CN101966352B - Bioartificial liver support system and combined type liquid storage tank thereof - Google Patents
Bioartificial liver support system and combined type liquid storage tank thereof Download PDFInfo
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- CN101966352B CN101966352B CN 201010281676 CN201010281676A CN101966352B CN 101966352 B CN101966352 B CN 101966352B CN 201010281676 CN201010281676 CN 201010281676 CN 201010281676 A CN201010281676 A CN 201010281676A CN 101966352 B CN101966352 B CN 101966352B
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- 239000007788 liquid Substances 0.000 title claims abstract description 204
- 210000004185 liver Anatomy 0.000 title claims abstract description 42
- 210000002381 plasma Anatomy 0.000 claims abstract description 60
- 210000003677 hemocyte Anatomy 0.000 claims description 4
- 229940000351 hemocyte Drugs 0.000 claims description 4
- 206010019663 Hepatic failure Diseases 0.000 abstract description 32
- 208000007903 liver failure Diseases 0.000 abstract description 32
- 231100000835 liver failure Toxicity 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 23
- 239000000463 material Substances 0.000 abstract description 3
- 238000000746 purification Methods 0.000 description 11
- 210000003494 hepatocyte Anatomy 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000010338 mechanical breakdown Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 210000003850 cellular structure Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 210000005229 liver cell Anatomy 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000037593 Non-syndromic bilambdoid and sagittal craniosynostosis Diseases 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002337 anti-port Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001691 poly(ether urethane) Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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Abstract
The invention discloses a bioartificial liver support system and a combined type liquid storage tank thereof, wherein the combined type liquid storage tank comprises a closed liquid inlet tank and a closed liquid return tank; the top of the liquid inlet tank is provided with a first liquid inlet and a first air pressure balancing hole; the bottom of the liquid inlet tank is provided with a first liquid outlet and a second liquid inlet; the top of the liquid return tank is provided with a third liquid inlet and a second air pressure balancing hole; the bottom of the liquid return tank is provided with a second liquid outlet and a third liquid outlet; and the second liquid outlet is communicated with the second liquid inlet by a first communicating pipe which is provided with a direction and flow control device. The invention can improve material interchange efficiency between hepatic failure blood plasma and a bioreactor, avoids futile cycle, does not need to depend on the chimney effect of pumps, has simple structure and stable operation and has improvement of the bioartificial liver support system. In the invention, volume of the liquid inlet tank and the liquid return tank can be adjusted according to specific requirements to suit clinical application.
Description
Technical field
The present invention relates to a kind of armarium be used to carrying out bioartificial liver treatment, but particularly a kind of device of Effective Raise bioartificial liver therapeutic effect and combination type liquid storage tank thereof belong to field of biomedicine technology.
Background technology
Biological artificial liver support system is a kind of device that provides external liver function to support for the liver failure patient, and new way has been opened up in the treatment that appears as liver failure of this technology.Its ultimate principle is that the liver cell line (immortalized hepatocyte strain etc.) with the primary hepatocyte of in-vitro separation (porcine hepatocyte, human liver cell etc.) or In vitro culture places bioreactor, make the blood plasma of hepatic failure patients carry out mass exchange by having certain molecular retention amount semipermeable membrane and hepatocyte, thereby reach therapeutic purposes such as correcting metabolism disorder.In this field, be two large focuses for the research of cell source and bioreactor.But some other problemses during biological artificial liver support system makes up such as the design of liquid storage tank, also have important using value, but do not obtain deep research.
Liquid storage tank is one of assembly in the biological artificial liver support system, and liquid storage tank reasonable in design can improve the mass exchange efficient between hepatic failure patients blood plasma (or blood) and the bioreactor, improves curative effect.The external ripe biological artificial liver support system of having researched and developed has AMC-BAL, BLSS, ELAD, HepatAssist, MELS etc., roughly there are two class problems: 1) liquid storage tank is not installed, the liver failure plasma flow only can be consistent with the draw speed of liver failure blood plasma in patient body through the speed of bioreactor, and the draw speed of blood plasma in the hepatic failure patients body to be physiological situation according to the patient be subject to strict restriction, affected the mass exchange efficient between liver failure blood plasma and the bioreactor.2) use single chamber liquid storage tank, although the liver failure plasma flow can substantially exceed the draw speed of liver failure blood plasma in patient body through the speed of bioreactor, but the purification blood plasma of the bioreactor of having flowed through directly mixes with the liver failure blood plasma of the bioreactor of not flowing through, can't avoid part liver failure blood plasma not with bioreactor in the hepatocyte effect namely return in the patient body, the existence of invalid circulation is its major defect.
For addressing this problem, Chinese patent application 200910155039.X discloses a kind of dual-cavity liquid storage tank for biological artificial liver support system.But carry out in bioartificial liver's therapeutic process at this dual-cavity liquid storage tank of application, the purification blood plasma of bioreactor effect and be that swabbing action by pump realizes without the one-way flow between the liver failure blood plasma of bioreactor effect, when meeting with the mechanical breakdown such as unexpected termination of pumping and operation mistake, the one-way flow of blood plasma can be interfered in the two-chamber.
Summary of the invention
The object of the invention is to remedy the deficiencies in the prior art, a kind of biological artificial liver support system and combination type liquid storage tank thereof of the bioartificial liver's of being applicable to treatment is provided.
The objective of the invention is to be achieved through the following technical solutions: the combination type liquid storage tank that should be used for biological artificial liver support system comprise that being positioned at closed on the same level face entered liquid pool and the closed liquid pool that returns, the top that enters liquid pool is provided with first liquid entrance and the first air equalizer opening, and the bottom that enters liquid pool is provided with first liquid outlet and second liquid entrance; The top of returning liquid pool is provided with the 3rd liquid inlet and the second air equalizer opening, and the bottom of returning liquid pool is provided with second liquid outlet and the 3rd liquid outlet; The second liquid outlet is equipped with direction and volume control device by being communicated with the second liquid entrance the first communicating pipe on the first communicating pipe.
Further, direction of the present invention and volume control device comprise unidirectional valve and pinch valve, and described unidirectional valve and pinch valve were installed on respectively on the first communicating pipe.
Further, the diameter of the first air equalizer opening of the present invention and the second air equalizer opening is 0.5cm.
The biological artificial liver support system of use combinations thereof formula liquid storage tank of the present invention comprises plasma separator and bioreactor, also comprise combination type liquid storage tank and tee T, described combination type liquid storage tank comprises that being positioned at closed on the same level face enters liquid pool and the closed liquid pool that returns, the top that enters liquid pool is provided with first liquid entrance and the first air equalizer opening, and the bottom that enters liquid pool is provided with first liquid outlet and second liquid entrance; The top of returning liquid pool is provided with the 3rd liquid inlet and the second air equalizer opening, and the bottom of returning liquid pool is provided with second liquid outlet and the 3rd liquid outlet; The second liquid outlet is equipped with direction and volume control device by being communicated with the second liquid entrance the first communicating pipe on the first communicating pipe; Described first liquid outlet is communicated with by the second communicating pipe with the entrance of bioreactor, in the second communicating pipe circulating pump is installed; Described the 3rd liquid outlet is connected with the first arm of described tee T, and the outlet of the hemocyte of described plasma separator is connected with the second arm of described tee T, is equipped with at the first arm of described tee T and returns stock pump; Described the 3rd liquid inlet is communicated with the outlet of bioreactor; Described first liquid entrance is communicated with by the third connecting pipe with the blood plasma outlet of plasma separator, at the third connecting pipe separate pump is installed; The entrance of described plasma separator was connected with for the 4th communicating pipe.
Further, direction of the present invention and volume control device comprise unidirectional valve and pinch valve, and described unidirectional valve and pinch valve were installed on respectively on the first communicating pipe.
Further, the diameter of the first air equalizer opening of the present invention and the second air equalizer opening is 0.5cm.
Compared with prior art, usefulness of the present invention is: when combination type liquid storage tank of the present invention is applied to biological artificial liver support system, can improve the mass exchange efficient between liver failure blood plasma and the bioreactor, avoid invalid circulation, and the purification blood plasma of bioreactor effect and utilized for the first communicating pipe realized by the poor and unidirectional valve of gravitional force as medium without the one-way flow between the liver failure blood plasma of bioreactor effect, rather than the swabbing action of dependence pump, simple in structure, stable, be conducive to improve the curative effect of biological artificial liver support system.Biological artificial liver support system provided by the invention can according to real needs, adjust liquid pool and the volume that returns liquid pool, to be suitable for clinical practice with the combination type liquid storage tank.
Description of drawings
Fig. 1 is the perspective view that the present invention is used for the combination type liquid storage tank of biological artificial liver support system.
Fig. 2 is the structural representation of biological artificial liver support system of the present invention.
The specific embodiment
The below describes the present invention with reference to the accompanying drawings in detail, will make purpose of the present invention and effect be easier to understand.
As shown in Figure 1, the present invention's combination type liquid storage tank of being used for biological artificial liver support system mainly enters liquid pool 1 and the closed liquid pool 2 that returns forms by closed.Enter liquid pool 1 and return liquid pool 2 to can be the identical hydrostatic column of size, made by transparent organic glass; Remove wall thickness, the high 7cm in pond, bottom surface diameter 6cm, the about 200ml of volume.The top that enters liquid pool 1 has first liquid entrance 4 and the first air equalizer opening 7, and the bottom has first liquid outlet 5 and second liquid entrance 6.The 3rd liquid inlet 8 and the second air equalizer opening 11 are arranged at the top of returning liquid pool 2, and second liquid outlet the 9 and the 3rd liquid outlet 10 is arranged at the bottom.The caliber of above all liq entrance and liquid outlet all can be set to the about 0.6cm of interior diameter, outer length 1cm.The first air equalizer opening 7 and the second air equalizer opening 11 can be used for keeping the pond inside and outside air pressure balance, their radius all can be 0.5cm, the hole is in-built, and the aperture is arranged is 0.22 micron microporous filter membrane, can stop antibacterial to enter in the pond, and the microporous filter membrane material can be polyvinylidene fluoride etc.Return the second liquid outlet 9 of liquid pool 2 bottoms via being connected with the second liquid entrance 6 that enters liquid pool 1 bottom the first communicating pipe 3, namely the two ends of the first communicating pipe 3 are connected with the second liquid entrance 6 that enters liquid pool 1 bottom with the second liquid outlet 9 of returning liquid pool 2 bottoms respectively, the tube chamber interior diameter of the first communicating pipe 3 is 0.5cm, made by silica gel, in the first communicating pipe 3 unidirectional valve 12 and pinch valve 13 are installed, flow direction and the flow of liquid are controlled being used for.Unidirectional valve 12 can be made by materials such as poly(ether-urethane)s, cross section is circular, interior diameter is 1.5cm, from the pressure of second liquid outlet 9 greater than from the pressure of second liquid entrance 6 time, unidirectional valve 12 automatic openings, otherwise unidirectional valve 12 is autoshutdown under pressure, has guaranteed that liquid exports 9 to second liquid entrance 6 one-way flow that enter liquid pool 1 bottom from the second liquid that returns liquid pool 2 bottoms.Pinch valve 13 is made by rigid plastics, can press from both sides at any time when needed and close for the first communicating pipe 3.
When combination type liquid storage tank of the present invention was used for biological artificial liver support system, biological artificial liver support system comprised that mainly plasma separator 16, bioreactor 19 and described combination type liquid storage tank consist of.Wherein, the first liquid outlet that enters liquid pool 1 of combination type liquid storage tank 5 is communicated with by the second communicating pipe 23 with the entrance of bioreactor 19, in the second communicating pipe 23 circulating pump 18 is installed; The 3rd liquid outlet 10 that returns liquid pool 2 is connected with the first arm 14 of tee T, and the outlet of the hemocyte of plasma separator 16 is connected with the second arm 15 of described tee T, is equipped with at the first arm 14 of described tee T and returns stock pump 20; The 3rd liquid inlet 8 of returning liquid pool 2 in the combination type liquid storage tank is communicated with the outlet of bioreactor 19; The first liquid entrance 4 that enters liquid pool 1 is communicated with by third connecting pipe 24 with the blood plasma outlet of plasma separator 16, at third connecting pipe 24 separate pump 17 is installed; The entrance of plasma separator 16 was connected with for the 4th communicating pipe 22.
As shown in Figure 1 and Figure 2, when using biological artificial liver support system of the present invention, blood is drawn from the vein of hepatic failure patients, through the plasma separator 16 of flowing through the 4th communicating pipe 22, the cell component of blood directly returns human body through the second arm 15 and the 3rd arm 21 of tee T by the hemocyte outlet of separator 16; Liver failure blood plasma then is separated under the swabbing action of separate pump 17 by the blood plasma outlet of separator 16, is entered into liquid pool 1 by the first liquid entrance 4 that enters liquid pool 1 top through third connecting pipe 24, mixes mutually with the 100ml ringer's solution that enters liquid pool 1 interior pre-punching.Under the swabbing action of circulating pump 18, the liver failure blood plasma that enters in the liquid pool 1 is drawn via the first liquid outlet 5 of bottom, pond, through the bioreactor 19 of flowing through the second communicating pipe 23, after hepatocyte effect in the bioreactor 19, become purification blood plasma, enter via the 3rd liquid inlet 8 of returning liquid pool 2 tops and to return liquid pool 2, mix mutually with the 100ml ringer's solution that returns liquid pool 2 interior pre-punchings.The purification blood plasma that a part is returned in the liquid pool 2 is drawn through the 3rd liquid outlet 10 of bottom, pond under the swabbing action of returning stock pump 20, advance the first arm 14 and the 3rd arm 21 of people's tee T, in the 3rd arm 21, the cell component of blood mixes mutually with blood plasma, jointly returns in the hepatic failure patients body.Owing to enter liquid pool 1 and return liquid pool 2 and place the same level height, and the flow velocity of circulating pump 18 is greater than returning stock pump 20, liquid levels in the liquid pool 2 can occur returning and surpass rapidly trend into the liquid level in the liquid pool 1, causing the liver failure blood plasma in the liquid pool 1 and returning between the purification blood plasma in the liquid pool 2 exists gravitional force poor, from the pressure of the second liquid outlet 9 of returning liquid pool 2 bottoms greater than the pressure from the second liquid entrance 6 that enters liquid pool 1 bottom, unidirectional valve 12 is automatic opening under pressure, the second liquid outlet 9 of purification blood plasma from the bottom, pond that a part is returned in the liquid pool 2 entered for the first communicating pipe 3, second liquid entrance 6 through entering liquid pool 1 bottom is back into liquid pool 1, the bioreactor 19 of repeatedly flowing through, realized the hepatocellular repeatedly effect in liver failure blood plasma and the bioreactor 19, improve mass exchange efficient, helped to strengthen the curative effect of biological artificial liver support system.Since the blood plasma that bioreactor effect purifies with without the one-way flow between the liver failure blood plasma of bioreactor effect by the poor realization of gravitional force, the liquid level liquid level interior with returning liquid pool 2 that enters in the liquid pool 1 can trend towards balance automatically.Because the existence of unidirectional valve 12, even in mechanical breakdown or manual operation mistakes such as the 18 unexpected terminations of pumping of experience circulating pump, during such as the situations such as antiport of circulating pump 18, the liquid level that enters in the liquid pool 1 surpasses the liquid level that returns in the liquid pool 2, unidirectional valve 12 is autoshutdown under pressure, enter liver failure blood plasma in the liquid pool 1 and still can not flow into and return liquid pool 2, guarantee liver failure blood plasma can be not with bioreactor 19 in the hepatocyte effect namely return in the hepatic failure patients body.Before treatment finishes, stop first separate pump 17 and return stock pump 20, the liver failure blood plasma that enters in the liquid pool 1 continues repeatedly to flow through bioreactor 19 under the swabbing action of circulating pump 18, after it is fully purified, folder closes the pinch valve 13 on communicating pipe 3, purify blood plasma and stop to entering the mobile of liquid pool 1 by returning liquid pool 2, enter all liver failure blood plasma in the liquid pool 1 and under the swabbing action of circulating pump 18, enter and return liquid pool 2.Start simultaneously and return stock pump 20, all purification blood plasma that return in the liquid pool 2 slowly return in the dried depleted patient body, and treatment finishes.
Biological artificial liver support system of the present invention combination type liquid storage tank, it returns the purification blood plasma that only holds bioreactor effect in the liquid pool, can definitely avoid directly returning in the patient body without the liver failure blood plasma of bioreactor effect, thereby avoided invalid circulation, improved mass exchange efficient, compare with common single chamber liquid storage tank, obvious innovation is arranged.In addition, biological artificial liver support system provided by the present invention is compared with existing dual-cavity liquid storage tank for biological artificial liver support system with the combination type liquid storage tank, and obvious improvement is also arranged.In the running of dual-cavity liquid storage tank for biological artificial liver support system, the purification blood plasma of bioreactor effect and be that swabbing action by pump realizes without the one-way flow between the liver failure blood plasma of bioreactor effect, when meeting with the mechanical breakdown such as unexpected termination of pumping and operation mistake, the one-way flow of blood plasma can be interfered in the two-chamber.Biological artificial liver support system provided by the present invention combination type liquid storage tank, not only possesses the function that dual-cavity liquid storage tank for biological artificial liver support system improves the mass exchange efficient between hepatic failure patients blood plasma and the bioreactor, and the purification blood plasma of bioreactor effect and utilized for the first communicating pipe realized by the poor and unidirectional valve of gravitional force as medium without the one-way flow between the liver failure blood plasma of bioreactor effect, rather than the effect of dependence pump, be not subjected to mechanical breakdown and human operational error's etc. interference, simple in structure and operation is more stable, more be conducive to improve the curative effect of biological artificial liver support system.
Biological artificial liver support system provided by the present invention combination type liquid storage tank, rationally novel in design, but the mass exchange efficient in the Effective Raise bioartificial liver therapeutic process, and stable, easy operating has a good application prospect in bioartificial liver's treatment field.
Claims (6)
1. combination type liquid storage tank that is used for biological artificial liver support system, it is characterized in that: comprise that being positioned at closed on the same level face enters liquid pool (1) and the closed liquid pool (2) that returns, the top that enters liquid pool (1) is provided with first liquid entrance (4) and the first air equalizer opening (7), and the bottom that enters liquid pool (1) is provided with first liquid outlet (5) and second liquid entrance (6); The top of returning liquid pool (2) is provided with the 3rd liquid inlet (8) and the second air equalizer opening (11), and the bottom of returning liquid pool (2) is provided with second liquid outlet (9) and the 3rd liquid outlet (10); Second liquid outlet (9) is equipped with direction and volume control device by being communicated with second liquid entrance (6) the first communicating pipe (3) on the first communicating pipe (3).
2. the combination type liquid storage tank for biological artificial liver support system according to claim 1, it is characterized in that: described direction and volume control device comprise unidirectional valve (12) and pinch valve (13), and described unidirectional valve (12) and pinch valve (13) were installed on respectively on the first communicating pipe (3).
3. the combination type liquid storage tank for biological artificial liver support system according to claim 1, it is characterized in that: the diameter of described the first air equalizer opening (7) and the second air equalizer opening (11) is 0.5cm.
4. a right to use requires the biological artificial liver support system of 1 combination type liquid storage tank, comprise plasma separator (16) and bioreactor (19), it is characterized in that: also comprise combination type liquid storage tank and tee T, described combination type liquid storage tank comprises that being positioned at closed on the same level face enters liquid pool (1) and the closed liquid pool (2) that returns, the top that enters liquid pool (1) is provided with first liquid entrance (4) and the first air equalizer opening (7), and the bottom that enters liquid pool (1) is provided with first liquid outlet (5) and second liquid entrance (6); The top of returning liquid pool (2) is provided with the 3rd liquid inlet (8) and the second air equalizer opening (11), and the bottom of returning liquid pool (2) is provided with second liquid outlet (9) and the 3rd liquid outlet (10); Second liquid outlet (9) is equipped with direction and volume control device by being communicated with second liquid entrance (6) the first communicating pipe (3) on the first communicating pipe (3); Described first liquid outlet (5) is communicated with by the second communicating pipe (23) with the entrance of bioreactor (19), in the second communicating pipe (23) circulating pump (18) is installed; Described the 3rd liquid outlet (10) is connected with first arm (14) of described tee T, the outlet of the hemocyte of described plasma separator (16) is connected with second arm (15) of described tee T, is equipped with at first arm (14) of described tee T and returns stock pump (20); Described the 3rd liquid inlet (8) is communicated with the outlet of bioreactor (19); Described first liquid entrance (4) is communicated with by third connecting pipe (24) with the blood plasma outlet of plasma separator (16), at third connecting pipe (24) separate pump (17) is installed; The entrance of described plasma separator (16) is connected with the 4th communicating pipe (22).
5. biological artificial liver support system according to claim 4, it is characterized in that: described direction and volume control device comprise unidirectional valve (12) and pinch valve (13), and described unidirectional valve (12) and pinch valve (13) were installed on respectively on the first communicating pipe (3).
6. biological artificial liver support system according to claim 4, it is characterized in that: the diameter of described the first air equalizer opening (7) and the second air equalizer opening (11) is 0.5cm.
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| WO1996039817A1 (en) * | 1995-06-07 | 1996-12-19 | Circe Biomedical, Inc. | Apparatus for bioprocessing a circulating fluid |
| CN101401979A (en) * | 2008-10-28 | 2009-04-08 | 浙江大学 | Extracorporeal circulation pool of artificial liver support system |
| CN101732770A (en) * | 2009-12-14 | 2010-06-16 | 浙江大学 | Dual-cavity liquid storage tank for biological artificial liver support system |
| CN101732771A (en) * | 2009-12-17 | 2010-06-16 | 中日友好医院 | Cell reactor and artificial liver support system comprising same |
| CN201871013U (en) * | 2010-09-10 | 2011-06-22 | 浙江大学 | Bioartificial liver support system and combined liquid storage tank |
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2010
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039817A1 (en) * | 1995-06-07 | 1996-12-19 | Circe Biomedical, Inc. | Apparatus for bioprocessing a circulating fluid |
| CN101401979A (en) * | 2008-10-28 | 2009-04-08 | 浙江大学 | Extracorporeal circulation pool of artificial liver support system |
| CN101732770A (en) * | 2009-12-14 | 2010-06-16 | 浙江大学 | Dual-cavity liquid storage tank for biological artificial liver support system |
| CN101732771A (en) * | 2009-12-17 | 2010-06-16 | 中日友好医院 | Cell reactor and artificial liver support system comprising same |
| CN201871013U (en) * | 2010-09-10 | 2011-06-22 | 浙江大学 | Bioartificial liver support system and combined liquid storage tank |
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Assignee: Weihai Weigao Life Science & Technology Co., Ltd. Assignor: Zhejiang University Contract record no.: 2012330000164 Denomination of invention: Bioartificial liver support system and combined type liquid storage tank thereof License type: Exclusive License Open date: 20110209 Record date: 20120411 |
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