CN102121914B - Electrochemical power supply method and device - Google Patents
Electrochemical power supply method and device Download PDFInfo
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- CN102121914B CN102121914B CN 201010003403 CN201010003403A CN102121914B CN 102121914 B CN102121914 B CN 102121914B CN 201010003403 CN201010003403 CN 201010003403 CN 201010003403 A CN201010003403 A CN 201010003403A CN 102121914 B CN102121914 B CN 102121914B
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- 238000000034 method Methods 0.000 title claims abstract description 33
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- 238000013098 chemical test method Methods 0.000 claims description 70
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 21
- 239000008103 glucose Substances 0.000 claims description 21
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- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
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- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
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- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention provides an electrochemical power supply method and device which are applied to measuring the concentration of a reactant to be measured in a specimen to be measured. The method comprises the following steps: firstly supplying an initial voltage to an electrochemical reaction zone so as to detect whether the specimen to be measured is embedded into the electrochemical reaction zone;if yes, stopping supplying the initial voltage, providing waiting time so that the electrochemical reaction zone is filled with the specimen to be measured, and then supplying a reset voltage signal to the electrochemical reaction zone so as to reset the chemical reaction in the electrochemical reaction zone; supplying a reaction voltage to the electrochemical reaction zone, and supplying gradually raised measuring voltages to the electrochemical reaction zone after reaction so as to generate stable measuring current; and finally measuring and converting the numerical value of the measuring current so as to obtain the concentration of the reactant to be measured in the specimen to be measured.
Description
Technical field
The present invention relates to a kind of method of supplying power to and device thereof, refer in particular to a kind of method of supplying operating voltage and device thereof of electrochemical reaction.
Background technology
Development along with the biological sensing technology, many bio-sensing equipment in conjunction with biological nature and electronic technology are also invented in succession, similarly be blood sugar machine, blood fat machine, uric acid measurement instrument or cholesterol measuring instrument etc., the physics that it utilizes active substance and test substance to react to cause or the change of chemical characteristic, measure and convert and draw the amount of test substance, to reach the measurement purpose.
According to the difference of measuring on equipment and the mode, in general the kind of bio-sensing equipment has electrochemica biological sensor, semiconductor ion transducer, optical fiber biosensor, piezoelectric crystal biology sensor etc.Wherein, electrochemica biological sensor is by measuring reactions such as reactant to be measured and bioactivator, ferment or antibody, the change of the electrical conductivity that produces, voltage or electric current etc., and converting draws the amount of reactant to be measured.
And because the seasoning periods before not being used such as prepositioned active substance, ferment or antibody, may be because of the influence of ambient light energy, heat energy or moisture etc., chemical reaction in unexpected takes place, if use this bio-sensing equipment to measure reactant to be measured this moment, it is unexpected that chemical reaction will influence the correctness of measurement data, becomes the main source of error.
Except because unexpected impurity reacts the error that causes before measuring, when numerical measuring, also may cause error.For instance, please refer to Figure 1A, be the structural representation of existing blood glucose test 40, wherein a corpse or other object for laboratory examination and chemical testing to be measured (being blood in the present embodiment) splashes into from posting port 41, because the cause of siphonage, a corpse or other object for laboratory examination and chemical testing to be measured can be inhaled into siphon groove 42 gradually.And respond in the blood glucose test 40 district 43, L type electrode 45 and 47, after a corpse or other object for laboratory examination and chemical testing to be measured splashes into from posting port 41, can touch electrode 45 earlier, just be full of reaction zone 43 then gradually, when a corpse or other object for laboratory examination and chemical testing to be measured is run into electrode 47, namely represent a corpse or other object for laboratory examination and chemical testing to be measured and be full of reaction zone 43.
That is to say, biology sensor can be on L type electrode 45,47 supply small voltage earlier, in the time of at the beginning because be dry status between the L type electrode 45,47, so the measured impedance of biology sensor is very high.And when a corpse or other object for laboratory examination and chemical testing to be measured was full of reaction zone 43 and contacts with L type electrode 45 and 47, biology sensor just can detect impedance suddenly and descend significantly, had just known that therefore a corpse or other object for laboratory examination and chemical testing to be measured inserts in the blood glucose test 40, and had been full of reaction zone 43.Cooperate L type electrode 45,47 according to the method, just can confirm whereby that time point that electrochemical reaction begins is to carry out the timing in reaction time, but to make and get the principal reaction start time point in this way, just need with the blood glucose test with special electrodes structure, similarly be electrode 45 and 47 in this example for special L type, just restricted in the use.
Then as shown in Figure 1B, oscillogram for existing biology sensor supply voltage and kinetic current, please cooperate with reference to Figure 1A, response voltage 11 determines a corpse or other object for laboratory examination and chemical testing to be measured when biology sensor and begins to supply after time point t0 is full of reaction zone 43, produces the required energy of chemical reaction so that reactant to be measured in the corpse or other object for laboratory examination and chemical testing to be measured and the active substance in the reaction zone 43 or ferment to be provided.Along with the carrying out of chemical reaction, have kinetic current 21 and produce, then through behind one section special time, response voltage 11 stop supplies, reactant to be measured and ferment or active substance had and left standstill reaction this moment, thereby electric current 23 is left standstill in generation.Next, biology sensor just can provide measuring voltage 13, measure (for example measuring at time point t1) to produce measurement electric current 27, the numerical value according to measured measurement electric current 27 converts at last, just can learn the concentration of reactant to be measured in a corpse or other object for laboratory examination and chemical testing to be measured.
Because leaving standstill between the reaction period before beginning to supply to measuring voltage 13 after response voltage 11 stop supplies, therefore reaction can produce the small electric current 23 that leaves standstill also in continuing to carry out but in fact.If this moment is the measuring voltage 13 that supply skyrockets, measure the phenomenon that electric current 27 just has unsettled excess current 25 (overshooting), influence is measured the waveform of electric current 27 and at the numerical value of the measured measurement electric current 27 of time point t1, is caused the incorrect of measurement result.And if will make reaction result not have too big deviation, measure again when electric current 27 is comparatively stablized though can measure by the time, will certainly prolong Measuring Time thus and cause energy dissipation, reduce the efficient of measuring.
Summary of the invention
In view of this, technical matters to be solved by this invention is, by the change of power supply mode, removes the restriction of electrode structure and the measuring error of reduction biology sensor, promotes correctness and the efficient of measurement.
In order to achieve the above object, according to a scheme of the present invention, provide a kind of galvanochemistry electric supply installation, include an electrochemical reaction district, a voltage feeding unit, a current measuring unit and a processing unit.Wherein the electrochemical reaction district allows reactant to be measured in the corpse or other object for laboratory examination and chemical testing to be measured carry out the zone of chemical reaction, and the voltage feeding unit is coupled to this electrochemical reaction district, be used for after a corpse or other object for laboratory examination and chemical testing to be measured is inserted the electrochemical reaction district, provide the reset voltage signal in the electrochemical reaction district eliminating impurity electric current and other interference currents, and provide response voltage and measuring voltage.Current measuring unit is coupled to the electrochemical reaction district, in order to measuring the electric current that produces in the electrochemical reaction district, and is sent to the computing that processing unit is made reactant concentration to be measured.Processing unit is coupled to this voltage feeding unit and this current measuring unit, with the measurement result according to this current measuring unit, does the computing of this reactant concentration to be measured.
What deserves to be mentioned is, when the voltage feeding unit is used for producing the measuring voltage of measuring electric current in supply, be to supply with the mode that rises gradually, allows measure the phenomenon generation that electric current does not have excess current.In addition, the voltage feeding unit can provide initial voltage in the electrochemical reaction district before a survey corpse or other object for laboratory examination and chemical testing is inserted, and whether be used for detecting has a corpse or other object for laboratory examination and chemical testing to be measured to insert.
Whether according to another aspect of the present invention, provide a kind of galvanochemistry method of supplying power to, include the supply initial voltage in the electrochemical reaction district, detecting has a corpse or other object for laboratory examination and chemical testing to be measured to insert.Of particular note, the electrochemical reaction district is arranged in the test piece of biological sensing, and after a corpse or other object for laboratory examination and chemical testing to be measured splashes into from the posting port of test piece, can be full of the electrochemical reaction district gradually by siphon principle.And after a corpse or other object for laboratory examination and chemical testing to be measured splashed into, the impedance meeting in the electrochemical reaction district between two transmitting electrodes descended suddenly, and biology sensor can judge whether that by detecting two interelectrode impedances a corpse or other object for laboratory examination and chemical testing to be measured splashes in the electrochemical reaction district.
When having detected a corpse or other object for laboratory examination and chemical testing to be measured when inserting the electrochemical reaction district, just stop supplies initial voltage, leaving standstill the first-class chien shih of biding one's time surveys a corpse or other object for laboratory examination and chemical testing and can be full of the electrochemical reaction district, supply the reset voltage signal afterwards again in this electrochemical reaction district, to eliminate impurity electric current and other interference currents, the electrochemical reaction of reactant to be measured of resetting allows the time of chemical reaction start at again.Wherein, the reset voltage signal can be the polarization phenomena that remove reactive ion with form arbitrarily, similarly is reverse voltage pulse etc.
Then supply response voltage, the chemical reaction of reactant to be measured and ferment, antibody or active substance can be proceeded, after question response is intact, supplies measuring voltage again and measure electric current to produce.The size of wherein measuring electric current can be different along with the concentration of reactant to be measured in a corpse or other object for laboratory examination and chemical testing to be measured, therefore in case learn the size of measuring electric current, just knows concentration of reactants to be measured through converting, and obtains required measurement result.
In other words, the invention provides a kind of galvanochemistry method of supplying power to, comprising: supply an initial voltage in an electrochemical reaction district; When a corpse or other object for laboratory examination and chemical testing to be measured was inserted this electrochemical reaction district, this initial voltage of stop supplies was in this electrochemical reaction district; And supply a reset voltage signal in this electrochemical reaction district, to eliminate impurity electric current and other interference currents, the electrochemical reaction of a reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured of resetting.
According to another scheme of the present invention, a kind of galvanochemistry method of supplying power to is provided, include the supply initial voltage and detect in the electrochemical reaction district and whether have a corpse or other object for laboratory examination and chemical testing to be measured to insert, when detecting a corpse or other object for laboratory examination and chemical testing to be measured when inserting the electrochemical reaction district, i.e. stop supplies initial voltage.Then, the supply response voltage makes reactant to be measured and ferment, active substance or antibody etc. in the corpse or other object for laboratory examination and chemical testing to be measured carry out electrochemical reaction, and the measuring voltage of supplying rising gradually again after question response is complete is measured electric current in this electrochemical reaction district to produce.
In other words, the present invention also provides a kind of galvanochemistry method of supplying power to, comprising: when a corpse or other object for laboratory examination and chemical testing to be measured is inserted an electrochemical reaction district, supply a response voltage in this electrochemical reaction district, make the reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured carry out electrochemical reaction; And the measuring voltage that supply is risen is gradually measured electric current in this electrochemical reaction district to produce one.
Wherein measuring voltage is supplied with the mode that rises gradually, can avoid measuring the phenomenon that electric current produces excess current (overshooting), promote the correctness of measurement result, and the size that will measure electric current is namely known the concentration of reactant to be measured in a corpse or other object for laboratory examination and chemical testing to be measured after through conversion.
By being provided earlier, the reset voltage signal eliminates the start time point of unexpected impurity reaction and replacement electrochemical reaction before response voltage is provided, and when measuring, provide the measuring voltage that rises gradually to avoid measuring the excess current phenomenon of electric current, reach the effect that reduces measuring error, promote accuracy and the efficient measured.
Above general introduction and ensuing embodiment all are the effects in order to further specify technological means of the present invention and to reach, yet the embodiment that narrates and accompanying drawing only provide reference explanation usefulness, and the present invention is limited.
Description of drawings
Figure 1A is the synoptic diagram of existing blood glucose test structure;
Figure 1B is voltage and the current waveform figure of existing galvanochemistry method of supplying power to;
Fig. 2 is the calcspar of a kind of embodiment of biology sensor of the present invention;
Fig. 3 A is the structural representation of a kind of embodiment of blood glucose test of the present invention;
Fig. 3 B is voltage and the current waveform figure of a kind of embodiment of galvanochemistry method of supplying power to of the present invention; And
Fig. 4 is the process flow diagram of a kind of embodiment of galvanochemistry method of supplying power to of the present invention.
[main element description of reference numerals]
11,11 ' response voltage
13,13 ' measuring voltage
15 initial voltages
17 reset voltage signals
20 initial currents
21,21 ' kinetic current
23,23 ' leave standstill electric current
25 excess current
27,27 ' measure electric current
31 processing units
33 voltage feeding units
35 electrochemical reaction districts
37 current measuring units
40,50 blood glucose test
41,51 posting ports
42,52 siphon grooves
43 reaction zones
45,47,55,57 electrodes
Tb, t0, t1, t2, t3 time point
S401～S409 flow chart step explanation
Embodiment
By begin reaction at reactant to be measured before, provide the reset voltage signal to eliminate the impurity reaction earlier, with the replacement electrochemical reaction, and when measuring, provide the measuring voltage that rises gradually to produce stable measurement electric current, promote correctness and the efficient of measurement result.
Please refer to Fig. 2, the calcspar for a kind of embodiment of biology sensor comprises a processing unit 31, a voltage feeding unit 33, an electrochemical reaction district 35 and a current measuring unit 37.Wherein insert in advance in the electrochemical reaction district 35 to carry out Activity of Chemical Reaction material, ferment or antibody etc. with a reactant to be measured.For example, if this biology sensor is the blood sugar machine, electrochemical reaction district 35 namely is a certain end that is arranged at concentration calibrating test piece (being blood glucose test in the present embodiment), splashes into the concentration analysis that blood is made blood sugar for the user.Voltage feeding unit 33 is supplied in electrochemical reaction district 35 by voltage or the measuring voltage that two electrodes will react required, current measuring unit 37 then is to measure the current values that produces in the electrochemical reaction district 35 by those electrodes, and is sent to processing unit 31 and carries out the conversion of reactant concentration to be measured.
Please refer to Fig. 3 A, structural representation for a kind of embodiment of blood glucose test 50, include posting port 51, siphon groove 52, electrochemical reaction district 35 and electrode 55 and 57, wherein a corpse or other object for laboratory examination and chemical testing to be measured is to splash into from posting port 51, and enters among the electrochemical reaction district 35 by the siphon principle of siphon groove 52.With existing different be, electrode 55 in the present embodiment, 57 is strip and the dual-side that is positioned over reaction zone, therefore when a corpse or other object for laboratory examination and chemical testing to be measured touches impedance that electrode 55,57 makes the blood sugar machine detect simultaneously and descends suddenly, can not determine whether a corpse or other object for laboratory examination and chemical testing to be measured " is full of " electrochemical reaction district 35 fully, in identifiable just " having a corpse or other object for laboratory examination and chemical testing to be measured to insert " electrochemical reaction district 35.
Then, please refer to Fig. 3 B, voltage and current waveform figure for a kind of embodiment of galvanochemistry method of supplying power to please cooperate with reference to Fig. 2 and Fig. 3 A.This method is applied to the measurement of reactant to be measured (as: glucose) concentration in the corpse or other object for laboratory examination and chemical testing to be measured (as: blood), reactant to be measured carries out chemical reaction with the active substance, ferment or the antibody that are positioned over electrochemical reaction district 35 in advance, cause the change of physics or chemical characteristic, change as electrical conductivity, voltage or electric current etc., by measuring those change amounts (being to measure the magnitude of current with current measuring unit 37 in this example), can convert draws the concentration of reactant to be measured in a corpse or other object for laboratory examination and chemical testing to be measured.
As shown in Fig. 3 B, to be a corpse or other object for laboratory examination and chemical testing to be measured splash into the time point of posting port 51 by siphon principle to time point tb, and can produce an initial current 20 suddenly in electrochemical reaction district 35 this moment.And voltage feeding unit 33 is after sensing a corpse or other object for laboratory examination and chemical testing to be measured and splashing into, initial voltage 15 (just as the time point t2 among Fig. 3 B) that can stop supplies.Wherein initial voltage 15 is to supply by electrode 55 and 57, whether can be used for detecting has a corpse or other object for laboratory examination and chemical testing to be measured to insert electrochemical reaction district 35, the detecting principle is because of being dry between two electrodes 55,57 at the beginning, what biology sensor was measured is high impedance, so can produce any electric current hardly when providing initial voltage 15 at first on two electrodes 55,57.And when a corpse or other object for laboratory examination and chemical testing to be measured was inserted electrochemical reaction district 35 and touched two electrodes 55 and 57 simultaneously, the impedance that biology sensor just can measure suddenly between two electrodes 55,57 declined to a great extent, and can judge whereby has a corpse or other object for laboratory examination and chemical testing to be measured to insert electrochemical reaction district 35.
As above-mentioned, when having detected a corpse or other object for laboratory examination and chemical testing to be measured when inserting electrochemical reaction district 35, voltage feeding unit 33 is stop supplies initial voltage 15 (time point t2) just, and provides first-class to treat the time that (can decide according to the mean value of experimental data) allows a corpse or other object for laboratory examination and chemical testing to be measured be full of electrochemical reaction district 35 really.Perhaps, voltage feeding unit 33 can additionally arrange one at the lower area in electrochemical reaction district 35 and survey the blood electrode, by survey measuring the impedance of blood electrode and 55 at electrode, or the impedance of 57 at measurement blood electrode and electrode, can learn whether a corpse or other object for laboratory examination and chemical testing to be measured riddles in the electrochemical reaction district 35.That is to say, when a corpse or other object for laboratory examination and chemical testing to be measured riddles in the electrochemical reaction district 35, the impedance meeting that the impedance that survey blood electrode and electrode are 55 or survey blood electrode and electrode are 57 descends, and therefore, can be used to just confirm by measuring resistance value whether a corpse or other object for laboratory examination and chemical testing to be measured riddles in the electrochemical reaction district 35.
And after a corpse or other object for laboratory examination and chemical testing to be measured riddles the electrochemical reaction district, it (can be the polarization phenomena of eliminating reactive ion with form arbitrarily that voltage feeding unit 33 just can provide reset voltage signal 17, as reverse voltage pulse etc.) in electrochemical reaction district 35, be used for eliminating the impurity reaction before the time point t2 of initial voltage 15 stop supplies, and the start time point of chemical reaction is started at again.Wherein the reason that produces of impurity reaction normally active substance, ferment or antibody etc. because the moisture of environment or the factor that shines upon etc., or the chemical reaction that produces because of mixing of some impurity, can cause having some reaction electric charges to residue in electrochemical reaction district 35, those residual electric charges then can allow the result who measured afterwards produce deviation, therefore just need its elimination.
What deserves to be mentioned is, provide the stand-by period to allow a corpse or other object for laboratory examination and chemical testing to be measured be full of electrochemical reaction district 35 really by this, and provide reset voltage signal 17 to eliminate impurity react the to reset mode of electrochemical reaction, even if do not use existing L type electrode, also can accurately set the start time point of electrochemical reaction, thus, electrode 55,57 shape just can not be restricted, and can be designed to shape structure arbitrarily.
After having eliminated impurity reaction, voltage feeding unit 33 is namely supplied response voltage 11 ' in electrochemical reaction district 35, with the energy that provides the reactant to be measured that enough makes in the corpse or other object for laboratory examination and chemical testing to be measured and active substance, ferment or antibody etc. to carry out chemical reaction.At this moment, because chemical reaction begins to carry out, produce some ions and electric charge, therefore just have kinetic current 21 ' by being placed in the electrode 55,57 in the electrochemical reaction district 35.With the example that is measured as of blood sugar concentration, its chemical equation is as follows:
Glucose+GO/FAD→δ-Gluconolactone+GO/FADH
2
GO/FADH
2+O
2→GO/FAD+H
2O
2
H
2O
2→2H
++O
2+2e
-
Wherein Glucose is glucose, just blood sugar to be measured.GO is glucose oxidase (glucose oxidase), and itself and glucose produce a series of chemical reaction, produce hydrogen ion and electric charge at last.Those electric charges are placed in the electrode 55 in the electrochemical reaction district 35,57 receptions, will form electric current, and because hydrogen ion is more and more, being applied to the electric current that the response voltage 11 ' in electrochemical reaction district 35 produces also will be more and more higher, therefore comprehensive the above, kinetic current 21 ' will raise as shown in FIG. gradually.
Consult Fig. 3 B again, at supply response voltage 11 ' certain hour, make after reactant to be measured and ferment, active substance or the antibody response, voltage feeding unit 33 just can stop supplies response voltage 11 '.And begin to supply during this period of time to measuring voltage 13 ' in stop supplies response voltage 11 ', still have the so-called reaction of leaving standstill, so even voltage feeding unit 33 does not provide voltage, it still has the faint electric current 23 ' that leaves standstill and produces.
When wanting measurement data, voltage feeding unit 33 of the present invention can provide the measuring voltage 13 ' that rises gradually in electrochemical reaction district 35, measures electric current 27 ' to produce.Then, current measuring unit 37 is measured the value of this measurement electric current 27 ' at time point t3, can carry out what relevant (in general the more big representative concentration of electric current are more high) of chemical reaction amount along with reactant to be measured and ferment, active substance or antibody etc. because of the size of measuring electric current 27 ' numerical value, so convert finally by crossing, can learn concentration of reactants to be measured.What deserves to be mentioned is, provide measuring voltage 13 ' with the mode that rises gradually, just can not produce unsettled excess current (overshooting) as the existing measurement electric current 27 ' that makes, therefore can promote accuracy and the efficient of DATA REASONING.
Then see also Fig. 4, the process flow diagram for a kind of embodiment of galvanochemistry method of supplying power to please cooperate with reference to Fig. 2 and Fig. 3 B.This method is applied to the measurement (for example measuring the concentration of glucose in the blood) of a reactant concentration to be measured in the corpse or other object for laboratory examination and chemical testing to be measured, step includes: at first, supply initial voltage 15 is in electrochemical reaction district 35 (S401), whether wherein this initial voltage 15 can be used to detecting has a corpse or other object for laboratory examination and chemical testing to be measured (as blood) to insert in the electrochemical reaction district 35 (as the reaction zone of blood glucose test), the method of detecting in the preamble explanation, therefore just repeats no more.
When having detected a corpse or other object for laboratory examination and chemical testing to be measured when inserting electrochemical reaction district 35, voltage feeding unit 33 just stops the supply (S403) of initial voltage 15, and provides first-class to treat the time, allows a corpse or other object for laboratory examination and chemical testing to be measured can be full of electrochemical reaction district 35 really.Then, voltage feeding unit 33 can provide reset voltage signal 17 in electrochemical reaction district 35 (S405), and to eliminate the residual electric charge of impurity reaction, the chemical reaction in the replacement electrochemical reaction district 35 allows the initial time of reaction start at again.Voltage feeding unit 33 is just supplied response voltage 11 ' in electrochemical reaction district 35 (S407) then, carries out the chemical reaction energy needed so that reactant to be measured (as glucose) and active substance, ferment or antibody to be provided.
After a bit of time of response voltage 11 ' stop supplies, voltage feeding unit 33 is namely supplied the measuring voltage 13 ' of rising gradually in electrochemical reaction district 35, produces and measures electric current 27 ' (S409), to measure.At last, the numerical values recited by measuring this measurement electric current 27 ' also converts, just can learn the concentration of reactant to be measured (as glucose) in a corpse or other object for laboratory examination and chemical testing to be measured (as blood).What deserves to be mentioned is, supply measuring voltage 13 ' with the mode that rises gradually, is to produce unsettled excess current phenomenon for fear of measuring electric current 27 ', increases the accuracy of measurement result.
In sum, by beginning at reactant to be measured and ferment, active substance or antibody before the reaction, provide the reset voltage signal to eliminate the influence that impurity reaction institute may cause earlier, the replacement electrochemical reaction is also started at the zero-time of chemical reaction again, and allowing electrode shape construct can be unrestricted.In addition, when measurement data, provide measuring voltage with the mode that rises gradually, avoiding measuring the phenomenon that electric current produces unstable excess current, and then reduce the error of measurement result and promote data veracity.
The above is explanation and the accompanying drawing of specific embodiments of the invention, any those skilled in the art in the field of the invention, can think easily and variation or revise all can be encompassed in the protection domain that the present invention defines.
Claims (19)
1. a galvanochemistry method of supplying power to is characterized in that, comprising:
Supply an initial voltage in an electrochemical reaction district, insert an active substance, a ferment or an antibody in this electrochemical reaction district in advance, with a corpse or other object for laboratory examination and chemical testing to be measured in a reactant to be measured carry out electrochemical reaction;
When this corpse or other object for laboratory examination and chemical testing to be measured was inserted this electrochemical reaction district, this initial voltage of stop supplies was in this electrochemical reaction district; And
Supply a reset voltage signal in this electrochemical reaction district, to eliminate impurity electric current and other interference currents, the electrochemical reaction of this reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured of resetting;
Supply a response voltage in this electrochemical reaction district, the electrochemical reaction of this reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured can be continued;
The measuring voltage that supply is risen is gradually measured electric current in this electrochemical reaction district to produce one.
2. galvanochemistry method of supplying power to as claimed in claim 1 is characterized in that, more comprises before the step of this reset voltage signal of supply:
Provide first-class to treat the time, allow this corpse or other object for laboratory examination and chemical testing to be measured can be full of this electrochemical reaction district.
3. galvanochemistry method of supplying power to as claimed in claim 1 is characterized in that, this response voltage provides is enough to make this reactant to be measured to carry out the energy of electrochemical reaction.
4. galvanochemistry method of supplying power to as claimed in claim 1 is characterized in that, the magnitude of current that this measures electric current draws the concentration content of this reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured in order to conversion.
5. galvanochemistry method of supplying power to as claimed in claim 1 is characterized in that, whether this initial voltage has this corpse or other object for laboratory examination and chemical testing to be measured to insert this electrochemical reaction district with detecting.
6. galvanochemistry method of supplying power to as claimed in claim 1 is characterized in that, this electrochemical reaction district is arranged in the concentration calibrating test piece.
7. galvanochemistry method of supplying power to as claimed in claim 6 is characterized in that, this concentration calibrating test piece is a blood glucose test.
8. a galvanochemistry method of supplying power to is characterized in that, comprising:
When a corpse or other object for laboratory examination and chemical testing to be measured is inserted an electrochemical reaction district, supply a reset voltage signal in this electrochemical reaction district, insert an active substance, a ferment or an antibody in this electrochemical reaction district in advance, with this corpse or other object for laboratory examination and chemical testing to be measured in a reactant to be measured carry out electrochemical reaction;
Supply a response voltage in this electrochemical reaction district, make this reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured carry out electrochemical reaction; And
The measuring voltage that supply is risen is gradually measured electric current in this electrochemical reaction district to produce one.
9. galvanochemistry method of supplying power to as claimed in claim 8 is characterized in that, this response voltage provides is enough to make this reactant to be measured to carry out the energy of electrochemical reaction.
10. galvanochemistry method of supplying power to as claimed in claim 8 is characterized in that, the magnitude of current that this measures electric current draws the concentration content of this reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured in order to conversion.
11. galvanochemistry method of supplying power to as claimed in claim 8 is characterized in that, this electrochemical reaction district is arranged in the concentration calibrating test piece.
12. galvanochemistry method of supplying power to as claimed in claim 11 is characterized in that, this concentration calibrating test piece is a blood glucose test.
13. a galvanochemistry electric supply installation is characterized in that, comprising:
One electrochemical reaction district allows a reactant to be measured in the corpse or other object for laboratory examination and chemical testing to be measured carry out the zone of chemical reaction, inserts an active substance, a ferment or an antibody in this electrochemical reaction district in advance, with this corpse or other object for laboratory examination and chemical testing to be measured in this reactant to be measured carry out electrochemical reaction;
One voltage feeding unit, be coupled to this electrochemical reaction district, after this corpse or other object for laboratory examination and chemical testing to be measured is inserted this electrochemical reaction district, provide a reset voltage signal in this electrochemical reaction district, to eliminate impurity electric current and other interference currents, provide a response voltage in this electrochemical reaction district again, the measuring voltage that supply is afterwards risen is gradually measured electric current in this electrochemical reaction district to produce one;
One current measuring unit is coupled to this electrochemical reaction district, to measure the electric current that produces in this electrochemical reaction district; And
One processing unit is coupled to this voltage feeding unit and this current measuring unit, with the measurement result according to this current measuring unit, does the computing of this reactant concentration to be measured.
Whether 14. galvanochemistry electric supply installation as claimed in claim 13 is characterized in that, this voltage feeding unit is supplied an initial voltage, have this corpse or other object for laboratory examination and chemical testing to be measured to insert this electrochemical reaction district with detecting.
Whether 15. galvanochemistry electric supply installation as claimed in claim 13 is characterized in that, this voltage feeding unit more includes one and surveys the blood electrode, is arranged at this electrochemical reaction district, riddled in this electrochemical reaction district with this corpse or other object for laboratory examination and chemical testing to be measured of detecting.
16. galvanochemistry electric supply installation as claimed in claim 13 is characterized in that this current measuring unit is measured the numerical value of this measurement electric current, and the numerical value that will measure electric current is sent to this processing unit.
17. galvanochemistry electric supply installation as claimed in claim 16 is characterized in that, this processing unit is measured the numerical value of electric current according to this, and converting obtains the concentration content of this reactant to be measured in this corpse or other object for laboratory examination and chemical testing to be measured.
18. galvanochemistry electric supply installation as claimed in claim 13 is characterized in that, this electrochemical reaction district is arranged in the concentration calibrating test piece.
19. galvanochemistry electric supply installation as claimed in claim 18 is characterized in that, this concentration calibrating test piece is a blood glucose test.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010003403 CN102121914B (en) | 2010-01-11 | 2010-01-11 | Electrochemical power supply method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010003403 CN102121914B (en) | 2010-01-11 | 2010-01-11 | Electrochemical power supply method and device |
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| CN102121914A CN102121914A (en) | 2011-07-13 |
| CN102121914B true CN102121914B (en) | 2013-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201010003403 Expired - Fee Related CN102121914B (en) | 2010-01-11 | 2010-01-11 | Electrochemical power supply method and device |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109758164B (en) * | 2017-11-10 | 2024-03-08 | 上海瀚联医疗技术股份有限公司 | Blood glucose monitoring method of blood glucose meter |
| CN109781803B (en) * | 2017-11-10 | 2024-01-26 | 上海瀚联医疗技术股份有限公司 | Blood glucose monitor |
Citations (4)
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|---|---|---|---|---|
| US5312590A (en) * | 1989-04-24 | 1994-05-17 | National University Of Singapore | Amperometric sensor for single and multicomponent analysis |
| CN1188545A (en) * | 1995-06-19 | 1998-07-22 | 梅姆泰克美国有限公司 | Electrochemical detector |
| CN1445541A (en) * | 1995-11-16 | 2003-10-01 | 利费斯坎公司 | Electrochemical process |
| CN1558224A (en) * | 2003-02-11 | 2004-12-29 | �����ι�˾ | Methods of determining the concentration of an analyte in a fluid test sample |
-
2010
- 2010-01-11 CN CN 201010003403 patent/CN102121914B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5312590A (en) * | 1989-04-24 | 1994-05-17 | National University Of Singapore | Amperometric sensor for single and multicomponent analysis |
| CN1188545A (en) * | 1995-06-19 | 1998-07-22 | 梅姆泰克美国有限公司 | Electrochemical detector |
| CN1445541A (en) * | 1995-11-16 | 2003-10-01 | 利费斯坎公司 | Electrochemical process |
| CN1558224A (en) * | 2003-02-11 | 2004-12-29 | �����ι�˾ | Methods of determining the concentration of an analyte in a fluid test sample |
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| CN102121914A (en) | 2011-07-13 |
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