CN102049109A - Method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field - Google Patents
Method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field Download PDFInfo
- Publication number
- CN102049109A CN102049109A CN2011100020124A CN201110002012A CN102049109A CN 102049109 A CN102049109 A CN 102049109A CN 2011100020124 A CN2011100020124 A CN 2011100020124A CN 201110002012 A CN201110002012 A CN 201110002012A CN 102049109 A CN102049109 A CN 102049109A
- Authority
- CN
- China
- Prior art keywords
- flow
- cavitation
- additional heat
- microvesicle
- focused ultrasound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
The invention discloses a method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in a focused ultrasound field. When focused ultrasound acts on a local medium containing flow liquid, microbubble is injected into the medium and arrives at the focused ultrasound field following the flow liquid. Under the action of the focused ultrasound, the additional heat generated by utilizing a flow microbubble cavitation synergistic mechanism is used for compensating the heat carried away by the flow liquid, thereby promoting the rising of the temperature of the local medium nearby a pipeline. In the invention, transient physics of the flow microbubble, such as cavitation and the like, occur under the action of ultrasound and the effects of reflection, scattering and the like on the ultrasound are enhanced; the additional heat generated by utilizing the flow microbubble cavitation synergistic mechanism can be used for compensating the heat carried away by the flow, thereby enhancing the heating efficiency of the ultrasound.
Description
Technical field:
The invention belongs to the focus supersonic field, be specifically related to a kind of additional heat that utilizes the microvesicle cavitation that flows in the focus supersonic field to produce and take away the method that heat compensates flowing.
Background technology:
When propagating in medium, the part ultrasonic energy is absorbed by medium and is converted into heat energy, thereby causes the rising of medium temperature when ultrasonic.Utilize focus supersonic can externally converge, fast, the advantage of aspect such as local heat, particularly use high intensity focused ultrasound, in the clinical tumor thermotherapy, obtained challenging initiative achievement.But problems such as this focus supersonic local heat technology still exists, and efficient is low, the time is long have to be solved.Owing to when containing more working fluid in the conduction of heat, particularly medium,, reduced the efficient of focus supersonic local heat because fluxion strap is walked the rising that heat hinders medium temperature.Therefore, need to improve the focus supersonic efficiency of heating surface in the medium that contains working fluid.Increase the single ultrasonic power or can improve the target area temperature action time, but can make on the transonic path simultaneously and the temperature of target area periphery normal structure too high, produce toxic and side effects.In addition, by blocking-up blood for and mode such as injection iodized oil etc. can reduce the influence that fluxion strap is walked heat, but this class mode of infection increases people's misery and strengthens risk.
Summary of the invention:
The present invention proposes a kind of microvesicle cavitation that flows of utilizing and produces the mobile method of taking away heat of additional heat compensation in conjunction with microcapsular ultrasound cavitation synergistic mechanism in the focus supersonic field.
In order to realize above-mentioned task, the present invention takes following solution:
The microvesicle cavitation that flows in a kind of focus supersonic field produces the method for the mobile thermal loss of additional heat compensation, it is characterized in that: the focus supersonic field action is when containing the medium of working fluid, arrive focus supersonic field Jiao Qu in the microvesicle injected media and with working fluid, under the focus supersonic effect, the additional heat that utilizes microcapsular ultrasound cavitation synergistic mechanism to produce, the heat that the compensation liquid flow is taken away, thereby near the rising of the medium temperature promotion pipeline.
Among the present invention, transient state physics such as cavitation take place in the microvesicle that flows under ultrasonication, and strengthen effects such as ultransonic reflection, scatterings, can utilize the microcapsular ultrasound cavitation synergistic mechanism that flows to produce additional heat, and the heat that compensation is flowed and taken away improves the ultrasonic efficiency of heating surface.
Description of drawings:
Fig. 1 utilizes the microvesicle cavitation that flows to produce the flow method sketch map of thermal loss of additional heat compensation in the focus supersonic field that proposes of the present invention;
Fig. 2 is that the microvesicle cavitation that utilize to flow in the focus supersonic field produces the result that heat that additional heat convection cell takes away compensates.
The specific embodiment:
For a more clear understanding of the present invention, the embodiment that provides below in conjunction with accompanying drawing and inventor is described in further detail:
Embodiment 1: the microvesicle cavitation that utilize to flow in a kind of focus supersonic field produces the method that heat that additional heat convection cell takes away compensates, as shown in Figure 1.
In the auxiliary focus supersonic thermotherapy of microvesicle, use the imitative transparency of organization phantom of inner negotiable microvesicle solution, the pipeline in the imitative body is perpendicular to the ultrasonic therapeutic acoustic axis, and regulates the ultrasonic therapeutic focus by three-dimensional mobile device and be arranged in pipeline.In microvesicle solution flow in pipes, control its flow velocity by microvesicle flow speed control pump.Use the burnt territory of focus supersonic to act on the part, target area afterwards, utilize microcapsular ultrasound cavitation synergistic mechanism to produce additional heat, thus the heat that compensation is flowed and taken away, near the rising of the temperature promotion pipeline.
Embodiment 2: the microvesicle cavitation that utilize to flow in the focus supersonic field produces the result that heat that additional heat convection cell takes away compensates, as shown in Figure 2.
Under the room temperature condition, in transparent artificial body pipeline, inject the microvesicle solution of variable concentrations, under the condition that liquid flow velocity is identical in ultrasonic power, action time and pipeline, measure transparent artificial body inner tubal wall temperature curve over time under different microvesicle solution concentration conditions.Proportionally, with the microvesicle and the 100ml 0.9% injection normal saline uniform mixing of various dose, thus the microvesicle solution of formation variable concentrations.Employed microvesicle solution concentration scope from 0.001% to 0.1%.When in the transparent artificial body pipeline 0.9% normal saline only being arranged (the microvesicle solution concentration is 0%), tube wall temperature is along with the increase of focus supersonic action time and raise, but liquid flow is taken away heat, limited the rising of tube wall temperature, at once, tube wall temperature is increased to 37 ℃ after ultrasonication finishes.Afterwards with in the microvesicle solution flow in pipes for preparing, and make the enough time of microvesicle flow of solution guarantee evenly to be full of microvesicle solution in the transparent artificial body pipeline.When the microvesicle solution concentration is 0.001%, tube wall temperature is along with the increase of focus supersonic action time and speeding up of raising, the microvesicle cavitation produces the heat that additional heat convection cell takes away and compensates, make ultrasonication finish after at once tube wall temperature be higher than tube wall temperature when 0.9% normal saline is only arranged.Along with the raising of microvesicle solution concentration, at once tube wall temperature constantly increases after ultrasonication finishes.When the microvesicle solution concentration reached 0.1%, the microvesicle cavitation produced the heat that how additional heat convection cell takes away and compensates, make ultrasonication finish after at once the tube wall temperature of tube wall temperature when only normal saline being arranged exceed nearly 5 ℃.This result confirms, can utilize the microvesicle cavitation that flows to produce the heat that additional heat convection cell takes away in the focus supersonic field and compensate, thereby promote near the rising of the medium temperature pipeline.
Above content is to further describing that the present invention did in conjunction with concrete preferred implementation; can not assert that the specific embodiment of the present invention only limits to this; for the general technical staff of the technical field of the invention; without departing from the inventive concept of the premise; can also make some simple deduction or replace, all should be considered as belonging to the present invention and determine scope of patent protection by claims of being submitted to.
Claims (1)
1. the microvesicle cavitation that flows in the focus supersonic field produces the flow method of thermal loss of additional heat compensation, it is characterized in that: when focus supersonic acts on the local medium that contains working fluid, arrive focus supersonic field Jiao Qu in the microvesicle injected media and with working fluid; Under the focus supersonic effect, the additional heat that utilizes microcapsular ultrasound cavitation synergistic mechanism to produce, the heat that the compensation liquid flow is taken away, thereby near the rising of the local medium temperature promotion pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100020124A CN102049109A (en) | 2011-01-06 | 2011-01-06 | Method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100020124A CN102049109A (en) | 2011-01-06 | 2011-01-06 | Method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102049109A true CN102049109A (en) | 2011-05-11 |
Family
ID=43954115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100020124A Pending CN102049109A (en) | 2011-01-06 | 2011-01-06 | Method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102049109A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864636A (en) * | 2005-05-17 | 2006-11-22 | 株式会社日立制作所 | Ultrasonic apparatus for diagnosis and therapy |
| CN101028524A (en) * | 2006-03-03 | 2007-09-05 | 重庆融海超声医学工程研究中心有限公司 | Supersonic microvesicle target positioning controlled-release/gene device and target transferring method |
| CN101291705A (en) * | 2005-06-07 | 2008-10-22 | 皇家飞利浦电子股份有限公司 | Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids |
| CN101484081A (en) * | 2006-07-04 | 2009-07-15 | 布拉科成像S.P.A.公司 | Device for localized thermal ablation of biological tissue, particularly tumoral tissues or the like |
| CN101530320A (en) * | 2009-03-31 | 2009-09-16 | 西安交通大学 | Real-time extracting device and detection method for focused ultrasonic cavitation and microbubbles thereof |
| CN101623203A (en) * | 2009-08-07 | 2010-01-13 | 西安交通大学 | Multi-mode multi-parameter synchronous detection imaging monitoring system in transient physical process and monitoring method |
| CN101670155A (en) * | 2009-10-16 | 2010-03-17 | 绵阳索尼克电子有限责任公司 | Digitalization high sound pressure ultrasound non-invasive therapy system |
-
2011
- 2011-01-06 CN CN2011100020124A patent/CN102049109A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864636A (en) * | 2005-05-17 | 2006-11-22 | 株式会社日立制作所 | Ultrasonic apparatus for diagnosis and therapy |
| CN101291705A (en) * | 2005-06-07 | 2008-10-22 | 皇家飞利浦电子股份有限公司 | Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids |
| CN101028524A (en) * | 2006-03-03 | 2007-09-05 | 重庆融海超声医学工程研究中心有限公司 | Supersonic microvesicle target positioning controlled-release/gene device and target transferring method |
| CN101484081A (en) * | 2006-07-04 | 2009-07-15 | 布拉科成像S.P.A.公司 | Device for localized thermal ablation of biological tissue, particularly tumoral tissues or the like |
| CN101530320A (en) * | 2009-03-31 | 2009-09-16 | 西安交通大学 | Real-time extracting device and detection method for focused ultrasonic cavitation and microbubbles thereof |
| CN101623203A (en) * | 2009-08-07 | 2010-01-13 | 西安交通大学 | Multi-mode multi-parameter synchronous detection imaging monitoring system in transient physical process and monitoring method |
| CN101670155A (en) * | 2009-10-16 | 2010-03-17 | 绵阳索尼克电子有限责任公司 | Digitalization high sound pressure ultrasound non-invasive therapy system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2011348392A8 (en) | Fluid circulation system | |
| HK1168641A1 (en) | Gas lift pump apparatus with ultrasonic energy generator and method | |
| CN102049109A (en) | Method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field | |
| CN103372382B (en) | A kind of preparation facilities of therapeutic type micro air bubble ultrasonic contrast medium and method | |
| CN102049108A (en) | System and method for compensating flow heat loss by utilizing additional heat generated through flow microbubble cavitation in focused ultrasound field | |
| CN205795892U (en) | A kind of portable head low temperature induction device | |
| CN201810928U (en) | Liquid conveying heating pipe | |
| CN203989521U (en) | Coupling liquid supply arrangement for high-strength focus supersonic therapeutic system | |
| CN205586298U (en) | Transfer line of accurate control temperature | |
| CN111110963A (en) | Axial flow guiding reinforced capillary structure | |
| CN203749198U (en) | Solar water dispenser | |
| CN204105711U (en) | Electricity digester | |
| CN208492842U (en) | A kind of hepatology Dual-head infusion device | |
| Aliseda et al. | Microbubbles as drug-delivery vectors: steering ultrasound contrast agents in arterial flow using the Bjerknes force | |
| Li et al. | Microfluidic Production of Monodisperse Perfluorocarbon Microdroplets | |
| CN208339889U (en) | A kind of transfusion auxiliary device | |
| CN206924442U (en) | Vacuum concentrating apparatus based on plurality of raw materials mixing | |
| Menon et al. | Device specific analysis of neonatal aortic outflow cannula jet flows for improved cardiopulmonary bypass hemodynamics | |
| Carr et al. | Peristaltic Pumping in an Elliptical-Annulus Model of a Perivascular Space | |
| CN104248791A (en) | Electric heating structure for infusion tubes | |
| Mathijssen et al. | Delivery of Microcargoes by Artificial Microtubules | |
| CN204193193U (en) | A kind of transfusion device with heater | |
| CN204283773U (en) | Relative temperature difference power generation system | |
| CN202619955U (en) | Heating and heat-insulating device for tumescent anesthesia | |
| Sharon et al. | Shooting inertial wave packets into rotating turbulence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110511 |