CN102019013A

CN102019013A - Novel imbibition device and application thereof

Info

Publication number: CN102019013A
Application number: CN2009101695609A
Authority: CN
Inventors: 张文芳; 杨国梁
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-09-09
Filing date: 2009-09-09
Publication date: 2011-04-20

Abstract

The present invention discloses a flexible imbibition device equipped with a micropore, wherein the imbibition device is used for accurately absorbing and injecting liquid. The imbibition device comprises an imbibition capsule, a pipette, and an injection head with the micropore. Before absorbing liquid, the imbibition capsule is in the vacuum state. The pipette has a seal joint. Liquid penetrates into the imbibition device under the pressure effect when the seal joint is opened. The injection head with the micropore can be installed on the pipette. The syringe can be used as a drug storing apparatus and is applied to needleless injectors which can generate the instantaneous motive force through the high driving force.

Description

A kind of novel aspirator and application thereof

Affiliated technical field

The present invention relates to a kind of novel aspirator, comprise a liquid sucking bag 1, pipette 2 and have the injection head 3 of micropore 4, be used for accurately drawing and atomizing of liquids, can be used in by on the needleless injector of strong driving force effect as device for storing liquid, belong to medical instruments field.

Background technology

Traditional syringe is by the mode imbitition of syringe needle is installed, use loaded down with trivial details, especially after using, a large amount of disposable syringes promptly become the medical waste of threatening environment health, cause the problem of environmental protection, select new injection system for use is that medical worker needs always, avoid the use of syringe needle, needleless injection technique for safety injection is the focus of international this domain expert's research always.

The main points of needleless injection technique are that the injecting type of realizing medicine imports, need the strong and dynamical system that respond fast of driving force for this reason, provide impulsive force with the piston in impact and the propelling sealing medicament reservoir, producing high voltage transient forces medicament to be extruded from minute aperture, form the microjet of high velocity jet, penetrate human body or animal body skin rapidly, arrive the drug absorption optimal site.Present existing dynamical system substantially can be divided into three kinds technically: Compressed Gas, fuel and hard spring, relevant patent of invention open at home and abroad or authorize in respect of 20 remainders.

Needleless injection technique researcher door is hankered after the improvement of dynamical system always, for the improvement of syringe but few people do, the mode of drawing medicinal liquid in the needleless injection product of listing is also more loaded down with trivial details than traditional syringe even, the present invention is through repeatedly test, find to improve drug reservoir, not only can make things convenient for the doctor to operate, also can reduce pollution, be with a wide range of applications and vast market prospect environment.

Summary of the invention

The present invention relates to a kind of flexible aspirator that micropore 4 is housed, be used for accurately drawing and atomizing of liquids, comprise a liquid sucking bag 1, pipette 2 and have the injection head 3 of micropore 4, not before the imbitition, liquid sucking bag 1 is in vacuum state, pipette 2 has seal nipple, open seal nipple, liquid enters in the aspirator by the pressure effect, the injection head 3 that has micropore 4 can be installed on the pipette 2, the liquid that will be filled under the effect of pressure in the liquid sucking bag 1 of liquid is extruded, can be applied in by on the needleless injector of strong driving force effect as device for storing liquid.

Liquid sucking bag 1 of the present invention selects easy deformation and rubber, plastics or resin that material itself can not change owing to the pressure effect, and preferred biodegradable environment-friendly materials are such as high molecule plastic PLA, PHA, PPC etc.

Pipette 2 of the present invention, the material of selecting for use has certain rigidity, and deformation can not take place in liquid in the process of going out, can select metal or nonmetallic materials for use, and preferred degradable environment friendly material is such as high molecule plastic PLA, PHA, PPC etc.

The injection head 3 that has micropore 4 of the present invention, wherein micropore 4 magnitude range are the 30-200 micron, preferred 50-100 micron, injection head 3, can be directly to be buckled on the pipette 2, also can be threaded with pipette 2 on screw thread close the rotation after screw on, injection head 3 can have dimpling and go out contact component, material is selected from: Stainless Steel, Nitinol and similar biocompatible materials, when acting on experimenter's skin, described dimpling goes out not produce visual wound or hemorrhage, it can be the microtubule 5 with sharp-pointed outlet that the dimpling of contact component goes out, and also can be to have the microtubule 5 that sharp-pointed outlet and sidewall have aperture, also can be the microtubule 5 with sharp-pointed outlet and sidewall fluting, go out the quantity of microtubule 5 according to the different dimpling of the different choice of injected dose, the density that dimpling goes out microtubule 5 is every square centimeter of 10-1000; It is different according to different injection objects that dimpling goes out microtubule 5 length, and for example to the infant injection, its length is given old adult's injection at the 20-50 micron, and its length is given animal vaccine between the 50-200 micron, and its length is between the 100-1000 micron.

The flexible aspirator that micropore 4 is housed of the present invention, can be used for doing the medicine storage device of the needleless injector that power makes by spring, machinery or Compressed Gas, the liquid of drawing preferably has active chemical compound, it can be micromolecular compound, also can be macromolecule polyalcohol, such as: chemicals, growth hormone, insulin, polypeptide, protein, oligonucleotide, nucleic acid and polysaccharide etc.

Description of drawings

Fig. 1 is a first embodiment of the invention vertical section structure sketch map.

Fig. 2 is a second embodiment of the invention vertical section structure sketch map.

Fig. 3 is a micropin series of the present invention.

The numbering explanation:

1,

liquid sucking bag

1,2,

pipette

2,3 and have

injection head

3,4,

micropore

4,5, the variform micropin of micropore 4,6, the micropin permutation

Specific embodiment one

Liquid sucking bag adopts oval structure.

Liquid sucking bag is in vacuum state before not having imbitition, the liquid sucking bag front end has a sealed end, sealed end is broken off with the fingers and thumb to have no progeny with tweezers and is inserted at once in the medicinal liquid, liquid sucking bag is tightened on the pipette by the screw socket or the injection head that directly will have a micropore because the difference of inside and outside atmospheric pressure sucks liquid in the blister cavities.

Specific embodiment two:

Liquid sucking bag adopts cylindrical structure.

Syringe of the present invention is not limited to the foregoing description, still comprises other all modification.

Claims

1. flexible aspirator that micropore is housed is used for accurately drawing and atomizing of liquids, comprises liquid sucking bag, a pipette and has the injection head of micropore, it is characterized in that:

(1) not before the imbitition, liquid sucking bag is in vacuum state, and pipette has seal nipple;

(2) open seal nipple, liquid enters in the aspirator by the pressure effect;

(3) injection head that has a micropore can be installed on the pipette.

2. flexible aspirator according to claim 1 is characterized in that, liquid is extruded in the liquid sucking bag pressurization that is filled liquid.

3. according to the described flexible aspirator of claim 1-2, it is characterized in that, can be used as device for storing liquid and be applied in by strong driving force such as spring, machinery or Compressed Gas and do on the power actuated needleless injector.

4. the liquid sucking bag in the flexible aspirator according to claim 1, it is characterized in that to select easy deformation for use and rubber, plastics or resin that material itself can not change owing to the pressure effect, preferred degradable environment friendly material, shape can be oval or circular, also can be other shapes.

5. pipette according to claim 1 is characterized in that the material of selecting for use has certain rigidity, and liquid deformation can not take place in the process of going out, and can select metal or nonmetallic materials for use, preferred degradable environment friendly material.

6. the injection head that has micropore according to claim 1 is characterized in that the micropore magnitude range is the 30-200 micron, preferred 50-100 micron.

7. the injection head that has micropore according to claim 1 can be directly to be buckled on the pipette, also can be threaded with pipette on screw thread close the rotation after screw on.

8. the injection head that has micropore according to claim 1, can have dimpling and go out contact component, material is selected from: Stainless Steel, Nitinol and similar biocompatible materials, when acting on experimenter's skin, described dimpling goes out not produce visual wound or hemorrhage.

9. dimpling according to claim 8 goes out contact component, it is characterized in that, it can be the microtubule with sharp-pointed outlet that the dimpling that dimpling goes out contact component goes out, also can be to have the microtubule that sharp-pointed outlet and sidewall have aperture, it also can be microtubule with sharp-pointed outlet and sidewall fluting, go out the quantity of microtubule according to the different dimpling of the different choice of injected dose, the density that dimpling goes out microtubule is 10～1000 every square centimeter; It is different according to different injection objects that dimpling goes out microtubule length, and for example to the infant injection, its length is given old adult's injection at 20～50 microns, and its length is given animal vaccine between 50～200 microns, and its length is between 100～1000 microns.

10. according to the described flexible aspirator that micropore is housed of claim 1-9, it is characterized in that, the liquid of drawing preferably has active chemical compound, it can be micromolecular compound, also can be macromolecule polyalcohol, such as: chemicals, growth hormone, insulin, polypeptide, protein, oligonucleotide, nucleic acid and polysaccharide etc.