CN102028836A - Medicine dropping pill used for clearing heat and diminishing swelling and preparation method thereof - Google Patents
Medicine dropping pill used for clearing heat and diminishing swelling and preparation method thereof Download PDFInfo
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- CN102028836A CN102028836A CN2010105841039A CN201010584103A CN102028836A CN 102028836 A CN102028836 A CN 102028836A CN 2010105841039 A CN2010105841039 A CN 2010105841039A CN 201010584103 A CN201010584103 A CN 201010584103A CN 102028836 A CN102028836 A CN 102028836A
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Abstract
The invention relates to a medicine dropping pill used for clearing heat and diminishing swelling and a preparation method thereof. The invention comprises main ingredients of cinnabar, realgar, sodium borate, sanguis draconis, myrrh, frankincense, bufonid, bezoar, agilawood and pearls and also comprises additive polyethylene glycol, wherein the weight ratio of the polyethylene glycol to the main ingredients is 3:1. The preparation method comprises the following steps: (1) fusing the mixed matrix of polyethylene glycol (PEG) PEG-6000 and PEG-4000; (2) mixing and smashing the main ingredients into fine powder, and sieving; (3) adding the fine powder into an additive, and stirring, thus the fine powder is suspended into the additive; (4) maintaining constant temperature of 80-100 DEG C, dropping the obtained additive into condensate at constant speed by a water dropper, and condensing, so as to obtain pills sunk to the bottom of a container; and (5) taking out the pills, washing off the condensate, and drying. The medicine in the invention has rapid curative effect, high bioavailability and convenience for administration.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation method, be specifically related to a kind of preparation method that is used for the clearing heat for detumescence medicine.
Background technology
Major ingredient Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha each, the prescription formed of Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita is used for heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is mainly used in toxic swelling from the beginning of symptoms such as, throat, gingival swelling and pain, aphtha of the mouth and tongue, thirsty, constipations.Be processed into pill with power at present and be called " plum blossom tongue ball ", this ball specifically is processed into watered pill dosage form.Watered pill dosage form is easily dissolved absorption, the content of dispersion height, but because the preparation section time of the watered pill is longer, easily pollute, to major ingredient content and the difficult control of dissolving time limit, and bioavailability is lower.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, it is few to have designed and developed out a kind of production process, pollution-free, clearing heat for detumescence drop pill that bioavailability is high and preparation method thereof.
The present invention is achieved by the following technical solutions:
A kind of preparation method that is used for the clearing heat for detumescence medicine, comprise major ingredient Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha each, Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita;
The weight ratio of described Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha, Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita is 2: 2: 2: 2: 2: 1: 1: 1: 1: 0.6;
Also comprise the additives Polyethylene Glycol, the weight ratio of Polyethylene Glycol and major ingredient is 3: 1;
Described method prepares according to the following steps:
(1) with the additives fusion;
(2) the major ingredient mixed powder is broken into fine powder, and sieves;
(3) described fine powder is added in the additives, and stirring is suspended in the additives;
(4) keep 80～100 ℃ of steady temperatures, through water dropper, constant speed splashes in the condensed fluid, solidifies the formation pill and sinks at the bottom of the device;
(5) take out pill, the flush away condensed fluid, after the drying promptly.
A kind of preparation method that is used for the clearing heat for detumescence medicine, described additives Polyethylene Glycol are the mixed-matrix of PEG-6000 and PEG-4000.
A kind of preparation method that is used for the clearing heat for detumescence medicine, described condensed fluid are the mixing material of paraffin and silicone oil.
The present invention has adopted drops, makes the plum blossom tongue drop pill of preparing have the following advantages:
(1) curative effect is rapid, the bioavailability height, because the dispersion of medicine in substrate is the crystallization of micropowder shape, be the high degree of dispersion state, and additives are water miscible Polyethylene Glycol, then can increase or improve the solubility property of medicine, accelerate the dissolution rate and the infiltration rate of medicine, thereby improve bioavailability.
(2) workshop does not have dust, and production process is pollution-free, and equipment is simple, and operation is few, and is with short production cycle, and production cost is relatively low.
(3) the drop pill agents area is many, can be oral, tract is with, external, can play long-acting.
The present invention shows after the white mice experiment carrying out, medicine of the present invention has raise immunity, can significantly increase the mouse immune organ weight, improve phagocytosis of macrophages, promote hemolysin to form, the effect of this enhance immunity does not exist only under the normal physiological state of animal, also is present in to use after the immunosuppressant and on one's body the mice of lotus tumor.Medicine of the present invention has the obvious treatment effect to mouse transplanting tumor.Suppression ratio to the S180 solid tumor is 43.55%, is 21.81% to the increase in life span of inoculating ECA power thing.With the mitomycin C with C effect, above-mentioned effect can obviously strengthen.This medicine still has preventive effect to transplanted tumor.
The specific embodiment
The present invention includes major ingredient Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha each, Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita; The weight ratio of Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha, Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita is 2: 2: 2: 2: 2: 1: 1: 1: 1: 0.6; Also comprise the additives Polyethylene Glycol, additives are the mixed-matrix of PEG-6000 and PEG-4000, and the weight ratio of additives and major ingredient is 3: 1; The method of preparation prepares according to the following steps: (1) is with the mixed-matrix fusion of PEG-6000 and PEG-4000; (2) the major ingredient mixed powder is broken into fine powder, and sieves; (3) described fine powder is added in the additives, and stirring is suspended in the additives; (4) keep 80～100 ℃ of steady temperatures, through water dropper, constant speed splashes in the condensed fluid, solidifies the formation pill and sinks at the bottom of the device; (5) take out pill, the flush away condensed fluid, after the drying promptly.Condensed fluid is the mixing material of paraffin and silicone oil.
Claims (4)
1. medicinal dropping ball that is used for clearing heat for detumescence, it is characterized in that comprising major ingredient Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha each, Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita;
The weight ratio of described Cinnabaris, Realgar, Borax, Sanguis Draxonis, Myrrha, Olibanum, Bufo siccus, Calculus Bovis, Lignum Aquilariae Resinatum, Margarita is 2: 2: 2: 2: 2: 1: 1: 1: 1: 0.6;
Also comprise additives Polyethylene Glycol, condensed fluid; The weight ratio of Polyethylene Glycol, condensed fluid and major ingredient is 3: 2: 1.
2. a kind of preparation method that is used for the clearing heat for detumescence medicinal dropping ball as claimed in claim 1 is characterized in that preparing according to the following steps:
(1) with the additives fusion;
(2) the major ingredient mixed powder is broken into fine powder, and sieves;
(3) described fine powder is added in the additives, and stirring is suspended in the additives;
(4) keep 80～100 ℃ of steady temperatures, through water dropper, constant speed splashes in the condensed fluid, solidifies the formation pill and sinks at the bottom of the device;
(5) take out pill, the flush away condensed fluid, after the drying promptly.
3. a kind of preparation method that is used for the clearing heat for detumescence medicine according to claim 1 and 2 is characterized in that described additives Polyethylene Glycol is the mixed-matrix of PEG-6000 and PEG-4000.
4. a kind of preparation method that is used for the clearing heat for detumescence medicine according to claim 1 and 2 is characterized in that described condensed fluid is the mixing material of paraffin and silicone oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105841039A CN102028836A (en) | 2010-12-10 | 2010-12-10 | Medicine dropping pill used for clearing heat and diminishing swelling and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105841039A CN102028836A (en) | 2010-12-10 | 2010-12-10 | Medicine dropping pill used for clearing heat and diminishing swelling and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102028836A true CN102028836A (en) | 2011-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105841039A Pending CN102028836A (en) | 2010-12-10 | 2010-12-10 | Medicine dropping pill used for clearing heat and diminishing swelling and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417795A (en) * | 2013-08-12 | 2013-12-04 | 江西天施康中药股份有限公司 | Medicine composition for detoxicating and relieving sore throat, and preparation method of medicine composition |
| CN103721011A (en) * | 2013-12-14 | 2014-04-16 | 郑明立 | Medicine for treating deep-rooted boil and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100462092C (en) * | 2006-06-24 | 2009-02-18 | 广东皮宝制药股份有限公司 | Externally-applied Chinese medicine and its preparation |
-
2010
- 2010-12-10 CN CN2010105841039A patent/CN102028836A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100462092C (en) * | 2006-06-24 | 2009-02-18 | 广东皮宝制药股份有限公司 | Externally-applied Chinese medicine and its preparation |
Non-Patent Citations (3)
| Title |
|---|
| 《中医杂志》 19880630 张奇文 中医儿科中药剂型改革刍议 第52-53页 1-4 , 第6期 2 * |
| 《中华人民共和国药典2005年版一部》 20051231 国家药典委员会 梅花点舌丸 第593-594页 1-4 , 1 * |
| 《现代中药制剂新技术》 20070228 赵浩如 滴丸剂 江苏科学技术出版社 第180-184页 1-4 , 1 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417795A (en) * | 2013-08-12 | 2013-12-04 | 江西天施康中药股份有限公司 | Medicine composition for detoxicating and relieving sore throat, and preparation method of medicine composition |
| CN103417795B (en) * | 2013-08-12 | 2015-03-18 | 江西天施康中药股份有限公司 | Medicine composition for detoxicating and relieving sore throat, and preparation method of medicine composition |
| CN103721011A (en) * | 2013-12-14 | 2014-04-16 | 郑明立 | Medicine for treating deep-rooted boil and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Open date: 20110427 |