CN101991760A - Chinese patent medicine for treating climacteric syndrome and preparation method thereof - Google Patents
Chinese patent medicine for treating climacteric syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese patent medicine for treating climacteric syndrome and a preparation method thereof. The Chinese patent medicine is a pure traditional Chinese medicine capsule preparation, does not have any chemical pharmaceutical ingredient and any toxic or side effect, has the advantages of convenient use, short course of treatment, rapid effect taking and stable curative effect and is a first-choice Chinese patent medicine for treating climacteric syndrome. The Chinese patent medicine is prepared from the Chinese medicinal herbs of epimedium herbs, oyster, rhizoma anemarrhenae, cherokee rose fruits, golden cypress, plantain seeds, ginseng, mulberry, Chinese angelica, walnut kernels, pilos antler, malaytea scurfpea fruits, teasel roots, vine of multiflower knotweed, white paeony roots, fleece-flower roots (prepared), bidentate achyranthes roots, licorice roots, prepared rehmannia roots and the like as raw materials by combining traditional and modern Chinese medicine theories through optimized combination and scientific compatibility. The capsule dosage for treating climacteric syndrome is prepared by using the advanced modern Chinese medicine preparation technology through raw material pretreatment, water extraction, alcohol precipitation, concentration, granulation, capsule packing, inspection, identification and the like. The capsule has the functions of nourishing the heart and the kidney, regulating and supplementing Chong and Ren Channels and is used for treating climacteric syndrome comprising insomnia, palpitation, tinnitus, suspiciousness, sentimentalism, sweating, dysphoria, irritability, backache and the like occurring before and after menopause, and has obvious effect of alleviating intractable pain of patients with climacteric syndrome.
Description
Technical field
The present invention relates to a kind of Chinese Traditional Medicines for the treatment of climacteric syndrome and preparation method thereof.
Background technology
People in middle age, physiological function begins to change.Especially middle aged women closed on before and after menopause, the alleged menopause syndrome of medical science will occur.Usually show as neurasthenia, uneasy sleeping at night, insomnia and dreamful sleep, cardiopalmus tinnitus, unstable blood pressure, suspicious sentimental, being happy and angry uncertainly, warm sweating, dysphoria, easily fly into a rage, aching pain in waist and back, the whole body is uncomfortable and even various symptoms performances such as anorexia, depression, hallucination occur, these are commonly referred to as climacteric syndrome.It not only has a strong impact on patient's quality of life, and also infringement is physically and mentally healthy greatly, even produces adverse consequences.To this, the opinion patient who has takes automatic control measure, and " peaceful transition " worries along this difficult " climacteric ", and its symptom will be eliminated naturally; This obviously is a kind of very painful and dangerous selection.And take the specific aim Drug therapy mostly, but this takes stopgap measures and does not effect a permanent cure, and the treatment cost is also than higher.According to theory of Chinese medical science, only take nourish heart foster kidney, tonifying Chong and Ren channels, the treatment by Chinese herbs method of comprehensively regulating just can be taken stopgap measures and effect a permanent cure, thereby reaches ideal therapeutic effect.
At present, the medicine of treatment climacteric syndrome is a lot, the still Chinese herbal medicine that curative effect is relatively more good.But Chinese herbal medicine mostly is decoction or powder, electuary and makes tablet etc., and curative effect differs, and the course of treatment is longer, takes inconvenience, takes effect slowly.The Chinese Traditional Medicines of treatment climacteric syndrome need be optimized and revised prescription, improve dosage form, improve curative effect, to adapt to the demand of extensive patients.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese Traditional Medicines for the treatment of climacteric syndrome and preparation method thereof.Its main feature is the pure Chinese medicine capsule preparation, does not contain any chemicals composition, and is without any side effects, easy to use, short treating period, instant effect, and stable curative effect is the first-selected Chinese patent medicine of treatment climacteric syndrome.
It is with Herba Epimedii, Concha Ostreae, the Rhizoma Anemarrhenae, Fructus Rosae Laevigatae, Cortex Phellodendri, Semen Plantaginis, Radix Ginseng, Fructus Mori, Radix Angelicae Sinensis, Semen Juglandis, Cornu Cervi Pantotrichum, Fructus Psoraleae, Radix Dipsaci, Caulis Polygoni Multiflori, the Radix Paeoniae Alba, the Radix Polygoni Multiflori (system), Radix Achyranthis Bidentatae, Radix Glycyrrhizae, 19 flavor Chinese herbal medicine such as Radix Rehmanniae Preparata, combine according to tradition and modern Chinese medicine theory, optimum organization, the science compatibility, the adding appropriate amount of starch is an adjuvant, adopt advanced modernized Chinese medicine preparation technology, make a kind of capsule formulation, at the treatment climacteric syndrome, its function is the foster kidney that nourishes heart, tonifying Chong and Ren channels, be used for the uneasy sleeping at night that the menopause front and back occur, cardiopalmus, tinnitus, suspicious sentimental, warm sweating, irritated irritability, the happy capsule of the climacteric of symptoms such as aching pain in waist and back, this is the classical good merchantable brand in motherland's medicine treasure-house, and the persistent ailment misery of releasing being suffered from the patient of climacteric syndrome has remarkable result.
Specific implementation method
1, raw material and prescription (parts by weight)
(1) Herba Epimedii 120～130 (2) Concha Ostreaes 120～130
(3) Rhizoma Anemarrhenae 20～30 (4) Fructus Rosae Laevigatae 40～45
(5) Cortex Phellodendri 20～30 (6) Semen Plantaginiss 60～65
(7) Radix Ginseng 20～30 (8) Fructus Moris 60～65
(9) Radix Angelicae Sinensis 60～65 (10) Semen Juglandis 60～65
(11) Cornu Cervi Pantotrichum 7～9 (12) Fructus Psoraleaes 60～65
(13) Radix Dipsaci 60～65 (14) Caulis Polygoni Multiflori 120～130
(15) Radix Paeoniae Alba 60～65 (16) Radixs Polygoni Multiflori (system) 120～130
(17) Radix Achyranthis Bidentatae 40～45 (18) Radix Glycyrrhizaes 20～30
(19) Radix Rehmanniae Preparata 30～40
2, pretreatment of raw material
(1) all raw materials all must be according to " Chinese pharmacopoeia and regulation of inspection can use after carrying out an acceptance inspection;
(2) Radix Ginseng, Cornu Cervi Pantotrichum fleece-flower root (system) in the 19 flavor medicines are ground into coarse powder with pulverizer, the back of sieving is stand-by; It is stand-by that medical starch is sieved;
(3) ten Six-elements such as all the other Herba Epimedii are decocted with water 2 times, adding for the first time 10 times of water gagings decocted 2 hours, adding for the second time 8 times of water gagings decocted 1.5 hours, filter, merging filtrate, adopt double-effect evaporation to be concentrated into density and be 〉=1.16 (80 ℃ of heat are surveyed), 95% ethanol that adds 1 times of amount then, stir evenly, placed 24 hours, and got supernatant, continue to be condensed into the thick paste that relative density is 1.20～1.28 (80 ℃ of heat are surveyed), stand-by (4) thick paste after with above-mentioned concentrate and the medicated powder and the appropriate amount of starch mix homogeneously of (2) crushing screening are pulverized after being dried to moisture≤9% under 60～80 ℃ of temperature atmospheric pressure states again.
3, pharmaceutical preparation (preparation process)
(1) will use 90% alcohol granulation through pretreated raw material (dry powdery);
(2) said medicine granule (semi-finished product) is incapsulated by every 0.3g amount;
(3) by the actual formula ratio of per 1000 capsules be:
(1) Herba Epimedii 125g (2) Concha Ostreae 125g
(3) Rhizoma Anemarrhenae 25g (4) Fructus Rosae Laevigatae 42g
(5) Cortex Phellodendri 25g (6) Semen Plantaginis 62.5g
(7) Radix Ginseng 25g (8) Fructus Mori 62.5g
(9) Radix Angelicae Sinensis 62.5g (10) Semen Juglandis 62.5g
(11) Cornu Cervi Pantotrichum 8g (12) Fructus Psoraleae 62.5g
(13) Radix Dipsaci 62.5g (14) Caulis Polygoni Multiflori 125g
(15) Radix Paeoniae Alba 62.5g (16) Radix Polygoni Multiflori (system) 125g
(17) Radix Achyranthis Bidentatae 42g (18) Radix Glycyrrhizae 25g
(19) Radix Rehmanniae Preparata 35g
(4) medicinal aluminium-plastic bubble plate packing, 15/plate.
4, function cure mainly, usage and dosage and effect duration
(1) function cures mainly: the foster kidney that nourishes heart, tonifying Chong and Ren channels.The uneasy sleeping at night that is used for occurring before and after the menopause, cardiopalmus, tinnitus, suspicious sentimental, warm sweating, irritated irritability, aching pain in waist and back.
(2) usage and dosage: oral, 3 times on the one, one time 4.
(3) sealing is deposited, and effect duration is 18 months.
5, untoward reaction, taboo and points for attention
(1) untoward reaction, still indeterminate;
(2) taboo is still indeterminate;
(3) points for attention:
A avoids pungent food, and few oil-feed is greasy.
The obvious person of b cardiopalmus symptom should remove earlier examination in hospital, medication under the doctor instructs.
The c 4 all symptoms of taking medicine do not have improvement, required hospital therapy.
D takes by usage and dosage, takes for a long time and should seek advice to the doctor.
E should not take this medicine during flu.
Rhizoma et radix veratri (Radix Rhizoma Veratri), Oletum Trogopterori, Fructus Gleditsia or its preparation should not be taken simultaneously when f takes this medicine, Radix Raphani should not be had tea and eat, in order to avoid influence drug effect.
G is to this medicine allergy sufferers forbidding, the careful usefulness of allergic constitution person.
When changing, the h property of drug forbids taking.
I please is placed on the place that the child can not touch with this medicine.
J please Ref Dr or pharmacist before use this product as taking other medicines.
6, the examination and test of products [discriminating]
(1) get this product content, put microscopically and observe: GUSUIPIAN light gray, brown or faint yellow is irregular fragment, the fine and closely woven texture of surface tool, bone lacuna is more, mostly is similar round or class fusiformis, size and arrangement differ, and the marginal bone tubule mays be seen indistinctly, and is radial rill.Conduit is mainly bordered pit vessel, and diameter is 170 μ m, and bordered pit is fine and closely woven.
(2) get this product content 1.5g, porphyrize adds 70% ethanol 20ml reflux 15 minutes, filters, filtrate is flung to ethanol, adds water 15ml, and mixing extracts with ethyl acetate 15ml jolting, divide and to get ethyl acetate and be concentrated into driedly, residue adds methanol 2ml dissolving, as need testing solution.Other gets the icariin reference substance, adds methanol and makes the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw each 3 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with ethyl acetate-acetone-formic acid-water (8: 3: 0.5: be developing solvent 1), launch, take out, dry.Spray, is put under the ultra-violet lamp (365nm) and is inspected 105 ℃ of bakings several minutes with 5% aluminum trichloride solution.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(3) get this product content 4.5g, porphyrize, add 50% methanol 50ml and add backflow 15 minutes, filter, filtrate is waved most ethanol, adding water 30ml again extracts with water saturated n-butyl alcohol 50ml jolting, divide and to get n-butanol extracting liquid, be concentrated into driedly, residue adds 80% methanol makes dissolving in right amount, admix a little medium-sized aluminium oxide (200～300 order), evaporate to dryness in the water-bath, the medium-sized aluminium oxide (200～300 orders, the 1g that pack into and fill in advance, internal diameter 1～1.5cm) little column top, with 80% methanol 40ml eluting, collect eluent, evaporate to dryness, residue adds methanol 1ml dissolving, as need testing solution.Other gets the peoniflorin reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with chloroform-methanol (3: 1) is developing solvent, launch, take out, dry, spray is with 5% vanillin sulfuric acid solution, and hot blast blows to clear spot.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(4) get the emodin reference substance, add methanol and make the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw need testing solution and each 10 μ l of reference substance solution under the item of [discriminating] (2), put respectively on same silica gel g thin-layer plate, with petroleum ether (30～60 ℃): Ethyl formate: formic acid: the upper solution of (15: 5: 1) is developing solvent, launches, takes out, dries.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(5) get this product content 4.5g, add methanol 50ml, supersound process (power 250W, frequency 40kHz) 30 minutes filters, and filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Fructus Psoraleae control medicinal material 1g, adds methanol 20ml, supersound process (power 250W, frequency 40kHz) 30 minute, filter, filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, medical material solution in contrast, according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate (4: 1) is developing solvent, launches, takes out, dries.Spray is put under the ultra-violet lamp (365nm) and is inspected with 10% potassium hydroxide-ethanol solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the fluorescence speckle of same color.
(6) get this product content 4.5g, add chloroform 40ml, add and refluxed 1 hour, discard chloroform liquid, medicinal residues are flung to solvent, after adding water 1.5ml and mixing moistening thoroughly, add water saturated n-butyl alcohol 30ml, supersound process (power 250W, frequency 40kHz) 30 minutes, get supernatant, add the triplication ammonia solution, shake up, place layering, get upper strata liquid evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets Radix Dipsaci control medicinal material 3g, adding water 30ml decocted 1 hour, filter, the filtrate evaporate to dryness, residue adds methanol 30ml, supersound process (power 250W, frequency 40kHz) 30 minutes filters, the filtrate evaporate to dryness, residue adds methanol 1ml makes dissolving, and medical material solution is tested according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005) in contrast, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, (4: 1: 5: upper solution 1) was developing solvent, launched, takes out, dried with n-butyl alcohol-glacial acetic acid-water-chloroform.Spray is with 5% vanillin sulfuric acid solution, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(7) inspection should meet every regulation relevant under the capsule item (appendix IL of Chinese Pharmacopoeia version in 2005).Its assay is measured according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2005).Every of this product contains Herba Epimedii with icariin (C
33H
40O
15) meter, must not be less than 0.20mg.
7, this product is Class A over-the-counter drug (OTC), and fully by GMP requirement check and sale, by specification uses or buys and use under the pharmacist instructs.
Claims (7)
1. Chinese patent medicine for the treatment of climacteric syndrome, it is characterized in that at the treatment climacteric syndrome, treatment by Chinese herbs method by nourish heart foster kidney, tonifying Chong and Ren channels, comprehensively regulating, be used for the treatment of the uneasy sleeping at night that occurs before and after the menopause, cardiopalmus, tinnitus, suspicious sentimental, warm symptoms such as sweating, irritated irritability, aching pain in waist and back.
2. a Chinese patent medicine for the treatment of climacteric syndrome is characterized in that a kind of pure Chinese medicine capsule preparation, does not contain any chemicals composition, and is without any side effects, easy to use, short treating period, instant effect, stable curative effect.
3. Chinese patent medicine for the treatment of climacteric syndrome is characterized in that being made up of following various raw materials and parts by weight:
(1) Herba Epimedii 120～130 (2) Concha Ostreaes 120～130
(3) Rhizoma Anemarrhenae 20～30 (4) Fructus Rosae Laevigatae 40～45
(5) Cortex Phellodendri 20～30 (6) Semen Plantaginiss 60～65
(7) Radix Ginseng 20～30 (8) Fructus Moris 60～65
(9) Radix Angelicae Sinensis 60～65 (10) Semen Juglandis 60～65
(11) Cornu Cervi Pantotrichum 7～9 (12) Fructus Psoraleaes 60～65
(13) Radix Dipsaci 60～65 (14) Caulis Polygoni Multiflori 120～130
(15) Radix Paeoniae Alba 60～65 (16) Radixs Polygoni Multiflori (system) 120～130
(17) Radix Achyranthis Bidentatae 40～45 (18) Radix Glycyrrhizaes 20～30
(19) Radix Rehmanniae Preparata 30～40
4. the feature of the preparation method of a Chinese patent medicine for the treatment of climacteric syndrome is:
(1) pretreatment of raw material
All raw materials of a all must be according to " Chinese pharmacopoeia and regulation of inspection can use after carrying out an acceptance inspection;
B is ground into coarse powder with Radix Ginseng, the Cornu Cervi Pantotrichum fleece-flower root (system) in 19 flavors with pulverizer, and the back of sieving is stand-by; It is back stand-by that medical starch is sieved;
C decocts with water ten Six-elements such as all the other Herba Epimedii 2 times, add for the first time 10 times of water gagings and decocted 2 hours, add 8 times of water gagings for the second time and decocted 1.5 hours, filter, merging filtrate, adopt double-effect evaporation to be concentrated into density and be 〉=1.16 (80 ℃ of heat are surveyed), add 95% ethanol of 1 times of amount then, stir evenly, placed 24 hours, get supernatant, continue to be condensed into the thick paste that relative density is 1.20～1.28 (80 ℃ of heat are surveyed), stand-by
The thick paste of d after with above-mentioned concentrate and (b) medicated powder and the appropriate amount of starch mix homogeneously of crushing screening are pulverized after being dried to moisture≤9% under 60～80 ℃ of temperature atmospheric pressure states again.
(2) pharmaceutical preparation (preparation process)
A will use 90% alcohol granulation through pretreated raw material (dry powdery);
B incapsulates said medicine granule (semi-finished product) by every 0.3g amount;
The actual formula ratio of per 1000 capsules of c is:
(1) Herba Epimedii 125g (2) Concha Ostreae 125g
(3) Rhizoma Anemarrhenae 25g (4) Fructus Rosae Laevigatae 42g
(5) Cortex Phellodendri 25g (6) Semen Plantaginis 62.5g
(7) Radix Ginseng 25g (8) Fructus Mori 62.5g
(9) Radix Angelicae Sinensis 62.5g (10) Semen Juglandis 62.5g
(11) Cornu Cervi Pantotrichum 8g (12) Fructus Psoraleae 62.5g
(13) Radix Dipsaci 62.5g (14) Caulis Polygoni Multiflori 125g
(15) Radix Paeoniae Alba 62.5g (16) Radix Polygoni Multiflori (system) 125g
(17) Radix Achyranthis Bidentatae 42g (18) Radix Glycyrrhizae 25g
(19) Radix Rehmanniae Preparata 35g
The medicinal aluminium-plastic bubble plate packing of d, 15/plate.
5. outside the feature of the happy capsule Chinese patent medicine of climacteric such as the claim (1) (2) (3), it is characterized in that:
(1) function cures mainly and is the foster kidney that nourishes heart, tonifying Chong and Ren channels, the uneasy sleeping at night that is used for occurring before and after the menopause, cardiopalmus tinnitus, suspicious sentimental, warm sweating, irritated irritability, aching pain in waist and back.
(2) usage and dosage: oral, 3 times on the one, one time 4.
(3) sealing is deposited, and effect duration is 18 months.
(4) untoward reaction and taboo, still indeterminate.
(5) points for attention:
A avoids pungent food, and few oil-feed is greasy.
The obvious person of b cardiopalmus symptom should remove earlier examination in hospital, medication under the doctor instructs.
The c 4 all symptoms of taking medicine do not have improvement, required hospital therapy.
D takes by usage and dosage, takes for a long time and should seek advice to the doctor.
E should not take this medicine during flu.
Rhizoma et radix veratri (Radix Rhizoma Veratri), Oletum Trogopterori, Fructus Gleditsia or its preparation should not be taken simultaneously when f takes this medicine, Radix Raphani should not be had tea and eat, in order to avoid influence drug effect.
G is to this medicine allergy sufferers forbidding, the careful usefulness of allergic constitution person.
When changing, the h property of drug forbids taking.
I please is placed on the place that the child can not touch with this medicine.
J please Ref Dr or pharmacist before use this product as taking other medicines.
6. the feature of the happy capsule Chinese patent medicine of climacteric in its examination and test of products [discriminating] method is:
(1) get this product content, put microscopically and observe: GUSUIPIAN light gray, brown or faint yellow is irregular fragment, the fine and closely woven texture of surface tool, bone lacuna is more, mostly is similar round or class fusiformis, size and arrangement differ, and the marginal bone tubule mays be seen indistinctly, and is radial rill.Conduit is mainly bordered pit vessel, and diameter is 170 μ m, and bordered pit is fine and closely woven.
(2) get this product content 1.5g, porphyrize adds 70% ethanol 20ml reflux 15 minutes, filters, filtrate is flung to ethanol, adds water 15ml, and mixing extracts with ethyl acetate 15ml jolting, divide and to get ethyl acetate and be concentrated into driedly, residue adds methanol 2ml dissolving, as need testing solution.Other gets the icariin reference substance, adds methanol and makes the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw each 3 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with ethyl acetate-acetone-formic acid-water (8: 3: 0.5: be developing solvent 1), launch, take out, dry.Spray, is put under the ultra-violet lamp (365nm) and is inspected 105 ℃ of bakings several minutes with 5% aluminum trichloride solution.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(3) get this product content 4.5g, porphyrize, add 50% methanol 50ml and add backflow 15 minutes, filter, filtrate is waved most ethanol, adding water 30ml again extracts with water saturated n-butyl alcohol 50ml jolting, divide and to get n-butanol extracting liquid, be concentrated into driedly, residue adds 80% methanol makes dissolving in right amount, admix a little medium-sized aluminium oxide (200～300 order), evaporate to dryness in the water-bath, the medium-sized aluminium oxide (200～300 orders, the 1g that pack into and fill in advance, internal diameter 1～1.5cm) little column top, with 80% methanol 40ml eluting, collect eluent, evaporate to dryness, residue adds methanol 1ml dissolving, as need testing solution.Other gets the peoniflorin reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with chloroform-methanol (3: 1) is developing solvent, launch, take out, dry, spray is with 5% vanillin sulfuric acid solution, and hot blast blows to clear spot.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(4) get the emodin reference substance, add methanol and make the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw need testing solution and each 10 μ l of reference substance solution under the item of [discriminating] (2), put respectively on same silica gel g thin-layer plate, with petroleum ether (30～60 ℃): Ethyl formate: formic acid: the upper solution of (15: 5: 1) is developing solvent, launches, takes out, dries.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(5) get this product content 4.5g, add methanol 50ml, supersound process (power 250W, frequency 40kHz) 30 minutes filters, and filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Fructus Psoraleae control medicinal material 1g, adds methanol 20ml, supersound process (power 250W, frequency 40kHz) 30 minute, filter, filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, medical material solution in contrast, according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate (4: 1) is developing solvent, launches, takes out, dries.Spray is put under the ultra-violet lamp (365nm) and is inspected with 10% potassium hydroxide-ethanol solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the fluorescence speckle of same color.
(6) get this product content 4.5g, add chloroform 40ml, add and refluxed 1 hour, discard chloroform liquid, medicinal residues are flung to solvent, after adding water 1.5ml and mixing moistening thoroughly, add water saturated n-butyl alcohol 30ml, supersound process (power 250W, frequency 40kHz) 30 minutes, get supernatant, add the triplication ammonia solution, shake up, place layering, get upper strata liquid evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets Radix Dipsaci control medicinal material 3g, adding water 30ml decocted 1 hour, filter, the filtrate evaporate to dryness, residue adds methanol 30ml, supersound process (power 250W, frequency 40kHz) 30 minutes filters, the filtrate evaporate to dryness, residue adds methanol 1ml makes dissolving, and medical material solution is tested according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005) in contrast, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, (4: 1: 5: upper solution 1) was developing solvent, launched, takes out, dried with n-butyl alcohol-glacial acetic acid-water-chloroform.Spray is with 5% vanillin sulfuric acid solution, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(7) inspection should meet every regulation relevant under the capsule item (appendix IL of Chinese Pharmacopoeia version in 2005).Its assay is measured according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2005).Every of this product contains Herba Epimedii with icariin (C
33H
40O
15) meter, must not be less than 0.20mg.
The happy capsule Chinese patent medicine of climacteric be characterized as Class A over-the-counter drug (0TC), fully by GMP requirement check with sell, by specification uses or buys under the pharmacist instructs and use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100727439A CN101991760A (en) | 2009-08-27 | 2009-08-27 | Chinese patent medicine for treating climacteric syndrome and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100727439A CN101991760A (en) | 2009-08-27 | 2009-08-27 | Chinese patent medicine for treating climacteric syndrome and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101991760A true CN101991760A (en) | 2011-03-30 |
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ID=43782836
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009100727439A Pending CN101991760A (en) | 2009-08-27 | 2009-08-27 | Chinese patent medicine for treating climacteric syndrome and preparation method thereof |
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| Country | Link |
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| CN (1) | CN101991760A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311566A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Pharmaceutical composition containing folium artemisiae argyi for treating climacteric syndrome in women |
| CN111655273A (en) * | 2017-10-27 | 2020-09-11 | 天然恩朵技术株式会社 | Antioxidant, anti-inflammatory or for inhibiting osteoclast differentiation composition |
-
2009
- 2009-08-27 CN CN2009100727439A patent/CN101991760A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311566A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Pharmaceutical composition containing folium artemisiae argyi for treating climacteric syndrome in women |
| CN111655273A (en) * | 2017-10-27 | 2020-09-11 | 天然恩朵技术株式会社 | Antioxidant, anti-inflammatory or for inhibiting osteoclast differentiation composition |
| US11452752B2 (en) | 2017-10-27 | 2022-09-27 | Natural Endotech Co., Ltd. | Composition for antioxidation, anti-inflammation, or osteoclast differentiation inhibition |
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Open date: 20110330 |