CN102114400B - Method for preparing sodium alginate-iron chlorophyllin sodium microcapsule - Google Patents
Method for preparing sodium alginate-iron chlorophyllin sodium microcapsule Download PDFInfo
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- CN102114400B CN102114400B CN2010106125322A CN201010612532A CN102114400B CN 102114400 B CN102114400 B CN 102114400B CN 2010106125322 A CN2010106125322 A CN 2010106125322A CN 201010612532 A CN201010612532 A CN 201010612532A CN 102114400 B CN102114400 B CN 102114400B
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- sodium
- iron chlorophyllin
- sodium alginate
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- capsule
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Abstract
The invention relates to a method for improving the shape of a capsule in the field of food color and medicine health protection, in particular to a method for preparing a sodium alginate-iron chlorophyllin sodium microcapsule. The method comprises the following steps that deionized water is added into a beaker, sodium alginate is added into the beaker slowly and is stirred at the same time, and mixed liquor is left to stand for a night after the sodium alginate is dissolved completely so as to obtain sodium alginate solution; iron chlorophyllin sodium powder is weighed and dissolved in deionized water, and iron chlorophyllin sodium solution is obtained after the iron chlorophyllin sodium powder is dissolved completely; iron chlorophyllin sodium solution and sodium alginate solution are mixed, wall material and core material are added according to the volume of mixed liquor which is then stirred so as to obtain the uniform mixture, and the mixture is kept under constant temperature in a constant temperature water bath kettle and then is homogenized; and calcium chloride solution that is curing agent is prepared. Pelletization is carried out through a high-voltage electrostatic field device, and greenish black finished granulums with round particle shape are obtained. By adopting a high-voltage electrostatic field method, the shape of the microcapsule can be obviously improved, the entrapment rate and the drug-loading rate of the microcapsule and the production efficiency can be improved, and the requirements of the microcapsule for the industrialized production can be well satisfied.
Description
Technical field
The present invention relates to the method that food colour, medicines and health protection field improve scrotiform, particularly a kind of industrialization prepares the method for sodium alginate-sodium iron chlorophyllin micro-capsule in a large number.
Background technology
Sodium iron chlorophyllin is except that can be used as food coloring; Pharmaceutically also can be used as ferrous-fortifier; Recently external pharmacological research thinks that sodium iron chlorophyllin has effects such as antibiotic, antiviral, antiallergy and promotion regeneration; Be a kind of good hematopoietic cell complexing agent, leukopenia and various anaemia that a variety of causes is caused have therapeutic action.It is prepared into micro-capsule both can strengthens its stability, can reach the purpose of slow releasing function again, can further enlarge its range of application.Adopt orifice method to prepare micro-capsule at present, this method is owing to prepare limited speed, and microcapsule diameter is bigger, and the capsule grain is inhomogeneous.
Summary of the invention
The objective of the invention is to prepare the micro-capsule limited speed to the prior art orifice method; Microcapsule diameter is bigger; The uneven defective of capsule grain; A kind of method for preparing sodium alginate-sodium iron chlorophyllin micro-capsule with the sodium alginate for the capsule material is provided, and this method adopts high-voltage electrostatic field method, and the circular smooth uniformity of the micro-capsule of preparation is better.The present invention can significantly improve the micro-capsule profile through above new method, improves microencapsulation rate and medicine carrying amount, enhances productivity, and can satisfy the micro-capsule industrial production requirement well.
Realize that above-mentioned purpose adopts following technical scheme: a kind of method for preparing sodium alginate-sodium iron chlorophyllin micro-capsule, said method are is the capsule material with the sodium alginate, adopt the high-voltage electrostatic field legal system to be equipped with the method for sodium iron chlorophyllin micro-capsule, the steps include:
(1) preparation of sodium alginate soln
In beaker, add the deionized water about 45～60 ℃, slowly add sodium alginate while stirring, fully after the dissolving; Hold over night; Make water be penetrated into the sodium alginate granule interior, reach fully dissolving, process mass concentration and be 1.5～5.0% sodium alginate soln;
(2) preparation of iron chlorophyllin sodium solution
Take by weighing 5.00g sodium iron chlorophyllin powder and be dissolved in the 100mL deionized water, after treating to dissolve fully, process mass concentration and be 1.0～6.0% iron chlorophyllin sodium solution;
(3) mixed liquor of preparation sodium iron chlorophyllin and sodium alginate soln
Step (2) iron chlorophyllin sodium solution is mixed with step (1) sodium alginate soln, add wall material, core at 1: 1 by its volume, stir, make it mixing, constant temperature 25～35min in 25～35 ℃ of thermostat water baths carries out homogeneous then;
(4) preparation of curing agent calcium chloride solution
Take by weighing 2.5～10.0g calcium chloride solid and be dissolved in the 250mL water, be mixed with mass concentration and be 1.0～4.0% CaCl
2Solution;
(5) preparation of sodium alginate-sodium iron chlorophyllin micro-capsule
With the granulation of high-pressure electrostatic field device, voltage 8～15kV, temperature are that 15～55 ℃, mixing speed are 450～850r/min, following height 5～10cm, and the mixed solution droplet that splashes into is at CaCl
2Under the solidification of solution, form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidify the blackish green granule that obtained profile particle rounding in 20 minutes in the solution, be finished product.
Adopt technique scheme, compared with prior art, the present invention adopts the high-voltage electrostatic field method; Can significantly improve the micro-capsule profile, improve microencapsulation rate and medicine carrying amount, enhance productivity; Overcome the shortcoming of micro-capsule adhesion, scrotiform difference, improved the stability of sodium iron chlorophyllin, reached the purpose of slow releasing function; Improve the medical value and the range of application of sodium iron chlorophyllin, can satisfy the micro-capsule industrial production requirement well.Characteristics simple in structure, easy to operate, function admirable that high-pressure electrostatic system bag apparatus has can prepare circular smooth uniformity micro-capsule preferably fast, in a large number.The present invention is a kind of practical, be suitable for the method for suitability for industrialized production micro-capsule.
The specific embodiment
Below in conjunction with embodiment the present invention is done further description.
Present embodiment is the method that is equipped with the sodium iron chlorophyllin micro-capsule with the high-voltage electrostatic field legal system.The high voltage electrostatic device that adopts is the CZGF-120kV/2mA high voltage direct current generator that Jiangsu Province Yangzhou Baoce Electric Co., Ltd. produces.It is the mixed solution that sodium alginate and sodium iron chlorophyllin are housed in syringe that the high-voltage electrostatic field legal system is equipped with sodium alginate-sodium iron chlorophyllin micro-capsule preparation method; Under certain altitude, voltage; Mixed liquor in the syringe is dripped through syringe needle; Drop repels because of having like charges each other, in the spraying of syringe needle interruption-forming, falls into and fills CaCl
2Solidify in the receiver of solution.
Specific embodiment
Embodiment 1:
(1) preparation of sodium alginate soln
In beaker, add the deionized water about 45～60 ℃, slowly add the 10.0g sodium alginate while stirring, make its fully dissolving just; Hold over night; Make water be penetrated into the sodium alginate granule interior fully, reach dissolving fully, process the sodium alginate soln that concentration is 2.0g/100mL.
(2) preparation of iron chlorophyllin sodium solution
Take by weighing 2.50g sodium iron chlorophyllin powder and be dissolved in the deionized water of 100mL, after treating to dissolve fully, be diluted to the iron chlorophyllin sodium solution that 250mL processes 1.0g/100mL.
(3) sodium iron chlorophyllin and sodium alginate soln mixes
Added wall material, core in by volume 1: 1, stir, make it mixing, constant temperature 30min in 30 ℃ of thermostat water baths carries out homogeneous then.
(4) preparation of curing agent calcium chloride solution
Take by weighing 2.5g calcium chloride solid and be dissolved in the 250mL water, the CaCl of preparation 1.0g/100mL
2Solution.
(5) preparation of sodium alginate-sodium iron chlorophyllin micro-capsule
With the granulation of high-pressure electrostatic field device, control certain voltage, thermostat temperature, mixing speed and following height.The mixed solution droplet that splashes into is at CaCl
2Under the solidification of solution (room temperature), form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution.
The prepared sodium iron chlorophyllin micro-capsule product of present embodiment is blackish green granule, profile particle rounding, and smooth surface is mellow and full, and size is even, no adhesion phenomenon.
Embodiment 2:
1) preparation of sodium alginate soln
In beaker, add the deionized water about 45～60 ℃, slowly add the 15.0g sodium alginate while stirring, make its fully dissolving just; Hold over night; Make water be penetrated into the sodium alginate granule interior fully, reach dissolving fully, process the sodium alginate soln that concentration is 3.0g/100mL.
(2) preparation of iron chlorophyllin sodium solution
Take by weighing 5.00g sodium iron chlorophyllin powder and be dissolved in the appropriate amount of deionized water, after treating to dissolve fully, process the iron chlorophyllin sodium solution of 2.0g/100mL.
(3) sodium iron chlorophyllin and sodium alginate soln mixes
Added wall material, core in by volume 1: 1, stir, make it mixing, constant temperature 30min in 30 ℃ of thermostat water baths carries out homogeneous then.
(4) preparation of curing agent calcium chloride solution
Take by weighing 5.0g calcium chloride solid and be dissolved in the 250mL water, the CaCl of preparation 2.0g/100mL
2Solution.
(5) preparation of sodium alginate-sodium iron chlorophyllin micro-capsule
With the granulation of high-pressure electrostatic field device, control certain voltage, thermostat temperature, mixing speed and following height.The mixed solution droplet that splashes into is at CaCl
2Under the solidification of solution (room temperature), form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution.
The sodium iron chlorophyllin micro-capsule product design particle rounding that present embodiment is prepared, smooth surface is mellow and full, and size is even, and envelop rate is greater than 80%.
Embodiment 3:
(1) preparation of sodium alginate soln
In beaker, add the deionized water about 45～60 ℃, slowly add the 20.0g sodium alginate while stirring, make its fully dissolving just; Hold over night; Make water be penetrated into the sodium alginate granule interior fully, reach dissolving fully, process the sodium alginate soln that concentration is 4.0g/100mL.
(2) preparation of iron chlorophyllin sodium solution
Take by weighing 7.50g sodium iron chlorophyllin powder and be dissolved in the appropriate amount of deionized water, after treating to dissolve fully, process the iron chlorophyllin sodium solution of 3.0g/100mL.
(3) sodium iron chlorophyllin and sodium alginate soln mixes
Added wall material, core in by volume 1: 1, stir, make it mixing, constant temperature 30min in 30 ℃ of thermostat water baths carries out homogeneous then.
(4) preparation of curing agent calcium chloride solution
Take by weighing 7.5g calcium chloride solid and be dissolved in the 250mL water, the CaCl of preparation 3.0g/100mL
2Solution.
(5) preparation of sodium alginate-sodium iron chlorophyllin micro-capsule
With the granulation of high-pressure electrostatic field device, control certain voltage, thermostat temperature, mixing speed and following height.The mixed solution droplet that splashes into is at CaCl
2Under the solidification of solution (room temperature), form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution.
The prepared sodium iron chlorophyllin micro-capsule product of present embodiment is blackish green granule, profile particle rounding, and smooth surface is mellow and full, and size evenly possesses herbaceous taste, and average grain diameter is less than 200 μ m.
Embodiment 4:
Each step is identical with embodiment 1 or 2, unique different be step (5) with the granulation of high-pressure electrostatic field device, control voltage 9kV, 30 ℃ of thermostat temperatures, mixing speed 600r/min and following be 5cm highly.The mixed solution droplet that splashes into is at CaCl
2Under the solidification that solution is 30 ℃, form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution.
Embodiment 5:
Each step is identical with embodiment 1 or 2, unique different be step (5) with the granulation of high-pressure electrostatic field device, control voltage 12kV, 40 ℃ of thermostat temperatures, mixing speed 650r/min and following be 8cm highly.The mixed solution droplet that splashes into is at CaCl
2Under the solidification that solution is 40 ℃, form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution.
Embodiment 6:
Each step is identical with embodiment 1 or 2, unique different be step (5) with the granulation of high-pressure electrostatic field device, control voltage 14kV, 45 ℃ of thermostat temperatures, mixing speed 700r/min and following be 10cm highly.The mixed solution droplet that splashes into is at CaCl
2Under the solidification that solution is 45 ℃, form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution.
When the high-voltage electrostatic field legal system was equipped with the sodium iron chlorophyllin micro-capsule, along with the change of iron chlorophyllin na concn, the micro-capsule metamorphosis was not obvious, but concentration is excessive, and envelop rate reduces gradually.Therefore, in preferred version, chlorophyllin sodium mass concentration is 1.0～6.0%.
When the high-voltage electrostatic field legal system was equipped with the sodium iron chlorophyllin micro-capsule, along with the increase of sodium alginate concentration, adhesion phenomenon appearred in micro-capsule, and the microencapsulation rate increases gradually.In preferred version, the sodium alginate mass concentration is 1.5～5.0%.
When the high-voltage electrostatic field legal system is equipped with the sodium iron chlorophyllin micro-capsule, CaCl
2The change of concentration directly affects the shape of encystation.CaCl
2When concentration is very little, Ca
2+Incomplete with sodium alginate cross-linking, solidification effect is poor, to such an extent as to the sheet micro-capsule occurred, i.e. encystation not.Along with CaCl
2The increase of concentration, what micro-capsule formed speeds up the corresponding increase of envelop rate.In preferred version, CaCl
2Mass concentration is 0.5～4.0%.
When temperature is low, little to the influence of micro-capsule form, when temperature is too high, influence the stability of sodium iron chlorophyllin, so envelop rate descends to some extent.In preferred version, temperature is 15～55 ℃.
Along with the increase of mixing speed, envelop rate is the trend that diminishes after the change greatly earlier.In preferred version, mixing speed is 450～850r/min.
Following highly too hour, can cause puncturing the overvoltage phenomenon.In preferred version, following highly is 5～10cm.
When voltage is excessive, the micro-capsule of smalls shape occurred, envelop rate reduces.In preferred version, voltage is 8～15kV.
The present invention is raw materials used to be the commercial goods with equipment.Wherein employed high voltage direct current generator is the product of Yangzhou Baoce Electric Co., Ltd., and model is CZGF-120kV/2mA.
More than disclosedly be merely specific embodiment of the present invention; Though the present invention discloses as above with preferred embodiment; But the present invention is not limited thereto, any those skilled in the art can think variation, in not breaking away from design philosophy of the present invention and scope; The present invention is carried out various changes and retouching, all should drop within protection scope of the present invention.
Claims (1)
1. a method for preparing sodium alginate-sodium iron chlorophyllin micro-capsule is characterized in that, said method is is the capsule material with the sodium alginate, adopt the high-voltage electrostatic field legal system to be equipped with the method for sodium iron chlorophyllin micro-capsule, the steps include:
(1) preparation of sodium alginate soln
In beaker, add deionized water 500mL, be heated to 45～60 ℃, slowly add 7.5～25.0g sodium alginate while stirring; Fully after the dissolving, hold over night makes water be penetrated into the sodium alginate granule interior; Reach fully dissolving, process mass concentration and be 1.5～5.0% sodium alginate soln;
(2) preparation of iron chlorophyllin sodium solution
Take by weighing 2.5～15.0g sodium iron chlorophyllin powder respectively and be dissolved in the 100mL deionized water, after treating to dissolve fully, be diluted to 250mL, process mass concentration and be 1.0～6.0% iron chlorophyllin sodium solution;
(3) mixed liquor of preparation sodium iron chlorophyllin and sodium alginate soln
Step (2) iron chlorophyllin sodium solution is mixed with step (1) sodium alginate soln, add wall material, core at 1: 1 by its volume, stir, make it mixing, constant temperature 25～35min in 25～35 ℃ of thermostat water baths carries out homogeneous then;
(4) preparation of curing agent calcium chloride solution
Take by weighing 2.5～10.0g calcium chloride solid and be dissolved in the 250mL water, be mixed with mass concentration and be 1.0～4.0% CaCl
2Solution;
(5) preparation of sodium alginate-sodium iron chlorophyllin micro-capsule
With the granulation of high-pressure electrostatic field device, voltage 8～15kV, temperature are that 15～55 ℃, mixing speed are 450～850r/min, following height 5～10cm, and the mixed solution droplet that splashes into is at CaCl
2Under the solidification of solution, form sodium alginate-sodium iron chlorophyllin micro-capsule, and with the sodium iron chlorophyllin micro-capsule that makes at CaCl
2Solidified 20 minutes in the solution, obtain the blackish green granule of profile particle rounding, be finished product.
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| CN2010106125322A CN102114400B (en) | 2010-12-30 | 2010-12-30 | Method for preparing sodium alginate-iron chlorophyllin sodium microcapsule |
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| CN2010106125322A CN102114400B (en) | 2010-12-30 | 2010-12-30 | Method for preparing sodium alginate-iron chlorophyllin sodium microcapsule |
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| CN102114400B true CN102114400B (en) | 2012-12-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108719566A (en) * | 2018-05-14 | 2018-11-02 | 中玺（天津）枣业技术工程中心 | The sandwich soft sweets of jujube and processing method |
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| CN102258481B (en) * | 2011-08-19 | 2013-02-20 | 薛巍 | Method for preparing self-assembled medicine-carried microspheres by combining high-voltage electrostatic liquid droplet method and layer-by-layer self-assembly method |
Citations (1)
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| CN101015537A (en) * | 2007-02-15 | 2007-08-15 | 河北理工大学 | Preparation method of sodium iron chlorophyllin-ethyl cellulose microcapsule |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015537A (en) * | 2007-02-15 | 2007-08-15 | 河北理工大学 | Preparation method of sodium iron chlorophyllin-ethyl cellulose microcapsule |
Non-Patent Citations (2)
| Title |
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| 刘欣 等.海藻酸钠为囊材锐孔法制备铁叶绿酸钠微囊.《现代食品科技》.2009,第25卷(第9期),第1015页，第1043-1045页. * |
| 李保国 等.高压静电成囊法工艺参数的优化.《中国医药工业杂质》.2004,第35卷(第8期),第472-474页. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719566A (en) * | 2018-05-14 | 2018-11-02 | 中玺（天津）枣业技术工程中心 | The sandwich soft sweets of jujube and processing method |
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