CN101974190A - Gelatin/polyvinyl alcohol composite sponge and preparation method thereof - Google Patents
Gelatin/polyvinyl alcohol composite sponge and preparation method thereof Download PDFInfo
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- CN101974190A CN101974190A CN 201010523342 CN201010523342A CN101974190A CN 101974190 A CN101974190 A CN 101974190A CN 201010523342 CN201010523342 CN 201010523342 CN 201010523342 A CN201010523342 A CN 201010523342A CN 101974190 A CN101974190 A CN 101974190A
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Abstract
The invention relates to a gelatin/polyvinyl alcohol composite sponge which is a porous material suitable for stopping bleeding and being applied to wounds. The composite sponge is prepared with gelatin and polyvinyl alcohol as the raw materials and comprises the following raw materials by weight: 1-9% of gelatin, 7-9% of polyvinyl alcohol, 7-10% of inorganic acid, 7-12% of formaldehyde, 0.6-4% of foaming agent and the balance water. A preparation method of the composite sponge comprises thermal dissolution, acetalization and foaming of polyvinyl alcohol and compositing of polyvinyl alcohol and gelatin. During preparation, the polyvinyl alcohol which undergoes complete alcoholysis or incomplete alcoholysis and has degree of polymerization of 1700-2000 is selected as the raw material, the gelatin and the polyvinyl alcohol are mixed in water and heated and dissolved, then acid, formaldehyde and the foaming agent are added to the mixture to be blended and the mixture is heated and formed in an oven, thus obtaining the composite sponge. The method can prepare the composite sponge with higher water absorbing capacity, better flexibility and viscoelasticity and good biocompatibility and the advantages of low cost, environmental protection and simple process, and the obtained material can be applied to treating wound cavity infection, burns, skin grafting, etc.
Description
Technical field
The present invention relates to the polymer material science field, also belong to the natural polymer field, particularly relate to a kind of gelatin/polyvinyl alcohol compound sponge and preparation method thereof.
Background technology
Gelatin is a kind of polypeptide mixture, is to be got by the collagen hydrolysate in the reticular tissue such as the skin that is present in higher animal, bone, because it and biological tissue have good affinity, thereby it is widely used at medical field.Gelatin has the function of repairing wound, and gelatin can be the damage location replenishing collagen, for skin provides nutrition, promotes the metabolism of cell growth and skin histology, enables repair tissue, healing wound, skin care and repair process is quickened greatly.Gelatin energy activated macrophage can promote erythrocytic generation and improve blood circulation, can improve thrombocyte and white corpuscle, also has anastalsis.Studies show that: gelatin is nontoxic to human body, and good biocompatibility can biological degradation, and it often is used to make wound dressing, hemostatic material and artificial skin.
In view of polyvinyl alcohol has favorable tissue consistency and mechanical property, have no side effect, snappiness is good, tensile strength is higher, be widely used in peritoneal dialysis, suture material, treatment, plastic surgery and the vascular surgery of burn or wound, this patent are intended according to these characteristics polyvinyl alcohol and gelatin cross-blend being prepared gelatin/polyvinyl alcohol foam sponge.
The report of at present relevant polyvinyl alcohol foam sponge is all less both at home and abroad, mainly concentrates on the research to pure polyvinylalcohol sponge, does not still have report for gelatin/polyvinyl alcohol foam sponge.
Summary of the invention
Technical problem to be solved by this invention: a kind of gelatin/polyvinyl alcohol compound sponge with strong water-retaining capacity, better snappiness and visco-elasticity, good biocompatibility and preparation method thereof is provided.
The present invention solves its technical problem and adopts following technical scheme:
Gelatin/polyvinyl alcohol compound sponge provided by the invention, it is to be that feedstock production forms with gelatin and polyvinyl alcohol, the shared weight percent of each raw material is: the preferred 4-5wt% of gelatin 1-9%(), the preferred 7-8wt% of polyvinyl alcohol 7-9%(), the preferred 8-9wt% of mineral acid 7-10%(), the preferred 8-9wt% of formaldehyde 7-12%(), the preferred 4wt% of whipping agent 0.6-4%(), water surplus.
Above-mentioned gelatin/polyvinyl alcohol compound sponge provided by the invention, its preparation method comprises: polyvinyl alcohol heat of solution, acetalation and foaming, and compound with gelatin.During preparation, with the polymerization degree is that the polyvinyl alcohol of 1700 ~ 2000 complete alcoholysis or not exclusively alcoholysis is a raw material, and the Hybrid Heating dissolving in water with gelatin and polyvinyl alcohol adds mineral acid, formaldehyde and whipping agent blend again, hot briquetting in baking oven gets gelatin/polyvinyl alcohol compound sponge.
The temperature range of described polyvinyl alcohol and gelatin heating for dissolving is 90-100 ℃, and the time of heating for dissolving is 100-120min.
The processing condition of described hot briquetting are: the temperature of thermoforming is 60-100 ℃, and hot forming time is 4-12h.
Described mineral acid can adopt sulfuric acid or hydrochloric acid.
Described whipping agent can adopt sodium bicarbonate or sodium lauryl sulphate.
Above-mentioned gelatin/polyvinyl alcohol compound sponge provided by the invention can be used for hemostasis, infects, burns or skin-grafting in treatment wound chamber.
The present invention compared with prior art has following main beneficial effect:
The present invention is by simple mechanical blending process, can be with gelatin and material such as two kinds of macromolecular compounds of polyvinyl alcohol (PVA) are made membranaceous or water-setting is gluey or spongy, reach the synergy of two kinds of material physiological functions, make prepared material have the advantage that does not possess when two kinds of materials use separately.The present invention is with the carrier of polyvinyl alcohol as foam sponge, has that technology is simple, safety and environmental protection, quality product are easy to control, characteristics such as with low cost, easy to use, and specific surface area is big after the moulding, and biological associativity is good.Gelatin is as a kind of hydrophilic biomacromolecule, be introduced into the water-intake rate that sponge can greatly improve composite sponge, and since gelatin in the present invention with formaldehyde generation schiff base reaction, can make gelatin better be incorporated among the composite sponge, when strengthening the sponge mechanical property, can increase the aperture of composite sponge again and then improve the water-intake rate of sponge.The hemostatic mechanism of gelatin be it is generally acknowledged: it is acceleration rupture and separate out the blood coagulation quality that thrombocyte is met gelatin, forms platelet thrombus, and the formation fibrin clot that continues is blocked wound, and plays the hemostasis effect.In addition, the anastalsis of gelfoam is because volumetric expansion behind its a large amount of absorption moisture content plays sizable homogeneous mechanical contention effect to the hemorrhage surface of a wound, makes stopped bleeding.This gelatin/polyvinyl alcohol compound sponge provided by the invention has advantages such as strong water-retaining capacity, better snappiness and visco-elasticity.And this kind composite sponge has good biocompatibility, promotes wound healing and anastalsis characteristics, can be widely used as hemostatic material, wound dressings, artificial skin surrogate etc.Experiment shows that the elongation at break of the composite sponge of addressing among the present invention is higher, and optimum elongation at break can reach more than 370% (be common sponge two to three times); And for the crucial index of wound healing---water absorbent rate reaches as high as (being more than ten times of common sponge) more than 1265%.Above data prove absolutely that gelatin/polyvinyl alcohol compound sponge has excellent performance.Therefore gelatin/polyvinyl alcohol compound sponge has the incomparable advantage of common sponge, so having a high potential of using of this product promotion, market outlook are very wide.
Description of drawings
Fig. 1 is the scanning electron microscope collection of illustrative plates of the pure polyvinylalcohol sponge of comparative example 1 of the present invention;
Fig. 2 is the scanning electron microscope collection of illustrative plates of the polyvinyl alcohol/gelatin-compounded sponge of the embodiment of the invention 1;
Fig. 3 is the scanning electron microscope collection of illustrative plates of the polyvinyl alcohol/gelatin-compounded sponge of the embodiment of the invention 2;
Fig. 4 is the scanning electron microscope collection of illustrative plates of the polyvinyl alcohol/gelatin-compounded sponge of the embodiment of the invention 3.
Embodiment
In order to understand the present invention better, further illustrate content of the present invention below in conjunction with embodiment, but content of the present invention not only is confined to the following examples.
Comparative example 1:
The preparation method of pure polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 9wt%, water 73wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding hydrochloric acid 10wt%, formaldehyde 7wt% and sodium lauryl sulphate 1wt%, after mixing, blend is poured in the mould, and 80 ℃ of thermoforming 10h make pure polyvinylalcohol sponge in baking oven.The elongation at break of the pure polyvinylalcohol sponge of gained is 301%, and water-intake rate is 1115%.The pore texture of the pure polyvinylalcohol sponge of gained is shown in Fig. 1.Fig. 1 has shown the internal networking structure of pure polyvinylalcohol sponge, and we can be clearly seen that the hole of pure polyvinylalcohol sponge is an internal communication from Fig. 1, and this kind structure has guaranteed the high water absorbing capacity of pure polyvinylalcohol sponge.
Embodiment 1:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 9 wt %, gelatin 1wt %, water 72wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding hydrochloric acid 10wt%, formaldehyde 7wt% and sodium lauryl sulphate 1wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 348%, and water-intake rate is 1261%.The pore texture of gained gelatin/polyvinyl alcohol compound sponge is shown in Fig. 2.Fig. 2 has shown the internal networking structure of gelatin/polyvinyl alcohol compound sponge, we can be clearly seen that the hole of gelatin/polyvinyl alcohol compound sponge is an internal communication from Fig. 2, and than comparative example 1(Fig. 1) the pure polyvinylalcohol sponge aperture of gained increases to some extent, as seen the introducing of gelatin increases the aperture in gelatin/polyvinyl alcohol compound sponge hole to some extent, that is water-intake rate increases to some extent.
Embodiment 2:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 9wt%, gelatin 3.86wt%, water 69.14wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding hydrochloric acid 10wt%, formaldehyde 7wt% and sodium lauryl sulphate 1wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 353%, and water-intake rate is 1255%.The pore texture of gained gelatin/polyvinyl alcohol compound sponge is shown in Fig. 3.Fig. 3 has shown the internal networking structure of gelatin/polyvinyl alcohol compound sponge, and we can be clearly seen that the hole of gelatin/polyvinyl alcohol compound sponge is an internal communication from Fig. 3.But than embodiment 1(Fig. 2) gelatin/polyvinyl alcohol compound sponge aperture of gained slightly reduces.
Embodiment 3:
The preparation method of gelatin/polyvinylalcohol sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 9wt%, gelatin 9wt%, water 64wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding hydrochloric acid 10wt%, formaldehyde 7wt% and sodium lauryl sulphate 1wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 326%, and water-intake rate is 1249%.The pore texture of gained gelatin/polyvinyl alcohol compound sponge is shown in Fig. 4.Fig. 4 has shown the internal networking structure of gelatin/polyvinyl alcohol compound sponge, we can be clearly seen that the hole of gelatin/polyvinyl alcohol compound sponge is an internal communication from Fig. 4, and than embodiment 2(Fig. 3) gelatin/polyvinyl alcohol compound sponge aperture of gained slightly reduces.The above fact proves absolutely the part by weight of gelatin in composite sponge when a certain specified proportion, and the composite sponge water-intake rate just can obtain optimum value.
Embodiment 4:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 6wt%, water 66wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 120min, pour solution in the beaker adding sulfuric acid 7wt%, formaldehyde 11wt% and sodium lauryl sulphate 2wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 8h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 312%, and water-intake rate is 1249%.
Embodiment 5:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 7wt%, gelatin 2wt%, water 67wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding hydrochloric acid 9wt%, formaldehyde 12wt% and sodium bicarbonate 3wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 8h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 316%, and water-intake rate is 1218%.
Embodiment 6:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 3wt%, water 69wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 120min, pour solution in the beaker adding sulfuric acid 10wt%, formaldehyde 7wt% and sodium lauryl sulphate 3wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 307%, and water-intake rate is 1252%.
Embodiment 7:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 7wt%, gelatin 4wt%, water 69wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 110min, pour solution in the beaker adding hydrochloric acid 8wt%, formaldehyde 8wt% and sodium bicarbonate 4wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 379%, and water-intake rate is 1276%.
Embodiment 8:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 5wt%, water 65wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 120min, pour solution in the beaker adding sulfuric acid 9wt%, formaldehyde 9wt% and sodium lauryl sulphate 4wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 372%, and water-intake rate is 1265%.
Embodiment 9:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 7wt%, gelatin 6wt%, water 68.4wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding sulfuric acid 8wt%, formaldehyde 10wt% and sodium bicarbonate 0.6wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinylalcohol sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 360%, and water-intake rate is 1183%.
Embodiment 10:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 2wt%, water 71.4wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 120min, pour solution in the beaker adding sulfuric acid 7wt%, formaldehyde 11wt% and sodium lauryl sulphate 0.6wt%, after mixing, blend is poured in the mould, 90 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 362%, and water-intake rate is 1177%.
Embodiment 11:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 7wt%, gelatin 3wt%, water 70wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 120min, pour solution in the beaker adding hydrochloric acid 7wt%, formaldehyde 12wt% and sodium bicarbonate 1wt%, after mixing, blend is poured in the mould, 100 ℃ of thermoforming 12h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 340%, and water-intake rate is 1109%.
Embodiment 12:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 4wt%, water 70wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 110min, pour solution in the beaker adding sulfuric acid 10wt%, formaldehyde 7wt% and sodium lauryl sulphate 1wt%, after mixing, blend is poured in the mould, 90 ℃ of thermoforming 8h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 358%, and water-intake rate is 1197%.
Embodiment 13:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 7wt%, gelatin 5wt%, water 69wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 120min, pour solution in the beaker adding sulfuric acid 9wt%, formaldehyde 8wt% and sodium bicarbonate 2wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 10h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 343%, and water-intake rate is 1246%.
Embodiment 14:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 6wt%, water 68wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 110min, pour solution in the beaker adding hydrochloric acid 7wt%, formaldehyde 9wt% and sodium lauryl sulphate 2wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 12h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 339%, and water-intake rate is 1175%.
Embodiment 15:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 1700 polyvinyl alcohol 7wt%, gelatin 2wt%, water 70wt%, add in the there-necked flask, behind 90 ℃ of following condensing reflux dissolving 110min, pour solution in the beaker adding sulfuric acid 8wt%, formaldehyde 10wt% and sodium bicarbonate 3wt%, after mixing, blend is poured in the mould, 80 ℃ of thermoforming 12h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 366%, and water-intake rate is 1148%.
Embodiment 16:
The preparation method of gelatin/polyvinyl alcohol compound sponge comprises the steps:
With polyvinyl alcohol and gelatin according to the shared weight percent of each raw material be: the polymerization degree is 2000 polyvinyl alcohol 8wt%, gelatin 3wt%, water 68wt%, add in the there-necked flask, behind 100 ℃ of following condensing reflux dissolving 100min, pour solution in the beaker adding sulfuric acid 7wt%, formaldehyde 11wt% and sodium lauryl sulphate 3wt%, after mixing, blend is poured in the mould, 90 ℃ of thermoforming 12h make gelatin/polyvinyl alcohol compound sponge in baking oven.The elongation at break of gained gelatin/polyvinyl alcohol compound sponge is 327%, and water-intake rate is 1230%.
Claims (9)
1. a gelatin/polyvinyl alcohol compound sponge is that 1700～2000 polyvinyl alcohol, the mineral acid of 7-10wt%, the formaldehyde of 7-12wt%, the whipping agent of 0.6-4wt% and the water of surplus are prepared from by the gelatin of 1-9wt%, the polymerization degree of 7-9wt%.
2. gelatin/polyvinyl alcohol compound sponge according to claim 1, the consumption that it is characterized in that described each material: gelatin is that 4-5wt%, the polymerization degree are that 1700～2000 polyvinyl alcohol 7-8wt%, mineral acid are that 8-9wt%, formaldehyde are that 8-9wt%, whipping agent are 4wt%, and all the other are water.
3. gelatin/polyvinyl alcohol compound sponge according to claim 1 and 2 is characterized in that: described mineral acid is sulfuric acid or hydrochloric acid.
4. gelatin/polyvinyl alcohol compound sponge according to claim 1 and 2 is characterized in that: described whipping agent is sodium bicarbonate or sodium lauryl sulphate.
5. the preparation method of claim 1 or 2 described gelatin/polyvinyl alcohol compound sponges, may further comprise the steps: according to described each raw material consumption, with the polymerization degree is 1700～2000 polyvinyl alcohol and gelatin Hybrid Heating dissolving in water, add mineral acid, formaldehyde and whipping agent blend then, hot briquetting in baking oven gets gelatin/polyvinyl alcohol compound sponge.
6. the preparation method of gelatin/polyvinyl alcohol compound sponge according to claim 5 is characterized in that described polyvinyl alcohol and gelatin Hybrid Heating dissolved temperature range are 90-100 ℃, and the time of heating for dissolving is 100～120min.
7. according to the preparation method of claim 5 or 6 described gelatin/polyvinyl alcohol compound sponges, it is characterized in that the processing condition of hot briquetting in the baking oven are: the temperature of thermoforming is 60-100 ℃, and hot forming time is 4～12h.
8. according to the preparation method of claim 5 or 6 described gelatin/polyvinyl alcohol compound sponges, it is characterized in that described mineral acid is sulfuric acid or hydrochloric acid.
9. according to the preparation method of claim 5 or 6 described gelatin/polyvinyl alcohol compound sponges, it is characterized in that described whipping agent is sodium bicarbonate or sodium lauryl sulphate.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147646A (en) * | 2014-08-19 | 2014-11-19 | 张秀华 | Compound Callicarpa macrophylla Vahl sponge for surgical hemostasis, and preparation method thereof |
| CN106349617A (en) * | 2015-07-15 | 2017-01-25 | 宿迁嘉禾塑料金属制品有限公司 | Starch-free PVA collodion cotton and preparation method thereof |
| CN107022163A (en) * | 2017-06-13 | 2017-08-08 | 浙江理工大学 | A kind of polyvinyl alcohol collodion and preparation method thereof |
| CN110251718A (en) * | 2019-06-13 | 2019-09-20 | 山东省药学科学院 | A kind of preparation method of gelatin nose cavity hemostatic sponge |
| CN114887111A (en) * | 2022-03-28 | 2022-08-12 | 四川大学 | Bioabsorbable composite hemostatic material and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101381500A (en) * | 2008-10-16 | 2009-03-11 | 武汉理工大学 | Chitin/polyvinyl alcohol composite foam material and preparation method thereof |
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| CN101381500A (en) * | 2008-10-16 | 2009-03-11 | 武汉理工大学 | Chitin/polyvinyl alcohol composite foam material and preparation method thereof |
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| 《中国博士学位论文全文数据库医药卫生科技辑》 20080415 吴佳奇 新型多孔PVA及其复合物修复兔膝关节骨软骨缺损的实验研究 第E066-26页 1-9 , 第4期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147646A (en) * | 2014-08-19 | 2014-11-19 | 张秀华 | Compound Callicarpa macrophylla Vahl sponge for surgical hemostasis, and preparation method thereof |
| CN106349617A (en) * | 2015-07-15 | 2017-01-25 | 宿迁嘉禾塑料金属制品有限公司 | Starch-free PVA collodion cotton and preparation method thereof |
| CN107022163A (en) * | 2017-06-13 | 2017-08-08 | 浙江理工大学 | A kind of polyvinyl alcohol collodion and preparation method thereof |
| CN107022163B (en) * | 2017-06-13 | 2020-04-03 | 浙江理工大学 | Polyvinyl alcohol collodion and preparation method thereof |
| CN110251718A (en) * | 2019-06-13 | 2019-09-20 | 山东省药学科学院 | A kind of preparation method of gelatin nose cavity hemostatic sponge |
| CN110251718B (en) * | 2019-06-13 | 2021-07-09 | 山东省药学科学院 | Preparation method of gelatin nasal cavity hemostatic sponge |
| CN114887111A (en) * | 2022-03-28 | 2022-08-12 | 四川大学 | Bioabsorbable composite hemostatic material and preparation method and application thereof |
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Application publication date: 20110216 |