CN102000397A - Tumor treatment new method based on laser-induced gold nanorods - Google Patents
Tumor treatment new method based on laser-induced gold nanorods Download PDFInfo
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- CN102000397A CN102000397A CN2010105064707A CN201010506470A CN102000397A CN 102000397 A CN102000397 A CN 102000397A CN 2010105064707 A CN2010105064707 A CN 2010105064707A CN 201010506470 A CN201010506470 A CN 201010506470A CN 102000397 A CN102000397 A CN 102000397A
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Abstract
The invention belongs to the technical field of nano-biomedicine. The existing tumor treatment method is difficult to treat all tumors due to the diversity of the tumors and the individual differences and has great toxicity and side effects, and the new method of the invention has the advantages of a wide range of applications and small toxicity and side effects. The new method comprises the following steps: utilizing solution of gold nanorods with the surface combined with cancer targeting molecules and surfactant, intravenously injecting the solution into a human body and leading the solution to participate in circulation in the human body; due to the specific combination of cancer cells and the targeting molecules on the surface of the gold nanorods, the gold nanorods can stay in the cancer cells or on the surface of the cancer cells, then a large number of the gold nanorods can be enriched in tumor tissues after a period of time (12-24h), at this time, near-infrared waveband laser with the selected wavelength is used for in vitro radiation of the tissues, and then the gold nanorods can strongly absorb incident laser energy, cause the temperature rise in the surrounding tissues and cause the death of the cancer cells when the temperature is higher than the temperature value (41 DEG C) which can be born by the cancer cells, thereby curing the tumors. As the gold nanorods in other tissues are not specifically combined with the targeting molecules, the gold nanorods can be successively excreted via urine and feces.
Description
Technical field
The present invention relates to a kind of oncotherapy new method based on the induced with laser gold nanorods, be used for the treatment of benign tumor and malignant tumor, can treat the tumor in epithelial tissue tumor and the part organ, range of application comprises: skin carcinoma, oral cancer, esophageal carcinoma, gastric cancer, intestinal cancer, breast carcinoma, cervical cancer etc.
Background technology
Cancer is one of high-risk disease that threatens the human life, is to cause human dead first cause, and its mortality rate is very high, presses for effective new method that cancer is cured in research.
Operation, X-ray therapy, chemotherapy and tcm therapy are several main therapies of always using at present.Operation is the most direct treatment method for cancer, adopts the direct tumor resection of operating method, since the size of tumor, reasons such as lesions position, and its limitation is very big, generally is used for the auxiliary treatment of early stage carcinoid treatment and some tumors; X-ray therapy is used gamma-rays, several rays is concentrated on blood vessel, lymphatic vessel and the connective tissue of tumor, cuts off the nutrition supply to tumor, makes the tumor atrophy, and this method side effect is big, and method is loaded down with trivial details, costs an arm and a leg; Chemotherapy adopts tumor chemotherapeutic drug, reach the effect that suppresses growth of tumour cell, kills tumor cell by suppressing tumor cell DNA, protein synthesis, cell division or directly destroying tumor cell, but also can produce certain lethal effect simultaneously to the vigorous cell of division in the health, tissue, as gastrointestinal tract mucous cell, hair follicle, bone marrow etc., very big to the human injury; Tcm therapy has certain curative effect, but varies with each individual, and is mostly to delay the state of an illness, and curative effect is not very good.
The present invention adopts laser technology, nanotechnology and biotechnology to combine, and is a kind of new Therapeutic Method.Gold nanorods has had very perfect chemical preparation process, and we have produced all kinds of gold nanorods, and not only draw ratio is controlled, and size can prepare for a short time of 5nm, and surface combination has cancer targeted molecular and surfactant, can preserve for a long time; 700nm also is a kind of mature technique to the laser of 900nm, can buy by market to obtain.Previous work in conjunction with us comprises test cell line, and experiment on mice, and monkey experiment illustrate that the present invention can realize.
Advantages such as the present invention has that can to treat the tumor kind many, and toxic and side effects is little, and treatment cycle is short, and is can be handling strong are one of effective ways of treatment of cancer.
Summary of the invention
The present invention is the treatment of cancer new method, is used to remedy the limitation of existing cancer treatment method.The present invention is that selected material is a gold nanorods, and its material is a gold, and surface combination has cancer targeted molecular and surfactant, and its diameter range is: 5nm～15nm, length and diameter ratio scope are 2.5-5.Selected light source is a near infrared band laser, its wave-length coverage be 700nm to 900nm, power is greater than 100 milliwatts.Selected temperature survey mode is a contactless temperature-measuring, as thermal infrared imager or Radiation Temperature Measurement Instrument etc.Therapeutic Method be laser at extracorporeal irradiation tumor tissues position because 700nm has good transmitance to the 900nm wave band of laser in tissue, thereby can reach in the tissue of certain depth.Because gold nanorods is to the intensive absorption of this wave band of laser, make incident laser energy change the heat energy of gold nanorods into, the gold nanorods temperature raises, be transmitted on every side in the tumor tissues, cause that the tumor tissues temperature raises, when temperature is increased to more than 42 ℃, causes death of neoplastic cells, thereby realize tumor treatment.Then, the gold nanorods in normal structure and the body fluid will go out externally along with urine and defecate, and after 72 hours, most of gold nanorods will be excreted to external.
Description of drawings
Fig. 1 is the gold nanorods sketch map that surface combination has cancer targeted molecular and surfactant;
Fig. 2 is the absorption spectrum and the TEM figure of gold nanorods;
Fig. 3 is cancer treatment procedure figure.
The specific embodiment
1. dispose gold nanorods solution, the ratio of solution and body weight is 10mg/kg, and perhaps the prescription according to the doctor carries out;
2. adopt intravenous injection in human body;
3. waiting for 12-24 hour, is gold nanorods enrichment in tumor tissues;
4. laser radiation, the temperature of tumor area will be increased to 42-55 ℃ during irradiation, and the persistent period is greater than half an hour, kill cancer cell;
5. the drainage phase, after injection 72 hours, the most of gold nanorods in the normal structure will go out external by urine and defecate.
6. excrete.
Claims (7)
1. based on the oncotherapy new method of induced with laser gold nanorods, it is characterized in that: the intravenous injection gold nanorods, after waiting for a period of time, adopt the laser irradiation tumor area, make temperature raise, thus kill tumor.
2. the oncotherapy new method based on the induced with laser gold nanorods according to claim 1, it is characterized in that the gold nanorods that adopted, its material is a gold, surface combination has cancer targeted molecular and surfactant, its diameter range is: 5nm～15nm, length and diameter ratio scope are 2.5-5, and its absorption spectrum ranges is 700-900nm.
3. the oncotherapy new method based on the induced with laser gold nanorods according to claim 1, it is characterized in that gold nanorods by intravenous injection in human body, participant's body-internal-circulation, under the effect of targeted molecular, gold nanorods finally arrives cancerous tissue and stops, through 12 to 24 hours body fluid circulation, gold nanorods enrichment in tumor tissues was got up.
4. the oncotherapy new method based on the induced with laser gold nanorods according to claim 1, it is characterized in that the selected irradiating laser wave-length coverage and the absorption spectra of gold nanorods are complementary, wave-length coverage is that 700nm is to 900nm, for the length of gold nanorods and the ratio of diameter is 2.5-5, and needed laser irradiation power is greater than 100 milliwatts.
5. the oncotherapy new method based on the induced with laser gold nanorods according to claim 1, it is characterized in that irradiating laser is at extracorporeal irradiation, because 700nm has good transmitance to the 900nm wave band of laser in tissue, thereby can reach in the tissue of certain depth.
6. the oncotherapy new method based on the induced with laser gold nanorods according to claim 1 is characterized in that the caused irradiation area temperature range of laser irradiation is elevated to 42-55 ℃, and temperature raises and adopts contactless radiation temperature measurement method.
7. the oncotherapy new method based on the induced with laser gold nanorods according to claim 1, after it is characterized in that gold nanorods is expelled in the body, gold nanorods in blood and the normal structure, will be through urine and feces, excrete successively, after 72 hours, most of gold nanorods will be excluded external.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105064707A CN102000397A (en) | 2010-10-14 | 2010-10-14 | Tumor treatment new method based on laser-induced gold nanorods |
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| CN2010105064707A CN102000397A (en) | 2010-10-14 | 2010-10-14 | Tumor treatment new method based on laser-induced gold nanorods |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813673A (en) * | 2012-08-02 | 2012-12-12 | 中国科学技术大学 | Use of gold nanorod in male contraception |
| WO2014153774A1 (en) * | 2013-03-29 | 2014-10-02 | Kuo Wen-Shuo | Method for killing and tracing bacteria by coating same with self-assembled gold nanoshell layer and producing photothermal decomposition and cold light by means of laser |
-
2010
- 2010-10-14 CN CN2010105064707A patent/CN102000397A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813673A (en) * | 2012-08-02 | 2012-12-12 | 中国科学技术大学 | Use of gold nanorod in male contraception |
| CN102813673B (en) * | 2012-08-02 | 2014-07-09 | 中国科学技术大学 | Use of gold nanorod in male contraception |
| WO2014153774A1 (en) * | 2013-03-29 | 2014-10-02 | Kuo Wen-Shuo | Method for killing and tracing bacteria by coating same with self-assembled gold nanoshell layer and producing photothermal decomposition and cold light by means of laser |
| CN105228698A (en) * | 2013-03-29 | 2016-01-06 | 郭文硕 | Utilize the gold nano shell coated bacteria of self assembly and kill and the method for following the trail of antibacterial by laser generation photothermal decomposition and cold light |
| US9381375B2 (en) | 2013-03-29 | 2016-07-05 | Wen-Shuo Kuo | Method for killing and tracing bacteria by coating same with self-assembled gold nanoshell layer and producing photothermal decomposition and cold light by means of laser |
| CN105228698B (en) * | 2013-03-29 | 2017-06-23 | 郭文硕 | Using the gold nano shell coated bacteria and the method that by laser produces photothermal decomposition and cold light to kill and follow the trail of bacterium of self assembly |
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Application publication date: 20110406 |