CN102000372A - Intelligent insulin pump system - Google Patents
Intelligent insulin pump system Download PDFInfo
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- CN102000372A CN102000372A CN201010579981.1A CN201010579981A CN102000372A CN 102000372 A CN102000372 A CN 102000372A CN 201010579981 A CN201010579981 A CN 201010579981A CN 102000372 A CN102000372 A CN 102000372A
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 298
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Abstract
The invention relates to an intelligent insulin pump system comprising an open-ring type insulin pump which is provided with an electric control unit, the electric control unit of the insulin pump is bidirectionally connected with an upper computer through a wireless module or a USB interface, insulin injecting management software is arranged in the upper computer which receives equipment information, setting information and insulin injection historical information from the insulin pump, and an insulin secretion curve model is generated by the insulin injecting management software and then is inputted to the electric control unit of the insulin pump to control the operation of the insulin pump. Because the insulin secretion curve model is automatically generated or manually established in the insulin injecting management software on the upper computer and is transmitted to the insulin pump by utilizing modules comprising Zigbee and the like in a wireless form or utilizing the USB interface in a wired form, the intelligent insulin pump system dispenses with the trouble of setting a large number of insulin outputting parameters in only several keys and LCD (Liquid Crystal Display) layering menus, thereby being convenient for the operation of users.
Description
Technical field
The present invention relates to the injection of insulin device,, be a kind of intelligent insulin pump systems at the open loop injection of insulin.
Background technology
Insulin pump is a kind of infusion of insulin system that is used for simulating human body pancreatic secretion insulin, its effect is that the simulation human body provides lasting basal insulin secretory volume, also can be in the dining prerequisite for heavy dose of insulin, the control postprandial hyperglycemia, basically reached the function of simulation pancreatic secretion insulin, make it near physiology insulin level round the clock, thereby make 24 hours glycemic control of diabetics a desirable level.
Present open loop insulin pump only comprises a pump housing, and the pump housing is mainly by forming with the lower part: pump main frame, medicine storage and the infusion pipeline that is attached thereto, and that infusion pipeline front end has a guide needle to penetrate is subcutaneous.The pump main frame mainly is made up of battery, MCU, control circuit, LCD demonstration, button and CD-ROM drive motor and speed adjusting gear, drive system etc.Its principle is: by the piston on MCU and the control circuit CD-ROM drive motor promotion medicine storage, the dosage according to setting injects insulin in the patient body by the infusion pipeline.The doctor must utilize several key switches of installing on the pump housing, demand by patient's reality is provided with different periods and dosage and other relevant parameter, and it is deposited in the memorizer, insulin injection amount is controlled by MCU, basis amount and heavy dose of before the meal can be set, so that the whole day glycemic control is in desirable level.But for the ease of carrying, the volume of insulin infusion pump is all little usually, be subjected to volume restrictions, the button that insulin pump is set is also little, and all be to be provided with by 4～6 buttons, this set method is an extremely complicated task to the doctor, and patient itself does not have ability to carry out the setting of relevant parameter at all, the setting up procedure of insulin pump has very strong professional, the volume of the pump housing own is very little, a few button cooperates the LCD hierarchical menu to operate complicated unusually on the narrow space, and very easily make mistakes, in case patient's diet and living habit change, will readjust insulin basal dose and setting such as dosage before the meal, repeat the setting up procedure of above-mentioned complexity again, this has also greatly limited using and promoting of insulin pump, also be that its price is high, usually can only be in hospital, a major reason of manipulating by the doctor.
Summary of the invention
The problem to be solved in the present invention is: the setting operation complexity of existing open loop insulin infusion pump especially concerning the patient, is difficult to operation.
Technical scheme of the present invention is: a kind of intelligent insulin pump systems, comprise the open loop type insulin pump, insulin pump is provided with ECU, the ECU of insulin pump and host computer are by wireless module or USB interface is two-way is connected, be provided with the injection of insulin management software in the described host computer, host computer receives the facility information that comes from insulin pump, configuration information, the infusion of insulin historical information, generate the insulin secretion curve model by the injection of insulin management software, described insulin secretion curve model is imported the ECU of insulin pump again, the work of control insulin pump.
Described injection of insulin management software comprises user management module, data access module, and the data show analysis module, insulin secretion curve MBM, infusion curve download module and data print module:
User management module is provided with user account and authority;
Data access module, the insulin pump information of obtaining is also preserved;
The data show analysis module, blood sugar measured in a period of time carried out curve and histogrammic demonstration, blood glucose value in the seclected time section is carried out statistical analysis, calculate maximum, minima, meansigma methods and variance, predict the fluctuation tendency in its following a period of time;
Insulin secretion curve MBM, according to doctor's experience, the blood glucose level data that the patient surveyed in a period of time, sex, age, height, body weight, rule of life, dietary structure and moving situation in conjunction with the patient, set up the relational model between required injection of insulin dosage of patient and patient's the blood glucose fluctuation level, comprise foundation rate modeling, heavy dose of modeling before the meal, interim foundation rate modeling and interim heavy dose of modeling, relational model adopts matched curve to generate or manually be provided with generation automatically;
Infusion curve download module, the insulin secretion curve model that insulin secretion curve MBM is generated downloads in the insulin pump housing;
The data print module is with the data printout of injection of insulin management software.
The ECU of insulin pump comprises the MCU chip, LCD, key-press module, real-time clock RTC, memory element, USB interface, wireless module, motor drive module, motor, power module and lithium battery module, LCD, key-press module, real-time clock RTC, memory element, USB interface, wireless module, motor drive module connects MCU respectively, motor-driven outfan connects motor, motor is provided with photoswitch and photoelectric coded disk, whether the monitoring motor operational failure occurs, if break down, then the information transmission is reported to the police in MCU, the lithium battery module is supplied with MCU and motor by power module after with the voltage voltage stabilizing, and the lithium battery module connects external charging equipment by USB interface; Carry out the setting of infusion of insulin dosage by key-press module operation and the demonstration of LCD.
Wireless module comprises IrDA, Bluetooth and Zigbee module.
The present invention has the following advantages:
One, whole insulin pump systems is made up of intelligent insulin pump and host computer and infusion of insulin management software thereof, can connect with wired form by USB interface between insulin pump and the host computer, also can connect with wireless, be used for bi-directional transfer of data between insulin pump and host computer by modules such as Zigbee;
Two, can cooperate the display menu of LCD to carry out the relevant setting of required infusion of insulin dosage diabetics every day by button operation to insulin pump, comprise a day infusion total amount, corresponding basis amount and foundation rate in the segmented mode of 24 hours every days and every section, heavy dose of before the meal, the setting of interim foundation rate and interim dosage, but this set operation is extremely complicated, and have very strong professional, the present invention can generate or the manual insulin secretion curve model of setting up in the infusion of insulin management software on host computer automatically, comprise foundation rate secretion model, heavy dose of before the meal model, interim foundation rate model and heavy dose of model, utilize modules such as Zigbee to be transferred in the insulin pump with wired form with wireless or USB interface, save and in only several buttons and LCD stratification menu, carried out the trouble that a large amount of insulin output parameters are provided with, made things convenient for doctor and patient's operation;
Three, the historical infusion information of insulin pump users and relative parameters setting also can be transferred in the host computer by USB interface or wireless module, for the analysis of host computer infusion of insulin management software, demonstration, file, review, retrieval etc., both can be used for providing reference for following infusion of insulin conceptual design, also can provide objective basis for doctor-patient dispute in the future, host computer is compared insulin pump and is had better storage and data analysis performance;
Four, host computer can read the blood sugar test historical information of storing in the special-purpose blood glucose meter that has USB interface or wireless module, the blood glucose level data that the patient was detected in a period of time is analyzed and is shown, and, also can be used for simultaneously in assess patient a period of time by insulin pump treatment back Blood glucose control situation with the reference data of these data as the modelling of patient's insulin secretion.
Description of drawings
Fig. 1 is the present invention's intelligence insulin pump systems block diagram.
Fig. 2 is the present invention's intelligence insulin pump body portion The general frame.
Fig. 3 divides block diagram for the present invention's intelligence insulin pump housing electric control part.
Fig. 4 is the software operation flow process of insulin pump of the present invention.
Fig. 5 is a host computer infusion of insulin management software functional block diagram of the present invention.
The specific embodiment
As Fig. 1, the present invention includes the open loop type insulin pump, insulin pump is provided with ECU, the ECU of insulin pump and host computer are by wireless module or USB interface is two-way is connected, be provided with the injection of insulin management software in the described host computer, host computer receives facility information, configuration information, the infusion of insulin historical information that comes from insulin pump, generate the insulin secretion curve model by the injection of insulin management software, described insulin secretion curve model is imported the ECU of insulin pump again, the work of control insulin pump.
Whole system is divided into the pump housing and two parts of host computer, pump housing part can be finished the infusion of insulin task of every day, by button and LCD layering display menu on the operation pump housing infusion parameters can be set, as time, date, dosage etc., by drive motors and infusion pipeline the insulin in the liquid storage cylinder is injected in the human body then.Parameters such as infusion of insulin dosage also can be set on the host computer, and can realize the infusion management, as analysis, demonstration, file, review, retrieval etc. by software.The host computer and the pump housing can as modules such as IrDA, Bluetooth, Zigbee, communicate by wired USB interface or wireless module, realize the two-way exchange of data.
Fig. 2 is intelligent insulin pump body portion The general frame, native system pump housing part mainly is to rotate by the ECU drive motors, the rotation of driven by motor reducing gear, reducing gear promotes moving drive mechanism (feed screw nut and piston) insulin in the liquid storage cylinder is imported in the infusion pipeline, is expelled in the human body stomach wall by remaining needle at last.In the ECU drive motors, be contained in photoswitch on the motor and coding disk and also can feed back fault message and give ECU, such as the motor stall or lose the step etc.
Fig. 3 is that intelligent insulin pump housing electric control part is divided block diagram, and this part is the control centre of whole system, can allocate the work of various piece.What supply module used is rechargeable lithium battary, can charge to it by USB interface.Lithium battery is supplied with MCU and motor module by power module after with the supply voltage voltage stabilizing.Sample among the MCU by the charge value of battery electric quantity monitoring modular, the low pressure alarming threshold value is set in advance, real-time battery electric quantity and low pressure alarming information are passed to user by dot matrix LCD display and buzzer with lithium battery.MCU control motor drive module makes motor rotate according to the pattern of setting, thereby insulin liquor is injected into human body quantitatively.Photoswitch and photoelectric coded disk are housed on the motor, can be used for monitoring motor and operational failure whether occur, if when breaking down, then information is sent among the MCU, MCU control buzzer sends the alarm sound of corresponding manner.Native system can be set some parameters by key-press module and LCD screen, and as time, date, alarm clock and dosage, dosage comprises basis amount, heavy dose of and interim dosage etc. before the meal, and can look back injection information in the past.Can control insulin injection and conduit be carried out operation such as aerofluxus by button.MCU can store former injection information in the memory element, both among the interior Flash of sheet.MCU can communicate with host computer by USB interface or wireless module, also can realize operations such as infusion parameters setting, the review of historical infusion information by host computer, and can further realize the infusion management.
Fig. 4 is the software operation flow process of insulin pump, and this flow process is equivalent to the actions menu of system.Whole system is divided into two menu hierarchy, is a menu hierarchy after powering on, and needs real-time clock information such as setting-up time date, can select factory reset.Enter another menu hierarchy afterwards, promptly normal main menu system, this is a multiwalled menu structure, wherein first order menu is divided into clock, dosage, powder charge, four options of review.The second-level menu of clock option is divided into day settings and two options of time set, is used for the date and time of initialization system respectively.That the second-level menu of dose options is divided into before the meal is heavy dose of, basis amount and interim heavy dose of three options: after entering heavy dose of before the meal option, can set the meal time and need the insulin dose of infusion before the meal; After entering basis amount option, can set one day 24 hours segmented mode, configure segments after, further set every section piecemeal in the accumulated dose and the infusion foundation rate of required infusion; After entering interim heavy dose of option, can be according to being dosage and the infusion foundation rate that the required input of interim heavy dose of input pattern is determined in motion or feed.The second-level menu of powder charge option is divided into reset motor and two options of aerofluxus, and reset motor is the motor playback operation of carrying out when insulin liquor uses up in liquid storage cylinder, and purpose is for new liquid storage cylinder is installed; Aerofluxus is the operation of carrying out behind the liquid storage cylinder changing, and purpose is that the air in the whole medicinal liquid pipeline is drained only.The second-level menu of looking back option is divided into a day TDI review, the heavy dose of review of breakfast, lunch and dinner, interim dosage is looked back and the review of aerofluxus number of times, can help doctor and patient in time to understand the record of infusion of insulin dosage in a period of time, in conjunction with the Blood glucose control situation, so that instruct patient's formulation of infusion scheme in the future.
The present invention generates the insulin secretion curve model and downloads the infusion of insulin model in the insulin pump housing by wireless module or USB interface, then by the piston on MCU and the control circuit CD-ROM drive motor promotion medicine storage, according to the infusion of insulin dosage that configures, insulin secretion curve model just, by the infusion pipeline insulin is injected in the patient body, so that patient's whole day glycemic control is a desirable level., running down of battery, empty needle intact when the insulin liquor infusion or come off, pipeline is obstructed and triggers the warning function of insulin pump when phenomenon takes place immediately.
Fig. 5 is a host computer infusion of insulin management software functional block diagram, it has described task that host computer infusion of insulin management software can finish and mutual logical relation thereof, patient's infusion of insulin parameter can be set in host computer like a cork, and can select to be sent among the MCU of insulin pump by USB interface or wireless module, save like this on the pump housing and the loaded down with trivial details and inconvenient of infusion of insulin parameter has been set with button, make that the setting up procedure of parameter is directly perceived, convenient, efficient and be difficult for makeing mistakes, be very easy to the setting of doctor to relevant parameters such as the required infusion of insulin dosage of patient, even patient oneself also can the training of specialty with instruct after relevant infusion of insulin parameter is set voluntarily, make the patient use insulin pump no longer to be confined to the scope of hospital, or the setting of sending for a doctor to injection of insulin of frequent district hospital is adjusted, the infusion of insulin management software mainly comprises following six parts, it is respectively user management module, data access module, the data show analysis module, insulin secretion curve MBM, infusion curve download module and data print module:
User management module is provided with user account and authority; In order to increase the safety of infusion of insulin, be provided with subscriber management function in the software, the user is divided into doctor user and patient user's two classes, two class users have number of the account separately respectively and authority are set, the doctor is provided with the authority that is provided with that authority is higher than the patient, generally, the doctor can have the bigger scope that is provided with to relevant dosimetry parameter;
Data access module, the insulin pump information of obtaining is also preserved; Utilize USB interface or wireless module that the information of insulin injection of preserving in the blood glucose measurement information of preserving in the special-purpose blood glucose meter or the pump housing is read in the upper computer software, the blood sugar measured or infusion of insulin dose value in a period of time can also be saved as file.
The data show analysis module, blood sugar measured in a period of time carried out curve and histogrammic demonstration, blood glucose value in the seclected time section is carried out statistical analysis, calculate maximum, minima, meansigma methods and variance, predict the fluctuation tendency in its following a period of time; Can carry out the demonstration of forms such as curve and rectangular histogram to the insulin dose of historical infusion, review history infusion information is carried out relevant statistical analysis;
Insulin secretion curve MBM, according to doctor's experience, the blood glucose level data that the patient surveyed in a period of time, sex, age, height, body weight, rule of life, dietary structure and moving situation in conjunction with the patient, set up the relational model between required injection of insulin dosage of patient and patient's the blood glucose fluctuation level, comprise foundation rate modeling, heavy dose of modeling before the meal, interim foundation rate modeling and interim heavy dose of modeling, relational model adopts matched curve to generate or manually be provided with generation automatically; Can regulate the needed insulin dose of patient intelligently, can control patient's blood glucose at any time, flexible and convenient has deducted the trouble that much is provided with;
Infusion curve download module, the insulin secretion curve model that insulin secretion curve MBM is generated downloads in the insulin pump housing, make insulin pump according to the infusion model work that configures, the infusion of insulin model can be selected the usb data transmission mode for use or transmit with wireless module.When if current infusion of insulin model does not satisfy the glycemic control target of diabetics, perhaps diabetics has changed dietary habit, dietary and dietary structure, when perhaps having changed the working law and the characteristics of motion, can in the infusion of insulin management software of host computer, regenerate the infusion of insulin model that is complementary with new diet of patient and mechanics, lay equal stress on newly downloaded new model in the insulin pump housing, so that insulin pump carries out work according to new infusion of insulin model.The whole operation process is simple, efficient, has save numerous and diverse property of constantly carrying out button and menu conversion operations on the insulin pump housing, saved a large amount of operating times, and whole process is difficult for makeing mistakes.
The data print module with the data printout of injection of insulin management software, as blood glucose information and the printout of infusion of insulin historical information that blood glucose meter is recorded, offers a complete historical blood sugar test of diabetics and insulin pump treatment report.
Claims (5)
1. intelligent insulin pump systems, comprise the open loop type insulin pump, it is characterized in that insulin pump is provided with ECU, the ECU of insulin pump and host computer are by wireless module or USB interface is two-way is connected, be provided with the injection of insulin management software in the described host computer, host computer receives facility information, configuration information, the infusion of insulin historical information that comes from insulin pump, generate the insulin secretion curve model by the injection of insulin management software, described insulin secretion curve model is imported the ECU of insulin pump again, the work of control insulin pump.
2. a kind of intelligent insulin pump systems according to claim 1, it is characterized in that described injection of insulin management software comprises user management module, data access module, data show analysis module, insulin secretion curve MBM, infusion curve download module and data print module:
User management module is provided with user account and authority;
Data access module, the insulin pump information of obtaining is also preserved;
The data show analysis module, blood sugar measured in a period of time carried out curve and histogrammic demonstration, blood glucose value in the seclected time section is carried out statistical analysis, calculate maximum, minima, meansigma methods and variance, predict the fluctuation tendency in its following a period of time;
Insulin secretion curve MBM.According to doctor's experience, the blood glucose level data that the patient surveyed in a period of time, sex, age, height, body weight, rule of life, dietary structure and moving situation in conjunction with the patient, set up the relational model between required injection of insulin dosage of patient and patient's the blood glucose fluctuation level, comprise foundation rate modeling, heavy dose of modeling before the meal, interim foundation rate modeling and interim heavy dose of modeling, relational model adopts matched curve to generate or manually be provided with generation automatically;
Infusion curve download module, the insulin secretion curve model that insulin secretion curve MBM is generated downloads in the insulin pump housing;
The data print module is with the data printout of injection of insulin management software.
3. a kind of intelligent insulin pump systems according to claim 1 and 2, the ECU that it is characterized in that insulin pump comprises the MCU chip, LCD, key-press module, real-time clock RTC, memory element, USB interface, wireless module, motor drive module, motor, power module and lithium battery module, LCD, key-press module, real-time clock RTC, memory element, USB interface, wireless module, motor drive module connects MCU respectively, motor-driven outfan connects motor, motor is provided with photoswitch and photoelectric coded disk, whether the monitoring motor operational failure occurs, if break down, then the information transmission is reported to the police in MCU, the lithium battery module is supplied with MCU and motor by power module after with the voltage voltage stabilizing, and the lithium battery module connects external charging equipment by USB interface; Carry out the setting of infusion of insulin dosage by key-press module operation and the demonstration of LCD.
4. a kind of intelligent insulin pump systems according to claim 1 and 2 is characterized in that wireless module comprises IrDA, Bluetooth and Zigbee module.
5. a kind of intelligent insulin pump systems according to claim 3 is characterized in that wireless module comprises IrDA, Bluetooth and Zigbee module.
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| CN201010579981.1A CN102000372A (en) | 2010-12-09 | 2010-12-09 | Intelligent insulin pump system |
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| CN201010579981.1A CN102000372A (en) | 2010-12-09 | 2010-12-09 | Intelligent insulin pump system |
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| CN102580182A (en) * | 2012-03-06 | 2012-07-18 | 南京大学 | Insulin infusion treatment system based on Zigbee technology |
| CN102836481A (en) * | 2012-09-29 | 2012-12-26 | 哈尔滨工业大学 | Novel insulin pump |
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| CN111261256A (en) * | 2020-01-19 | 2020-06-09 | 湖南盈赛缇思人工智能公共数据平台有限公司 | Insulin administration method, storage medium and system based on big data |
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