CN102085379A - Medicinal barium sulfate micelle - Google Patents
Medicinal barium sulfate micelle Download PDFInfo
- Publication number
- CN102085379A CN102085379A CN2011100252649A CN201110025264A CN102085379A CN 102085379 A CN102085379 A CN 102085379A CN 2011100252649 A CN2011100252649 A CN 2011100252649A CN 201110025264 A CN201110025264 A CN 201110025264A CN 102085379 A CN102085379 A CN 102085379A
- Authority
- CN
- China
- Prior art keywords
- barium sulfate
- medicinal
- micelle
- constipation
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention relates to a medicinal barium sulfate micelle. The barium sulfate micelle is characterized by being a sphere with a diameter of 1.5-4.5mm, wherein the sphere is filled with a mixture of barium sulfate, medicinal gelatin and water; the barium sulfate and the medicinal gelatin are mixed according to a ratio of 10:1, and are conglobated by water; and the outer spherical shell is made of medicinal ethylene-propylene rubber. The medicinal barium sulfate micelle contains the barium sulfate as the main component, has a specific gravity similar to that of chyme and feces, can be clearly displayed, can not be absorbed, can not be conglobated, and has the advantages of no toxin and no irritant. The invention fills up the blank in China. If popularized, the invention can surely provide great convenience for inspection of lots of patients, so that individual treatment can be implemented to relieve the pain of the patients.
Description
Technical field:
The invention belongs to field of medicaments.
Background technology:
The diagnosis of chronic constipation needs standardization, sequencing, at first we should be clear and definite what belong to constipation, although this class patient majority is a functional disease, but to get rid of the constipation that organic disease causes.
According to the standard of Rome III, constipation is defined as: 1. difficult defecation, and firmly just, stool reduces or defecation is felt not to the utmost; 2. complete defecation＜3 times weekly, every day feces volume＜35g; 3. full gastrointestinal or colon pass through time lengthening.Gastrointestinal tract rotation situation is recommended to judge with international Bristol feces typing, is met constipation standard person and mostly be BristolI one II type.
Inspection causes constipation patient such as thyroid illness, diabetes, systemic disease etc. to being suspected to have systemic disease, should carry out relevant biochemical aspect inspection, fecal occult blood testing should be classified routine as, to more than 40 years old, for getting rid of intestinal pathological changes such as tumor, inflammation, feasible intestinal mirror, colon barium agent radiography; The severe obstipation the is suspected to have the intestinal pseudo obstruction feasible plain abdominal radiograph of person.Though emulation intestinal mirror has the non-people's of invading characteristics, the testing cost costliness can not obtain pathological diagnosis, also can only be clinical examination even use.The detection method of intestinal function and power, though be not that clinical diagnosis institute is necessary, but for science assessment intestinal function, constipation classification, the assessment of medicine, scientific research is necessary, particularly to obstipation, Drug therapy is invalid or as fullying understand intestinal function before the surgical operation, recommend method commonly used comprises: gastrointestinal transmission test, anus, rectomanometry.
The gastrointestinal transport test is to take the photograph sheet by X line continuous time (72h-120h) abdominal part, observe running orbit and the drainage situation of video picture granule in colon, estimate the transfer function of colon, the method is the unique objective indicator of diagnosis chronic slow-transit constipation, is again the unique objective basis of operative treatment constipation.In the gastrointestinal transport test the most the major technology key be that the particulate material of video picture is selected, particulate size and number, coating of particles and physical characteristic.At present domesticly do not develop commercialization as yet and get the video picture granule, the video picture granule can't be bought, and this check can't be implemented and popularize.We have carried out correlational study at this problem, and have prepared the video picture granule, have obtained satisfied result of study.
Video picture preparation of granules success back selects 6 routine normal persons to carry out clinical experiment, and its development as a result and drainage all meet international standard.Fully confirmed this particulate applicability and advance.
So far, we and No.1 Hospital of Jilin Univ.'s knot anorectum surgery cooperation have been applied to 37 routine patients, 9 routine diagnosing chronic colon mode transmission constipation, and 6 examples are diagnosed as the constipation by outlet obstruction, and 22 examples are got rid of this disease.Behind the 5 routine chronic colon mode transmission constipation patient operative treatments respond well (following up a case by regular visits to 1.5 years).Calamity before the 3 routine rectum, behind the operative treatment, constipation is alleviated
Summary of the invention:
The purpose of this invention is to provide a kind of required video picture granule of gastrointestinal transport test that is used for, i.e. the little glue granule of medicinal barium sulfate.
The little glue granule of a kind of medicinal barium sulfate, the little glue granule of described barium sulfate is that diameter is the spheroid of 1.5mm to 4.5mm, and it is inner to be the mixture that barium sulfate and medical gelatin add water, and wherein barium sulfate and medical gelatin are pressed 10: 1 mixed, it is agglomerating to add water, and outside spherical shell is medical poly-third ethylene.
Beneficial effect: the little glue granule of medicinal barium sulfate main component is a barium sulfate, and it is similar to chyme and feces proportion, and clear display, do not absorb, do not assemble agglomerating; Nontoxic, nonirritant.The present invention has filled up domestic blank, if can promote out, and will provide great convenience for many patients, takes the treatment of individuation then, removes patient's misery.
Description of drawings:
In conjunction with the accompanying drawings, be described as follows:
Fig. 1 to Fig. 3 is a colonic transit test, and the people swallows and takes the photograph sheet by X line continuous time (72h-120h) abdominal part behind 20 little glue granules of medicinal barium sulfate, and the bright spot among the figure is the little glue granule of medicinal barium sulfate.
The specific embodiment:
1. the particulate principle technology of the little glue of medicinal barium sulfate:
Raw material → mixing → rolling balling-up → coating → molding
2. the particulate concrete technology of the little glue of medicinal barium sulfate:
Barium sulfate and medical gelatin by 10: 1 mixed, are added entry and are stirred to agglomerating → barium sulfate mixture → be processed into barium sulfate particle → little glue granule of usefulness material coating → finished product barium sulfate
3d taboo clothes cathartic reaches influential medicine of digestive tract motor function and irritable food before checking, life and dietary habit are constant during the inspection, and record defecation frequency and time.After preceding 1 day lunch of person under inspection afternoon 16: 1 20 video picture granules of swallowing, after this respectively at 24,48,72,96h takes the photograph 1 of plain abdominal radiograph, when mark quantity≤4.Stipulating behind the oral mark to be detained in the 72nd hour 80% mark (16) prompting according to diagnostic criteria has full intestinal transport time lengthening type constipation to exist.Still retain after 120 hours, be diagnosed as Colonic Slow Transit Constipation.
Claims (1)
1. little glue granule of medicinal barium sulfate, it is characterized in that: the little glue granule of described barium sulfate is that diameter is the spheroid of 1.5mm to 4.5mm, it is inner to be the mixture that barium sulfate and medical gelatin add water, wherein barium sulfate and medical gelatin are pressed 10: 1 mixed, it is agglomerating to add water, and outside spherical shell is medical poly-third ethylene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100252649A CN102085379A (en) | 2011-01-24 | 2011-01-24 | Medicinal barium sulfate micelle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100252649A CN102085379A (en) | 2011-01-24 | 2011-01-24 | Medicinal barium sulfate micelle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102085379A true CN102085379A (en) | 2011-06-08 |
Family
ID=44097538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100252649A Pending CN102085379A (en) | 2011-01-24 | 2011-01-24 | Medicinal barium sulfate micelle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102085379A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103495184A (en) * | 2013-10-15 | 2014-01-08 | 长春博研科学仪器有限责任公司 | Medical polystyrene barium-coating method |
| CN105776305A (en) * | 2016-05-09 | 2016-07-20 | 郭迎庆 | Method for preparing medical ultrafine barium sulfate |
| CN111870704A (en) * | 2020-07-15 | 2020-11-03 | 上海鋆通医疗科技发展有限公司 | Novel gastrointestinal motility marker capsule and preparation method thereof |
-
2011
- 2011-01-24 CN CN2011100252649A patent/CN102085379A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103495184A (en) * | 2013-10-15 | 2014-01-08 | 长春博研科学仪器有限责任公司 | Medical polystyrene barium-coating method |
| CN105776305A (en) * | 2016-05-09 | 2016-07-20 | 郭迎庆 | Method for preparing medical ultrafine barium sulfate |
| CN111870704A (en) * | 2020-07-15 | 2020-11-03 | 上海鋆通医疗科技发展有限公司 | Novel gastrointestinal motility marker capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102271578B (en) | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same | |
| Miley et al. | Video capsule endoscopy and ingestible electronics: emerging trends in sensors, circuits, materials, telemetry, optics, and rapid reading software | |
| Hoover et al. | Simultaneous gastric and small intestinal trichobezoars—a hairy problem | |
| Mau et al. | Ingestible devices for long-term gastrointestinal residency: A review | |
| Cengel et al. | The role of ultrasonography in the imaging of body packers comparison with CT: a prospective study | |
| CN102085379A (en) | Medicinal barium sulfate micelle | |
| Ibrahim et al. | Ileocecal intussusception in the adult population: case series of two patients | |
| Rao | Approach to the patient with constipation | |
| Green | Gastrointestinal disorders in the athlete | |
| CN106492234A (en) | A kind of barium agent label of colonic transportation test and preparation method thereof | |
| Manuelyan et al. | Common urinary and bowel disorders in the geriatric population | |
| Samdani et al. | An apricot story: view through a keyhole | |
| Ogunlesi et al. | Infantile hypertrophic pyloric stenosis with unusual presentations in Sagamu, Nigeria: a case report and review of the literature | |
| Malberg et al. | Small intestinal enterolith in a dog presenting for a suspected gastric foreign body | |
| Wang et al. | The evaluation of GI-pill gastrointestinal electronic capsule for colonic transit test in patients with slow transit constipation | |
| Howarth et al. | Management of chronic constipation in children | |
| Sidhu et al. | Capsule endoscopy in the evaluation of gastrointestinal disease | |
| Riney et al. | Menarche? a case of abdominal pain and vaginal bleeding in a preadolescent girl | |
| Kanodia et al. | A personalized systems medicine approach to refractory rumination | |
| Mahmoud et al. | Microscopic colitis: a report of two cases | |
| Bertrand et al. | Teaching basic gastrointestinal physiology using classic papers by Dr. Walter B. Cannon | |
| Wong et al. | Perforated Meckel's diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn's disease: a case report | |
| Stamboldjiev | Management of Irritable Bowel Syndrome in Primary Care | |
| CN1704124A (en) | Isotonicity rapid intestinal tract contrast agent | |
| Sheehan | Monolateral purple urine bag syndrome in a patient with bilateral nephrostomy tubes. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20110608 |