CN102020682A - Preparation method of neuchebulagicacid - Google Patents
Preparation method of neuchebulagicacid Download PDFInfo
- Publication number
- CN102020682A CN102020682A CN2010105353675A CN201010535367A CN102020682A CN 102020682 A CN102020682 A CN 102020682A CN 2010105353675 A CN2010105353675 A CN 2010105353675A CN 201010535367 A CN201010535367 A CN 201010535367A CN 102020682 A CN102020682 A CN 102020682A
- Authority
- CN
- China
- Prior art keywords
- type
- preparation
- chebulagic acid
- macroporous adsorbent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011347 resin Substances 0.000 claims abstract description 23
- 229920005989 resin Polymers 0.000 claims abstract description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 13
- 238000000605 extraction Methods 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 6
- 238000010828 elution Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 6
- 238000004064 recycling Methods 0.000 claims abstract description 6
- 238000005406 washing Methods 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims abstract description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 28
- 229920002052 Chebulagic acid Polymers 0.000 claims description 24
- HGJXAVROWQLCTP-YABCKIEDSA-N Chebulagic acid Chemical compound O([C@H]1[C@H]2[C@H]3OC(=O)C4=CC(O)=C(O)C(O)=C4C4=C(O)C(O)=C(O)C=C4C(=O)OC[C@@H](O1)[C@H]3OC(=O)[C@@H](CC(O)=O)[C@@H]1[C@@H](C(OC=3C(O)=C(O)C=C(C1=3)C(=O)O2)=O)O)C(=O)C1=CC(O)=C(O)C(O)=C1 HGJXAVROWQLCTP-YABCKIEDSA-N 0.000 claims description 22
- UGIVASYMZSZAMP-UHFFFAOYSA-N chebulagic acid Natural products OC1C2c3c(OC1=O)c(O)c(O)cc3C(=O)OC4C(OC(=O)c5cc(O)c(O)c(O)c5)OC6COC(=O)c7cc(O)c(O)c(O)c7c8c(O)c(O)c(O)cc8C(=O)OC4C6OC(=O)C2(O)C(=O)O UGIVASYMZSZAMP-UHFFFAOYSA-N 0.000 claims description 21
- 239000003463 adsorbent Substances 0.000 claims description 13
- 239000012141 concentrate Substances 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 8
- 230000002378 acidificating effect Effects 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241001534869 Terminalia Species 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 238000002425 crystallisation Methods 0.000 claims description 5
- 230000008025 crystallization Effects 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- -1 filter Substances 0.000 claims description 5
- 235000012054 meals Nutrition 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000005265 energy consumption Methods 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 3
- 235000015489 Emblica officinalis Nutrition 0.000 abstract 2
- 244000277583 Terminalia catappa Species 0.000 abstract 2
- 235000011517 Terminalia chebula Nutrition 0.000 abstract 2
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 230000003321 amplification Effects 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 229940023913 cation exchange resins Drugs 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000009330 Terminalia Nutrition 0.000 description 5
- 241000407877 Combretum Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 241000001522 Terminalia chebula Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 241000132536 Cirsium Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001093760 Sapindaceae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010535367 CN102020682B (en) | 2010-11-09 | 2010-11-09 | Preparation method of neuchebulagicacid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010535367 CN102020682B (en) | 2010-11-09 | 2010-11-09 | Preparation method of neuchebulagicacid |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102020682A true CN102020682A (en) | 2011-04-20 |
CN102020682B CN102020682B (en) | 2013-06-05 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201010535367 Active CN102020682B (en) | 2010-11-09 | 2010-11-09 | Preparation method of neuchebulagicacid |
Country Status (1)
Country | Link |
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CN (1) | CN102020682B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102329342A (en) * | 2011-05-31 | 2012-01-25 | 苏州派腾生物医药科技有限公司 | Preparation method of elaeocarpusin |
CN104817567A (en) * | 2015-04-03 | 2015-08-05 | 宝鸡市虹源生物科技有限公司 | Method for preparing high-purity ellagic acid by using macroporous resin method to purify tannin |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1398871A (en) * | 2002-09-10 | 2003-02-26 | 北京富邦博尔生物科技有限公司 | Tannic acid purifying process |
CN101134766A (en) * | 2006-08-30 | 2008-03-05 | 上海康文医药中间体有限公司 | Method for preparing high-purity maple tannin by acer ginnala leaf |
CN101265279A (en) * | 2008-04-29 | 2008-09-17 | 云南省化工研究院 | Method for extracting tannin from tarra bean-pod by micro-wave method |
-
2010
- 2010-11-09 CN CN 201010535367 patent/CN102020682B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1398871A (en) * | 2002-09-10 | 2003-02-26 | 北京富邦博尔生物科技有限公司 | Tannic acid purifying process |
CN101134766A (en) * | 2006-08-30 | 2008-03-05 | 上海康文医药中间体有限公司 | Method for preparing high-purity maple tannin by acer ginnala leaf |
CN101265279A (en) * | 2008-04-29 | 2008-09-17 | 云南省化工研究院 | Method for extracting tannin from tarra bean-pod by micro-wave method |
Non-Patent Citations (4)
Title |
---|
BRUNO FOGLIANI,等: "Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia", 《PHYTOCHEMISTRY》 * |
K.B.契莫托夫: "《离子交换剂的理论与实际应用》", 30 November 1958, 科学出版社 * |
QUANBIN HAN,等: "Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography", 《JOURNAL OF SEPARATION SCIENCE》 * |
丁岗,等: "诃子中主要可水解丹宁的结构鉴定", 《中国药科大学学报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102329342A (en) * | 2011-05-31 | 2012-01-25 | 苏州派腾生物医药科技有限公司 | Preparation method of elaeocarpusin |
CN104817567A (en) * | 2015-04-03 | 2015-08-05 | 宝鸡市虹源生物科技有限公司 | Method for preparing high-purity ellagic acid by using macroporous resin method to purify tannin |
Also Published As
Publication number | Publication date |
---|---|
CN102020682B (en) | 2013-06-05 |
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Owner name: NANJING ZELANG AGRICULTURAL DEVELOPMENT CO., LTD. Free format text: FORMER OWNER: SUZHOU PAITENG BIOPHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20130422 |
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Free format text: CORRECT: ADDRESS; FROM: 215011 SUZHOU, JIANGSU PROVINCE TO: 211225 NANJING, JIANGSU PROVINCE |
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Effective date of registration: 20130422 Address after: 211225 Lishui County, Nanjing province Baima town industrial concentration zone, food Park, No. 3 Applicant after: Nanjing Zelang Agricultural Development Co., Ltd. Address before: 215011 Jiangsu high tech Zone Suzhou City Binhe Road, No. 1326 Applicant before: Suzhou Paiteng Biopharmaceutical Technology Co., Ltd. |
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Address after: 211225 Lishui County, Nanjing province Baima town industrial concentration zone, food Park, No. 3 Patentee after: NANJING ZELANG BIOTECHNOLOGY CO., LTD. Address before: 211225 Lishui County, Nanjing province Baima town industrial concentration zone, food Park, No. 3 Patentee before: Nanjing Zelang Agricultural Development Co., Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of helile ellagic acid Effective date of registration: 20210420 Granted publication date: 20130605 Pledgee: Jiangsu bank Limited by Share Ltd. Lishui branch Pledgor: NANJING ZELANG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021980002822 |
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Date of cancellation: 20220420 Granted publication date: 20130605 Pledgee: Jiangsu bank Limited by Share Ltd. Lishui branch Pledgor: NANJING ZELANG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021980002822 |