CN102121914B - Electrochemical power supply method and device - Google Patents

Electrochemical power supply method and device Download PDF

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CN102121914B
CN102121914B CN 201010003403 CN201010003403A CN102121914B CN 102121914 B CN102121914 B CN 102121914B CN 201010003403 CN201010003403 CN 201010003403 CN 201010003403 A CN201010003403 A CN 201010003403A CN 102121914 B CN102121914 B CN 102121914B
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electrochemical
reaction zone
test
voltage
current
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CN 201010003403
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CN102121914A (en
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史德智
许礼汎
王殿臣
洪国永
阮弼群
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明志科技大学
长庚医学科技股份有限公司
长庚医疗科技(厦门)有限公司
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Abstract

一种电化学供电方法及其装置,应用于待测检体中的待测反应物浓度的测量,步骤包含有:首先,供应初始电压于电化学反应区,来侦测有无待测检体置入电化学反应区;若有,便停止初始电压的供应且提供等待时间让待测检体能够充满电化学反应区,并接着提供重置电压信号于电化学反应区,以重置电化学反应区中的化学反应;接着再供应反应电压于电化学反应区,待反应完后,便供应逐渐上升的测量电压于电化学反应区,以产生稳定的测量电流;最后通过测量并换算测量电流的数值,便可以得知待测反应物于待测检体中的浓度。 An electrochemical power supply method and apparatus used to measure the concentration of the test the reaction of the test specimen, comprising the steps: First, the initial voltage is supplied to an electrochemical reaction zone, to detect the presence or absence of the test specimen into an electrochemical reaction; if so, stops the supply voltage and provides the initial waiting time for the test specimen can be filled with an electrochemical reaction zone, and the reset voltage signal is then provided to an electrochemical reaction zone, to reset the electrochemical the reaction zone a chemical reaction; the reaction followed supply voltage to an electrochemical reaction zone, the reaction to be complete, then the measured voltage is supplied is gradually increased in an electrochemical reaction zone, to produce a stable current measurement; and finally by measuring the conversion of the measured current values, that can be tested in the concentration of reactants in the test specimen.

Description

电化学供电方法及其装置 Electrochemical power supply method and apparatus

技术领域 FIELD

[0001 ] 本发明涉及一种供电方法及其装置,尤其是指一种电化学反应的电压供应方法及其装置。 [0001] The present invention relates to a power supply method and apparatus, particularly to a method and apparatus for supplying a voltage electrochemical reaction.

背景技术 Background technique

[0002] 随着生物感测技术的发展,许多结合生物特性以及电子技术的生物传感器材也相继被发明,像是血糖机、血脂机、尿酸测量仪、或胆固醇测量仪等等,其利用活性物质与待测物质进行反应所造成的物理或化学特性的改变,来测量并换算得出待测物质的量,以达到测量目的。 [0002] With the development of bio-sensing technologies, many biological properties and electronic technology in conjunction with biosensors materials also have been invented, such as blood glucose meter, blood lipids machine, measuring instrument uric acid, cholesterol or the like measuring device which utilizes an active substance test substance that changes the physical or chemical properties of the resulting reaction, and measuring the amount of test substance in terms of stars, to achieve the object of measurement.

[0003] 依照测量器材及方式上的不同,一般来说生物传感器材的种类有电化学生物传感器、半导体离子传感器、光纤生物传感器、压晶体管生物传感器等等。 [0003] In accordance with a different embodiment the measuring equipment and, in general type electrochemical biosensor biosensor material, a semiconductor ion sensor, fiber optic biosensor, the biosensor voltage transistor and the like. 其中,电化学生物传感器是通过测量待测反应物与生物活性物质、酵素或抗体等反应,所产生的导电度、电压或电流等的改变,来换算得出待测反应物的量。 Wherein the electrochemical biosensor was tested by measuring the reactants with the biologically active substance, enzyme or the like antibody reaction, and changes in conductivity, voltage or current generated to be measured in terms of the amount of reactant derived.

[0004] 而因为预先放置的活性物质、酵素或抗体等在未被使用前的贮放时期,可能会因为环境光能、热能或湿气等的影响,发生非预期中的化学反应,若此时使用该生物传感器材测定待测反应物,非预期的化学反应将会影响测量数据的正确性,成为误差的主要来源。 [0004] and the like as the active material is placed in advance, enzymes or antibodies period before storage is not used, may be due to environmental influence of light, heat or moisture, chemically react in an unintended, if this when using the biosensor test reaction was measured material, unexpected chemical reaction will affect the accuracy of measurement data, a major source of error.

[0005] 除了因为测量前非预期的杂质反应所造成的误差,在数值测量时也可能会造成误差。 [0005] In addition to the measurement error because the first unintended impurities resulting from the reaction, when the measured values ​​may also cause errors. 举例来说,请参照图1A,为现有血糖试片40的结构示意图,其中待测检体(本实施例中为血液)从置入口41处滴入,因为虹吸现象的缘故,待测检体会逐渐被吸入虹吸槽42。 For example, please refer to FIGS. 1A, a structure diagram of a conventional blood glucose test strip 40, wherein the test sample (blood in this embodiment) was added dropwise from the opposite inlet 41, since the siphon phenomenon reason, the test specimen experience siphon groove 42 is progressively drawn. 而血糖试片40中有反应区43、L型电极45和47,当待测检体从置入口41滴入后,会先触碰到电极45,然后才逐渐充满反应区43,一直到待测检体碰到电极47时,即代表待测检体已充满反应区43。 While the blood glucose test strip 40 has a reaction zone 43, L-shaped electrodes 45 and 47, when the test specimen was dropped from the inlet device 41, will first touch the electrode 45, and then gradually fill the reaction zone 43, up to be measured against an electrode when the specimen 47, which represents the test subject has filled the reaction zone 43.

[0006] 也就是说,生物传感器可以在L型电极45、47上先供应小电压,一开始时因为L型电极45、47之间为干燥的状态,所以生物传感器所测量到的阻抗很高。 [0006] That is, the biosensor can be supplied to a small voltage on the L-shaped electrodes 45 and 47, since the L-shaped electrode 45, 47 between a dry state at the outset, the biosensor measured impedance is high . 而当待测检体充满反应区43且与L型电极45及47接触时,生物传感器便会突然侦测到阻抗大幅度下降,因此就可知道有待测检体置入血糖试片40中,并且已充满反应区43。 When filled with the test sample in contact with the reaction zone 43 and L-shaped electrodes 45 and 47, the biosensor will detect sudden significant decline impedance, it can be measured to know the subject test strip into the glucose 40 and it has been filled with reaction zone 43. 依照此方法配合L型电极45、47,便可借此确认电化学反应开始的时间点以进行反应时间的计时,不过要使用这种方式得知反应起始时间点,便需要用具有特定电极构造的血糖试片,像是本例中的电极45和47为特殊的L型,在使用上就有限制。 According to this method with the L-shaped electrodes 45, 47 can thereby confirm the time point of electrochemical reaction for timing the reaction time, but to use this method that the reaction time of the starting point, they need to use an electrode having a specific blood glucose test strip configuration, such as in the present embodiment the electrodes 45 and 47 for a particular L-shaped, it is limited in use.

[0007] 接着如图1B所示,为现有生物传感器供应电压以及反应电流的波形图,请配合参照图1A,反应电压11是当生物传感器确定待测检体于时间点t0充满反应区43后开始供应的,以提供待测检体中的待测反应物与反应区43中的活性物质或酵素产生化学反应所需的能量。 [0007] Next, as shown in FIG. 1B, for the supply of voltage and current waveform diagram of a conventional biosensor reaction, please mating 1A, the reactor 11 is the voltage determined when the biosensor reaction zone filled with the test sample 43 at time point t0 after the start of the supply, to provide a test of the test subject with the reactants in the reaction zone 43 or enzymes active energy required to produce a chemical reaction. 随着化学反应的进行,会有反应电流21产生,接着经过一段特定时间后,反应电压11停止供应,此时待测反应物与酵素或活性物质会有静置反应,因而产生静置电流23。 As the chemical reaction, the reaction will produce a current 21, and then after a certain period of time, the reaction stops supply voltage 11, this time the reaction was tested with the active substance or enzyme reaction will be allowed to stand, thereby generating standing current 23 . 接下来,生物传感器便会提供测量电压13,以产生测量电流27来进行测量(例如在时间点tl进行测量),最后依照所测量到的测量电流27的数值进行换算,便可得知待测反应物在待测检体中的浓度。 Next, the biosensor 13 will provide a measurement of voltage, to generate a measurement current to be measured 27 (e.g. measured at the time point TL), and finally converted in accordance with the measured value of the measured current 27, that can be tested concentration of the reaction was measured in the subject.

[0008] 但实际上,因为在反应电压11停止供应后到测量电压13开始供应前的静置反应期间,反应还在持续进行中,因此会产生微小的静置电流23。 [0008] But in fact, because the reaction stops supplying the voltage to the measurement voltage 11 during the reaction was allowed to stand before the start of the supply 13, the reaction is still ongoing, it will produce a current 23 minute stand. 此时若供应陡升的测量电压 At this time, when the measurement voltage supply renewed

13,测量电流27就会有不稳定的过电流25 (overshooting)的现象,影响测量电流27的波形以及在时间点tl所测量到的测量电流27的数值,造成测量结果的不正确。 13, there will be 27 measuring the current through the current instability phenomenon 25 (overshooting), the impact of measuring the current waveform of 27, and the value measured at the time point tl to the measured current 27, resulting in incorrect measurements. 而若要使反应结果不会有太大的偏差,虽然可以等到测量电流27较为稳定时再进行测量,但如此一来势必会延长测量时间以及造成能量耗损,降低测量的效率。 The reaction to the results will not be much deviation, then the measurement Although you can wait until a more stable measure the current 27, but this way is bound to extend the measurement time and cause energy consumption, reduce the efficiency measurement.

发明内容 SUMMARY

[0009] 有鉴于此,本发明所要解决的技术问题在于,借助供电方式的改变,去除电极构造的限制并降低生物传感器的测量误差,来提升测量的正确性以及效率。 [0009] Accordingly, the present invention is to solve the technical problem, by varying the power supply, the electrode structure and removing the restrictions reduce the measurement error of the biosensor, to improve the measurement accuracy and efficiency.

[0010] 为了达到上述目的,根据本发明的一方案,提供一种电化学供电装置,包括有一电化学反应区、一电压供应单元、一电流测量单元以及一处理单元。 [0010] To achieve the above object, according to an embodiment of the present invention, there is provided an electrochemical power device, comprising an electrochemical reaction zone, a voltage supply unit, a current measuring unit and a processing unit. 其中电化学反应区是用来让待测检体中的待测反应物进行化学反应的区域,而电压供应单元耦接于该电化学反应区,用来在待测检体置入电化学反应区后,提供重置电压信号于电化学反应区以消除杂质电流与其他干扰电流,以及提供反应电压和测量电压。 Wherein the electrochemical reaction is used to allow the test zone of the test specimen was subjected to a chemical reaction in the reaction zone, and the voltage supply unit coupled to the electrochemical reaction zone, into the subject to be tested in an electrochemical reaction back region, the reset voltage signal to provide an electrochemical reaction zone to remove impurities and other current interference current, and providing a reaction voltage and the measured voltage. 电流测量单元耦接于电化学反应区,用以测量电化学反应区中产生的电流,并传送至处理单元作待测反应物浓度的运算。 Current measuring unit is coupled to an electrochemical reaction zone, an electrochemical reaction zone to measure the current generated, and transmitted to the processing unit for calculation of the concentration of the analyte reaction. 处理单元,耦接于该电压供应单元以及该电流测量单元,以依据该电流测量单元的测量结果,作该待测反应物浓度的运算。 A processing unit coupled to the voltage supply unit and the current measuring means to measure the result of the current measuring unit basis, as a reaction of the analyte concentration calculations.

[0011] 值得一提的是,电压供应单元在供应用来产生测量电流的测量电压时,是用逐渐上升的方式来供应,让测量电流不会有过电流的现象产生。 [0011] It is worth mentioning that, when supplied with a voltage supply unit for generating a measuring voltage current is gradually increased with the approach to the supply, so that the phenomenon of the measured current without excessive current generated. 另外,电压供应单元在测检体置入前会提供初始电压于电化学反应区,用来侦测是否有待测检体置入。 Further, the voltage supply unit into the sample prior to measuring an initial voltage to provide an electrochemical reaction zone, to detect whether there is placed the test specimen.

[0012] 根据本发明的另一方案,提供一种电化学供电方法,包括有供应初始电压于电化学反应区,来侦测是否有待测检体置入。 [0012] According to another aspect of the present invention, there is provided an electrochemical power supply method comprising supplying an initial voltage to an electrochemical reaction zone, to detect whether there is placed the test specimen. 需要特别说明的是,电化学反应区可以是设置于生物感测的试片上,而待测检体从试片的置入口滴入后,会借助虹吸原理逐渐充满电化学反应区。 Of particular note, the electrochemical reaction zone may be provided on a biosensing test strip, the test specimen was dropped from the rear entrance of the test piece, by means of siphon principle will be gradually filled with the electrochemical reaction zone. 而当待测检体滴入后,电化学反应区中两供电电极之间的阻抗会突然下降,生物传感器通过侦测两电极间的阻抗即可判断是否有待测检体滴入电化学反应区中。 When the test sample was added dropwise, the reaction zone in an electrochemical impedance between two supply electrodes drops abruptly, by detecting the impedance of the biosensor between the electrodes to determine whether the test specimen dripped electrochemical reaction area.

[0013] 当侦测到有待测检体置入电化学反应区时,便停止供应初始电压,静置一等待时间使测检体能够充满电化学反应区,之后再供应重置电压信号于该电化学反应区,以消除杂质电流与其他干扰电流,重置待测反应物的电化学反应,让化学反应的时间重新起算。 [0013] When there is detected the test sample into an electrochemical reaction zone, an initial voltage supply is stopped, a waiting time for the measured standing subject electrochemical reaction zone can be filled, after a reset voltage signal is then supplied to a the electrochemical reaction zone to remove impurities and other current interference current, the electrochemical reaction reset test reactants, the reaction time of the chemical make re-starting. 其中,重置电压信号可以是用任意的形式来去除反应离子的极化现象,像是一反向电压脉冲 Wherein the reset voltage signal may be removed by any form of reactive ion polarization phenomena, such a reverse voltage pulse

坐坐寸寸ο Begins to sit ο

[0014] 接着供应反应电压,让待测反应物与酵素、抗体或活性物质的化学反应能够继续进行,待反应完后,再供应测量电压以产生测量电流。 [0014] The reaction is then supply voltage, so that the reaction was measured with an enzyme, an antibody or a chemically reactive substance can be continued until the reaction was completed, and then measuring the supply voltage to generate a measurement current. 其中测量电流的大小会随着待测反应物在待测检体中的浓度大小而有所不同,因此一旦得知测量电流的大小,经过换算便可知道待测反应物的浓度,得到所需的测量结果。 Wherein the size of the measuring current may be measured as the concentration of the reactants in the size of the test specimen body varies, so that once the size of the measuring current, after conversion can be measured to know the concentration of the reactants, to yield the desired measurement results.

[0015] 换句话说,本发明提供一种电化学供电方法,包括:供应一初始电压于一电化学反应区;当一待测检体置入该电化学反应区时,停止供应该初始电压于该电化学反应区;以及供应一重置电压信号于该电化学反应区,以消除杂质电流与其他干扰电流,重置该待测检体中一待测反应物的电化学反应。 [0015] In other words, the present invention provides an electrochemical power supply method comprising: supplying an initial voltage to an electrochemical reaction zone; when a test sample into the electrochemical reaction zone, stops supplying the initial voltage in the electrochemical reaction zone; and a reset voltage signal supplied to the electrochemical reaction zone to remove impurities and other current interference currents, reset the test specimen in a test electrochemical reaction of the reactants.

[0016] 根据本发明的又一方案,提供一种电化学供电方法,包括有供应初始电压于电化学反应区来侦测是否有待测检体置入,当侦测到待测检体置入电化学反应区时,即停止供应初始电压。 [0016] According to a further embodiment of the present invention, there is provided an electrochemical power supply method comprising supplying an initial voltage to an electrochemical reaction zone to detect whether there is placed the test specimen when the test specimen is set to detect when the electrochemical reaction zone, i.e., stops supplying the initial voltage. 接着,供应反应电压使待测检体中的待测反应物与酵素、活性物质或抗体等进行电化学反应,待反应完全后再供应逐渐上升的测量电压于该电化学反应区,以产生测量电流。 Next, the supply voltage so that the reaction of the test specimen was tested with enzyme reaction, the active substances or antibodies such as electrochemical reaction, until the reaction was complete after the supply voltage is gradually increased is measured in the electrochemical reaction zone, to produce a measurement current.

[0017] 换句话说,本发明还提供一种电化学供电方法,包括:当一待测检体置入一电化学反应区时,供应一反应电压于该电化学反应区,使该待测检体中的一待测反应物进行电化学反应;以及供应逐渐上升的一测量电压于该电化学反应区,以产生一测量电流。 [0017] In other words, the present invention also provides an electrochemical power supply method, comprising: when a test sample into an electrochemical reaction zone, supplying a voltage to the reaction zone of the electrochemical reaction, so that the test the specimen was subjected to a reaction test electrochemical reaction; and supplying a measured voltage gradually rises in the electrochemical reaction zone, to produce a measurement current.

[0018] 其中测量电压用逐渐上升的方式供应,可以避免测量电流产生过电流(overshooting)的现象,提升测量结果的正确性,而将测量电流的大小经过换算后即可知道待测反应物于待测检体中的浓度。 [0018] wherein the measured voltage gradually rises with supply mode, to avoid an over-current measurement current (overshooting) phenomenon, improve accuracy of measurement results, and the measured magnitude of the current to be measured after conversion to know the reaction was the concentration of the test specimen.

[0019] 借助在提供反应电压前先提供重置电压信号来消除非预期的杂质反应以及重置电化学反应的起始时间点,并在测量时提供逐渐上升的测量电压以避免测量电流的过电流现象,来达到降低测量误差的效果,提升测量的准确度以及效率。 [0019] means to provide the reset voltage signal prior to providing the reaction start time point voltage to eliminate unintended reaction impurities and a reset electrochemical reaction, and to provide a gradual increase in the measurement voltage measured by measuring the current in order to avoid the current phenomenon to achieve the effect of reducing the measurement error, measurement accuracy, and enhance efficiency.

[0020] 以上的概述与接下来的实施例,皆是为了进一步说明本发明的技术手段与达到的功效,然而所叙述的实施例与附图仅提供参考说明用,并非用来对本发明加以限制。 [0020] The above description and the following examples, all technical means in order to further illustrate the present invention and the effect achieved, however, only described with reference to the embodiments described with the accompanying drawings, is not intended to limit the present invention .

附图说明 BRIEF DESCRIPTION

[0021] 图1A为现有血糖试片结构的示意图; [0021] FIG 1A is a schematic configuration of a conventional test strip blood glucose;

[0022] 图1B为现有电化学供电方法的电压与电流波形图; [0022] FIG. 1B voltage and current waveform diagram of the conventional power supply method of electrochemically;

[0023] 图2为本发明生物传感器的一种实施例的方块图; A block diagram of an embodiment of [0023] FIG. 2 biosensor of the present invention;

[0024] 图3A为本发明的血糖试片的一种实施例的结构示意图; A blood glucose test strip of [0024] FIG 3A is a schematic structural diagram of the present invention embodiment;

[0025] 图3B为本发明电化学供电方法的一种实施例的电压与电流波形图;以及 One kind of [0025] FIG. 3B power supply method of the present invention is an electrochemical voltage and current waveforms of the embodiment of FIG embodiment; and

[0026] 图4为本发明电化学供电方法的一种实施例的流程图。 One kind of [0026] FIG 4 an electrochemical power supply method of the present invention, a flow diagram of the embodiment.

[0027]【主要元件附图标记说明】 [0027] The main element Description of Symbols

[0028] iiur反应电压 [0028] iiur reactor voltage

[0029] 13、13'测量电压 [0029] 13, 13 'measured voltage

[0030] 15初始电压 [0030] 15 initial voltage

[0031] 17重置电压信号 [0031] The reset voltage signal 17

[0032] 20初始电流 [0032] 20 initial current

[0033] 21、21'反应电流 [0033] 21, 21 'reaction current

[0034] 23、23'静置电流 [0034] 23, 23 'standing current

[0035] 25过电流 [0035] 25 Overcurrent

[0036] 27、27'测量电流 [0036] 27, 27 'measured current

[0037] 31处理单元 [0037] The processing unit 31

[0038] 33电压供应单元 [0038] The voltage supply unit 33

[0039] 35电化学反应区 [0039] The electrochemical reaction zone 35

[0040] 37电流测量单元[0041] 40、50血糖试片 [0040] The current measuring unit 37 [0041] 40, 50 glucose test strip

[0042] 41、51 置入口 [0042] 41, 51 facing the inlet

[0043] 42、52 虹吸槽 [0043] The siphon groove 42, 52

[0044] 43反应区 [0044] The reaction zone 43

[0045] 45、47、55、57 电极 [0045] The electrodes 45,47,55,57

[0046] tb、t0、tl、t2、t3 时间点 [0046] tb, t0, tl, t2, t3 time point

[0047] S401〜S409流程图步骤说明 [0047] S401~S409 flowchart of steps described

具体实施方式 Detailed ways

[0048] 通过在待测反应物开始反应前,先提供重置电压信号来消除杂质反应,以重置电化学反应,并在测量时提供逐渐上升的测量电压以产生稳定的测量电流,来提升测量结果的正确性以及效率。 [0048] The test is eliminated by the reaction prior to the reaction was started, the reset voltage signal to provide a reaction impurities, to reset the electrochemical reaction, and provides a measure of the voltage gradually rises during the measurement to produce a measurement of the current stabilization, to enhance correctness and efficiency measurement results.

[0049] 请参照图2,为生物传感器的一种实施例的方块图,包括一处理单元31、一电压供应单元33、一电化学反应区35、以及一电流测量单元37。 [0049] Referring to FIG 2, a block diagram of an embodiment of a biosensor, comprising a processing unit 31, a voltage supply unit 33, an electrochemical reaction zone 35, and a current measuring unit 37. 其中电化学反应区35中预先置入用来与一待测反应物进行化学反应的活性物质、酵素或抗体等。 Wherein the electrochemical reaction zone 35 to be placed in previously active substances such as chemical reactions, enzyme or antibody with a test reactant. 例如,若该生物传感器为血糖机,电化学反应区35即是设置于浓度检定试片(本实施例中是血糖试片)的某一端,供使用者滴入血液作血糖的浓度分析。 For example, if the biosensor is a blood glucose meter, an electrochemical reaction zone 35 that is disposed at one end of the concentration of the test specimen (in the present embodiment is a blood glucose test strip), for analysis of glucose concentrations in blood for the user added dropwise. 电压供应单元33通过两电极将反应所需的电压或是测量用的电压供应于电化学反应区35,而电流测量单元37则是通过该些电极来测量电化学反应区35中所产生的电流数值,并传送至处理单元31进行待测反应物浓度的换算。 Measuring voltage or voltage supply unit 33 of the two electrodes by supplying the desired reaction in the electrochemical reaction zone 35, and the current measuring unit 37 is to measure the electrochemical reaction zone 35, the current generated by the plurality of electrodes value, and transmits to the processing unit 31 in terms of the concentration of the reactants tested.

[0050] 请参照图3A,为血糖试片50的一种实施例的结构示意图,包括有置入口51、虹吸槽52、电化学反应区35以及电极55和57,其中待测检体是从置入口51滴入,并借助虹吸槽52的虹吸原理进入电化学反应区35之中。 [0050] Referring to Figure 3A, a schematic structural diagram of the embodiment as a blood glucose test strip 50 comprises an inlet 51 is set, the siphon groove 52, the electrochemical reaction zone 35 and the electrodes 55 and 57, wherein the test sample is from was added dropwise opposite inlet 51, by means of the siphon and the siphon groove 52 in the zone 35 into the electrochemical reaction. 与现有不同的是,本实施例中的电极55、57为长条状并放置于反应区的两侧边,因此当待测检体同时接触到电极55、57使得血糖机所侦测到的阻抗突然下降时,并不能确定待测检体是否已“完全充满”电化学反应区35,可以确认的只是“有待测检体置入”电化学反应区35中。 The difference is that the conventional, in this embodiment the electrodes 55, 57 is elongated and placed on both sides of the reaction zone, so that when the test specimen 55 and 57 while contacting to the electrode such that blood glucose machine detected when a sudden drop in impedance, and can not determine whether the test subject has been "fully charged" electrochemical reaction zone 35, it was confirmed that only "has placed the test specimen" electrochemical reaction zone 35.

[0051 ] 接着,请参照图3B,为电化学供电方法的一种实施例的电压与电流波形图,请配合参照图2以及图3A。 [0051] Then, referring to Figure 3B, the voltage and current waveforms showing an embodiment of an electrochemical power of methods, with reference to FIG. 2 and FIG. 3A. 该方法应用于一待测检体(如:血液)中一待测反应物(如:葡萄糖)浓度的测量,待测反应物与预先放置于电化学反应区35的活性物质、酵素或抗体进行化学反应,造成物理或化学特性的改变,如导电度、电压或电流等的改变,通过测量该些改变量(本例中是用电流测量单元37测量电流量),即可换算得出待测反应物于待测检体中的浓度。 The method is applied to a test specimen (such as: blood) to be tested in a reactant (such as: glucose) measuring the concentration of the test reaction was placed in previously active substance, enzyme or antibody electrochemical reaction zone 35 is chemical reaction, changes cause changes in physical or chemical properties, such as conductivity, voltage, current, or the like, by measuring the amount of change of the plurality of (in this case by the current measuring unit 37 measures the amount of current) can be measured in terms of stars the reaction was tested at a concentration in the specimen.

[0052] 如图3B中所示,时间点tb是待测检体借助虹吸原理滴入置入口51的时间点,此时会突然产生一初始电流20于电化学反应区35中。 [0052] As shown in FIG. 3B, a time point tb is measured by siphoning dropwise specimen opposite the entry point of time 51, this time suddenly generates an initial current 20 in an electrochemical reaction zone 35. 而电压供应单元33在感应到待测检体滴入后,会停止供应的初始电压15 (也就是如图3B中的时间点t2)。 And voltage supply unit 33 is sensed after the test sample was added dropwise, 15 stops the supply of the initial voltage (i.e. FIG. 3B time point t2). 其中初始电压15是通过电极55和57作供应,能够用来侦测是否有待测检体置入电化学反应区35,侦测原理是因为一开始两电极55、57之间是干燥的,生物传感器所测量到的是高阻抗,所以最初提供初始电压15于两电极55、57上时几乎不会产生任何的电流。 15 wherein the initial voltage by electrodes 55 and 57 for supply, it is possible to detect whether there is an electrochemical test specimen into the reaction zone 35, the detection principle is because a beginning is dried between two electrodes 55, 57, biosensor was measured to a high impedance, so the initial 15 to provide an initial voltage hardly any current when the two electrodes 55,57. 而当待测检体置入电化学反应区35并同时接触到两电极55和57时,生物传感器便会突然测量到两电极55、57之间的阻抗大幅下降,借此即可判断有待测检体置入电化学反应区35。 When the test specimen and placed in an electrochemical reaction zone 35 simultaneously contact the two electrodes 55 and 57, the biosensor will measure suddenly dropped to the impedance between the two electrodes 55 and 57, whereby the determination can be The electrochemical test specimen into the reaction zone 35. [0053] 如上述,当侦测到有待测检体置入电化学反应区35时,电压供应单元33便停止供应初始电压15 (时间点t2),并提供一等待时间(可依据实验数据的平均值而定)让待测检体确实充满电化学反应区35。 [0053] As described above, when it is detected that there is an electrochemical test specimen into the reaction zone 35, the voltage supply unit 33 stops the initial voltage supply 15 (time point T2), and provides a waiting time (can be based on experimental data the average may be) to be tested so that the sample does electrochemical reaction zone 35 is filled. 或者,电压供应单元33可在电化学反应区35的下部区域额外设置一测血电极,通过测测量血电极与电极55间的阻抗,或是测测量血电极与电极57间的阻抗,即可得知待测检体是否充满于电化学反应区35中。 Alternatively, the voltage supply unit 33 may be additionally provided with a blood testing electrodes in the lower region of the electrochemical reaction zone 35, 55 by measuring the blood impedance measuring electrode and the electrode, or Blood test measuring the impedance between the electrode and the electrode 57 can to know whether the test specimen is filled in the electrochemical reaction zone 35. 也就是说,当待测检体充满于电化学反应区35中时,测血电极与电极55间的阻抗或是测血电极与电极57间的阻抗会下降,因此,通过测量阻抗值便可用来确认待测检体是否充满于电化学反应区35中。 That is, when the test specimen is filled in the electrochemical reaction zone 35, the impedance of the impedance 57 or blood testing electrode and the electrode 55 of the sensing electrode and the electrode will decrease the blood, and therefore, the resistance value can be measured by using to confirm whether the test specimen is filled in the electrochemical reaction zone 35.

[0054] 而在待测检体充满于电化学反应区后,电压供应单元33便会提供重置电压信号17(可以是用任意的形式来消除反应离子的极化现象,如反向电压脉冲等等)于电化学反应区35,用来消除在初始电压15停止供应的时间点t2之前的杂质反应,并使化学反应的起始时间点重新起算。 [0054] After the test specimen is filled in the electrochemical reaction zone, the voltage supply unit 33 will provide a reset voltage signal 17 (in any form may be used to eliminate the polarization reactive ion, such as a reverse voltage pulse etc.) in an electrochemical reaction zone 35, the reaction for removing impurities prior to the point t2 to stop the supply of the voltage 15 at the initial time, and the start time point of re-starting the chemical reaction. 其中杂质反应产生的原因通常是活性物质、酵素或抗体等因为环境的湿气或太阳照射等的因素,或是因为一些杂质的掺入而产生的化学反应,会导致有一些反应电荷残留于电化学反应区35,而该些残留的电荷则会让后来测量的结果产生偏差,因此便需要将其消除。 One reason impurities generated by the reaction is generally like active substance, enzyme or antibody or moisture because of factors such as sun exposure environment, or because of some chemical reaction generated impurity-doped, can cause some reaction to the electric charge remains chemical reaction zone 35, and the plurality of charge remaining in the subsequent measurement will bias the results, so it needs to be eliminated.

[0055] 值得一提的是,通过这种提供等待时间让待测检体确实充满电化学反应区35,并提供重置电压信号17来消除杂质反应来重置电化学反应的方式,就算不使用现有的L型电极,也能够准确设定电化学反应的起始时间点,如此一来,电极55、57的形状就不会受到限制,能够设计成任意的形状构造。 [0055] It is worth mentioning is to provide such a waiting time does make test specimen filled electrochemical reaction zone 35, and provides a reset voltage signal 17 is reset to remove the reaction impurities embodiment electrochemical reaction, if not using conventional L-type electrode, it is possible to accurately set the start time point of the electrochemical reaction, thus, the shape of the electrodes 55, 57 will not be restricted, can be designed in an arbitrary shape configuration.

[0056] 在消除了杂质反应之后,电压供应单元33即供应反应电压11'于电化学反应区35,以提供足够使待测检体中的待测反应物与活性物质、酵素或抗体等进行化学反应的能量。 [0056] After eliminating the impurities of the reaction, i.e., the voltage supply unit 33 supplies a voltage reactor 11 'to an electrochemical reaction zone 35 to provide sufficient to test the test specimen was subjected to the reaction with other active substances, enzymes or antibodies energy of a chemical reaction. 此时,因为化学反应开始进行,产生出一些离子与电荷,因此便会有反应电流21'通过置放于电化学反应区35中的电极55、57。 At this time, because the chemical reaction starts to produce ions with some charge, there will be a reaction current 21 'through the electrodes 55 and 57 placed in the electrochemical reaction zone 35. 以血糖浓度的测量为例,其化学反应式如下: To measure blood glucose concentration for example, the chemical reaction is as follows:

[0057] Glucose+GO/FAD — δ-Gluconolactone+G0/FADH2 [0057] Glucose + GO / FAD - δ-Gluconolactone + G0 / FADH2

[0058] G0/FADH2+02 — G0/FAD+H202 [0058] G0 / FADH2 + 02 - G0 / FAD + H202

[0059] H2O2 — 2H++02+2e [0059] H2O2 - 2H ++ 02 + 2e

[0060] 其中Glucose是葡萄糖,也就是待测的血糖。 [0060] wherein Glucose is glucose, blood glucose is measured. GO是葡萄糖氧化酶(glucoseoxidase),其与葡萄糖产生一连串的化学反应,最后产生氢离子以及电荷。 GO is glucose oxidase (glucoseoxidase), which generates a series of chemical reactions of glucose, to generate hydrogen ions, and the final charge. 该些电荷被置于电化学反应区35中的电极55、57所接收,就会形成电流,而又因为氢离子越来越多,施加在电化学反应区35的反应电压11'所产生的电流也就会越来越高,因此综合以上所述,反应电流21'就会如图中所示逐渐升高。 These charges are placed in the reaction zone in an electrochemical electrodes 55 and 57 received 35, a current will form, but as more of hydrogen ions, the voltage applied to the electrochemical reaction in the reaction zone 35 of the 11 'produced by current will be higher and higher, so the above synthesis, the reaction current 21 'will be gradually increased as shown in FIG.

[0061] 再参阅图3B,在供应反应电压11' 一定时间,使待测反应物与酵素、活性物质或抗体反应之后,电压供应单元33便会停止供应反应电压11'。 [0061] Referring again to FIG. 3B, in the reaction voltage supply 11 'after some time the enzyme reaction was measured, with the active substance or antibody response, the voltage supply unit 33 will stop the reaction voltage supply 11'. 而在停止供应反应电压11'到测量电压13'开始供应的这段时间,仍会有所谓的静置反应,所以即使电压供应单元33并未提供电压,其仍然会有微弱的静置电流23'产生。 Current is allowed to stand in 23 stops supplying the reaction voltage 11 'to the measured voltage 13' is served this time, the reaction was allowed to stand still so-called, even if the voltage supply unit 33 does not supply a voltage, which will still be weak 'produce.

[0062] 当要测量数据时,本发明的电压供应单元33会提供逐渐上升的测量电压13'于电化学反应区35,以产生测量电流27'。 [0062] When data is to be measured, the voltage supply unit 33 according to the present invention provides a gradually rising voltage is measured 13 'to an electrochemical reaction zone 35, to generate a measurement current 27'. 接着,电流测量单元37在时间点t3测量该测量电流27'的值,因测量电流27'数值的大小会随着待测反应物与酵素、活性物质或抗体等进行化学反应量的多少有关(一般来说电流越大代表浓度越高),所以最后经过换算,即可得知待测反应物的浓度。 Next, current measurement unit 37 measures 'values, due to the measurement current 27' of the current measurement time point t3 at 27 size values ​​may be related to how much amount of chemical reaction with the reactant with the enzyme test, the active substance or the like antibodies ( Generally the greater the current representative of the higher concentration), the final after conversion, the concentration that can be measured reactant. 值得一提的是,用逐渐上升的方式提供测量电压13',便不会像现有一般使测量电流27'产生不稳定的过电流(overshooting),因此可以提升数据测量的准确度以及效率。 It is worth mentioning that provides a measure of the voltage gradually rises by 13 mode ', will not typically cause as in the prior measurement current 27' destabilizing overcurrent (overshooting), it is possible to improve accuracy of the measurement data and the efficiency.

[0063] 接着请参阅图4,为电化学供电方法的一种实施例的流程图,请配合参照图2以及图3B。 [0063] Next, please refer to FIG. 4, a flow diagram of the power supply is an electrochemical method embodiment, please refer to FIG. 2, and with Figure 3B. 该方法应用于一待测检体中一待测反应物浓度的测量(例如测量血液中葡萄糖的浓度),步骤包括有:首先,供应初始电压15于电化学反应区35(S401),其中该初始电压15可用来侦测是否有待测检体(如血液)置入电化学反应区35(如血糖试片的反应区)中,侦测的方法已在前文说明,因此便不再赘述。 The method is applied to a test specimen in a test measuring the concentration of reactants (e.g., measuring the concentration of glucose in the blood), comprising the steps: First, an initial voltage supply 15 to the electrochemical reaction zone 35 (S401), wherein the 15 initial voltage used to detect whether a test subject (e.g., blood) is placed into an electrochemical reaction zone 35 (e.g., blood glucose test strip of the reaction zone), the method of detection has been described in the foregoing, and therefore will not be repeated.

[0064] 当侦测到有待测检体置入电化学反应区35时,电压供应单元33便停止初始电压15的供应(S403),并提供一等待时间,让待测检体能够确实充满电化学反应区35。 [0064] When there is detected the test sample into an electrochemical reaction zone 35, the voltage supply unit 33 stops the initial voltage supply (S403) 15, and provides a waiting time, so that the test specimen can be surely filled with The electrochemical reaction zone 35. 接着,电压供应单元33会提供重置电压信号17于电化学反应区35(S405),以消除杂质反应所残留的电荷,重置电化学反应区35中的化学反应,让反应起始的时间重新起算。 Next, the voltage supply unit 33 provides a reset voltage signal 17 to an electrochemical reaction zone 35 (S405), the reaction to remove the charge remaining impurities, a chemical reaction reset electrochemical reaction zone 35, so that the starting time of the reaction re-starting. 然后电压供应单元33才供应反应电压11'于电化学反应区35(S407),以提供待测反应物(如葡萄糖)与活性物质、酵素或抗体进行化学反应所需要的能量。 Voltage supply unit 33 is then supplied only to the reaction voltage 11 'to an electrochemical reaction zone 35 (S407), to provide a test reactant (such as glucose) energy required for a chemical reaction with the active substance, enzyme or antibody.

[0065] 在反应电压11'停止供应一小段时间之后,电压供应单元33即供应逐渐上升的测量电压13'于电化学反应区35,产生测量电流27'(S409),以进行测量。 [0065] In the reaction voltage 11 'stops supplying the short period of time after, i.e., the voltage supply unit 33 supplies the measured voltage gradually rises 13' to an electrochemical reaction zone 35, to generate measuring current 27 '(S409), for measurement. 最后,通过测量该测量电流27'的数值大小并进行换算,便可以得知待测反应物(如葡萄糖)在待测检体(如血液)中的浓度。 Finally, by measuring the current measurement 27 'and converting numerical size, the concentration that can be measured reactants (such as glucose) in a test sample (such as blood) was added. 值得一提的是,用逐渐上升的方式供应测量电压13',是为了避免测量电流27'产生不稳定的过电流现象,增加测量结果的准确度。 It is worth mentioning that, with a gradual increase in the measurement voltage supply way 13 ', 27 measure the current in order to avoid' generates accurate overcurrent instability, increased measurement results.

[0066] 综上所述,借助在待测反应物与酵素、活性物质或抗体开始反应之前,先提供重置电压信号消除杂质反应所可能造成的影响,重置电化学反应并重新起算化学反应的起始时间,让电极形状构造能够不受限制。 [0066] As described above, by means of enzyme before, the active material starts with the reaction of reactants or antibody test, to provide a reset voltage signal to eliminate the influence of impurities may cause reaction, electrochemical reaction reset and re-starting the chemical reaction start time, so that the shape of the electrode configuration without restriction. 另外,在测量数据时用逐渐上升的方式提供测量电压,以避免测量电流产生不稳定过电流的现象,进而减少测量结果的误差以及提升测量数据的准确度。 Further, when the measurement data provided by measuring the voltage gradually rising manner, to avoid an unstable over-current measurement current phenomenon, thereby reducing measurement errors and improve the accuracy of measurement data.

[0067] 以上所述为本发明的具体实施例的说明与附图,任何本领域技术人员在本发明的领域中,可轻易思及的变化或修改皆可涵盖在本发明所界定的保护范围内。 [0067] Description and drawings of the specific embodiment of the present invention above, any person skilled in the art of the present invention, and can easily think of variations or modifications encompassed Jieke scope of the invention as defined Inside.

Claims (19)

1.一种电化学供电方法,其特征在于,包括: 供应一初始电压于一电化学反应区,该电化学反应区中预先置入一活性物质、一酵素或一抗体,以与一待测检体中的一待测反应物进行电化学反应; 当该待测检体置入该电化学反应区时,停止供应该初始电压于该电化学反应区;以及供应一重置电压信号于该电化学反应区,以消除杂质电流与其他干扰电流,重置该待测检体中该待测反应物的电化学反应; 供应一反应电压于该电化学反应区,使该待测检体中的该待测反应物的电化学反应能够继续; 供应逐渐上升的一测量电压于该电化学反应区,以产生一测量电流。 1. An electrochemical power supply method comprising: supplying an initial voltage to an electrochemical reaction zone, the reaction zone of the electrochemical active material in a pre-placed, a an enzyme or an antibody to be tested with a the specimen was subjected to a reaction test electrochemical reaction; when the sample to be tested into the electrochemical reaction zone, stops supplying the initial voltage to the electrochemical reaction zone; and supplying a signal to the reset voltage the electrochemical reaction zone to remove impurities and other current interference current, the electrochemical reaction of the reset test specimen in the test reactants; supplying a voltage to the reaction zone of the electrochemical reaction, so that the test specimen the electrochemical reactions of reactant to continue the test; supplying a measured voltage gradually rises in the electrochemical reaction zone, to produce a measurement current.
2.如权利要求1所述的电化学供电方法,其特征在于,在供应该重置电压信号的步骤前更包括: 提供一等待时间,让该待测检体能够充满该电化学反应区。 The electrochemical method of the power supply as claimed in claim 1, characterized in that, further comprising before the step of supplying the reset voltage signal: providing a waiting time, so that the test specimen can be filled with the electrochemical reaction zone.
3.如权利要求1所述的电化学供电方法,其特征在于,该反应电压提供足以使该待测反应物进行电化学反应的能量。 The electrochemical power supply method according to claim 1, wherein the reaction of the test voltage provides sufficient reactants electrochemical reaction energy.
4.如权利要求1所述的电化学供电方法,其特征在于,该测量电流的电流量,用以换算得出该待测反应物在该待测检体中的浓度含量。 4. The electrochemical power supply method according to claim 1, characterized in that the current measuring current to obtain the concentration in terms of the content of the test reaction was measured in the specimen.
5.如权利要求1所述的电化学供电方法,其特征在于,该初始电压以侦测是否有该待测检体置入该电化学反应区。 5. The electrochemical power supply method according to claim 1, wherein the initial voltage to detect whether there is the electrochemical test specimen into the reaction zone. ` `
6.如权利要求1所述的电化学供电方法,其特征在于,该电化学反应区设置于一浓度检定试片上。 The electrochemical method of the power supply as claimed in claim 1, wherein the electrochemical reaction zone disposed on a test strip assay concentration.
7.如权利要求6所述的电化学供电方法,其特征在于,该浓度检定试片为一血糖试片。 7. The electrochemical power supply method according to claim 6, wherein the concentration of the assay test strip is a glucose test strip.
8.一种电化学供电方法,其特征在于,包括: 当一待测检体置入一电化学反应区时,供应一重置电压信号于该电化学反应区,该电化学反应区中预先置入一活性物质、一酵素或一抗体,以与该待测检体中的一待测反应物进行电化学反应; 供应一反应电压于该电化学反应区,使该待测检体中的该待测反应物进行电化学反应;以及供应逐渐上升的一测量电压于该电化学反应区,以产生一测量电流。 A method for electrochemical power supply, characterized by comprising: when a test sample into an electrochemical reaction zone, supplying a reset voltage signal in the electrochemical reaction zone, the reaction zone of the electrochemical pre into an active substance, an enzyme or an antibody to the test sample in a test reaction was carried out with an electrochemical reaction; supplying a voltage to the reaction zone of the electrochemical reaction, so that the test specimen of the reaction was tested for electrochemical reaction; and supplying a measured voltage gradually rises in the electrochemical reaction zone, to produce a measurement current.
9.如权利要求8所述的电化学供电方法,其特征在于,该反应电压提供足以使该待测反应物进行电化学反应的能量。 The electrochemical method of the power supply as claimed in claim 8, wherein the reaction of the test voltage provides sufficient reactants electrochemical reaction energy.
10.如权利要求8所述的电化学供电方法,其特征在于,该测量电流的电流量,用以换算得出该待测反应物在该待测检体中的浓度含量。 10. The electrochemical power supply method according to claim 8, characterized in that the current measuring current to obtain the concentration in terms of the content of the test reaction was measured in the specimen.
11.如权利要求8所述的电化学供电方法,其特征在于,该电化学反应区设置于一浓度检定试片上。 11. The electrochemical power supply method according to claim 8, wherein the electrochemical reaction zone disposed on a test strip assay concentration.
12.如权利要求11所述的电化学供电方法,其特征在于,该浓度检定试片为一血糖试片。 12. The electrochemical power supplying method according to claim 11, wherein the concentration of the assay test strip is a glucose test strip.
13.—种电化学供电装置,其特征在于,包括: 一电化学反应区,让一待测检体中的一待测反应物进行化学反应的区域,该电化学反应区中预先置入一活性物质、一酵素或一抗体,以与该待测检体中的该待测反应物进行电化学反应; 一电压供应单元,耦接于该电化学反应区,在该待测检体置入该电化学反应区后,提供一重置电压信号于该电化学反应区,以消除杂质电流与其他干扰电流,再提供一反应电压于该电化学反应区,之后供应逐渐上升的一测量电压于该电化学反应区,以产生一测量电流; 一电流测量单元,耦接于该电化学反应区,以测量该电化学反应区中产生的电流;以及一处理单元,耦接于该电压供应单元以及该电流测量单元,以依据该电流测量单元的测量结果,作该待测反应物浓度的运算。 13.- kinds of electrochemical power supply apparatus, comprising: an electrochemical reaction zone, so that a test of a test sample was subjected to the reaction zone a chemical reaction, the electrochemical reaction zone into a pre- active substance, an enzyme or an antibody to electrochemical reaction with the test specimen in this test reaction; a voltage supply unit, coupled to the electrochemical reaction zone, placed in the test specimen the electrochemical reaction zone, providing a reset voltage signal in the electrochemical reaction zone to remove impurities and other current interference current, and then providing a voltage to the reaction zone of the electrochemical reaction, then gradually increase the supply voltage to a measured the electrochemical reaction zone, to produce a measured current; a current measuring unit, coupled to the electrochemical reaction zone, to measure the current generated in the electrochemical reaction zone; and a processing unit, coupled to the voltage supply unit and current measuring means for measuring the current measuring means based on the results of the test for the calculation of the concentration of reactants.
14.如权利要求13所述的电化学供电装置,其特征在于,该电压供应单元供应一初始电压,以侦测是否有该待测检体置入该电化学反应区。 14. The electrochemical power supply apparatus according to claim 13, wherein the voltage supply unit supplies an initial voltage to detect whether there is the electrochemical test specimen into the reaction zone.
15.如权利要求13所述的电化学供电装置,其特征在于,该电压供应单元更包括有一测血电极,设置于该电化学反应区,以侦测该待测检体是否已充满于该电化学反应区中。 15. The electrochemical power supply apparatus according to claim 13, wherein the voltage supply unit further comprises a measurement of blood electrodes provided in the electrochemical reaction zone, to detect whether the test subject has filled in the the electrochemical reaction zone.
16.如权利要求13所述的电化学供电装置,其特征在于,该电流测量单元测量该测量电流的数值,并将该测量电流的数值传送至该处理单元。 16. The electrochemical power supply apparatus according to claim 13, wherein the current measuring unit measures the value of the current measured, and the measured current value is transmitted to the processing unit.
17.如权利要求16所述的电化学供电装置,其特征在于,该处理单元依据该测量电流的数值,换算得到该待测反应物于该待测检体中的浓度含量。 17. The electrochemical power supply apparatus according to claim 16, wherein the processing unit according to the measured current value, the concentration obtained by converting the content of the test reaction was measured in the subject.
18.如权利要求13所述的电化学供电装置,其特征在于,该电化学反应区设置于一浓度检定试片上。 18. The electrochemical power supply apparatus according to claim 13, wherein the electrochemical reaction zone disposed on a test strip assay concentration.
19.如权利要求18所述的电化学供电装置,其特征在于,该浓度检定试片为一血糖试片。 19. The electrochemical power supply apparatus according to claim 18, wherein the concentration of the assay test strip is a glucose test strip.
CN 201010003403 2010-01-11 2010-01-11 Electrochemical power supply method and device CN102121914B (en)

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US5312590A (en) 1989-04-24 1994-05-17 National University Of Singapore Amperometric sensor for single and multicomponent analysis
CN1188545A (en) 1995-06-19 1998-07-22 梅姆泰克美国有限公司 Electrochemical detector
CN1445541A (en) 1995-11-16 2003-10-01 利费斯坎公司 Electrochemical process
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US5312590A (en) 1989-04-24 1994-05-17 National University Of Singapore Amperometric sensor for single and multicomponent analysis
CN1188545A (en) 1995-06-19 1998-07-22 梅姆泰克美国有限公司 Electrochemical detector
CN1445541A (en) 1995-11-16 2003-10-01 利费斯坎公司 Electrochemical process
CN1558224A (en) 2003-02-11 2004-12-29 拜尔健康护理有限责任公司 Methods of determining the concentration of an analyte in a fluid test sample

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