CN102090424A - Method for producing nano water-soluble neem oil preparation - Google Patents
Method for producing nano water-soluble neem oil preparation Download PDFInfo
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- CN102090424A CN102090424A CN2009102633402A CN200910263340A CN102090424A CN 102090424 A CN102090424 A CN 102090424A CN 2009102633402 A CN2009102633402 A CN 2009102633402A CN 200910263340 A CN200910263340 A CN 200910263340A CN 102090424 A CN102090424 A CN 102090424A
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- neem oil
- nano
- interfacial agent
- water soluble
- oil preparation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention relates to a method for producing a nano water-soluble neem oil preparation, which comprises the following steps of: adding proper surfactants; directly dispersing water-insoluble neem oil in water; meanwhile controlling the regulation of combination of various processing parameters, wherein water-soluble neem oil can reach the size of nano-particles about 10-100nm; and then adding a proper amount of organic high polymer into a water dispersible solution to coat the nano neem oil so as to control the biological activity of azadirachtin. The water-soluble neem oil preparation of the invention has simple production process, low toxicity, no pollution on environment, favorable pesticide effect and quick desired effect.
Description
Technical field
The present invention relates to a kind of manufacture method of nano-water soluble neem oil preparation.
Background technology
Nimbin is the natural insect killing substance of internationally recognized wide spectrum, and its effect mainly is to reach preventive and therapeutic effect by insect antifeedant and growing of harmful insect of inhibition.But, as the nimbin of natural activity thing, have easy photodissociation, hydrolysis, easily oxidized, to the pH value responsive and non-water-soluble shortcoming, and sunshine can reduce the antifeedant activity of neem oil rapidly.These shortcomings are that the processing and the use of nimbin product brings negative effect.All being processed into the neem emulsifiable solution type at present both at home and abroad uses, not only to consume a large amount of emulsifier and increase product cost, wherein contain a large amount of pollutions that organic solvent causes natural environment again, so in fact be exactly the nimbin environment friendly agricultural to be processed into non-green preparation use, and nimbin emulsion type preparation drug effect is slow, generally behind dispenser 24h, just begin to take effect, far from each other with the effect of peasant's expectation " medicine is dead to worm ".Therefore, solve in the neem emulsifiable solution component organic solvent to pollution, the nimbin illumination of environment easily decompose fast down, drug effect slowly, problem such as reduce cost, develop and produce and have stability by force, the drug effect phase is long, the nimbin preparation that insecticidal rate is fast, cost is low has become the very urgent requirement in current domestic and international market.
Summary of the invention
The object of the present invention is to provide a kind of manufacture method of nano-water soluble neem oil preparation, solve above-mentioned difficult point.
The technical scheme that the present invention is taked for achieving the above object is: a kind of manufacture method of nano-water soluble neem oil preparation, and its step comprises: (1) is dissolved in neem oil in the low polar organic solvent of selecting for use, obtains to contain neem oil organic solution; (2) interfacial agent is added in the entry, obtain the aqueous solution that contains interfacial agent; (3) stir and/or vibration of ultrasonic wave under, the described organic solution that contains neem oil is slowly splashed into or spraying to add in the aqueous solution that contains interfacial agent obtains aqueous dispersion neem oil solution; (4) select the macromolecular compound of tool protectiveness for use, dissolve in the described aqueous dispersion neem oil solution, after stirring, promptly make and contain the nano-water soluble neem oil preparation that the neem oil particle size is 10～100nm again.
Be used for dissolving the low polar organic solvent of neem oil described in the above-mentioned manufacture method, be selected from isoamyl alcohol, phenol, ethyl acetate and dimethyl Asia wherein one or more, and the concentration that contains the neem oil organic solvent that forms is 1～80wt%.
That interfacial agent described in the above-mentioned manufacture method can be selected for use is cationic, anionic, amphoteric and non-ionic interfacial agent, and the addition of interfacial agent is 0.01～5wt%.
Macromolecular compound clad material described in the above-mentioned manufacture method be selected from polymine, spherical chitosan, copolymer of poly lactic acid, PLA or alignic wherein one or more, the about 0.1～8wt% of its addition.
The present invention adopts technique scheme, and manufacture process is simple, low toxicity, free from environmental pollution and manufacturing preparation good drug efficacy, instant effect.
Embodiment
A kind of manufacture method of nano-water soluble neem oil preparation, its step comprises: (1) is dissolved in neem oil in the phenol that concentration is 18wt%, obtains to contain neem oil organic solution; (2) be that the cationic interfacial agent of 0.5wt% adds in the entry with consumption, obtain the aqueous solution that contains interfacial agent; (3) stir and vibration of ultrasonic wave under, the organic solution spraying adding that will contain neem oil contains in the aqueous solution of interfacial agent and obtains aqueous dispersion neem oil solution; (4) be that the spherical chitosan of 2wt% dissolves in the aqueous dispersion neem oil solution with consumption, after stirring, promptly make and contain the nano-water soluble neem oil preparation that the neem oil particle size is 20nm again.
Claims (4)
1. the manufacture method of a nano-water soluble neem oil preparation, it is characterized in that: (1) is dissolved in neem oil in the low polar organic solvent of selecting for use, obtains to contain neem oil organic solution; (2) interfacial agent is added in the entry, obtain the aqueous solution that contains interfacial agent; (3) stir and/or vibration of ultrasonic wave under, the described organic solution that contains neem oil is slowly splashed into or spraying to add in the aqueous solution that contains interfacial agent obtains aqueous dispersion neem oil solution; (4) select the macromolecular compound of tool protectiveness for use, dissolve in the described aqueous dispersion neem oil solution, after stirring, promptly make and contain the nano-water soluble neem oil preparation that the neem oil particle size is 10～100nm again.
2. the manufacture method of a kind of nano-water soluble neem oil preparation according to claim 1, it is characterized in that the described low polar organic solvent that is used for dissolving neem oil, be selected from isoamyl alcohol, phenol, ethyl acetate and dimethyl Asia wherein one or more, and the concentration that contains the neem oil organic solvent that forms is 1～80wt%.
3. the manufacture method of a kind of nano-water soluble neem oil preparation according to claim 1, it is characterized in that described interfacial agent can select cationic, anionic, amphoteric and non-ionic interfacial agent for use, and the addition of interfacial agent is 0.01～5wt%.
4. the manufacture method of a kind of nano-water soluble neem oil preparation according to claim 1, it is characterized in that described macromolecular compound clad material be selected from polymine, spherical chitosan, copolymer of poly lactic acid, PLA or alignic wherein one or more, the about 0.1～8wt% of its addition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102633402A CN102090424A (en) | 2009-12-11 | 2009-12-11 | Method for producing nano water-soluble neem oil preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102633402A CN102090424A (en) | 2009-12-11 | 2009-12-11 | Method for producing nano water-soluble neem oil preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102090424A true CN102090424A (en) | 2011-06-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102633402A Pending CN102090424A (en) | 2009-12-11 | 2009-12-11 | Method for producing nano water-soluble neem oil preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN102090424A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053513A (en) * | 2012-12-28 | 2013-04-24 | 辽宁师范大学 | Pyraclostrobin nano-preparation and preparation method thereof |
-
2009
- 2009-12-11 CN CN2009102633402A patent/CN102090424A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053513A (en) * | 2012-12-28 | 2013-04-24 | 辽宁师范大学 | Pyraclostrobin nano-preparation and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110615 |