CN102114078B - Chinese medicine extract for promoting fracture healing and preparation method and application thereof - Google Patents
Chinese medicine extract for promoting fracture healing and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicine extract for promoting fracture healing and a preparation method thereof. The Chinese medicine extract for promoting fracture healing is prepared by extracting stems and barks of a fraxinus plant, i.e. fraxinus platypoda, with water or alcohol. The preparation method of the Chinese medicine extract for promoting fracture healing comprises the following steps of: a. drying: drying the stems and barks of fraxinus platypoda by a conventional method; b. pulverizing: pulverizing the dried stems and barks into powder by a conventional method; c. extracting: extracting the powder by water decoction extraction or alcohol reflux extraction; d. concentrating at a reduced pressure: concentrating the extracting solution into extractum at the reduced pressure; and e. obtaining the Chinese medicine extract: drying the extractum, pulverizing the dried extractum into fine powder or micro powder, and sealing and packaging the powder to obtain the Chinese medicine extract. The Chinese medicine extract prepared by adopting the preparation method of the invention can promote osteoblast formation, ensure that the poroma grows rapidly and maturely in a large amount, and has obvious treatment effect and less toxic and side effects. The Chinese medicine extract can be widely applied to treat various diseases, such as open fracture, non-open fracture, old fracture, thrypsis, bone split, injuries from falls, sprain, and the like.
Description
Technical field
The invention belongs to Chinese medicine extract and preparation method thereof field, specifically a kind of Chinese medicine extract that promotes union of fracture and its preparation method and application.
Background technology
Along with the development of social market economy, the rhythm of people's life becomes more and more faster, the high speed expansion of urban transportation and work rhythm, and the generation of fracture is soaring repeatedly.At present, fracture is most the patient is adopted play clamping plate, Gypsum Fibrosum is fixed and the traction etc. of performing the operation, through good reset and fix after, fracture is generally at 3-4 month or cured more than half a year, because convalescent period is longer, fracture patient will be handicapped for a long time, disability, the damage that causes is huge.Therefore, be badly in need of wanting a kind of method of quick promotion union of fracture to improve patients ' life quality and the massive losses that alleviates so bring.At present, the partner treatment fracture mainly contains some Chinese medicine compound, such as Yunnan BAIYAO, Anisodus carniolicoides C.Y.Wu et C.Chen, pill for traumatic injuries, GUZHE CUOSHANG JIAONANG etc.Because these compound recipe flavour of a drug are more, that have in addition tens the flavor medical materials, the result makes that composition is more complicated, taking dose is large, purity is not high, because the multi-flavor medical material is difficult to unified because of collecting season and place, the result causes the shortcomings such as drug quality is unstable, poor effect, the course for the treatment of is long, cost is high, the source owes to enrich, and can be because contain unmanageable toxicity medical material in the some drugs, the meetings such as heavy metal bring certain side effect or leave sequela to the patient.Simultaneously, By consulting literatures is not reported and development and use in the research aspect the promotion union of fracture sweet-scented osmanthus Ke Ash platymiscium Fraxinus platypoda Oliver at present.
Summary of the invention
Goal of the invention:Based on above reason, the present invention seeks to develop have the Fraxinus platypoda Oliver extract that promotes union of fracture and overcome present Chinese medicine compound complicated component, taking dose is large, purity is not high, quality is unstable, poor effect, the course for the treatment of long, high in cost of production shortcoming, provide that a kind of composition is relatively simple, steady quality, taking dose is little, purity is high, effect is remarkable, short treating period, single medicinal material extract that toxic and side effects is little are fractured as treatment ideal medicament.The present invention also provides the preparation method of the Chinese medicine extract that promotes union of fracture.
Technical scheme:A kind of Chinese medicine extract that promotes union of fracture, the Chinese medicine extract of this promotion union of fracture refer to sweet-scented osmanthus Ke Ash platymiscium Fraxinus platypoda Oliver (
Fraxinus platypoda Oliver)Peel of stem is through water or alcohol extraction and get.
A kind of preparation method that promotes the Chinese medicine extract of union of fracture may further comprise the steps: a. is dry: the Fraxinus platypoda Oliver peel of stem is dry with conventional method; B. pulverize: it is powder that the peel of stem of drying is pulverized with conventional breaking method; C. extract: water boiling and extraction or alcohol reflux extract; D. concentrating under reduced pressure: the extracting solution concentrating under reduced pressure becomes extractum; E. Chinese medicine extract: with extract dry, pulverize and be fine powder or micropowder, sealing packing and getting.
Water boiling and extraction described in the step c refers to add the heavy 8-30 of medicinal powder water doubly, decocts 1-3 hour, extracts 1-3 time.
Alcohol reflux described in the step c extracts, and refers to add the heavy 6-12 of medicinal powder alcohol doubly, backflow 1-3 hour, extracts 1-3 time.
Alcohol described in the step c refers to that volumetric concentration is methanol or the ethanol of 20%-95%.
The application of above-mentioned preparation-obtained Chinese medicine extract in preparation promotion union of fracture medicine.
Beneficial effect:The Chinese medicine extract of the present invention's preparation promotes a large amount of hypertrophy of osteoblast, growth of spur soon and amount is many and ripe, also have antiinflammatory and analgesic activity.Therapeutic effect significantly, short treating period, steady quality and toxic and side effects be little.Low, the wide material sources of cost of material of the present invention, preparation technology and equipment are simple, extract solvent cheap, reclaim easily, can reuse, free from environmental pollution.The various symptoms such as the Chinese medicine extract of preparation can be widely used in various explorative fracture, non-explorative fracture, becomes old property fracture, comminuted fracture, bone splits, traumatic injury, sprains, nonunion, delayed union.Simultaneously, according to demand, can make various preparations such as tablet, capsule, granule, electuary, tincture, extractum, drop pill, ointment etc. to Chinese medicine extract with acceptable adjuvant on the medicament and complementary composition according to a conventional method.
The specific embodiment
Below in conjunction with instantiation, further set forth the present invention.Should be understood that these embodiment only for the present invention will be described, do not consist of the restriction to the claim scope, other alternative means that it may occur to persons skilled in the art that are all in claim scope of the present invention.
Below in conjunction with concrete condition the specific embodiment of the present invention is elaborated.
Embodiment 1 Chinese medicine extract is on the impact test of rabbit fracture healing
1 test material
1.1 the preparation of Chinese medicine extract
(1) drying: with the Fraxinus platypoda Oliver peel of stem 60 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 40 mesh sieves, get powder;
(3) extract: add volumetric concentration that medicinal powder weighs 10 times of amounts for the first time and be 95% ethanol, soaked reflux, extract, 2 hours, filtration 1 hour; It is 95% alcohol reflux 1.5 hours that filtering residue adds volumetric concentration that the medical material powder weighs 8 times of amounts again, filters; It is 95% alcohol reflux 1 hour that filtering residue adds volumetric concentration that the medical material powder weighs 6 times of amounts again, filters, and merges 3 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) Chinese medicine extract: with the extractum vacuum drying, pulverize and be fine powder, with being to dissolve with warm water.
1.2 laboratory animal: New Zealand's large ear rabbit, Jiangning county Qinglongshan animal reproduction field provides.
1.3 positive control medicine: GUZHE CUOSHANG JIAONANG, Huayu Pharmaceutical Group Corp., Ltd., Harbin, product batch number, 20080504.
1.4 test reagent
Methanol, ethanol: Chemical Reagent Co., Ltd., Sinopharm Group, analytical pure.Distilled water: provided by this school laboratory.
Normal saline: this laboratory configuration.Calcium, phosphorus, alkaline phosphatase enzyme reagent kit: bio-engineering research institute is built up in Nanjing.
2 experimental techniques
All rabbits are divided into model group (negative control group), Chinese medicine extract group, GUZHE CUOSHANG JIAONANG group (positive controls), 12 every group by the principle of random packet with 36 New Zealand's large ear rabbits after adaptability is raised a week.Each organizes rabbit in the conventional depilation of modeling left upper extremity the previous day and numbering.Press the 30mg/kg body weight with 0.3% pentobarbital sodium during modeling, the auricular vein injecting anesthetic.Conventional iodine tincture, alcohol disinfecting, shop aseptic operation list, lower 1/3 place's longitudinal incision skin and subcutaneous tissue in scratching bone exposes and scratches lower 1/3 position in the bone.Cut periosteum at pronator ters insertion tendon far-end, cause the complete bony defect of 3mm with special hacksaw.Do not do any fixing, normal saline flushing otch, layer-by-layer suture otch.The Chinese medicine extract group is to 0.17 gram/kilogram, and the GUZHE CUOSHANG JIAONANG group is to 0.25 gram/kilogram, and model group gives normal saline, and one day twice, conventional feed and drinking-water.Postoperative muscle injection penicillin prevention infection.Each group is with 6 rabbit ear edge venous blood collections 14,21,28,35 days the time after the administration, and separation of serum is measured calcium, phosphorus, alkali phosphatase, the 14th and 28 day every group take 6 to take X-rays, callus and fracture line are marked.
4 result of the tests
4.1 Biochemical Indexes result
Alkali phosphatase (AKP), calcium (Ca), phosphorus (P) measurement result such as following table.
Osteoblast is as the bone formation cell, and is quite important in fracture healing process, and its significant composition is alkali phosphatase (AKP).Can find out that from above table model group blood AKP is slowly growth trend, just peaks at 28d.And Chinese medicine extract group and powder for fracture and trauma group AKP just reached the peak at the 21st day, and the appearance on AKP peak has shifted to an earlier date a week.And Chinese medicine extract group and fracture contusion group rear 14 days, the 21 days blood AKP that fracture are significantly higher than model group, and difference is (p＜0.01) extremely significantly.During by the 35th day, Chinese medicine extract group and powder for fracture and trauma group AKP descend in a large number, compare with model group, difference is (p＜0.01) extremely significantly, this moment, fracture was almost recovered, thereby the union of fracture that osteoblast is participated in tends towards stability, and model group AKP is also higher, illustrate also healing among.Above result shows that Chinese medicine extract has raising or transfers osteoblastic activity, promotes osteoblast to form, thereby accelerates the healing of fracture.
Calcium, phosphorus is as the main component of bone, its increase can accelerated bone mineralising.Can find out that from above table it is all basic identical at each time point respectively to organize calcium after the fracture, difference is (p〉0.05) not significantly, illustrate that Chinese medicine extract does not affect blood calcium.Serium inorganic phosphorus after fracture the 14th, 21 day with model group difference not significantly (p〉0.05), and significantly raise in the 28th, 35 day, with model group difference extremely significantly (p＜0.01), this may be to need P to participate in the mineralising of bone in the union of fracture later stage.
4.2 fracture line and callus appraisal result
Fracture line and callus standards of grading are as follows: 0 minute, fracture site was clear, without periosteal reaction, without callus as seen; 1 minute, fracture site edge trend was fuzzy, the periosteum mild reaction, without callus as seen; 2 minutes, broken ends of fractured bone edge blurry, periosteal reaction is light, and callus is a small amount of, and density is lighter, and the edge is irregular; 3 minutes, still as seen broken ends of fractured bone edge but approach to disappear, and periosteal reaction is darker, and yield of callus increases, but not yet filled up damagedly, and density increases deeply, and the edge is more clear; 4 minutes, the complete obiteration of broken ends of fractured bone edge, periosteal reaction density is similar to the bone shadow, and callus is filled up damaged, and is identical with cortical bone density and interconnect.
By taking X-ray, naked eyes are read sheet, and Chinese medicine extract group callus and fracture line appraisal result and model group compare in the time of the 14th day, and difference is (p＜0.01) extremely significantly; Powder for fracture and trauma group and model group compare, significant difference (p＜0.05).Illustrate that Chinese medicine extract has good facilitation to growth of spur, its effect is better than the powder for fracture and trauma group.Chinese medicine extract group and powder for fracture and trauma group and model group difference extremely significantly (p＜0.01) in the time of the 28th day.The result shows that Chinese medicine extract has good facilitation to growth of spur, and is better to the curative effect of union of fracture.
Embodiment 2 Chinese medicine extract are on the impact test of fracture healing in rats
1 test material
1.1 the preparation of Chinese medicine extract
(1) drying: with the Fraxinus platypoda Oliver peel of stem 60 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 20 mesh sieves, get powder;
(3) extract: add the water that medicinal powder weighs 25 times of amounts for the first time, soaked 1 hour, decocted 1 hour, filter; Filtering residue adds the water that the medical material powder weighs 20 times of amounts again, decocts 1 hour, filters; Filtering residue adds the water that the medical material powder weighs 15 times of amounts again, decocts 1 hour, filters, and merges 3 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) Chinese medicine extract: with the extractum spray drying, pulverize and be fine powder, the time spent dissolves with warm water.
1.2 laboratory animal: the Wistar rat, Jiangning county Qinglongshan animal reproduction field provides.
1.3 positive control medicine: GUZHE CUOSHANG JIAONANG, Huayu Pharmaceutical Group Corp., Ltd., Harbin, product batch number, 20080504.
1.4 test reagent
Methanol, ethanol: Chemical Reagent Co., Ltd., Sinopharm Group, analytical pure.
Distilled water: provided by this school laboratory.
Normal saline: this laboratory configuration.
Calcium, phosphorus, alkaline phosphatase enzyme reagent kit: bio-engineering research institute is built up in Nanjing.
2 experimental techniques
36 of the rats of this test employing 200-220 gram, minute Chinese medicine extract group, model group (negative control group), powder for fracture and trauma group (positive controls), 12 every group.During modeling with 0.3% pentobarbital sodium intraperitoneal injection of anesthesia.Conventional iodine tincture, alcohol disinfecting, shop aseptic operation list, lower 1/3 place's longitudinal incision skin and subcutaneous tissue in scratching bone exposes and scratches lower 1/3 position in the bone.Cut periosteum at pronator ters insertion tendon far-end, with bone shears radius is cut off.Do not do any fixing, normal saline flushing otch, layer-by-layer suture otch.The Chinese medicine extract group is by 0.18 gram/kilogram, and the GUZHE CUOSHANG JIAONANG group is by 0.25 gram/kilogram, and model group gives normal saline, and one day twice, conventional feed and drinking-water.Postoperative muscle injection penicillin prevention infection.7,14,21,28 days the time, get 8 rats for every group after the administration, the blood sampling of vena ophthalmica socket of the eye, separation of serum is measured calcium, phosphorus, alkali phosphatase.Take X-rays with 6 rats for every group when the 14th day and 28 days, to callus and fracture line scoring.
3 experimental results
3.1 Biochemical Indexes result
Can find out that from above table model group blood AKP is slowly growth trend, just peaks at 21d.And Chinese medicine extract group and powder for fracture and trauma group AKP just reached the peak at the 14th day, and the appearance on AKP peak has shifted to an earlier date a week.And Chinese medicine extract group and fracture contusion group rear 7 days, the 14 days blood AKP that fracture are significantly higher than model group, with model group relatively, difference is (p＜0.01) extremely significantly.During by the 28th day, Chinese medicine extract group and powder for fracture and trauma group AKP descend in a large number, compare with model group, difference is (p＜0.01) extremely significantly, this moment, fracture was almost recovered, thereby the union of fracture that osteoblast is participated in tends towards stability, and model group AKP is also higher, illustrate also healing among.Above result shows that Chinese medicine extract has raising or transfers osteoblastic activity, promotes osteoblast to form, thereby accelerates the healing of fracture.
Calcium, phosphorus is as the main component of bone, its increase can accelerated bone mineralising.Can find out that from above table it is all basic identical at each time point respectively to organize calcium after the fracture, difference is (p〉0.05) not significantly, illustrate that Chinese medicine extract does not affect blood calcium.Serium inorganic phosphorus after fracture the 14th, 21 day with model group significant difference (p＜0.05), and significantly raise in the 28th day, with model group difference extremely significantly (p＜0.01), this may be to need P to participate in the mineralising of bone in the union of fracture later stage.
By taking X-ray, naked eyes are read sheet, Chinese medicine extract group and powder for fracture and trauma group and model group difference extremely remarkable (p＜0.01) in the time of the 14th and 28 day.The result shows that Chinese medicine extract has good facilitation to growth of spur, and is better to the curative effect of union of fracture.
Embodiment 3 Chinese medicine extract are on the impact of goat union of fracture
The preparation of 1 Chinese medicine extract
(1) drying: with the Fraxinus platypoda Oliver peel of stem 80 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 40 mesh sieves, get powder;
(3) extract: add volumetric concentration that medicinal powder weighs 12 times of amounts for the first time and be 20% methanol, soaked reflux, extract, 3 hours, filtration 2 hours; It is that 20% methanol eddy extracted 2 hours that filtering residue adds volumetric concentration that the medical material powder weighs 8 times of amounts again, filters; It is that 20% methanol eddy extracted 1 hour that filtering residue adds volumetric concentration that the medical material powder weighs 6 times of amounts again, filters, and merges 3 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) the Chinese medicine extraction composition powders: with the extractum lyophilization, pulverize and be fine powder.
2 test methods
The right back foot of goat is owing to be sandwiched between tree, the result causes right tibia exogenous injury, the Chinese medicine fine powder made from this test adds Chinese liquor and makes the extractum external application, wrap up with gauze, external clamping plate folder is steady, every day is twice this Chinese medicine extract of usefulness soaking in Chinese liquor sooner or later, pours an amount of liquid medicine into, beats complete wet being advisable with gauze.Changed gauze in 3 days one time.The result is after treatment in 21 days, and bone injury returns to one's perfect health, the goat freedom of movement.
Embodiment 4 Chinese medicine extract are on the impact of Babalus bubalis L. union of fracture
The preparation of 1 Chinese medicine extract
(1) drying: with the Fraxinus platypoda Oliver peel of stem 40 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 20 mesh sieves, get powder;
(3) extract: add the water that medicinal powder weighs 30 times of amounts for the first time, soaked 2 hours, decocted 3 hours, filter; Filtering residue adds the water that the medical material powder weighs 8 times of amounts again, decocts 1 hour, filters.Merge 2 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) Chinese medicine extract: with the extractum vacuum drying, pulverize and be fine powder, sealing packing and getting.
2 test methods
A Babalus bubalis L. foot causes fracture of tarsus owing to be sandwiched between stone, bleeds profusely, and sleeping ground does not rise.The Chinese medicine fine powder made from this test adds warm water and makes the extractum external application, and with the gauze parcel, external clamping plate folder is steady, and every day is twice this Chinese medicine extract of usefulness warm water soaking sooner or later, pours an amount of liquid medicine into, beats complete wet being advisable with gauze.Changed gauze in 3 days one time.The result through 14 days the treatment after, union of fracture, the Babalus bubalis L. foot can be walked sleepingly.
The preparation of embodiment 5 tablets
(1) drying: with the Fraxinus platypoda Oliver peel of stem 100 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 80 mesh sieves, get powder;
(3) extract: get powder, add volumetric concentration that medicinal powder weighs 12 times of amounts for the first time and be 20% ethanol, soaked reflux, extract, 2 hours, filtration 2 hours; It is 20% alcohol reflux 1.5 hours that filtering residue adds volumetric concentration that the medical material powder weighs 10 times of amounts again, filters, and merges 2 times filtrate;
(4) concentrating under reduced pressure: it is strong that filtrate decompression is condensed into thick paste;
(5) the Chinese medicine extract tablet: add 15%wt soluble starch dextrin during thick paste is strong, mixing, 60 ℃ of oven dry are pulverized, and add 1% hard acid magnesium mixing, cross 20 mesh sieves, granulate, tabletting is made veneer coated tablet, 0.27 g/piece of every content of dispersion.Instructions of taking, each 3-4 sheet, 3 times on the 1st.
The preparation of embodiment 6 capsules
(1) drying: with the Fraxinus platypoda Oliver peel of stem 40 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 60 mesh sieves, get powder;
(3) extract: get powder, add volumetric concentration that medicinal powder weighs 12 times of amounts and be 80% ethanol, soaked 3 hours, reflux, extract, 3 hours is filtered, collection filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) the Chinese medicine extract capsule: with the extractum spray drying, pulverize and be micropowder, add 50% and cross 200 order crude drug powder, mixing 60 ℃ of dryings, is pulverized, and this medicated powder is made capsule by every explosive payload 0.25 gram/grain.Instructions of taking, each 3-4 grain, 3 times on the 1st.
The preparation of embodiment 7 capsules
(1) drying: with the Fraxinus platypoda Oliver peel of stem 60 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 40 mesh sieves, get powder;
(3) extract: add volumetric concentration that medicinal powder weighs 12 times of amounts for the first time and be 60% methanol, soaked reflux, extract, 2 hours, filtration 1 hour; It is that 60% methanol eddy extracted 2 hours that filtering residue adds volumetric concentration that the medical material powder weighs 10 times of amounts again, filters, and merges 2 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) the Chinese medicine extract capsule: with the extractum vacuum drying, pulverize and be fine powder, add 40% microcrystalline Cellulose, 2% Pulvis Talci, mixing gets medicated powder, and this medicated powder is made capsule by every explosive payload 0.25 gram/grain.Instructions of taking, each 3-4 grain, 3 times on the 1st.
The preparation of embodiment 8 powders
(1) drying: with the Fraxinus platypoda Oliver peel of stem 80 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 60 mesh sieves, get powder;
(3) extract: add volumetric concentration that medicinal powder weighs 8 times of amounts for the first time and be 95% methanol, soaked reflux, extract, 2 hours, filtration 2 hours; It is that 95% methanol eddy extracted 2 hours that filtering residue adds volumetric concentration that the medical material powder weighs 7 times of amounts again, filters; It is that 95% methanol eddy extracted 1 hour that filtering residue adds volumetric concentration that the medical material powder weighs 6 times of amounts again, filters, and merges 3 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) the Chinese medicine extraction composition powders: with the extractum lyophilization, pulverize and be micropowder, sealing packing, every pouch 0.80-1.10 gram.Instructions of taking, takes with warm water by each 1 bag.
The preparation of embodiment 9 capsules
(1) drying: with the Fraxinus platypoda Oliver peel of stem 80 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 40 mesh sieves, get powder;
(3) extract: add volumetric concentration that medicinal powder weighs 12 times of amounts and be 95% methanol, soaked 3 hours, reflux, extract, 3 hours is filtered collection filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) the Chinese medicine extract capsule: with the extractum vacuum drying, pulverize and be micropowder, add 50% starch, mixing 60 ℃ of dryings, is pulverized, and this medicated powder is made capsule by every explosive payload 0.25 gram/grain.Instructions of taking, each 3-4 grain, 3 times on the 1st.
The preparation of embodiment 10 capsules
(1) drying: with the Fraxinus platypoda Oliver peel of stem 60 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 40 mesh sieves, get powder;
(3) extract: add the water that medicinal powder weighs 25 times of amounts for the first time, soaked 1 hour, decocted 1 hour, filter; Filtering residue adds the water that the medical material powder weighs 20 times of amounts again, decocts 1 hour, filters; Filtering residue adds the water that the medical material powder weighs 15 times of amounts again, decocts 1 hour, filters, and merges 3 times filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) the Chinese medicine extract capsule: with the extractum spray drying, pulverize and be fine powder, add appropriate amount of starch, granulation, drying.Granule is incapsulated, and every fills 0.3 gram.Instructions of taking, each 3-4 grain, 3 times on the 1st.
The preparation of embodiment 11 powders
(1) drying: with the Fraxinus platypoda Oliver peel of stem 80 ℃ of drying baker dryings;
(2) pulverize: the peel of stem of drying is pulverized, crossed 60 mesh sieves, get powder;
(3) extract: add the water that medicinal powder weighs 30 times of amounts, soaked 3 hours, decocted 3 hours, filter, collect filtrate;
(4) concentrating under reduced pressure: filtrate decompression is condensed into extractum;
(5) Chinese medicine extract: with the extractum lyophilization, pulverize and be fine powder, sealing packing, every bag of 0.90-1.20 gram.Instructions of taking, takes with warm water by each 1 bag.
Claims (1)
1. a Chinese medicine extract promotes application in the union of fracture medicine in preparation, the Chinese medicine extract that it is characterized in that this promotion union of fracture refer to sweet-scented osmanthus section Ash platymiscium Fraxinus platypoda Oliver (
Fraxinus platypoda Oliver), peel of stem is through water or alcohol extraction and get.
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2011
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Non-Patent Citations (1)
| Title |
|---|
| 邬家林.四川梣属植物资源.《中国中药杂志》.1989,第14卷(第8期),4（452）. * |
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