CN102078509B - Traditional Chinese medicine preparation for treating ophthalmorrhagia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating ophthalmorrhagia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating ophthalmorrhagia and a preparation method thereof. The invention adopts the technical scheme comprising the following steps: screening and washing rhizoma anemarrhenae, Chinese yam, figwort, atractylodes rhizome, glehnia root, root of red rooted salvia, red peony root, kudzu root, motherwort fruit, root-bark of peony, angelica sinensis, rehmannia root, lotus node, ophiopogon root and yerbadetajo, then putting into an extracting pot, adding 8 times of water, soaking for 30 minutes, heating and stirring for boilingfor 1-2 hours, filtering to obtain the filtrate, adding 6 times of water to the residual dregs of decoction, heating and stirring for boiling for 1-2 hours, filtering to obtain the filtrate, concentrating the filtrate at the temperature of 75-85 DEG C into extract with the relative density of 1.25-1.35, cooling, adding ethanol until the alcohol content reaches 50-80%, homogenizing, standing for 24 hours, filtering, recovering ethanol from the filtrate, concentrating the filtrate into extract without alcohol smell, and drying at 60-80 DEG C under vacuum decompression to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation has the effects of removing heat from the blood to stop bleeding, nourishing yin and resolving heat, and is used for clinically treating the symptom of ophthalmorrhagia caused by deficiency of both qi and yin.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine preparation that is used to treat the retinal hemorrhage disease symptoms that deficiency of both QI and YIN causes and preparation method thereof particularly.
Background technology
At present, retinal hemorrhage is the sick common disease of various fundus.Like central retinal vein occlusion, periphlebitis of retina, hypertensive retinopathy, diabetic retinopathy, the exudative retina choroidopathy of centrality, senile degeneration of macula (moist) etc., belong to categories such as the traditional Chinese medical science " blurring of vission ", " sudden blindness ".Belong to the ophthalmology serious symptom, prevalence has the trend that increases year by year in China, and the harm vision is serious, and complication is many, and severe patient can blinding.Retinal hemorrhage can cause retinal hemorrhage because of a variety of causes, owing to effusive blood overflows in retina, the choroid local organization, or gets in the vitreous body, belongs to the internal hemorrhage category." interior warp " so-called " heart master blood ", " The spleen governs the blood ", " blood stored in the liver ", promptly blood of human body does not stop in the operation of arteries and veins internal recycle, is the promotion of leaning on the gas of heart-yang, and why blood is gone in arteries and veins and is unlikely to grow outside arteries and veins, is the function of having under one's command of leaning on spleen.Liver has stored blood and the function of regulating blood volume, so retinal hemorrhage and above visceral dysfunction relation are very close.In addition, the retinal hemorrhage reason is various, comparatively complicated diseases caused by exogenous pathogenic factor six climate exopathogens, and internal injury caused by excess of seven emotions, qi-blood disharmony, zang-fu disharmony, violence damage etc. all can cause retinal hemorrhage.Blood is cloudy smart, and its moving multidigit is in fire, the strain impairment of YIN, and the deficiency of YIN is given birth to interior-heat, water failing to restrain blazing fire, the blood of the cloudy branch of the easiest disturbance and cause retinal hemorrhage.The special key of order is in liver, and the master is in kidney.Kidney master water, deficiency of the kidney yin then asthenic fire is spontaneous, and the bright network of asthenic fire is then hemorrhage.The Jing-Yue Complete Works meaning: " principal essence class, and kidney master five liquid, so all sick blood persons, though distinguishing of the five internal organs arranged, so invariably because water loses, water loses then fire Sheng ... ".The Liver and kidney kidney-YIN being deficient, hyperactivity of deficient fire steams the sering of burning, bleeding due to blood-heat, overflowing in clear key is the important pathogenesis of primary disease.Therefore, a kind of Chinese traditional compound medicine of treating the eye hemorrhagic disease symptom that deficiency of both QI and YIN causes of development and preparation method thereof is the new problem that needs to be resolved hurrily both at home and abroad always.
Summary of the invention
The present invention provides a kind of hemorrhage Chinese medicine preparation of eye of treating, and its purpose is to treat the eye hemorrhagic disease symptom that is caused by deficiency of both QI and YIN.
The objective of the invention is to realize like this: a kind of hemorrhage Chinese medicine preparation of eye of treating is characterized in that comprising that following raw material medicaments in part by weight proportioning processes:
Rhizoma Anemarrhenae 6-16 part, Rhizoma Dioscoreae 9-26 part, Radix Scrophulariae 8-22 part, Rhizoma Atractylodis 4-12 part,
Radix Glehniae 4-12 part, Radix Salviae Miltiorrhizae 8-22 part, Radix Paeoniae Rubra 4-13 part, Radix Puerariae 4-15 part,
4-12 parts of Fructus Leonuris, Cortex Moutan 4-14 part, Radix Angelicae Sinensis 4-12 part, Radix Rehmanniae 7-20 part,
Nodus Nelumbinis Rhizomatis 7-20 part, Radix Ophiopogonis 6-18 part, Herba Ecliptae 6-16 part.
The dosage form of the Chinese medicine preparation that above-mentioned treatment eye is hemorrhage can be decoct, pill, tablet, granule, oral liquid, capsule, Emulsion or middle medicine film.
The method for preparing of the Chinese medicine preparation that above-mentioned treatment eye is hemorrhage, it is characterized in that method for preparing is: the proportioning by 15 kinds of above-mentioned crude drug is got material, through screening, drops in the extraction pot after the rinsing; Add the water of octuple amount, soaked 30 minutes, heated and stirred was boiled 1-2 hour, crossed leaching filtrating; The residue medicinal residues add the water of six times of amounts, and heated and stirred was boiled 1-2 hour, cross leaching filtrating; Discard medicinal residues, merging filtrate makes decoct; The filtrating that maybe will merge is concentrated into the clear paste that relative density is 1.25-1.35 under 75-85 ℃, be cooled to room temperature, adds ethanol and makes and contain alcohol amount and reach 50-80%, stirs, and leaves standstill 24 hours, filter, filtrate recycling ethanol and concentrate concentrated solution; Or with the concentrated solution vacuum decompression, 60-80 ℃ of drying pulverized, and processes dried cream powder; In concentrated solution or dried cream powder, add excipient, mix homogeneously is processed the Chinese medicine preparation of pill, tablet, granule, oral liquid, capsule, Emulsion or middle medicine film.
Described excipient is one or more mixing of solvent, disintegrating agent, correctives, antiseptic, coloring agent, dispersant, binding agent, thickening agent, lubricant or diluent.
Chinese medicine preparation that treatment eye of the present invention is hemorrhage and preparation method thereof compared with prior art its prescription is unique, hemorrhagely answers removing heat from blood, Liver and kidney kidney-YIN being deficient because of intimately rising, controlling; Hyperactivity of deficient fire, on attack the order network, can cause retinal hemorrhage, take cooling blood for hemostasis; The Therapeutic Principle of nourishing YIN and clearing away heat, simultaneously Chinese medicine preparation has taking convenience, the drug effect of the medical material of can maximum performance respectively distinguishing the flavor of; Curative effect is high, side effect is little, be easy to preserve, medicinal raw material be simple and easy to etc. advantage, will be widely used in the pharmaceuticals industry.
The specific embodiment:
Embodiment 1
Drop in the extraction pot after getting Rhizoma Anemarrhenae 160g, Rhizoma Dioscoreae 260g, Radix Scrophulariae 220g, Rhizoma Atractylodis 120g, Radix Glehniae 120g, Radix Salviae Miltiorrhizae 220g, Radix Paeoniae Rubra 130g, Radix Puerariae 150g, Fructus Leonuri 120g, Cortex Moutan 140g, Radix Angelicae Sinensis 120g, Radix Rehmanniae 200g, Nodus Nelumbinis Rhizomatis 200g, Radix Ophiopogonis 180g, Herba Ecliptae 160g rinsing, add the water of octuple amount, soaked 30 minutes; Heated and stirred was boiled 1-2 hour; Cross leaching filtrating, the residue medicinal residues add the water of six times of amounts, and heated and stirred was boiled 1-2 hour; Cross leaching filtrating; Discard medicinal residues, merging filtrate gets decoct;
The filtrating that maybe will merge is concentrated into the clear paste that relative density is 1.25-1.35 under 75-85 ℃, be cooled to room temperature, adds ethanol and makes and contain alcohol amount and reach 50-80%, stirs, and leaves standstill 24 hours, filters, and filtrate recycling ethanol also is concentrated into does not have the alcohol flavor, concentrated solution;
Or with the concentrated solution vacuum decompression, 60-80 ℃ of drying pulverized, and processes dried cream powder.
Embodiment 2
Drop in the extraction pot after getting Rhizoma Anemarrhenae 110g, Rhizoma Dioscoreae 170g, Radix Scrophulariae 150g, Rhizoma Atractylodis 80g, Radix Glehniae 80g, Radix Salviae Miltiorrhizae 120g, Radix Paeoniae Rubra 90g, Radix Puerariae 110g, Fructus Leonuri 90g, Cortex Moutan 100g, Radix Angelicae Sinensis 100g, Radix Rehmanniae 150g, Nodus Nelumbinis Rhizomatis 150g, Radix Ophiopogonis 150g, Herba Ecliptae 150g rinsing, add the water of octuple amount, soaked 30 minutes; Heated and stirred was boiled 1-2 hour; Cross leaching filtrating, the residue medicinal residues add the water of six times of amounts, and heated and stirred was boiled 1-2 hour; Cross leaching filtrating; Discard medicinal residues, merging filtrate gets decoct;
The filtrating that maybe will merge is concentrated into the clear paste that relative density is 1.25-1.35 under 75-85 ℃, be cooled to room temperature, adds ethanol and makes and contain alcohol amount and reach 50-80%, stirs, and leaves standstill 24 hours, filters, and filtrate recycling ethanol also is concentrated into does not have the alcohol flavor, concentrated solution;
Or with the concentrated solution vacuum decompression, 60-80 ℃ of drying pulverized, and processes dried cream powder.
Embodiment 3
Drop in the extraction pot after getting Rhizoma Anemarrhenae 60g, Rhizoma Dioscoreae 90g, Radix Scrophulariae 80g, Rhizoma Atractylodis 40g, Radix Glehniae 40g, Radix Salviae Miltiorrhizae 80g, Radix Paeoniae Rubra 40g, Radix Puerariae 40g, Fructus Leonuri 40g, Cortex Moutan 40g, Radix Angelicae Sinensis 40g, Radix Rehmanniae 70g, Nodus Nelumbinis Rhizomatis 70g, Radix Ophiopogonis 60g, Herba Ecliptae 60g rinsing, add the water of octuple amount, soaked 30 minutes; Heated and stirred was boiled 1-2 hour, crossed leaching filtrating, and the residue medicinal residues add the water of six times of amounts; Heated and stirred was boiled 1-2 hour, crossed leaching filtrating, discarded medicinal residues; Merging filtrate gets decoct;
The filtrating that maybe will merge is concentrated into the clear paste that relative density is 1.25-1.35 under 75-85 ℃, be cooled to room temperature, adds ethanol and makes and contain alcohol amount and reach 50-80%, stirs, and leaves standstill 24 hours, filters, and filtrate recycling ethanol also is concentrated into does not have the alcohol flavor, concentrated solution;
Or with the concentrated solution vacuum decompression, 60-80 ℃ of drying pulverized, and processes dried cream powder.
Embodiment 4The hemorrhage Chinese medicinal capsule agent of treatment eye
In any dried cream powder among embodiment 1 ~ embodiment 3, add 100-200g starch mixed pelletization, dry, sieve, adorn 1000 capsules and be capsule of the present invention.
Embodiment 5The hemorrhage Chinese medicinal tablet of treatment eye
In any dried cream powder among embodiment 1 ~ embodiment 3, add 100-200g starch mixed pelletization, dry, sieve, suppress 1000, be tablet of the present invention.
Embodiment 6The hemorrhage Chinese medicine granules of treatment eye
In any dried cream powder among embodiment 1 ~ embodiment 3, add dextrin 500-700g, the alcohol granulation with 70%, granulate, sieve, process granule 1000g, granule of the present invention.
Embodiment 7The hemorrhage Chinese medicine oral liquid of treatment eye
In any concentrated solution among embodiment 1 ~ embodiment 3, add an amount of antiseptic and correctives and be oral liquid of the present invention.
Among the present invention; Those skilled in the art can be according to the conventional knowledge of this area; Add conventional drug excipient such as solvent, disintegrating agent, correctives, antiseptic, coloring agent, dispersant, binding agent, thickening agent, lubricant, diluent etc. as required; According to existing production technology, Chinese medicine preparation of the present invention is processed pill, tablet, granule, oral liquid, capsule, Emulsion or middle medicine film then.
The granule (called after peace snow granule) that makes with prescription of the present invention and method for preparing for receiving the reagent thing, further specifies drug action of the present invention through Pharmacodynamic test of active extract:
1. experiment material
1.1 animal
Kunming mouse, body weight (20 ± 2) g; The SD rat, body weight (220 ± 20) g; Laboratory animal certification of fitness credit number: SCXK-(army) 0007-004
1.2 medicine
1.2.1 receive the reagent thing
Granule of the present invention (peace snow granule)
The YUNNAN BAIYAO capsule, Yunnan Paiyao Group Corp., Ltd, 20091203
1.2.2 other reagent
Glacial acetic acid, Chemical Reagent Co., Ltd., Sinopharm Group, T20070911; Azovan blue, Chemical Reagent Co., Ltd., Sinopharm Group, WC20090209; Heparin sodium, last Nereid analyses Chemical Industry Science Co., Ltd, and 060329; Ether, Chemical Reagent Co., Ltd., Sinopharm Group, 20080430; Normal saline, Zhiying Pharmaceutical Factory, Shenyang, 09021003
1.3 equipment and equipment
Ultrospec1000 UV, visible light spectrophotometer, Pharmacia Biotech company
2. experimental technique
2.1
The anastalsis test
Get 50 of kunming mices, body weight (20 ± 2) g is divided into 5 groups at random, and per 10 one group, male and female half and half.Be respectively: blank group (normal saline), YUNNAN BAIYAO Capsules group, the high, medium and low dose groups of peace snow granule.Adopt gastric infusion, every day 1 time, 7d continuously; 30min after the last administration, cross-section in order to cutting at each group mouse tail point 0.5cm place, timing when treating that blood flows out naturally; Every inhaled to dehematize with filter paper at a distance from 15 seconds drip once, stop the calculating bleeding time (BT) naturally until blood; Each one of the blood that will flow out simultaneously in the microscope slide two ends, the about 5mm of drop of blood diameter calculates its clotting time (CT) with stopwatch; Provoked once gently inwards from the drop of blood edge with the cleaning pin in per 30 seconds, and observe and to have or not the blood streak to provoke, end and be clotting time to provoking the blood streak from blood sampling.
2.2
Influence to the mouse peritoneal capillary permeability
Get 50 of kunming mices, body weight (20 ± 2) g is divided into 5 groups at random, and per 10 one group, male and female half and half.Be respectively: blank group (normal saline), YUNNAN BAIYAO Capsules group, the high, medium and low dose groups of peace snow granule.Adopt gastric infusion, every day 1 time, continuous 7d, 30min after the last administration; Mouse tail vein injection 2% azovan blue solution is pressed the 0.1ml/l0g body weight, and lumbar injection 0.6% acetum 0.2ml/ simultaneously, 30min post-tensioning cervical vertebra is put to death mice; Cut off the abdominal cavity,, collect flushing liquor with 5ml normal saline flushing abdominal cavity; Centrifugal, get supernatant in spectrophotometer 590nm place colorimetric, judge the mouse peritoneal capillary permeability with trap (OD) value.Between organizing with t check relatively.
2.3
Influence to the rat blood rheological characteristic
Get 50 of SD rats, body weight (200 ± 20) g is divided into 5 groups at random, and per 10 one group, male and female half and half.Be respectively: blank group (normal saline), YUNNAN BAIYAO Capsules group, the high, medium and low dose groups of peace snow granule.Adopt gastric infusion; Every day 1 time; Continuous 7d; 30min abdominal aortic blood after the last administration entrusts Liaoning Chinese Medicine Institute to measure WBV (1. the whole blood height is cut viscosity and 2. cut the 3. low viscosity of cutting of whole blood of viscosity in the whole blood), whole blood reduced viscosity (1. 2. reduction viscosity of blood cuts the 3. low reduced viscosity of cutting of whole blood of reduced viscosity in the whole blood), erythrocyte rigidity index, deformable index, erythrocyte aggregation index.
2.4
The mensuration of whole body heparinization clotting time of mice
Get 60 of kunming mices, be divided into 6 groups at random, 10 every group.Be divided into distilled water matched group, heparinization model group, heparinization model+YUNNAN BAIYAO Capsules group, the heparinization model+high, medium and low dose groups of peace snow granule.Each organizes mice gastric infusion every day 1 time, and distilled water matched group and model group are irritated stomach distilled water 20ml/kg, 7d continuously.The 7th day, 15min behind the gastric infusion, heparinization mouse tail vein injection 10u/ml heparin-saline 0.1ml/10g modeling.Each organizes 30min behind the mice last gastric infusion; Extract eyeball blood sampling 0.5ml; Splash in the test tube of long 10cm, internal diameter 9mm (37 ℃ of waters bath with thermostatic control); Whether whenever subsequently observe blood and flow at a distance from slowly tilt test tube 30 degree 1 time of 30s, the record autoblood splashes into test tube and rises to test tube to tilt for 90 immobilising times of blood (clotting time) when spending.
Experimental result
3.1 anastalsis experiment
The middle and high dose groups of peace snow, YUNNAN BAIYAO group can obviously shorten hemorrhage, the clotting time of mice docking, have more respectively significantly and highly significant difference with the normal control group.
3.2
Influence to the mouse peritoneal capillary permeability
Peace each dose groups of snow and YUNNAN BAIYAO group all can obviously reduce the mouse peritoneal capillary permeability.
3.3
Influence to the rat blood rheological characteristic
The middle and high dose groups of peace snow, YUNNAN BAIYAO group can obviously reduce rat blood viscosity, change hemorheological property.
3.4
The mensuration of whole body heparinization clotting time of mice
Clotting time obviously prolongs behind the model group injecting heparin normal saline; With the normal control group highly significant difference is arranged relatively; High, medium and low dose groups of peace snow and YUNNAN BAIYAO group can obviously shorten clotting time after the whole body heparinization, with model group highly significant difference are arranged relatively.
4
Discuss
Retinal hemorrhage is early stage, blood coagulation hemostasis, when confirm no fresh hemorrhage after, be main with the blood circulation promoting and blood stasis dispelling rule of treatment.The principle of treatment primary disease is a blood vessel dilating, reduces vascular resistance, increases the peripheral blood flow, and microcirculation improvement reduces capillary permeability, thereby improves the metabolism of tissue, promotes the absorption of pathological changes, is beneficial to the reparation of tissue.
Peace snow granule can suppress increasing of acetic acid induced mice abdominal cavity capillary permeability; The ability blood viscosity lowering; Change hemorheological property, have the effect of blood circulation promoting and blood stasis dispelling, peace snow granule can shorten mice docking hemostasis and clotting time; Can shorten whole body heparinization clotting time of mice, prompting peace snow granule has tangible anastalsis; Can be used to treat retinal hemorrhage.The research of this paper is further used clinically for peace snow granule the pharmacology is provided foundation.
The present invention is obtaining better curative effect through Shenyang Silver Sea (3S) Eye Hospital clinical observation for many years aspect the hemorrhage disease of treatment eye.Existing that the clinical practice situation report is following.
One, clinical data
The Shenyang Silver Sea (3S) Eye Hospital clinic case is added up, and totally 101 examples are 161, male 53 examples, and women 48 examples, age l8-76 year, the patient uses the western medicine poor effect.
Two, clinical observation
Use the Chinese traditional compound medicine (decoct) of prescription of the present invention and method for preparing preparation, take for the eye bleeding patients by doctor's advice, 7 days is a course of treatment.
Three, treatment situation
83 of treatment groups: 42 of produce effects, effective 32, invalid 9.Total effective rate is 89.2 %.
78 of matched groups: 30 of produce effects, effective 33, invalid 15, total effective rate is 80.8 %.
Four, model case
1, Wang, man, 46 years old, in June, 2003 morbidity; See unexpected anopia through looking into patient's disease, or visual deterioration, companion's dizziness and tinnitus, the optical fundus is visible: retinal hemorrhage is scarlet; Be prone to outbreak repeatedly, be diagnosed as the retinal hemorrhage patient, not obvious with its curative effect of Western medicine, take 3 courses of treatment of Chinese traditional compound medicine that prescription of the present invention and method for preparing prepare; The above-mentioned disease of patient is obviously improved, and continues to take 5 courses of treatment again, and disease disappears basically.
2, Cai, woman, 29 years old; In JIUYUE, 2005 morbidity, retinal hemorrhage is scarlet, is diagnosed as the retinal hemorrhage patient through looking into; Not obvious with its curative effect of Western medicine, take 4 courses of treatment of Chinese traditional compound medicine that prescription of the present invention and method for preparing prepare, patient's disease alleviates to some extent; Continue to take 3 courses of treatment again, disease disappears basically.
Five, brief summary
Chinese medicine preparation of the present invention has cooling blood for hemostasis, the effect of nourishing YIN and clearing away heat; Can reach treating both the principal and secondary aspects of a disease, solve patient suffering's effect, obvious to treatment eye hemorrhagic disease symptom curative effect; This medicine total effective rate of clinical observation proof is 90%, has application value widely.
Claims (4)
1. Chinese medicine preparation of treating retinal hemorrhage is characterized in that being processed by following raw material medicaments in part by weight proportioning:
Rhizoma Anemarrhenae 6-16 part, Rhizoma Dioscoreae 9-26 part, Radix Scrophulariae 8-22 part, Rhizoma Atractylodis 4-12 part,
Radix Glehniae 4-12 part, Radix Salviae Miltiorrhizae 8-22 part, Radix Paeoniae Rubra 4-13 part, Radix Puerariae 4-15 part,
Fructus Leonuri 4-12 part, Cortex Moutan 4-14 part, Radix Angelicae Sinensis 4-12 part, Radix Rehmanniae 7-20 part,
Nodus Nelumbinis Rhizomatis 7-20 part, Radix Ophiopogonis 6-18 part, Herba Ecliptae 6-16 part.
2. according to the Chinese medicine preparation of the described treatment retinal hemorrhage of claim 1, it is characterized in that: the dosage form of Chinese medicine preparation is decoct, pill, tablet, granule, oral liquid, capsule, Emulsion or middle medicine film.
3. the method for preparing of the Chinese medicine preparation of claim 1 or 2 described treatment retinal hemorrhage, it is characterized in that method for preparing is: the proportioning by claim 1 or 2 described 15 kinds of crude drug is got material, drops into after the rinsing in the extraction pot, adds the water of octuple amount; Soaked 30 minutes, heated and stirred was boiled 1-2 hour, crossed leaching filtrating; The residue medicinal residues add the water of six times of amounts, and heated and stirred was boiled 1-2 hour, cross leaching filtrating; Discard medicinal residues, merging filtrate makes decoct; The filtrating that maybe will merge is concentrated into the clear paste that relative density is 1.25-1.35 under 75-85 ℃, be cooled to room temperature, adds ethanol and makes and contain alcohol amount and reach 50-80%, stirs, and leaves standstill 24 hours, filter, filtrate recycling ethanol and concentrate concentrated solution; Or with the concentrated solution vacuum decompression, 60-80 ℃ of drying pulverized, and processes dried cream powder; In concentrated solution or dried cream powder, add excipient, mix homogeneously is processed the Chinese medicine preparation of pill, tablet, granule, oral liquid, capsule, Emulsion or middle medicine film.
4. according to the method for preparing of the Chinese medicine preparation of the described treatment retinal hemorrhage of claim 3, it is characterized in that described excipient is one or more mixing of solvent, disintegrating agent, correctives, antiseptic, coloring agent, dispersant, binding agent, thickening agent, lubricant or diluent.
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Effective date of registration: 20170531 Address after: 110000, 128 North Main Street, Yuhong District, Shenyang, Liaoning, the Yellow River Patentee after: Ho ho Eye Hospital of Shenyang Ltd. Address before: Gaokan town Shenyang Qipanshan scenic tourism development zone 110163 Liaoning city of Shenyang Province Patentee before: He Wei |