CN101966147B - Ibuprofen injection composite and preparation method thereof - Google Patents
Ibuprofen injection composite and preparation method thereof Download PDFInfo
- Publication number
- CN101966147B CN101966147B CN2010102933289A CN201010293328A CN101966147B CN 101966147 B CN101966147 B CN 101966147B CN 2010102933289 A CN2010102933289 A CN 2010102933289A CN 201010293328 A CN201010293328 A CN 201010293328A CN 101966147 B CN101966147 B CN 101966147B
- Authority
- CN
- China
- Prior art keywords
- injection
- ibuprofen
- arginine
- adds
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940088523 ibuprofen injection Drugs 0.000 title claims abstract description 61
- 238000002360 preparation method Methods 0.000 title abstract description 26
- 239000002131 composite material Substances 0.000 title abstract 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims abstract description 51
- 229960001680 ibuprofen Drugs 0.000 claims abstract description 50
- 239000007924 injection Substances 0.000 claims abstract description 40
- 238000002347 injection Methods 0.000 claims abstract description 40
- 229940090044 injection Drugs 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000000243 solution Substances 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 48
- 239000008215 water for injection Substances 0.000 claims description 34
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 26
- 239000003708 ampul Substances 0.000 claims description 26
- 239000004475 Arginine Substances 0.000 claims description 25
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 230000001954 sterilising effect Effects 0.000 claims description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims description 17
- 238000005303 weighing Methods 0.000 claims description 14
- 239000003610 charcoal Substances 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 13
- 238000012856 packing Methods 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940098416 ibuprofen 400 mg Drugs 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000006184 cosolvent Substances 0.000 abstract description 11
- 238000001990 intravenous administration Methods 0.000 abstract description 2
- 230000007547 defect Effects 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 57
- 238000012360 testing method Methods 0.000 description 34
- 238000009472 formulation Methods 0.000 description 32
- 238000007689 inspection Methods 0.000 description 24
- 230000000052 comparative effect Effects 0.000 description 20
- KEAGRYYGYWZVPC-UHFFFAOYSA-N 1-[4-(2-methylpropyl)phenyl]ethanone Chemical compound CC(C)CC1=CC=C(C(C)=O)C=C1 KEAGRYYGYWZVPC-UHFFFAOYSA-N 0.000 description 15
- 239000000126 substance Substances 0.000 description 15
- 239000003814 drug Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 238000001514 detection method Methods 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 239000011265 semifinished product Substances 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 229940093181 glucose injection Drugs 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 239000008354 sodium chloride injection Substances 0.000 description 10
- 238000001914 filtration Methods 0.000 description 8
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 7
- 239000004472 Lysine Substances 0.000 description 7
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 7
- 230000002949 hemolytic effect Effects 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 206010018910 Haemolysis Diseases 0.000 description 4
- 230000008588 hemolysis Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 230000010494 opalescence Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 239000000820 nonprescription drug Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000003725 endotheliocyte Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000003118 histopathologic effect Effects 0.000 description 1
- 229940082177 ibuprofen 800 mg Drugs 0.000 description 1
- 229940016803 ibuprofen chewable tablet Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007896 modified release capsule Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102933289A CN101966147B (en) | 2010-09-27 | 2010-09-27 | Ibuprofen injection composite and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010102933289A CN101966147B (en) | 2010-09-27 | 2010-09-27 | Ibuprofen injection composite and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101966147A CN101966147A (en) | 2011-02-09 |
CN101966147B true CN101966147B (en) | 2012-02-01 |
Family
ID=43545416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010102933289A Active CN101966147B (en) | 2010-09-27 | 2010-09-27 | Ibuprofen injection composite and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101966147B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103027890B (en) * | 2011-09-29 | 2014-06-18 | 天津市汉康医药生物技术有限公司 | Ibuprofen medicine composition for injection |
CN102579332A (en) * | 2012-03-26 | 2012-07-18 | 北京阜康仁生物制药科技有限公司 | Method for preparing ibuprofen injection |
CN102716069A (en) * | 2012-06-07 | 2012-10-10 | 无锡康福特药物科技有限公司 | Injection liquid containing ibuprofen and preparation process of injection liquid |
CN103893767A (en) * | 2013-09-17 | 2014-07-02 | 天津市嵩锐医药科技有限公司 | Ibuprofen medicine composition with stable quality |
CN106511360A (en) * | 2016-12-02 | 2017-03-22 | 上海芮范生物科技有限公司 | Composition containing ginsenoside Rg3 and silymarin and medicine |
CN108158980A (en) * | 2016-12-07 | 2018-06-15 | 浙江普利药业有限公司 | Arginine Ibuprofen parenteral solution and preparation method thereof |
CN108619087A (en) * | 2017-03-21 | 2018-10-09 | 长春海悦药业股份有限公司 | A kind of pharmaceutical composition containing brufen |
CN112957323B (en) * | 2021-03-29 | 2022-08-16 | 北京佳诚医药有限公司 | Dexibuprofen injection |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6727286B2 (en) * | 2001-11-02 | 2004-04-27 | Cumberland Pharmaceuticals Inc. | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
CN101810568A (en) * | 2010-03-29 | 2010-08-25 | 南京泛太化工医药研究所 | Injection containing ibuprofen and preparation method thereof |
-
2010
- 2010-09-27 CN CN2010102933289A patent/CN101966147B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6727286B2 (en) * | 2001-11-02 | 2004-04-27 | Cumberland Pharmaceuticals Inc. | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
CN101810568A (en) * | 2010-03-29 | 2010-08-25 | 南京泛太化工医药研究所 | Injection containing ibuprofen and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN101966147A (en) | 2011-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101966147B (en) | Ibuprofen injection composite and preparation method thereof | |
CN101244043A (en) | Bivalirudin freeze-dried injection and preparation thereof | |
CN110327339A (en) | A kind of compound Dextromethorphan oral administration solution and its preparation method and application | |
CN102160852A (en) | Ibuprofen injection and preparation method thereof | |
CN102008449B (en) | Lansoprazole enteric pellet and preparation method thereof | |
CN104840418A (en) | Fasudil hydrochloride injection composition and preparation method thereof | |
CN102335114B (en) | Stable ibuprofen arginine injection and preparation method thereof | |
CN101199514B (en) | Ketoralac ammonia butanetriol injection and preparing method thereof | |
CN102697718B (en) | Ibuprofen liquid injection composition and preparation method thereof | |
CN1814048B (en) | Chinese medicine liquid capsule of Folium callicarpae Nudiflorae, preparing method and quality control method | |
CN103860461A (en) | Medicinal composition containing active component ambroxol hydrochloride | |
CN102846561A (en) | Ozagrel sodium drug combination for injection | |
CN103520186B (en) | Pharmaceutical composition of a kind of fat-soluble vitamin for injection and preparation method thereof | |
CN102716069A (en) | Injection liquid containing ibuprofen and preparation process of injection liquid | |
CN106860446A (en) | Pediatric compound amino acid injection 19AA I compositions and the method for reducing its oxygen content | |
CN103222953B (en) | Fasudil hydrochloride injection composition and its preparation method | |
CN104146951B (en) | Dexibuprofen injection and preparation method thereof | |
CN103356478A (en) | Ibuprofen injection composition and preparation method thereof | |
CN105663107B (en) | Compound amino acid capsule agent | |
CN103816126A (en) | Pharmaceutical composition containing scopolamine butylbromide | |
CN102600143B (en) | Vinpocetine medicament composition and preparation method thereof | |
CN111166716A (en) | Naproxen injection and preparation method thereof | |
CN102988954B (en) | Medicinal composition containing thymopentin compound | |
CN103040737A (en) | Drug composition containing lansoprazole compound and preparation method of drug composition | |
CN107213122A (en) | A kind of injection omeprazole sodium freeze drying powder injection and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20110209 Assignee: Chengdu Easton Pharmaceutical Co.,Ltd. Assignor: SICHUAN SUNHEAL TECHNOLOGY Co.,Ltd. Contract record no.: 2012510000128 Denomination of invention: Ibuprofen injection composition and preparation method thereof Granted publication date: 20120201 License type: Exclusive License Record date: 20121121 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EM01 | Change of recordation of patent licensing contract |
Change date: 20180815 Contract record no.: 2012510000128 Assignee after: Chengdu Easton Biopharmaceuticals Co.,Ltd. Assignee before: Chengdu Easton Pharmaceutical Co.,Ltd. |
|
EM01 | Change of recordation of patent licensing contract | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230907 Address after: 611731 No. 8 Xiyuan Avenue, Chengdu High-tech Zone, Sichuan Province Patentee after: Chengdu Easton Biopharmaceuticals Co.,Ltd. Patentee after: SICHUAN SUNHEAL TECHNOLOGY Co.,Ltd. Address before: 6, building 1, No. 610041, south two, Ke garden, Chengdu hi tech Zone, Sichuan, Patentee before: SICHUAN SUNHEAL TECHNOLOGY Co.,Ltd. |
|
TR01 | Transfer of patent right |