CN102058908A

CN102058908A - Absorbable anti-adhesive material and preparation method thereof

Info

Publication number: CN102058908A
Application number: CN200910230138XA
Authority: CN
Inventors: 张博
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-11-18
Filing date: 2009-11-18
Publication date: 2011-05-18

Abstract

The invention belongs to the technical field of medical materials, and in particular relates to a medically absorbable anti-adhesive material based on a high polymer and a preparation method of the medically absorbable anti-adhesive material. The method comprises the following steps of, with polylactic acid and cellulose derivatives as main raw materials, processing the main raw materials into a medically absorbable anti-adhesive film under the certain technological conditions. Anti-adhesive films with different degradation rates are prepared through the proportion of the polylactic acid and the cellulose derivatives and different additions of other additives so as to be suitable for various medical requirements. The material prepared through the method has the advantages of good postoperative adhesion resistance and absorbability and wide medical clinical application value.

Description

Absorbability adherence preventing material and preparation method thereof

Technical field

The present invention relates to medical material tech field, be specifically related to a kind of absorbability anti product of making based on polylactic acid, cellulose derivative and preparation method thereof.

Background of invention

In the surgical operation, prevent that the wound surface adhesion from being the problem of not fine solution always, the operative site constant pain that tissue adhesion causes can be for the several years, have in addition cause operative site to lose function.The at present mineral oil of using clinically, hyaluronate sodium, all fourth matter glue etc., this class material all is fluid or semifluid shape, uses inconveniently, to some operation antiblocking weak effect, even does not have the effect of anti.

Recently, prevent that with absorbable physical barrier thing the surgical wound surface adhesion from having obtained good effect.As the INTERCEED fiber isolating membrane of U.S. ETHICON company exploitation, this film is to be made by the oxidation regeneration fiber, can absorb fully in 28 days in vivo.GENZYNE company develops the SEPRAFILM film, and it is mainly made by carboxymethylcellulomaterials materials, has tangible preventing adhesiving effect.But because of these two kinds of absorbing film main materials are cellulose, infiltration rate is fast, therefore must make very thick film and just can reach needed holding time, and be difficult to adapt in the clinical operation because of operative site not equal conditions change different requirements to the degradation rate of film.In addition, the hyaluronate sodium of GENZYNE company and cellulose composite membrane are used for anti after mixing the plain Pacilitaxel of angiogenesis inhibitor, the medicine that mainly concentrates on the nonporous film obstruct of hyaluronic acid, modified cellulose and other synthetic high polymer or introduce prevents to be organized in the more growth in district, has also influenced the normal healing of organizing simultaneously.

The purpose of this invention is to provide a kind of medical anti-adhesive film.Make it not only have good anti performance, and can make the Antiadhesive film product of different degradation rates, to adapt to various medical requirement by the different additions of additive.

Summary of the invention

An object of the present invention is defective, a kind of method for preparing the absorbability Antiadhesive film based on polylactic acid, cellulose derivative is provided at the prior art existence.Be cellular after making Antiadhesive film implant, outward appearance is transparent, translucent or other colored thin film, has both kept the characteristic of anti, has permeability again.

The preparation method of Antiadhesive film of the present invention mainly comprises the following steps:

1. dissolving: polymer dissolution is in solvent;

2. deaeration: the different polymer solutions after will dissolving mix, after the high-speed stirred, and deaeration;

3. film forming: on glass plate or other flat plate mold, add an amount of polymer solution, on the operating board of level, with the polymer solution levelling;

4. vacuum drying: can place fridge-20 in advance ℃ freezing about 4 hours, put into vacuum drying oven, drying.

5. taking-up Antiadhesive film, smooth, cutting, packing, sterilization obtain sample.

In the preparation method of Antiadhesive film of the present invention, polymer is one or more in DL-polylactic acid, L-polylactic acid, the cellulose derivative (comprising carboxymethyl cellulose, oxidized regenerated cellulose etc.), and the molecular weight of these materials is 5000～1,000,000; Solvent is ethyl acetate, dimethyl sulfoxide, chloroform, oxolane, butyl acetate, acetone, carbonic diester or normal saline.

Specific embodiments

Embodiment 1:

Take by weighing molecular weight and be respectively 100,000,300,000 DL-polylactic acid 1g, join in the 100ml ethyl acetate, airtight condition dissolves when stirring down fully, and ultrasonic or vacuum defoamation is poured into area with solution and is about 400cm ²Clean flat glass plate on, put into vacuum drying oven, drying at room temperature 1 day, smooth, again in vacuum drying oven dry good after, skinning, cutting, packing, sterilization, promptly.

Embodiment 2:

Take by weighing molecular weight and be respectively 200,000 L-polylactic acid 1g, join in the 100ml ethyl acetate, be stirred to dissolving fully under the airtight condition, add oxidized regenerated cellulose micropowder 75mg, high-speed stirred is extremely even, vacuum defoamation, solution is poured on the clean flat glass plate, put into vacuum drying oven, 5 ℃ of dryings 2 days, smooth, after drying is got well in vacuum drying oven again, skinning, cutting, packing, sterilization, promptly.

Embodiment 3:

Take by weighing sodium carboxymethyl cellulose 0.2g and be dissolved in the 4ml normal saline, adding molecular weight is the Polyethylene Glycol 0.9g of 4000-10000, heating and melting, and after stirring, lyophilization is pulverized.Take by weighing above-mentioned powder 1g and molecular weight and be 350,000 DL-polylactic acid 9g, join in the 100ml acetone, be stirred to dissolving fully under the airtight condition, vacuum defoamation is poured into solution on the clean flat glass plate, puts into vacuum drying oven, 0 ℃ of drying 2 days, smooth, after drying is got well in vacuum drying oven again, skinning, cutting, packing, sterilization, promptly.

Claims

1. absorbability anti product of making based on polylactic acid, cellulose derivative, it consists of: one or more in DL-polylactic acid, L-polylactic acid, the cellulose derivative.

2. based on the absorbability anti product of claim 1, its preparation method is: polymer dissolution, deaeration, film forming, vacuum drying, smooth, cutting, packing, sterilization is characterized in that the dissolving ultrasonic or vacuum defoamation in back, after 5～30 ℃ of film forming, 0～20 ℃ of low-temperature vacuum drying.

3. based on claim 1 or the described absorbability anti of claim 2 product, it is characterized in that, in the dissolving step, polymer molecular weight is 5000～1,000,000, and solvent is ethyl acetate, dimethyl sulfoxide, chloroform, oxolane, butyl acetate, acetone, carbonic diester or normal saline.

4. according to the made absorbability anti product of claim 1～3, it is characterized in that outward appearance is transparent membrane, translucent microporous membrane.