CN101979109B - Double-nasal cavity continuous nasal administration device - Google Patents
Double-nasal cavity continuous nasal administration device Download PDFInfo
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- CN101979109B CN101979109B CN2010105216979A CN201010521697A CN101979109B CN 101979109 B CN101979109 B CN 101979109B CN 2010105216979 A CN2010105216979 A CN 2010105216979A CN 201010521697 A CN201010521697 A CN 201010521697A CN 101979109 B CN101979109 B CN 101979109B
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- drug release
- protective sleeve
- nasal cavity
- nasal
- release head
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Abstract
The invention discloses a double-nasal cavity continuous nasal administration device and a using method thereof. The device comprises an osmotic pump (3), PE pipes (2), a medicament releasing head (1), a protective sleeve (4) and a tee pipe (5), wherein the osmotic pump (3) is communicated with two PE pipes (2) through the tee pipe (5); the opposite other ends of the two PE pipes (2) and the tee pipe (5) are communicated with one medicament releasing head (1) respectively; the medicament releasing head (1) is regular cone-shaped and a passage (6) in the medicament releasing head (1) is communicated with the PE pipes (2); the protective sleeve (4) is an independent body and is a regular frustum body corresponding to the medicament releasing head (1); the minimal inner diameter of the inner cavity passage (7) of the protective sleeve (4) is slightly greater than the maximal outer diameter of the medicament releasing head (1), so that the medicament releasing head (1) can conveniently slide in theinner cavity passage (7); and the protective sleeve (4) is used for sealing the inferior nasal meatus of the nasal cavity of a human body. The device can realize continuous administration and double-nasal cavity administration and prevents a medicament releaser from entering the oropharynx. The using method is simple and convenient.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of pair of nasal cavity and continue nose administration device and method for using thereof.
Background technology
Because the existence of blood brain barrier etc., medicine can not effectively arrive the central nervous system through peripherally administered (oral, vein etc.); Though the tricorn administration can directly get into the central nervous system,, receive very big restriction in clinical practice because it is traumatic.Like the nasal cavity structure chart of Fig. 1, nose administration can be walked around the medication of blood brain barrier through the nervi olfactory 1 direct central nervous system 4 of arrival of last nasal cavity 3, has noninvasive characteristics simultaneously, thereby is a kind of extensive potential applicability in clinical practice that has.
Yet traditional nose administration method has very big deficiency at present, has limited its application in clinical.Traditional nasal drip also is classic methods, and its defective is: (1) requires the patient to have special position, like Meccah position, makes the wish of patient's partner treatment reduce, and is difficult to especially carry out for the treatment of comatose patient; (2) be difficult to effectively arrive the top of nasal cavity, the drug absorption rate is lower, and the medicine less than about 1% can get into the central nervous system, wastes bigger; (3) blood vessel that most of medicine via intranasal application is abundant absorbs and enters into peripheral circulation, thereby has the possibility that produces potential side effect; (4) drip 100 μ l medicine major parts along with respiratory air flow gets into upper respiratory tract, the patient who disappears for swallowing reflex has the possibility of upper respiratory tract obstruction at every turn; (5) can only alternately give a nostril, administration simultaneously, (6) can not continue medication, and general administration time can only continue 20-30min.
The tubule nasal drip; This method is used superfine PE pipe; After connecting syringe medicine is directly sent into the nasal cavity top; Effectively improved traditional nasal drip and can not effectively pass through the defective of nasal cavity lobe, but the defective that this method has is: (1) is easy to get into through inferior nasal meatus 3 pharyngeal like the superfine pipe of Fig. 1, particularly patient's hazardous of pharyngeal reflex disappearance; In case and PE pipe mistake gets into inferior nasal meatus 3 administrations, medicine is breathed out or get into pulmonary, the blood vessel that perhaps most of medicine via intranasal application is abundant absorbs and enters into peripheral circulation, not only can not reach therapeutic effect, also can have the possibility that produces potential side effect; (2) superfine PE and nasal cavity are misfitted, to the nasal cavity effect; (3) syringe injects a large amount of medicines at every turn, and high amount of drug can not get into maincenter through tractus olfactorius, but gets into upper respiratory tract; (4) can only replace administration, administration simultaneously, (5) can not continue medication.
Nasal spray, this utilizes the mechanical spraying principle, and about 100 μ l medicines are once sprayed; Can effectively get into the nasal cavity top; This method has also been avoided the relatively poor shortcoming of tubule dose regimen toleration in addition, but it still has suitable defective: (1) each medicine that injects, and high amount of drug can not get into maincenter through tractus olfactorius; Get into upper respiratory tract, efficient is lower; (2) can only replace administration, administration simultaneously, (3) can not continue medication.
Summary of the invention
The object of the present invention is to provide a kind of pair of nasal cavity to continue the nose administration device.
Another object of the present invention is to provide a kind of pair of nasal cavity to continue the method for using of nose administration device.
The object of the invention can be realized through following technical scheme:
A kind of pair of nasal cavity continues the nose administration device; Comprise osmotic pumps, PE pipe, drug release head, protective sleeve and tee T; Described osmotic pumps is communicated with through tee T and two PE pipes, described two PE pipe, and its other end relative with tee T is communicated with a drug release head respectively; Described drug release head is positive taper, and in this drug release head, has a passage to communicate with the PE pipe; Described protective sleeve is a separate component; And be and the corresponding positive cone table of drug release head; The minimum diameter of its bore passages is slightly larger than the maximum outside diameter of drug release head, is convenient to the drug release head and slides in the passage of chamber within it, and described protective sleeve is used to seal the inferior nasal meatus of human body nasal cavity.
Above-mentioned two nasal cavities continue the nose administration device, and it is that described protective sleeve bore passages can be for cylindrical.
Above-mentioned two nasal cavities continue the nose administration device, and it is that passage and the PE of described drug release head manage a corresponding end and be funnel-form, can enlarge the contact area of medicine and last nasal cavity, improves the effective absorbance of medicine.
The positive taper tip designs of drug release head is smooth arc, can avoid damage or stimulate nasal cavity.
A kind of pair of nasal cavity continues the method for using of nose administration device, earlier protective sleeve placed a side nasal cavity, and the drug release head is gone up nasal cavity through the bore passages entering nasal cavity arrival of protective sleeve; The protective sleeve of dropping back then; According in the opposite side nasal cavity, inserting another protective sleeve with quadrat method, another drug release head gets into upward nasal cavity of opposite side nasal cavity arrival, the protective sleeve of dropping back then through the passage of protective sleeve; Adjustment osmotic pumps transporting velocity, administration.
Beneficial effect of the present invention:
1, adopts osmotic pumps as continuing conveyer device, can regulate drug conveying amount and drug conveying speed, and can quantitatively continue medication two weeks.
2, the shaped design of drug release head and last nasal cavity structure match; Not only can avoid the stimulation of nasal cavity but also can make the medicine release head, and medicine concentrated on the nervi olfactory, rather than be dispersed in the nasal cavity to greatest extent near the nervi olfactory administration; Both can improve the effective rate of utilization of medicine; The influence that again the administration process is not breathed is breathed out medicine or the suction trachea when avoiding breathing, thereby realizes two nasal-cavity administrations.
3, through protective sleeve the medicine release head is arrived smoothly and go up the nasal cavity tram; Prevent that the drug release head from getting into pharyngeal through inferior nasal meatus; To such an extent as to or prevent that drug release head mistake from getting into the abundant blood vessel absorption of the most of medicine via intranasal application of inferior nasal meatus administration and entering into peripheral circulation; Not only can not reach therapeutic effect, also can have the possibility that produces potential side effect.
Description of drawings
Fig. 1 nasal cavity structure chart.
Wherein: 1-nervi olfactory, 2-inferior nasal meatus 3-last nasal cavity 4-nervus centralis
The two nasal cavities of Fig. 2 continue nose administration device part section structural representation.
The longitudinal sectional drawing of the preferred version of Fig. 3 drug release head.
The specific embodiment
Like Fig. 2 is the part section structural representation that two nasal cavities continue the nose administration device; Comprise osmotic pumps 3, PE pipe 2, drug release head 1, protective sleeve 4 and tee T 5; Osmotic pumps 3 is communicated with through tee T 5 and two PE pipes 2; Two PE pipe 2 is communicated with a drug release head 1 respectively with the tee T 5 relative other ends, and drug release head 1 is positive taper, and in this drug release head 1, has a passage 6 and PE to manage 2 to communicate; Protective sleeve 4 is a separate component; And be and drug release head 1 corresponding positive cone table; The minimum diameter of its bore passages 7 is slightly larger than the maximum outside diameter of drug release head 1, is convenient to drug release head 1 and slides in the chamber passage 7 within it, and protective sleeve 4 is used to seal the inferior nasal meatus of human body nasal cavity.As a kind of preferred version, bore passages 7 is cylindric, and its somewhat larger in diameter is in the maximum outside diameter of drug release head 1, and the positive taper tip designs of drug release head 1 is smooth arc, can avoid damage or stimulate nasal cavity.
As a kind of preferred version, passage 6 is managed the 5 corresponding other ends with PE and is funnel-form like Fig. 3, and this structure can enlarge the medicine and the contact area of last nasal cavity that oozes out in the passage 6, the effective absorbance of raising medicine.
During use, earlier protective sleeve 4 is placed a side nasal cavity, drug release head 1 gets into upward nasal cavity of nasal cavity arrival through the bore passages 7 of protective sleeve 4; The protective sleeve 4 of dropping back then, according in the opposite side nasal cavity, inserting another protective sleeve 4 with quadrat method, the passage 7 of another drug release head 1 through protective sleeve 4 gets into the opposite side nasal cavities and arrives and go up nasal cavity; The protective sleeve 4 of dropping back is then adjusted the transporting velocity of osmotic pumps as required, and protecting osmotic pumps is the ALZET Osmotic pumps that ALZET company produces; This pump can be regulated the speed of conveying; And sustainable two weeks, getting into clinical use for many years, performance is comparatively stable.When protective sleeve 4 is inserted nasal cavity, can drug release head 1 and the inferior nasal meatus in the nasal cavity be kept apart, it is pharyngeal to avoid drug release head 1 to have inferior nasal meatus to get into; To such an extent as to or avoid drug release head 1 mistake to get into the abundant blood vessel of the most of medicine via intranasal application of inferior nasal meatus administration absorbing and enter into peripheral circulation; Not only can not reach therapeutic effect, also can have the possibility that produces potential side effect, drug release head 1 gets into nasal cavity smoothly and arrives when going up nasal cavity; Recession protective sleeve 4 keeps breathing unobstructed.
Protective sleeve 4 can adopt conventional medical grade rubber material smooth, that intensity is high slightly to process with drug release head 1.
Claims (3)
1. two nasal cavities continue the nose administration device; Comprise that osmotic pumps (3), PE manage (2), drug release head (1), protective sleeve (4) and tee T (5); Described osmotic pumps (3) is communicated with through tee T (5) and two PE pipes (2), described two PE pipes (2), and its other end relative with tee T (5) is communicated with a drug release head (1) respectively; It is characterized in that described drug release head (1) is positive taper, and in this drug release head (1), have a passage (6) to communicate with PE pipe (2); Described protective sleeve (4) is a separate component; And be and the corresponding positive cone table of drug release head (1); The minimum diameter of its bore passages (7) is slightly larger than the maximum outside diameter of drug release head (1); Be convenient to drug release head (1) and slide in the chamber passage (7) within it, described protective sleeve (4) is used to seal the inferior nasal meatus of human body nasal cavity.
2. pair nasal cavity according to claim 1 continues the nose administration device, it is characterized in that described protective sleeve (4) bore passages (7) is for cylindrical.
3. pair nasal cavity according to claim 1 continues the nose administration device, it is characterized in that the passage (6) of said drug release head (1) and PE pipe (2) corresponding end are funnel-form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105216979A CN101979109B (en) | 2010-10-27 | 2010-10-27 | Double-nasal cavity continuous nasal administration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105216979A CN101979109B (en) | 2010-10-27 | 2010-10-27 | Double-nasal cavity continuous nasal administration device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101979109A CN101979109A (en) | 2011-02-23 |
| CN101979109B true CN101979109B (en) | 2012-05-23 |
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ID=43599664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105216979A Expired - Fee Related CN101979109B (en) | 2010-10-27 | 2010-10-27 | Double-nasal cavity continuous nasal administration device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101979109B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247642B (en) * | 2011-04-26 | 2013-10-16 | 上海白塔医药科技有限公司 | Portable continuous intranasal administration device |
| CN115282411A (en) * | 2022-01-14 | 2022-11-04 | 温州医科大学 | Delivery system for delivering drugs into the brain using the nasal olfactory region and method of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6679265B2 (en) * | 2001-10-25 | 2004-01-20 | Worldwide Medical Technologies | Nasal cannula |
| US9101384B2 (en) * | 2004-04-21 | 2015-08-11 | Acclarent, Inc. | Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat |
| CN2882564Y (en) * | 2005-07-25 | 2007-03-28 | 李范珠 | Nasal medicine feeder for rodent |
| CN201275343Y (en) * | 2008-11-01 | 2009-07-22 | 王铖 | Administration device for nasal mucous membrane |
| CN201949493U (en) * | 2010-10-27 | 2011-08-31 | 刘新峰 | Continuous intranasal medicine application device for double nasal cavities |
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2010
- 2010-10-27 CN CN2010105216979A patent/CN101979109B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN101979109A (en) | 2011-02-23 |
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