CN101966189A - Amlodipine and olmesartan-containing compound preparation for treating hypertension - Google Patents
Amlodipine and olmesartan-containing compound preparation for treating hypertension Download PDFInfo
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- CN101966189A CN101966189A CN 201010234033 CN201010234033A CN101966189A CN 101966189 A CN101966189 A CN 101966189A CN 201010234033 CN201010234033 CN 201010234033 CN 201010234033 A CN201010234033 A CN 201010234033A CN 101966189 A CN101966189 A CN 101966189A
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- amlodipine
- olmesartan
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Abstract
The invention relates to an amlodipine and olmesartan-containing compound preparation for treating hypertension. The compound preparation consists of the following components: main ingredients including amlodipine or a pharmaceutically-acceptable salt thereof, hydrochlorothiazide and olmesartan or a pharmaceutically-acceptable salt thereof, and a pharmaceutically-acceptable carrier. The amlodipine and olmesartan-containing compound preparation has the advantages that: based on the mechanism that medicaments are used in combination to fully play the complementary actions of the medicaments, curative effect is enhanced, the standards are reached quickly, and the standard reaching rate of blood pressure reaches 82 percent, and the adverse reaction related with increase in a certain dose is reduced and the action lasts for a long time. The compound preparation has the characteristics of quick response, high standard reaching rate of the blood pressure, small side effect and low cost.
Description
Technical field:
The present invention relates to a kind of compound preparation that hypertension contains amlodipine and Olmesartan for the treatment of, belong to drug world.
Background technology:
Along with China's rapid growth of economy, the drastic change of people life style, the acceleration of urbanization, aging, the cardiovascular diseases has become first or second cause of the death of rural and urban population.Especially patients with hypertension, its sickness rate accounts for total population about 15%.Morbidity colony is so big, seeks medicine evident in efficacy, that side effect is little and seems more important.
The hypertensive medicine of treatment has multiple at present, such as calcium antagonist (CCBs), converting enzyme inhibitor (ACEI), angiotensin ii receptor antagonist (ARBs) etc., but single medicine treatment hypertension is difficult up to standard in a short time, and Most patients need be taken two or more antihypertensive drug can reach the blood pressure lowering target.Especially blood pressure exceeds desired value 20/10mmHg, and beginning need be taken two kinds of medicines often.Single medicine is prone to drug resistance, and because the bigger probability that toxicity occurs of dosage is also bigger.Majority is to give two or more drug administration treatments simultaneously.But several drugs is taken simultaneously, and patient's compliance is poor, and the collocation of the dosage of several drugs is not because the problem of formulation dosage and doctor's the degree of awareness often are optimized proportionings.In recent years, though the depressor of much new good effect few side effects is arranged, the controlling blood pressure compliance rate is relatively low.But drug combination can be used two or more depressor, and the dosage of every kind of medicine is little, and the therapeutical effect of medicine should have collaborative or the effect of addition at least, and its ill effect can be cancelled out each other or not overlapping at least or addition.Medicine kind number used during drug combination is too much unsuitable, and crossing to have complicated drug interaction at most.Therefore, select to merge very difficulty of medication amount and kind, need a large amount of development tests.
Therefore, a kind of new treatment pattern is applied to clinical gradually, and the compound hypertension medicine preparation is internationally recognized a kind of orientation treatment.Because the compound antihypertensive drug prescription is followed the principle that different mechanism of action medicines carry out proportioning usually, therefore show as the advantage that increases curative effect or reduce side effect, obtained better controlling of blood pressure effect.
Summary of the invention:
The object of the present invention is to provide a kind of side effect little, taking convenience can effectively be treated the compound preparation of hypertensive three kinds of antihypertensive drugs, and this compound preparation is controlling blood pressure effectively.
Purpose of the present invention is implemented by following technical scheme: a kind ofly treat the compound preparation that hypertension contains amlodipine and Olmesartan, include following composition: amlodipine (Amlodipine) or amlodipine officinal salt, hydrochlorothiazide (hydrochlorothiazide), Olmesartan (olmesartan) or its officinal salt are Main Ingredients and Appearance, being equipped with pharmaceutically suitable carrier forms, in wherein every preparation unit, described amlodipine (Amlodipine) or amlodipine officinal salt, count 2.5-10.0mg with amlodipine, described Olmesartan (olmesartan) or its officinal salt, count 2.0-10.0mg with Olmesartan, described hydrochlorothiazide (hydrochlorothiazide) is 6.25-25.0mg.
It is a kind of that to treat the compound preparation that hypertension contains amlodipine and Olmesartan be capsule, soft capsule, granule, tablet, powder, controlled release agent or injection dosage form.
Advantage of the present invention: be to give full play to the complementary mechanism of action of medicine according to drug combination to increase curative effect, up to standard fast, make the blood pressure compliance rate reach 80.25%, reduce the untoward reaction that increases the pass with a certain dosage.Compound formulation of the present invention has instant effect, blood pressure compliance rate height, and side effect is little, the characteristics that cost is low.
The specific embodiment:
Further set forth medicine of the present invention by the following examples, these embodiment are only presented for purposes of illustration, do not limit the scope of the invention.
Embodiment 1-4 is listed as follows:
Use the conventional method in the pharmaceuticals industry among the embodiment, the according to the form below formulation becomes tablet, makes the used pharmaceutically suitable carrier of tablet--and adjuvant is the conventional adjuvant of this area.Wherein the proportioning of its Main Ingredients and Appearance is as follows:
| Embodiment | In amlodipine (mg/ sheet) | In Olmesartan (mg/ sheet) | Hydrochlorothiazide (mg/ sheet) |
| 1 | Amlodipine 2.5 | Olmesartan 2.0 | Hydrochlorothiazide 6.25 |
| 2 | Amlodipine 2.5 | Olmesartan 5.0 | Hydrochlorothiazide 12.5 |
| 3 | Amlodipine 5.0 | Olmesartan 10.0 | Hydrochlorothiazide 25.0 |
| 4 | Amlodipine 10.0 | Olmesartan 5.0 | Hydrochlorothiazide 12.5 |
Use the conventional method in the pharmaceuticals industry simultaneously among the embodiment, can also be prepared into capsule, soft capsule, granule, powder, controlled release agent or injection dosage form,, pharmaceutically suitable carrier-used adjuvant is the conventional adjuvant of this area of this dosage form.
Embodiment 5: the present invention treats hypertensive compound preparation clinical trial:
Below will be by human body pharmacodynamic experiment explanation pharmaceutical composition of the present invention to hypertensive therapeutical effect.
1, physical data:
Clinical 400 routine hypertension philtrums, age 40--50 year, 140 examples; Age 51--60 year, 140 examples, age 61--70 year, 120 examples.
2, diagnostic criteria: according to " Chinese hypertension prevention and control guide ", hypertension is defined as: do not obey under the antihypertensive situation systolic pressure 〉=140mmHg and/or diastolic pressure 〉=90mmHg.
3, Therapeutic Method:, adopt randomized to be divided into 4 groups, every group of this compound formulation medicine that adopts embodiment of the invention 1-4 gained respectively with 400 routine hypertensive patients, make tablet, every day is once oral, according to the dose difference of tablet, each a slice or two took 6 days.
4, efficacy assessment standard:
Draft according to " Chinese hypertension prevention and control guide ".The target of antihypertensive therapy is blood pressure to be returned to " normally " or " ideal " level.40-60 year patient be depressurized to ideal or normal arterial pressure (≤130/85mmHg), 60-70 year patient be depressurized at least normal high value (≤140/90mmHg).
5, therapeutic outcome: administration begins to carry out respectively in the 1st day, 2 days, 3 days, 4 days, 5 days, 6 days blood pressure determination.The result shows that medication is after 6 days, 4 groups of the embodiment of the invention are totally 400 routine hypertension philtrums, and it is up to standard to amount to 320 routine patient's blood pressures, promptly returns to " normally " or " ideal " level, mean blood pressure compliance rate 80.25% illustrates that the present embodiment compound medicine has good curing hypertension effect.
Curative effect sees the following form:
| Case load | Blood pressure case sum up to standard | The below standard case sum of blood pressure | The mean blood pressure compliance rate |
| 400 | 321 | 79 | 80.25％ |
Discuss
This product is the hypertensive compound formulation of treatment, its blood pressure compliance rate higher 80.25%.
Claims (2)
1. treat the compound preparation that hypertension contains amlodipine and Olmesartan for one kind, it is characterized in that, it includes following composition: amlodipine or amlodipine officinal salt, hydrochlorothiazide, Olmesartan or its officinal salt be Main Ingredients and Appearance, be equipped with pharmaceutically suitable carrier forms, in wherein every preparation unit, described amlodipine or amlodipine officinal salt, count 2.5-10.0mg with amlodipine, described Olmesartan or its officinal salt, count 2.0-10.0mg with Olmesartan, described hydrochlorothiazide is 6.25-25.0mg.
2. a kind of compound preparation that hypertension contains amlodipine and Olmesartan for the treatment of according to claim 1 and 2 is characterized in that described compound preparation is capsule, soft capsule, granule, tablet, powder, controlled release agent or injection dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010234033 CN101966189A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and olmesartan-containing compound preparation for treating hypertension |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910139990 | 2009-07-14 | ||
| CN200910139990.6 | 2009-07-14 | ||
| CN 201010234033 CN101966189A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and olmesartan-containing compound preparation for treating hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101966189A true CN101966189A (en) | 2011-02-09 |
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Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010234028 Pending CN101966188A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and candesartan-containing compound preparation for treating hypertension |
| CN 201010233860 Pending CN102038687A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and losartan-containing compound preparation for treating hypertension |
| CN 201010234038 Pending CN101966191A (en) | 2009-07-14 | 2010-07-13 | Amlodipine- and telmisartan-containing compound preparation for curing high blood pressure |
| CN 201010234033 Pending CN101966189A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and olmesartan-containing compound preparation for treating hypertension |
| CN 201010234027 Pending CN101966187A (en) | 2009-07-14 | 2010-07-13 | Amlodipine- and erbesartan-containing compound preparation for treating hypertension |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010234028 Pending CN101966188A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and candesartan-containing compound preparation for treating hypertension |
| CN 201010233860 Pending CN102038687A (en) | 2009-07-14 | 2010-07-13 | Amlodipine and losartan-containing compound preparation for treating hypertension |
| CN 201010234038 Pending CN101966191A (en) | 2009-07-14 | 2010-07-13 | Amlodipine- and telmisartan-containing compound preparation for curing high blood pressure |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 201010234027 Pending CN101966187A (en) | 2009-07-14 | 2010-07-13 | Amlodipine- and erbesartan-containing compound preparation for treating hypertension |
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| CN (5) | CN101966188A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743381B (en) * | 2011-04-22 | 2014-08-27 | 重庆市力扬医药开发有限公司 | Stable candesartan cilexetil amlodipine pharmaceutical composition and its preparation method |
| CN102327272B (en) * | 2011-07-14 | 2013-08-14 | 海南锦瑞制药股份有限公司 | Oral solid pharmaceutical composition and preparation method thereof |
| CN102342943B (en) * | 2011-07-14 | 2013-07-10 | 海南锦瑞制药股份有限公司 | Brand new oral solid medicinal composition and its preparation method |
| PT3573620T (en) | 2017-01-25 | 2023-03-20 | The George Inst For Global Health | Compositions for the treatment of hypertension |
| CN110755390A (en) * | 2018-07-26 | 2020-02-07 | 北京市石景山区高血压联盟研究所 | Compound antihypertensive drug tablet and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450211A (en) * | 2007-12-07 | 2009-06-10 | 上海艾力斯医药科技有限公司 | Composite antihypertensive preparation |
-
2010
- 2010-07-13 CN CN 201010234028 patent/CN101966188A/en active Pending
- 2010-07-13 CN CN 201010233860 patent/CN102038687A/en active Pending
- 2010-07-13 CN CN 201010234038 patent/CN101966191A/en active Pending
- 2010-07-13 CN CN 201010234033 patent/CN101966189A/en active Pending
- 2010-07-13 CN CN 201010234027 patent/CN101966187A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450211A (en) * | 2007-12-07 | 2009-06-10 | 上海艾力斯医药科技有限公司 | Composite antihypertensive preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101966191A (en) | 2011-02-09 |
| CN101966187A (en) | 2011-02-09 |
| CN101966188A (en) | 2011-02-09 |
| CN102038687A (en) | 2011-05-04 |
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Open date: 20110209 |