CN102106842A - Levofloxacin hydrochloride micropill capsule and preparation method thereof - Google Patents
Levofloxacin hydrochloride micropill capsule and preparation method thereof Download PDFInfo
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- CN102106842A CN102106842A CN2009101569697A CN200910156969A CN102106842A CN 102106842 A CN102106842 A CN 102106842A CN 2009101569697 A CN2009101569697 A CN 2009101569697A CN 200910156969 A CN200910156969 A CN 200910156969A CN 102106842 A CN102106842 A CN 102106842A
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- levofloxacin hydrochloride
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- 239000002775 capsule Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000006187 pill Substances 0.000 claims abstract description 44
- 239000011248 coating agent Substances 0.000 claims abstract description 31
- 238000000576 coating method Methods 0.000 claims abstract description 31
- 239000010410 layer Substances 0.000 claims abstract description 27
- 238000013268 sustained release Methods 0.000 claims abstract description 18
- 239000012730 sustained-release form Substances 0.000 claims abstract description 18
- 239000011230 binding agent Substances 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 12
- 239000011247 coating layer Substances 0.000 claims abstract description 11
- 239000004014 plasticizer Substances 0.000 claims abstract description 9
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- 239000012530 fluid Substances 0.000 claims description 12
- 229930006000 Sucrose Natural products 0.000 claims description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 11
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- 238000001035 drying Methods 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000001069 triethyl citrate Substances 0.000 claims description 6
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000013769 triethyl citrate Nutrition 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 239000004925 Acrylic resin Substances 0.000 claims description 2
- 229920000178 Acrylic resin Polymers 0.000 claims description 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
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- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 description 6
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 6
- 229960003376 levofloxacin Drugs 0.000 description 6
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- 210000004369 blood Anatomy 0.000 description 5
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 description 4
- 229960001699 ofloxacin Drugs 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 3
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- 241000193830 Bacillus <bacterium> Species 0.000 description 2
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- 150000002148 esters Chemical class 0.000 description 2
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- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 2
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- 229920003163 Eudragit® NE 30 D Polymers 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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Abstract
The invention relates to a levofloxacin hydrochloride micropill capsule and a preparation method thereof. The levofloxacin hydrochloride micropill capsule comprises a pill core, a medicament-containing layer, a sustained-release coating layer and a quick-release layer, wherein levofloxacin hydrochloride is contained in the medicament-containing layer and the quick-release layer; and the sustained-release coating layer comprises the following materials in percentage by weight: 20 to 60 percent of levofloxacin hydrochloride, 30 to 55 percent of pill core, 10 to 25 percent of binding agent, 3 to 5 percent of sustained-release coating material, 0.3 to 3 percent of pore-forming agent and 0.1 to 1 percent of plasticizer. The levofloxacin hydrochloride micropill capsule has the advantages of high stability, small local stimulation of medicaments, high bioavailability and the like. Due to the adoption of a fluidized bed, the problems of large dust and low yield in a method of powder agglomerating in the background technology are solved.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of levofloxacin hydrochloride micro-pill capsule and preparation method thereof.
Background technology
Levofloxacin hydrochloride is the levo form of ofloxacin S configuration, is white or little yellow crystalline powder, and odorless, bitter in the mouth are met light gradual change color, are a third generation quinolones broad spectrum antibiotics.Glucose fungus, streptococcus, streptococcus pneumoniae, gonococcus, escherichia coli, citrobacter, bacillus dysenteriae, Fei Yankeleishi bacillus, Enterobacter, hemophilus influenza, acinetobacter calcoaceticus, pylori etc. had antibacterial action preferably.Bacillus pyocyaneus, chlamydia trachomatis, tubercule bacillus etc. had certain antibacterial activity.And toxicity is low, is quinolones toxic and side effects minimum in the marketed drug, and the side reaction rate is lower than 3%.Be used for the treatment of the infection such as acute and chronic gram negative bacteria at positions such as respiratory tract, throat, tonsil, urinary tract, skin and soft tissue, gallbladder and bile duct, middle ear, intestinal clinically.
The levofloxacin hydrochloride oral formulations of listing is mainly tablet and capsule at present, and its capsule mostly is powder and fills.The present invention is to provide and earlier crude drug is prepared into micropill, filled capsules has the bioavailability height then, and is little to GI irritation, and medicine stability is good.
The preparation of levofloxacin hydrochloride micro-pill and quality control (Chinese Pharmaceutical, 2005 the 14th volume o. 11ths, the 54-55 page or leaf) a kind of levofloxacin hydrochloride micro-pill capsule is disclosed, its micropill adopts the centrifugal granulating preparation, its technology is that powder plays the initial ball nuclear of female preparation 60-80 order, amplifies then.Its main deficiency has been that female dust is bigger, yield low (having only 77.8%), and levofloxacin hydrochloride is met light gradual change color, its effectively shading in addition.CN100361660C discloses the levofloxacin slow release micropill preparation, it is characterized in that being made up of the plain particles of 0-40% or the slow release pastille micropill of micropill and 60-100%.Its deficiency is how to guarantee mixing uniformity.
Patent publication No. is the disclosed a kind of levofloxacin controlled release pharmaceutical compositions of CN1552327, comprises following composition: 50～300mg levofloxacin; With cellulose esters or esters, wherein cellulose esters or esters are selected from 5～200mg hydroxypropyl emthylcellulose, 5～200mg carboxymethyl cellulose and 5～200mg polyvinylpyrrolidone; With 5～150mg fat acid, fatty acid.This patent of invention has solved the slow release problem of levofloxacin hydrochloride.
Summary of the invention
The object of the present invention is to provide a kind of good stability, the medicine local excitation is little, bioavailability is high levofloxacin hydrochloride micro-pill capsule.
Another object of the present invention is to provide the preparation method of the levofloxacin hydrochloride micro-pill capsule that a kind of dust is little, yield is high.
In order to realize the foregoing invention purpose, the present invention adopts following technical scheme:
A kind of levofloxacin hydrochloride micro-pill capsule, comprise ball core, medicated layer, sustained release coating layer and release layer, levofloxacin hydrochloride is included in wherein the medicated layer and release layer, the sustained release coating layer comprises sustained release coating material, porogen, plasticizer, comprise following material by weight percentage: levofloxacin hydrochloride 20%～60%, ball core 30%～55%, binding agent 10%～25%, sustained release coating material 3%～5%, porogen 0.3%～3%, plasticizer 0.1%～1%.
The coating material of described sustained release coating layer is a kind of or its mixing in ethyl cellulose, the acrylic resin.
Described porogen is one or more in Polyethylene Glycol, polyvidone, hydroxypropyl methylcellulose, methylcellulose, the sucrose.
Described plasticizer is one or more mixing in Polyethylene Glycol, triethyl citrate, dibutyl sebacate, the diethyl phthalate.
The invention also discloses a kind of preparation method of levofloxacin hydrochloride micro-pill capsule, comprise the steps:
(1) contain the preparation of pill core:
The binding agent of getting recipe quantity 30%～60% is dissolved in and obtains the binding agent alcoholic solution in the alcoholic solution, and the levofloxacin hydrochloride with recipe quantity 30%～60% is dissolved in the binding agent alcoholic solution again, stirs to make it form uniform suspension; The ball core of recipe quantity is placed fluidised bed granulator, the fluid bed parameter is set, above-mentioned suspension is sparged the ball wicking surface, treat that suspension adds, the dry micropill that gets;
(2) slow release layer coating:
Get sustained release coating material, porogen, the plasticizer configuration coating solution of recipe quantity, the micropill that step (1) is obtained places fluid bed, carries out coating; The coating after drying obtains slow-release micro-pill;
(3) release layer coating:
Remaining levofloxacin hydrochloride and binding agent are dissolved in the alcoholic solution, stir into suspension, the slow-release micro-pill that step (2) is obtained places fluid bed, suspension is sparged the slow-release micro-pill surface, treat that suspension uses up after drying, dried micropill cover capsule shells is obtained levofloxacin hydrochloride micro-pill capsule.
The present invention compared with prior art has following advantage:
1, the size of levofloxacin micropill of the present invention is even, and good fluidity is easy to handle, as divided dose, filled capsules etc.
2, the medicine local irritation is little, discharges medicine in the gastrointestinal tract because micropill is distributed in widely with the unit piller, has avoided the medicine local concentration excessive effectively, has reduced the zest of medicine.
3,, be subjected to digestive tract to carry the food rhythm and pace of moving things to influence little (close as pylorus etc.) because particle diameter is little.
4, big at the gastrointestinal tract distribution area, the bioavailability height.
5, improve medicine stability, cover disagreeable taste.
6, levofloxacin micropill skin of the present invention is a release layer, reaches effective blood drug concentration very soon, and internal layer is a slow release layer, keeps effective blood drug concentration, effectively reduces administration number of times.
7, levofloxacin micropill slow release layer of the present invention and release layer are on same micropill, and divided dose is accurate, good uniformity in batch.
Description of drawings
Fig. 1: the release curve of the embodiment of the invention 1;
Fig. 2: the release curve of the embodiment of the invention 2;
Fig. 3: the release curve of the embodiment of the invention 3.
The specific embodiment
The present invention is described further below by specific embodiment.
Embodiment 1: present embodiment adopts following prescription:
Levofloxacin hydrochloride (by ofloxacin) 200g
Sucrose ball core 153.4g
Polyvidone k30 18.4g
Ethyl cellulose 11.2g
Triethyl citrate 2.2g
Polyethylene glycol 6000 3.3g
Pulvis Talci is an amount of
Make 1000
Preparation technology:
(1) contain the preparation of pill core:
At first 9.2g polyvidone k30 is dissolved in the alcoholic solution, in the levofloxacin hydrochloride adding polyvidone alcoholic solution with 100g, and constantly stirring makes it become uniform suspension; 153.4g sucrose ball core is placed fluidized bed pelletizer, above-mentioned even suspension is sparged blank sucrose ball wicking surface, carry out micropill preparation, treat that suspension all adds, dry, screen micropill;
(2) sustained release coating layer:
The 9.2g ethyl cellulose is dissolved in the alcoholic solution, adds 2.2g triethyl citrate, 3.3g Polyethylene Glycol and an amount of Pulvis Talci, stir coating solution; The micropill that obtains in the step () is placed fluid bed, and the control parameter is carried out the coating of slow release layer, after coating is finished, and the dry slow-release micro-pill that gets;
(3) release layer coating:
The 3.7g binding agent is dissolved in the alcoholic solution, again remaining 100g levofloxacin hydrochloride is joined in the solution, constantly stir and obtain uniform suspension, the slow-release micro-pill that step (two) is prepared places fluid bed, and the control parameter sparges the micropill surface with above-mentioned even suspension and adds medicine to, treat that whole suspensions add, medicine-feeding is finished, and drying obtains micropill, micropill is filled in promptly gets levofloxacin hydrochloride micro-pill capsule in the capsule shells.
Levofloxacin hydrochloride micro-pill capsule to the present embodiment gained carries out the release test, the release curve is seen Fig. 1, and from the release curve, the levofloxacin hydrochloride micro-pill capsule of present embodiment is rapid release in 2 hours, stable then release kept necessary blood drug level.
Embodiment 2: present embodiment adopts following prescription:
Levofloxacin hydrochloride (by ofloxacin) 400g
Sucrose ball core 300g
Polyvidone k30 36g
Eudragit?NE30D 122g
Pulvis Talci 36.8g
Make 1000
Preparation technology:
(1) contain the preparation of pill core:
At first 21.6g polyvidone k30 is dissolved in the alcoholic solution, in the levofloxacin hydrochloride adding polyvidone alcoholic solution with 240g, and constantly stirring makes it become uniform suspension; 300g sucrose ball core is placed fluidized bed pelletizer, above-mentioned even suspension is sparged blank sucrose ball wicking surface, carry out micropill preparation, treat that suspension all adds, dry, screen micropill;
(2) sustained release coating layer:
The Eudragit NE30D and the Pulvis Talci of recipe quantity is water-soluble, stir coating solution; The micropill that obtains in the step () is placed fluid bed, and the control parameter is carried out the coating of slow release layer, after coating is finished, and the dry slow-release micro-pill that gets;
(3) release layer coating:
Remaining binding agent is dissolved in the alcoholic solution, again remaining levofloxacin hydrochloride is joined in the solution, constantly stir and obtain uniform suspension, the slow-release micro-pill that step (two) is prepared places fluid bed, and the control parameter sparges the micropill surface with above-mentioned even suspension and adds medicine to, treat that whole suspensions add, medicine-feeding is finished, and drying obtains micropill, micropill is filled in promptly gets levofloxacin hydrochloride micro-pill capsule in the capsule shells.
Levofloxacin hydrochloride micro-pill capsule to the present embodiment gained carries out the release test, the release curve is seen Fig. 2, and from the release curve, the levofloxacin hydrochloride micro-pill capsule of present embodiment is rapid release in 2 hours, stable then release kept necessary blood drug level.
Embodiment 3: present embodiment adopts following prescription:
Levofloxacin hydrochloride (by ofloxacin) 100g
Sucrose ball core 80g
Hydroxypropyl methylcellulose 20g
Ethyl cellulose 8g
Triethyl citrate 1.6g
Polyethylene glycol 6000 2.4g
Pulvis Talci is an amount of
Make 1000
Preparation technology:
(1) contain the preparation of pill core:
At first the 8g hydroxypropyl methylcellulose is dissolved in the alcoholic solution, in the levofloxacin hydrochloride adding polyvidone alcoholic solution with 40g, and constantly stirring makes it become uniform suspension; 80g sucrose ball core is placed fluidized bed pelletizer, above-mentioned even suspension is sparged blank sucrose ball wicking surface, carry out micropill preparation, treat that suspension all adds, dry, screen micropill;
(2) sustained release coating layer:
8g base cellulose dissolution in alcoholic solution, is added triethyl citrate, Polyethylene Glycol and an amount of Pulvis Talci, stir coating solution; The micropill that obtains in the step () is placed fluid bed, and the control parameter is carried out the coating of slow release layer, after coating is finished, and the dry slow-release micro-pill that gets;
(3) release layer coating:
Remaining binding agent is dissolved in the alcoholic solution, again remaining levofloxacin hydrochloride is joined in the solution, constantly stir and obtain uniform suspension, the slow-release micro-pill that step (two) is prepared places fluid bed, and the control parameter sparges the micropill surface with above-mentioned even suspension and adds medicine to, treat that whole suspensions add, medicine-feeding is finished, and drying obtains micropill, micropill is filled in promptly gets levofloxacin hydrochloride micro-pill capsule in the capsule shells.
Levofloxacin hydrochloride micro-pill capsule to the present embodiment gained carries out the release test, the release curve is seen Fig. 3, and from the release curve, the levofloxacin hydrochloride micro-pill capsule of present embodiment is rapid release in 2 hours, stable then release kept necessary blood drug level.
The levofloxacin hydrochloride micro-pill capsule of the embodiment of the invention 1,2,3 gained under illumination, high temperature, super-humid conditions, the relative data that recorded in the tenth day: character, content, related substance etc.
Table 1 embodiment 1 preliminarily stabilised test
Table 2 embodiment 2 preliminarily stabilised tests
Table 3 embodiment 3 preliminarily stabilised tests
Claims (5)
1. levofloxacin hydrochloride micro-pill capsule, it is characterized in that comprising ball core, medicated layer, sustained release coating layer and release layer, levofloxacin hydrochloride is included in wherein the medicated layer and release layer, the sustained release coating layer comprises sustained release coating material, porogen, plasticizer, comprise following material by weight percentage: levofloxacin hydrochloride 20%～60%, ball core 30%～55%, binding agent 10%～25%, sustained release coating material 3%～5%, porogen 0.3%～3%, plasticizer 0.1%～1%.
2. a kind of levofloxacin hydrochloride micro-pill capsule according to claim 1, the coating material that it is characterized in that described sustained release coating layer are a kind of or its mixing in ethyl cellulose, the acrylic resin.
3. a kind of levofloxacin hydrochloride micro-pill capsule according to claim 1 is characterized in that described porogen is one or more in Polyethylene Glycol, polyvidone, hydroxypropyl methylcellulose, methylcellulose, the sucrose.
4. a kind of levofloxacin hydrochloride micro-pill capsule according to claim 1 is characterized in that described plasticizer is one or more mixing in Polyethylene Glycol, triethyl citrate, dibutyl sebacate, the diethyl phthalate.
5. according to the preparation method of the described a kind of levofloxacin hydrochloride micro-pill capsule of claim 1～4, it is characterized in that comprising the steps:
(1) contain the preparation of pill core:
The binding agent of getting recipe quantity 30%～60% is dissolved in and obtains the binding agent alcoholic solution in the alcoholic solution, and the levofloxacin hydrochloride with recipe quantity 30%～60% is dissolved in the binding agent alcoholic solution again, stirs to make it form uniform suspension; The ball core of recipe quantity is placed fluidised bed granulator, the fluid bed parameter is set, above-mentioned suspension is sparged the ball wicking surface, treat that suspension adds, the dry micropill that gets;
(2) slow release layer coating:
Get sustained release coating material, porogen, the plasticizer configuration coating solution of recipe quantity, the micropill that step (1) is obtained places fluid bed, carries out coating; The coating after drying obtains slow-release micro-pill;
(3) release layer coating:
Remaining levofloxacin hydrochloride and binding agent are dissolved in the alcoholic solution, stir into suspension, the slow-release micro-pill that step (2) is obtained places fluid bed, suspension is sparged the slow-release micro-pill surface, treat that suspension uses up after drying, dried micropill cover capsule shells is obtained levofloxacin hydrochloride micro-pill capsule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910156969.7A CN102106842B (en) | 2009-12-24 | 2009-12-24 | Levofloxacin hydrochloride micropill capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910156969.7A CN102106842B (en) | 2009-12-24 | 2009-12-24 | Levofloxacin hydrochloride micropill capsule and preparation method thereof |
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| CN102106842B CN102106842B (en) | 2014-03-05 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488660A (en) * | 2011-12-15 | 2012-06-13 | 西安天一秦昆制药有限责任公司 | Sustained-release pellet containing pirfeudone |
| CN109330995A (en) * | 2018-12-05 | 2019-02-15 | 河北医科大学 | A kind of pellet and preparation method thereof containing short-acting antidiabetic drug |
| CN115227677A (en) * | 2022-08-12 | 2022-10-25 | 苏州弘森药业股份有限公司 | Levofloxacin hydrochloride capsule and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003300882A (en) * | 2002-04-11 | 2003-10-21 | St Marianna Univ School Of Medicine | Emulsion containing pyridonecarboxylic acid compound |
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| JP2003300882A (en) * | 2002-04-11 | 2003-10-21 | St Marianna Univ School Of Medicine | Emulsion containing pyridonecarboxylic acid compound |
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| CN1554346A (en) * | 2003-12-23 | 2004-12-15 | 广州市医药工业研究所 | Diltiazem hydrochloride control release capsule and its preparing method |
| CN1813758A (en) * | 2005-12-07 | 2006-08-09 | 范敏华 | Levofloxacin hydrochloride micro-pill capsule and its preparing method |
| CN1994285A (en) * | 2006-01-04 | 2007-07-11 | 上海医药工业研究院 | Sustained release micro-pellet of guaifenesin and preparation process thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102488660A (en) * | 2011-12-15 | 2012-06-13 | 西安天一秦昆制药有限责任公司 | Sustained-release pellet containing pirfeudone |
| CN109330995A (en) * | 2018-12-05 | 2019-02-15 | 河北医科大学 | A kind of pellet and preparation method thereof containing short-acting antidiabetic drug |
| CN109330995B (en) * | 2018-12-05 | 2021-05-18 | 河北医科大学 | Pellet coated with short-acting hypoglycemic agent and preparation method thereof |
| CN115227677A (en) * | 2022-08-12 | 2022-10-25 | 苏州弘森药业股份有限公司 | Levofloxacin hydrochloride capsule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102106842B (en) | 2014-03-05 |
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