CN102000159B - Composition with effect of treating gout - Google Patents
Composition with effect of treating gout Download PDFInfo
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- CN102000159B CN102000159B CN201010546590A CN201010546590A CN102000159B CN 102000159 B CN102000159 B CN 102000159B CN 201010546590 A CN201010546590 A CN 201010546590A CN 201010546590 A CN201010546590 A CN 201010546590A CN 102000159 B CN102000159 B CN 102000159B
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Abstract
The invention relates to a composition with effect of treating gout. The composition is characterized by consisting of the following ingredients in percentage by weight: 20 to 30 percent of codonopsis alpina, 20 to 30 percent of tinospora sinensis merr, 12 to 20 percent of costustoot, 12 to 20 percent of nardostachyos root and rhizome and 12 to 20 percent of northern corydalis bungeana. The composition of the invention has the effects of clearing heat and releasing toxin, eliminating swelling and stopping pain, and dispelling wind and removing dampness. The composition is mainly used for treating gout. The composition overcomes the defects that the symptoms can be cured, the root cause cannot be cured, the medicament has high toxicity, the disease is susceptible to relapse after treatment, and the total effect of the treatment is not good enough in the conventional treating method.
Description
Technical field
The present invention relates to a kind of Chinese prescription, be specifically related to a kind of compositions with treatment gout function.
Background technology
Gout is a kind of commonly encountered diseases, have uric acid too much more than people's twenty percent of China more than 30 years old, and hyperlithic people's percentage five to 1 12 develops into gout.The human appearance arranged on earth, just have gout to exist.
The gout main clinical characteristics is that gouty arthritis, gouty nephropathy, tophus and renal calculus form, and normal obesity, hypertension, hyperlipemia, diabetes, arteriosclerosis, coronary heart disease, the cerebrovascular disease etc. of merging.In the acute arthritis phase, uric acid is deposited in the joint tissue, and urate is engulfed by leukocyte, causes cell death and discharges lysosomal enzymes, causes acute arthritis disease.The chronic arthritis phase, urate around cartilage surface, synovial bursa, fascia surface and subcutaneous connective tissue etc. locate the formation of deposits tophus, cause chronic inflammatory disease, synovial bursa thickens, pannus forms, the cartilage degeneration, bone erosion and damaged, especially with the marrow osseous part for seeing more.Fibrosis around the bone edge hypertrophy, joint, so that osteoarthrosis deformity.Urate deposition causes that in renal tubules the atrophy of Henle loop changes, and the tube chamber expansion has the giant cell inflammatory reaction near the stroma, corresponding glomerule fibrosis, and capillary basement membrane thickens, and is the most obvious with medullary substance and cone portion.In a word, suffer from after the gout, sugar and fatty metabolic function can obviously reduce, and therefore easy concurrent various serious diseases are brought misery even life danger to the patient.
The medicine of present international and domestic treatment goat is many, but is Western medicine mostly, can only take stopgap measures, and can not effect a permanent cure, and the toxicity of medicine is big, the easily recurrence of treatment back, and the general effect of treatment is not good enough.Tibet is one of district occurred frequently of goat, the Tibetan medicine is with its unique theoretical system, in secular application practice, summed up the better medicine of treatment goat---the how lucky soup of sieve heap, improve after further research, the clinical practice proving effect is apparent in view, can accomplish treating both the principal and secondary aspects of a disease, reduce relapse rate greatly, alleviate patient's misery.
Summary of the invention
The object of the present invention is to provide a kind of compositions with treatment gout, solved in the prior treatment method and can only take stopgap measures, can not effect a permanent cure, the toxicity of medicine is big, the easily recurrence of treatment back, the shortcoming that the general effect of treatment is not good enough.
For achieving the above object, the technical solution adopted in the present invention is: by weight percentage said composition by: the Radix Aucklandiae of the high mountain Radix Codonopsis of 20-30%, the Herba Lycopodii of 20-30%, 12-20%, the Radix Et Rhizoma Nardostachyos of 12-20% and the Corydalis impatiens (Pall.) Fisch. of 12-20% are formed.
Compositions of the present invention has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling wind and removing dampness.Be mainly used in the treatment of goat.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.
Embodiment 1: said composition is made up of: 25% high mountain Radix Codonopsis, 25% Herba Lycopodii, 16.7% the Radix Aucklandiae, 16.7% Radix Et Rhizoma Nardostachyos and 16.6% Corydalis impatiens (Pall.) Fisch. by weight percentage.
Embodiment 2: said composition is made up of: 20% high mountain Radix Codonopsis, 30% Herba Lycopodii, 12% the Radix Aucklandiae, 20% Radix Et Rhizoma Nardostachyos and 18% Corydalis impatiens (Pall.) Fisch. by weight percentage.
Embodiment 3: said composition is made up of: 30% high mountain Radix Codonopsis, 20% Herba Lycopodii, 20% the Radix Aucklandiae, 18% Radix Et Rhizoma Nardostachyos and 12% Corydalis impatiens (Pall.) Fisch. by weight percentage.
Embodiment 4: said composition is made up of: 22% high mountain Radix Codonopsis, 28% Herba Lycopodii, 15% the Radix Aucklandiae, 15% Radix Et Rhizoma Nardostachyos and 20% Corydalis impatiens (Pall.) Fisch. by weight percentage.
Embodiment 5: said composition is made up of: 28% high mountain Radix Codonopsis, 24% Herba Lycopodii, 17% the Radix Aucklandiae, 12% Radix Et Rhizoma Nardostachyos and 19% Corydalis impatiens (Pall.) Fisch. by weight percentage.
One, function and the function of each raw material in compositions cures mainly
According to ancient prescription " five tastes sieve heap is how lucky " is main, is that important evidence employing modern science pharmaceutical technology is elaborated a kind of sick pure Tibetan medicine that ventilates for the treatment of that forms with the Tibetan medicine and pharmacology monumental work Four-Volume Medical Code, " ten million Buddhist relics " etc.
In the side function of high mountain Radix Codonopsis with cure mainly into: bitter, hot, puckery, cold.Yellow fluid reducing, detumescence.Cure mainly rheumatic arthritis, furuncle is swollen bitterly, leprosy.
In the side function of Radix Aucklandiae (Radix Vladimiriae) with cure mainly into: hot, bitter, temperature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Stomach warming, circulation of qi promoting, pain relieving, broken painful abdominal mass knot, granulation promoting.Cure mainly flatulence pain, " dragon is sick ", disorders of blood, diphtheria, pneumonopathy, " Baconic " is poly-to stagnate, diarrhea of heat type, the open sore part is not held back etc.
In the side function of Radix Et Rhizoma Nardostachyos with cure mainly into: hot, sweet, temperature.Return spleen, stomach warp.Heat-clearing and toxic substances removing, the cold relieving detumescence.Control pestilence disease, for a long time heat symptom-complex.
The function of Corydalis impatiens (Pall.) Fisch. is hardship, cold with curing mainly in the side.Heat-clearing and toxic substances removing, anti-inflammatory analgetic.Cure mainly the xerostomia that heat in blood causes, giddy, back pain, liver, gallbladder-heat disease, granulation promoting is wound more, the furuncle carbuncle.
In the side function of Herba Lycopodii with cure mainly into: sweet, bitter, puckery, cold.Heat clearing away is dispeled the wind.Cure mainly wind heat and do not conform to disease, heat symptom-complex due to " dragon ", " red crust ", " Baconic " three polymerization.To deficiency-heat and control goat good effect is arranged.
According to the Tibetan medicine and pharmacology theory, the present invention is that to close the cold both sexes disease of heat, Repercusion analgesia, the expelling wind and removing dampness that disease causes be monarch for blood circulation promoting and blood stasis dispelling, mediation " ' dragon ', ' red crust ', ' Baconic ' " three with high mountain Radix Codonopsis, Herba Lycopodii; With the Radix Aucklandiae (Radix Vladimiriae) is minister, strengthens the effect of blood circulation promoting and blood stasis dispelling, dredging collateral to stop pain; With the Corydalis impatiens (Pall.) Fisch. is assistant, and principal drug assistance is with expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, Repercusion analgesia; For making, the channels sootheing and network vessel quickening guide drugs works with Radix Et Rhizoma Nardostachyos.
To sum up state; It is that prescription of the present invention meets the Tibetan medicine and pharmacology theory that five tastes sieve is piled many Jis, and particularly proof five tastes sieve is piled many Jis and had the airy effect of significant treatment in the middle of secular clinical practice.Five tastes sieve is piled many Jis and can effectively be treated the ventilation disease and can curative effect preferably be arranged to rheumatism again.
Two, toxicity test
According to the specification requirement of new Chinese medicine toxicologic study, experimental study the acute toxicity of the how lucky preparation of sieve heap.The result shows, after the administration of the how lucky preparation mouse stomach of sieve heap, does not find obvious acute toxicity, and mice maximum dosage-feeding on the one is 130.4g crude drug/kg, is equivalent to clinical adult and intends 136 times of consumptions every day.
According to the clinical course of treatment of the how lucky preparation of sieve heap, according to the specification requirement of new Chinese medicine toxicologic study, this experimental study sieve pile how lucky granule to 6 months of rat (clinical course of treatment 6 times) long term toxicities.The result shows, with large, medium and small three dosage of the how lucky preparation of sieve heap (16,32,64g crude drug/kg, 20,40,80 times of consumption are equivalent to respectively to be grown up) give rat continuous irrigation stomach six months, general situation, hematology, blood biochemical, routine urinalysis, electrocardiogram, system's dissection, organ coefficient and histopathology to rat do not have obvious influence, do not find the overt toxicity reaction, convalescent period does not also have the retardance toxic reaction, and it is 64g crude drug/kg/ day that rat non-toxic reaction dosage is provided.But long-term heavy dose of medication notes the influence possible to female body weight, white blood count and differential and hepatic and renal function.
By toxicological test research, prove that the how lucky preparation of sieve heap do not find obvious acute toxicity, long term toxicity test proves drug safety, avirulence.
Three, pharmacodynamics confirmatory experiment
Sieve heap how lucky preparation has been carried out analgesia, antiinflammatory, the influence of rat hyperuricemia model and urate nephropathy etc. has been cured mainly relevant Pharmacodynamic test of active extract research with function.The result is as follows:
1, the how lucky preparation of sieve heap presses 9.71,19.42,38.86g crude drug/kg is to the mouse stomach administration, improve the threshold of pain of mice thermostimulation, compare with negative control group, 60min and 120min have significant difference (P＜0.05 or P＜0.01) after the middle dosage group administration, 30min, 60min and 120min have significant difference (P＜0.05 or P＜0.01) after the administration of heavy dose of group, and the pain that the how lucky granule of prompting sieve heap causes the mice thermostimulation has stronger analgesic activity; Obviously suppress the mouse writhing reaction that acetic acid stimulates, with negative control group relatively, in, heavy dose of group has significant difference (P＜0.01), the pain of the how lucky granule Dichlorodiphenyl Acetate stimulation of prompting sieve heap also has stronger analgesic activity.
2, the how lucky preparation of sieve heap presses 9.71,19.42,38.86g crude drug/kg is to the mouse stomach administration, suppress the acute exudative inflammation reaction that dimethylbenzene stimulates mice ear to bring out, the swelling degree is reduced, compare with negative control group, in, heavy dose of group has significant difference (P＜0.05), the how lucky granule of prompting sieve heap has the effect of anti-chmice acute exudative inflammation.The how lucky granule of sieve heap presses 6.79,13.58,27.16g crude drug/kg is to the rat oral gavage administration, the generation and the development of the rat acute inflammation that inhibition micro-crystal type uric acid sodium brings out, compare with negative control group, 30min, 2h have significant difference (P＜0.01) after the middle dosage group administration, 30min, 1h, 2h have significant difference (P＜0.05 or P＜0.01) after the administration of heavy dose of group, the rat acute exudative inflammation effect that the how lucky granule of prompting sieve heap has anti-micro-crystal type uric acid sodium to bring out.The how lucky granule of sieve heap by 3.62,7.24,14.48g crude drug/kg is to the rabbit gastric infusion, reduces leukocytic quantity in the gouty arthritis rabbit arthroedema, with model control group relatively, in, the heavy dose of group have significant difference (P＜0.05); The inflammation that alleviates gouty arthritis model rabbit synovium of joint changes, and the how lucky granule of prompting sieve heap has antiinflammatory action to the rabbit gouty arthritis.
3, the how lucky preparation of sieve heap presses 6.79,13.58,27.16g crude drug/kg is to the rat oral gavage administration, obviously reduce uric acid level in hyperuricemia and the urate nephropathy rat model blood, compare with model control group, each dosage group all has significant difference (P＜0.05 or P＜0.01); Slight reduce creatinine level in the blood, with model control group relatively, in, heavy dose of group has significant difference (P＜0.05); Slight reduction blood urea nitrogen level, but statistics there was no significant difference (P＞0.05); Protein in the blood is not had obvious influence, but can reduce T-CHOL and triglyceride in the blood.Common pathology inspection shows that the how lucky granule of sieve heap can reduce the deposition of hyperuricemia and urate nephropathy rat model kidney urate crystal, and the acute injury sexually transmitted disease (STD) that alleviates urate nephropathy becomes.The how lucky granule of results suggest sieve heap has uric acid in the blood of reduction, alleviates urate crystal and deposit at kidney hyperuricemia and urate nephropathy rat model, alleviate urate nephropathy the change of acute injury sexually transmitted disease (STD), improve the effect of renal function.
By the pharmacodynamics test research of novel formulation, prove that the how lucky preparation of sieve heap has analgesia, antiinflammatory action and uric acid reducing effect, has therapeutical effect to goat.Influence of rat hyperuricemia model and urate nephropathy etc. is cured mainly the effectiveness that relevant test has also illustrated preparation with function.
Claims (6)
1. compositions with treatment gout effect is characterized in that: by weight percentage said composition by: the Radix Aucklandiae of the high mountain Radix Codonopsis of 20-30%, the Herba Lycopodii of 20-30%, 12-20%, the Radix Et Rhizoma Nardostachyos of 12-20% and the Corydalis impatiens (Pall.) Fisch. of 12-20% are formed.
2. the compositions with treatment gout effect according to claim 1 is characterized in that: said composition is made up of: 25% high mountain Radix Codonopsis, 25% Herba Lycopodii, 16.7% the Radix Aucklandiae, 16.7% Radix Et Rhizoma Nardostachyos and 16.6% Corydalis impatiens (Pall.) Fisch. by weight percentage.
3. the compositions with treatment gout effect according to claim 1 is characterized in that: said composition is made up of: 20% high mountain Radix Codonopsis, 30% Herba Lycopodii, 12% the Radix Aucklandiae, 20% Radix Et Rhizoma Nardostachyos and 18% Corydalis impatiens (Pall.) Fisch. by weight percentage.
4. the compositions with treatment gout effect according to claim 1 is characterized in that: said composition is made up of: 30% high mountain Radix Codonopsis, 20% Herba Lycopodii, 20% the Radix Aucklandiae, 18% Radix Et Rhizoma Nardostachyos and 12% Corydalis impatiens (Pall.) Fisch. by weight percentage.
5. the compositions with treatment gout effect according to claim 1 is characterized in that: said composition is made up of: 22% high mountain Radix Codonopsis, 28% Herba Lycopodii, 15% the Radix Aucklandiae, 15% Radix Et Rhizoma Nardostachyos and 20% Corydalis impatiens (Pall.) Fisch. by weight percentage.
6. the compositions with treatment gout effect according to claim 1 is characterized in that: said composition is made up of: 28% high mountain Radix Codonopsis, 24% Herba Lycopodii, 17% the Radix Aucklandiae, 12% Radix Et Rhizoma Nardostachyos and 19% Corydalis impatiens (Pall.) Fisch. by weight percentage.
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| CN201010546590A CN102000159B (en) | 2010-11-17 | 2010-11-17 | Composition with effect of treating gout |
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| CN201010546590A CN102000159B (en) | 2010-11-17 | 2010-11-17 | Composition with effect of treating gout |
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| CN102000159A CN102000159A (en) | 2011-04-06 |
| CN102000159B true CN102000159B (en) | 2011-12-14 |
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| CN104771442B (en) * | 2015-02-15 | 2019-04-30 | 广西卫生职业技术学院 | A kind of Herba Lycopodii extract and its extracting method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106291A (en) * | 1994-02-04 | 1995-08-09 | 白玛加措 | Tibetan drug and its prepn. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106291A (en) * | 1994-02-04 | 1995-08-09 | 白玛加措 | Tibetan drug and its prepn. |
Non-Patent Citations (3)
| Title |
|---|
| 刘忠等.藏药七味罗堆多吉颗粒剂对大鼠高尿酸血症和尿酸性肾病的影响.《江苏中医药》.2009,第41卷(第01期),72-73. * |
| 刘忠等.藏药七味罗堆多吉颗粒剂镇痛、抗炎作用的实验研究.《江苏中医药》.2009,第41卷(第08期),74-76. * |
| 王聚乐等.藏药七味罗堆多吉颗粒剂工艺研究.《西藏大学学报(汉文版)》.2007,第22卷(第03期),115-117. * |
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