc oxide of high dose just to have convergence enteron aisle and antibacterial effect on the one hand; Have only the zinc oxide of high dose could partly keep away the destruction of hydrochloric acid in gastric juice on the other hand, performance anti diar rhea effect to zinc oxide.
Though high dose zinc oxide is fairly obvious to the effect of prevention grice diarrhoea, should not use for a long time, generally is no more than 2 time-of-weeks, long-term use can cause staple length, the colour of skin is pale and a series of harmful effect such as restriction late growing stage; The zinc oxide of high dose also can be broken the balance of original various trace element in animal body in the feed simultaneously, easily causes the absorption difficulty of elements such as copper, iron, and then causes the shortage of these nutrients; In addition, the zinc oxide of high dose RT in animal body is short, and absorption rate is low, and a large amount of zinc is excreted in the environment with ight soil etc., causes environmental pollution.
The residual method of raising zinc oxide bioavailability commonly used at present and bad border of minimizing is mainly nanometer and handles, but effect is not remarkable.The invention provides a kind of preparation method of microencapsulated coating zinc oxide, handle by zinc oxide being carried out coating, reduce the destruction of hydrochloric acid in gastric juice to zinc oxide, and can realize the slowly-releasing of zinc oxide in enteron aisle, improve the bioavailability of zinc oxide, reduce the use amount and the use cost of zinc oxide, reduce the generation of post-weaning diarrhea in piglet, the adverse effect of avoiding high dose zinc oxide that the piglet production performance is caused also can reduce environmental pollution simultaneously.
Summary of the invention
The object of the present invention is achieved like this: a kind of production method of zinc oxide microencapsulated coating preparation is characterized in that it forms (by mass percentage calculate) by following material:
Starch 5-20%
Sodium carboxymethylcellulose 5-10%
Zinc oxide powder 50-80%
Stearic acid 5-15%
Resin 3# 3-5%
Embodiments of the present invention are as follows: a kind of preparation method of novel microencapsulated coating zinc oxide, it is characterized in that earlier the starch of 5-20%, the Zinc oxide powder of 50-80%, the sodium carboxymethylcellulose of 5-10% and the stearic acid of 5-15% being mixed under 75 ℃ of heat-retaining conditions, after mixing, the extruding of 60 orders is granulated under heat-retaining condition, cooling immediately; Carry out the whole grain of 30 orders after the cooling; Get resin 3#3-5%, join in the ethanol as coating liquid; In encapsulation tool, with flow velocity 0.05-3L/min, EAT 40-80 ℃, leaving air temp normal temperature, time 3-4h carries out Cotton seeds.Product granularity is crossed 20 mesh sieves more than 85%.
Main feature of the present invention is: zinc oxide is carried out microencapsulated coating handle, zinc oxide behind the coating is in the micro-capsule packaging material, avoid the destruction of hydrochloric acid in gastric juice to zinc oxide, realize the long-acting slow-release of zinc oxide in the animal body enteron aisle, improve the bioavailability of animal to zinc oxide, reduce zinc oxide dosage and use cost, reduce ight soil zinc and drain and environmental pollution.
Description of drawings
Fig. 1 is processing process figure of the present invention
Fig. 2 is the equipment schematic diagram that the present invention uses
Embodiment 1
Take by weighing starch 500g, Zinc oxide powder 8000g, sodium carboxymethylcellulose 500g, stearic acid 500g, after 75 ℃ of insulations mixed 25min, the extruding of 60 orders was granulated, immediately cooling; The whole grain of 30 orders; Take by weighing 500g resin 3#, join fully dissolving in the 18000mL ethanol, as coating liquid; In encapsulation tool, with flow velocity 0.1L/min, 80 ℃ of EATs, leaving air temp normal temperature carries out Cotton seeds, and time 3h, product granularity cross 20 mesh sieves more than 85%.
Embodiment 2
Take by weighing starch 2000g, Zinc oxide powder 5000g, sodium carboxymethylcellulose 1000g, stearic acid 1500g, after 75 ℃ of insulations mixed 25min, the extruding of 60 orders was granulated, immediately cooling; The whole grain of 30 orders; Take by weighing 500g resin 3#, join fully dissolving in the 18000mL ethanol, as coating liquid; In encapsulation tool, with flow velocity 0.1L/min, 80 ℃ of EATs, leaving air temp normal temperature carries out Cotton seeds, and time 3h, product granularity cross 20 mesh sieves more than 85%.
Claims (7)
1. the preparation method of a microencapsulated coating zinc oxide is characterized in that it forms (counting by weight percentage) by following material
Starch 5-20%
Sodium carboxymethylcellulose 5-10%
Zinc oxide powder 50-80%
Stearic acid 5-15%
Resin 3# 3-5%.
2. the preparation method of microencapsulated coating zinc oxide according to claim 1 is characterized in that Zinc oxide powder is a feed grade.
3. the preparation method of microencapsulated coating zinc oxide according to claim 1, its zinc oxide content of microencapsulation zinc oxide preparation that is obtained is 50-80%.
4. the preparation method of microencapsulated coating zinc oxide according to claim 1 is characterized in that coated fertilizer is sodium carboxymethylcellulose, stearic acid and resin 3#.
5. Zinc oxide powder according to claim 2 is characterized in that Zinc oxide powder is the powder of ultramicro grinding, and granularity is the 100-150 order.
6. coated fertilizer according to claim 4 is characterized in that the organic solvent that resin 3# uses is ethanolic solution.
7. the preparation method of microencapsulated coating zinc oxide according to claim 1, it is characterized in that earlier the Zinc oxide powder of 50-80%, the starch of 5-20%, the sodium carboxymethylcellulose of 5-10% and the stearic acid of 5-15% being mixed under 75 ℃ of heat-retaining conditions, after mixing, the extruding of 60 orders is granulated under heat-retaining condition, cooling immediately; Carry out the whole grain of 30 orders after the cooling; Get resin 3#3-5%, join in the ethanol as coating liquid; In encapsulation tool, with flow velocity 0.05-3L/min, EAT 40-80 ℃, leaving air temp normal temperature, time 3-4h carries out Cotton seeds.Product granularity is crossed 20 mesh sieves more than 85%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100396316A CN102125171A (en) | 2010-01-12 | 2010-01-12 | Method for preparing microencapsulation envelope zinc oxide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100396316A CN102125171A (en) | 2010-01-12 | 2010-01-12 | Method for preparing microencapsulation envelope zinc oxide |
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| CN102125171A true CN102125171A (en) | 2011-07-20 |
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| CN2010100396316A Pending CN102125171A (en) | 2010-01-12 | 2010-01-12 | Method for preparing microencapsulation envelope zinc oxide |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308917A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel sustained release pellet for forage and preparation method thereof |
| CN102318750A (en) * | 2011-10-08 | 2012-01-18 | 成都巨星猪业有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN102326848A (en) * | 2010-07-13 | 2012-01-25 | 上海新菲尔生物制药工程技术有限公司 | Food preservative and preparation method thereof |
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN105639141A (en) * | 2015-12-29 | 2016-06-08 | 河南艾德昕生物科技有限公司 | Enteric-coated zinc oxide additive for feed and preparation method of additive |
| CN106562057A (en) * | 2016-11-02 | 2017-04-19 | 浙江大学 | Piglet intestine nutrition regulation and control feed containing cladded zinc oxide |
| CN108219201A (en) * | 2018-03-03 | 2018-06-29 | 洛阳和梦科技有限公司 | Super fine zinc oxide coating composition and preparation method thereof |
| CN109601746A (en) * | 2019-02-21 | 2019-04-12 | 武汉惠宝生物技术有限公司 | A kind of feed additive for weaning piglet and the preparation method and application thereof |
| WO2020073800A1 (en) * | 2018-10-08 | 2020-04-16 | 杭州康德权饲料有限公司 | Rumen protected choline chloride microcapsule and preparatin method thereof |
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| CN87108128A (en) * | 1986-12-15 | 1988-07-13 | 大川原化工机株式会社 | Microcyst and method for making thereof |
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| CN101554209A (en) * | 2009-05-15 | 2009-10-14 | 冯刚 | Application of coated zinc oxide as antiseptic feed additive |
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Patent Citations (5)
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| CN87108128A (en) * | 1986-12-15 | 1988-07-13 | 大川原化工机株式会社 | Microcyst and method for making thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102326848A (en) * | 2010-07-13 | 2012-01-25 | 上海新菲尔生物制药工程技术有限公司 | Food preservative and preparation method thereof |
| CN102308917A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel sustained release pellet for forage and preparation method thereof |
| CN102318750A (en) * | 2011-10-08 | 2012-01-18 | 成都巨星猪业有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN102318750B (en) * | 2011-10-08 | 2013-06-05 | 成都巨星农牧科技有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN105639141A (en) * | 2015-12-29 | 2016-06-08 | 河南艾德昕生物科技有限公司 | Enteric-coated zinc oxide additive for feed and preparation method of additive |
| CN106562057A (en) * | 2016-11-02 | 2017-04-19 | 浙江大学 | Piglet intestine nutrition regulation and control feed containing cladded zinc oxide |
| CN108219201A (en) * | 2018-03-03 | 2018-06-29 | 洛阳和梦科技有限公司 | Super fine zinc oxide coating composition and preparation method thereof |
| WO2020073800A1 (en) * | 2018-10-08 | 2020-04-16 | 杭州康德权饲料有限公司 | Rumen protected choline chloride microcapsule and preparatin method thereof |
| CN109601746A (en) * | 2019-02-21 | 2019-04-12 | 武汉惠宝生物技术有限公司 | A kind of feed additive for weaning piglet and the preparation method and application thereof |
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Application publication date: 20110720 |