CN101961526A - Tumor electronic treating device based on artificial immunological technology - Google Patents
Tumor electronic treating device based on artificial immunological technology Download PDFInfo
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- CN101961526A CN101961526A CN2009100239793A CN200910023979A CN101961526A CN 101961526 A CN101961526 A CN 101961526A CN 2009100239793 A CN2009100239793 A CN 2009100239793A CN 200910023979 A CN200910023979 A CN 200910023979A CN 101961526 A CN101961526 A CN 101961526A
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Abstract
The invention relates to a tumor electronic treating device based on an artificial immunological technology. The invention establishes human nerve cell 'action potential' activity information by applying a micro electronic technology and realizes an 'artificial bioelectric potential' technology. The technical parameter is suitable for the characteristics of human nerve cell physiological activity, effectively excites nerves, channels and the brain, exerts a whole body regulating function and improves the functions of organization cells, thereby establishing a human internal cause disease-resistant base to resist diseases. The device technology adopts an external power source and a transformer to transform, and a rectifier bridge, a diode and a capacitor to rectify and stabilize the voltage so as to obtain the direct current voltage needed by a circuit. The system reduces a nerve cell 'action potential' waveform data list into real waveforms by a D/A (Digital/Analog) converter integrated in a singlechip U1 C8051F020, acts on a human body through magnification and realizes a treating program.
Description
Affiliated technical field: the present invention relates to a kind of using artificial intelligent and the theory of neutral net and movable each parameter of human neuronal cell line (nerve fiber) " action potential " that technology is established, see Fig. 1, realize the cellular immunization regulation and control therapeutic instrument of a kind of " artificial bio-membrane's factor ", reach the purpose that is used the treatment tumor.
Background technology: tumor invasion is obviously relevant with the human body self immune functional state, and the immunocompromised person easily suffers from malignant tumor; After ill, cancerous cell secretion metabolism toxin damages each organs and tissues; Its main Therapeutic Method is operation, radiation and chemotherapy, and the mechanical injury of operation causes relevant internal organs disappearance and afunction, the local organs and tissues of radiation-induced damage irradiation field, the whole body seondary effect is also more obvious, and chemotherapeutics is with the blood flow whole body of circulating, and toxic and side effects is extensive, and heavier, even threat to life.Under above-mentioned factor effect, the immunity of cancer patient is very low usually.
Improve the related medical state of the art of immunologic function: the morbidity of human a lot of diseases is relevant with immune dysfunction, as the lupus erythematosus of connective tissue disease, autoimmune disease of immune disease or the like.The easy concurrent viral infection of immune dysfunction, as acquired immune deficiency syndrome (AIDS) (AIDS), common cold, influenza, hepatitis etc., and to virus how to no effect general medicine.Medical science mainly adopts hormone or antiviral therapy at present, and curative effect is limited, and side effect is more obvious, needs long-term prescription.Both with the immunosuppressant that suppresses relevant immune cell function, also adapted strengthened the immunostimulant of atypical immune cell function to some disease, and to improve the function of related immune cell, these medicines also have certain toxic and side effects.In a word, the disease kind that immune disease relates to is various, and Therapeutic Method is limited, and curative effect is undesirable, should make great efforts to excavate other effective Therapeutic Method.
Cancer and immune disease patient's the treatment that improves immunity, its main medicine has two classes, and the one, the Chinese medicine of China, preparation is various, and certain effect is arranged, and toxic and side effects is relatively low.Another kind of is the biological response modifier that prosperity in nearly 30 years is got up, as interferon, and lentinan, interleukin, thymosin or the like, the person's of having price is more expensive, and side effect is more obvious, and its application is restricted.Medicine is to bring into play its therapeutic effect by pharmacological action, certainly leads to certain toxic and side effects, and onset is slow, acts on faintly, does not reach the effect of comparatively fast, definitely improving immunity.
Disease is a human body under the effect of certain cause of disease infringement property, because of disorderly unusual life, the physiological activity process that takes place of homeostasis regulating action, related symptoms and sign occur and falls ill.Traditional motherland's medical science is recognized the pathogenic process of disease very early, just adopts acupuncture technique to stimulate meridian point to cure the disease over thousands of years, and many diseases are had good result, and at present many countries also adopt this technology.Medical research shows that the meridian point place has important nerve to pass through more, and acupoint has in fact also stimulated nerve.Modern acupuncture and meridian biophysical studies shows that meridians are atomic thin body fluid pipelines, have Low ESR conductive characteristic and meridians electrical potential activity.It " inline internal organs, outer network podomere runs through whole body, and the operation QI and blood is regulated negative and positive, keeps balance, correcting the deficiency and excess is located all kinds of diseases and ailments ", the adjusting of each organ function of human body is played an important role, improve the human body resistance against diseases, keep fit.Modern medicine has been done deep research to nerve, has surveyed neurocyte " action potential " waveform, the clear and definite feature and the relevant parameter of this waveform; Measured neural contained impedance Rn, capacitive reactance Cn and induction reactance Ln qualitative, quantitative, pointed out neurocyte that its suitableeest " current potential " motion frequency is arranged according to this, thereby the clear and definite active essence of nervous physiology is its special " action potential " activity.But acupuncture is a mechanical irritation, and its stimulus quality does not conform to fully with the essence of nerve and meridians physiological activity " current potential ", and curative effect is obviously limited.
Develop polytype electronic medical instruments in the last hundred years abroad, surplus in the of 50 year over China also use these equipment, for example the ultrasound wave cancer therapeutic equipment is to kill and wound cancerous cell by heat effect, is a local therapeutic approaches.This equipment therapeutic process complexity, bigger to patient's restriction, might damage the adjacent important organ of tumor, can not treat small metastatic carcinoma.The steep-sided pulse cancer therapeutic equipment, this equipment can cause the tumor cell membrane electroporation, changes its permeability, promotes that chemotherapeutic enters in the cell, and kill cancer cell is an auxiliary treatment, and itself does not have the cancer effect of controlling.The low frequency electric therapeutic apparatus that grows up on the acupuncture technique basis, product is more, produces ITO1200 type TENS therapeutic instrument, the U.S. as Japan and produces in AUTOGENICSA620 type brain electricity biological feedback system, China marine products G6805 type electric acupuncture apparatus etc.By stimulating meridian point and nerve, bring into play its opsonic action, improve immunity, diseases such as the heart, cerebrovascular disease, parkinson disease, disease of hematopoietic system, delayed ischemic neurological deficits are had certain curative effect, but, Shang Weijian is used for the treatment of malignant tumor.What the Medical Technology index of these electronic medical instrumentses adopted is square wave, sine wave, zigzag wave or its myriad combinations of electronics, and its waveform characteristics are physics waveforms, comes down to a kind of " artificial physical agent ".These waveform parameters and neurocyte institute each parameter of inherent " action potential " wave activity are incompatible fully, employed frequency is also very high, can not impel neurocyte " waveform response " and " frequency response ", can not facilitate " bio-resonance ", can not excite the reaction of neural initiatively responsiveness, therefore, effectively excitor nerve and meridians, improve their function, its curative effect is inevitable limited.
The impassivity of tumor own, people can not its existence of perception, when it increase to a certain degree, invade and normal surrounding tissue, cause symptom, when clarifying a diagnosis, normal boundary late period, shift, about 60% patient of American-European medical developed country has been in this state, in China, especially rural area, small towns, its rate of transform is higher.Therefore, most humans need operation, Comprehensive Treatment such as radiotherapy, chemotherapy.These methods all are exogen, damaging treatment means, and patient is in passive state fully and accepts its treatment, further reduces its immunity.Internal organs damaged, immunity reduce, and promptly patient has lost the cooperation on " the disease-resistant basis of endogenous cause of ill ", and the real difficulty of any Therapeutic Method obtains good effect.
Cell is the functional unit of human body minimum, makes various active substances, keeps normal physiological activity, and the antagonism disease keeps human body to be in health status.The active basis of cell physiological and take the form of its " bioelectric potential " information activity.Current medical science generally all adopts the method for medicine to improve organs and tissues function, treatment disease, the pharmacological action of medicine does not conform to fully with the physiological activity characteristics of human body cell " ", human body is in passive state fully and accepts its treatment, essence is an obsessive Therapeutic Method, therefore, curative effect is limited.The contradiction of different " matter " always will go to solve with method correspondingly, since the active essence of cell physiological is the activity of its special " ", so, adopt the method deburring of its corresponding " " to swash it, actually caught the core methed that improves cell function, might cause that " waveform response " and " frequency response " takes place cell, impel " bio-resonance ", reach excitatory cells and improve the purpose of its function.
Summary of the invention:
1. implementation process of the present invention
The present invention is the research of finishing in view of the above problems, its purpose is, the modern novel artificial intelligent means of computer of using are provided, with artificial neural network and artificial immune system by effective synergism mechanism, establish movable each parameter of human neuronal cell line " bioelectric potential ", realize " the physics waveform " of each electronic therapeutic instrument technical parameter of continuing to use by the past medical circle conversion to " biological waveform " this " matter ".Stimulate two particular acupoint places (containing nerve) body surface on the relevant meridians traveling of the human body approach, regulate by physiological, improve each organs and tissues function, function of immune system particularly, strengthen the inherent immune disease-resistance ability of human body self, keep health, the patient of hypoimmunities such as malignant tumor is brought into play excellent curative.
The present invention concentrates on studies and solves the result of above-mentioned problem, at first pass through " instrument for increasement of leucocyte " (hereinafter to be referred as " Bai Yi ", its patent No. is ZL 95 1 17623.4) clinical practice, discovery is treated through 528 routine malignant tumorization (putting)---and the nerve action potential waveform produces Study on Effect at human body, affirmed that the blood leukocytes counting minimizing to cancer patientization, caused by radiation has obvious lift-rising effect, simultaneously, other toxicities have also been alleviated.
The present inventor is research repeatedly further, nervous tissue and movable each parameter of its cell " bioelectric potential " have been simulated with microelectric technique, according to the clinical practice feedback information, the Medical Technology index is repeatedly improved and perfect, its clinical therapeutic efficacy improves a lot, especially appear suddenly out and control the cancer effect, so develop into " apparats for treating tumor " (hereinafter to be referred as tumor instrument).This technology was used for clinical in 1996, implemented conversion in 2000, on January 14th, 2004 the granted patent right, the patent No. is ZL 00 1 13777.8.Through how tame provincial hospital application, comparative study and and statistical procedures, all affirmed and significantly controlled the cancer effect, related hospitals has successively been delivered paper: " effect of bioelectric potential effect in esophageal carcinoma chemotherapy ", " research of bionic wave apparats for treating tumor combination chemotherapy late gastric cancer ", " bionic wave apparats for treating tumor " alleviate put, the observation of curative effect of chemotherapy toxic side effect ".
The Medical Technology index of former " Bai Yi " and " tumor instrument " two products has all been used I, II ripple, and science and technology is a gradual in-depth evolution, use I number " excited waveform ", former purpose is to improve local organization sensitivity, to strengthen the effect of follow-up II, III number treatment ripple, but observe through clinical practice in 10 years, its effect is unsatisfactory.II number " comprehensive nerve action potential waveform ", promptly the current potential by A, B, three types of neurocytes of C (fiber) is constituted, and its purpose is the whole function of improving one group of nervous tissue, Clinical Practice, comparative study, the curative effect of this waveform is also undesirable.More than two waveforms abandoned it in 1999, only kept the III waveform of former two product Medical Technology indexs, i.e. neurocyte " action potential " waveform carries out clinic trial and observes.It is because of being, at human body, one nervous tissue is contained usually a large amount of even hundreds thousand of, 1,000,000 neurocytes, the stimulus information (sensation) that is subjected to by acrognosis reaches brain, be to finish this information transmission by three grades of neurons (cell) with the relay form, the length of each neurocyte can reach tens of centimetres.They are not that parallel rule is arranged, but angulation, or twine mutually.Simultaneously, each neurocyte excitation time is also asynchronous, how survey its " action potential " in the microvolt level, single neurocyte " action potential " then fluctuates in 80～120 millivolts, the current potential numerical value that so is higher than one nervous tissue significantly, the current potential numerical value that is likely one group of nervous tissue are each neurocyte current potential " vector algebras and ".Adopt " comprehensive nerve action potential " waveform to stimulate one nervous tissue, can not reverse effective excited number various neurocyte also improves its function, and occupied for each 50% treatment time, according to clinical application effect, discarded II number " comprehensive nerve action potential waveform " is rational.To No. three ripples of above-mentioned two products, promptly single neurocyte " action potential " waveform characteristic has been done three by a relatively large margin improvement and perfect according to the clinical practice feedback information, and last typing in 2006 was used through 3 years, reached ideal effect.
Medical Technology index of the present invention is human neuronal cell line " action potential " waveform, its waveform constitutes: setting the highest forward absolute value of this waveform peak value is 1 unit (U), time sequencing according to each wavelet generation of waveform, from zero potential formation " a " wave band that rises more slowly, amplitude 0.3U, 0.5 millisecond of persistent period; Continue fast rise, form " b " wave band, amplitude 1.0U promptly drops to 0.4U fast, 1.0 milliseconds of persistent period, connects the c wave band down; C wave band amplitude 0.4U drops to zero potential, 2.2 milliseconds of persistent period, continued access " d " wave band; The initial zero potential of " d " wave band, oppositely descending, negative sense current potential absolute amplitude 0.26U, slow smooth change, after rise to zero potential, 5.3 milliseconds of persistent period, continued access " e " wave band; " e " wave band originates in zero potential, and forward rises and reaches amplitude 0.1U, 3 milliseconds of persistent period.More than each phase of wave connect, constitute neurocyte " action potential " forward potential waveform.Neurocyte has to be accepted to stimulate and characteristics excited, bi-directional information, and the present invention establishes neurocyte " action potential " negative sense potential waveform again, and is identical with each parameter absolute value of forward wave.Forward wave and negative wave alternately occur with 1: 1 relation, this design, the accumulation that can avoid therapeutic electrode to form at the tissue place.The present invention sees attached list shown in the 3-1 with the contrast that " Bai Yi " reaches " tumor instrument " Medical Technology index:
Table 3-1 the present invention reaches " apparats for treating tumor " Medical Technology index contrast table with " instrument for increasement of leucocyte "
According to shown in the last table, Medical Technology index of the present invention does not have excitation wave and comprehensive neuropotential waveform, has only the waveform of neurocyte action potential.In order to improve effect of stimulation, the wave amplitude of each wavelet of neurocyte potential waveform and persistent period and " Bai Yi " are reached " tumor instrument " compare, all done very cataclysm.
2. application innovation
Experimental prototype of the present invention was tried out in clinical in 1999, thereafter, according to the clinical practice feedback information, its Medical Technology index had been done three bigger improvement and perfect, and its curative effect improves one by one.Finalize the design its Medical Technology index at last in January, 2006, thereafter, present technique combined chemotherapy, the medical treatment method of promptly non-operation, non-radiotherapy, the complete remission rate (CR) of cancer patient is reached more than 35%, and the complete remission rate (CR) of " Bai Yi " and " tumor instrument " is all below 30%.The more important thing is that the medical treatment method of the non-operation of combined chemotherapy of the present invention, non-radiotherapy has made the tumor body complete obiteration of the intractable tumour patient of multidigit, repeatedly check over 3 years not have recurrence and shift sign.The present invention is in chemotherapy process, and many patients' numeration of leukocyte is the rising situation unexpectedly, becomes the strange thing in the chemotherapy of tumors process, and this phenomenon does not appear at the application phase of " Bai Yi " and " tumor instrument ".In addition, alleviating cancer pain, carcinous infection, improving patient quality of life aspect, its curative effect " Bai Yi " and " tumor instrument " all increases.
At first present technique is used for the human immunity treatment of diseases, for example the hepatitis B of the autoimmune disease of the lupus erythematosus of connective tissue disease, immune disease, viral infection and flu etc. have tentatively obtained more satisfactory effect.Should expand serious disease and case load from now on, continue in-depth research.
3. technical scheme
The present invention adopts external power supply, the transformator transformation, rectifier bridge, diode and capacitor rectifying and voltage-stabilizing, provide this project circuit required+3.3V ,+5V ,+12V ,+/-the 100V DC voltage.The core component central processing unit single-chip microcomputer of overall circuit, envelop of function obviously enlarges, and simplifies circuit design significantly.Neurocyte " action potential " Wave data table is stored in the integrated memorizer.During treatment, neurocyte " action potential " Wave data is reduced to the output of " action potential " waveform by transducer integrated in the single-chip microcomputer.This output waveform realizes the two-stage amplification by integrated operational amplifier, realizes driving through large power triode again and amplifies, and divides two-way to replace output.Regulate output intensity, frequency, conversion time by software processes, button operation, realize treatment procedure.
4. effect
The present invention is mainly used in the treatment of malignant tumor and relevant immune disease at present.
(1) World Health Organization (WHO) sees Table shown in the 3-2 about the objective efficacy assessment standard of malignant tumor:
The table objective efficacy assessment standard of 3-2 tumor (WHO)
| Grade | Evaluation criteria |
| Alleviate CR fully | The complete obiteration of finding tumor is also kept more than 4 weeks at least |
| Part is alleviated PR | The product in the maximum diameter of tumor focus and maximum perpendicular footpath thereof (two footpaths) reduces more than 50%, and keeps more than 4 weeks, and no new pathological changes occurs |
| No change NC | Two footpath products of tumor focus dwindle below 50% or increase below 25%, and no new pathological changes occurs |
| Worsen PD | Two footpath products of tumor focus increase more than 25% or new focus occurs |
(2) the independent cancer effect of using extremely of the present invention
Gastric cancer and primary hepatocarcinoma patient were once met by seminar of the present invention, and the state of an illness is too heavy, can not perform the operation, radiation and chemotherapy, and in the case, the purpose of present technique treatment is to alleviate cancer pain, abdominal distention, improving appetite and spirit.But treatment finds that less than January its tumor body disappears.
(3) the cancer effect extremely of present technique combined chemotherapy
1～2 cycle of present technique combination chemotherapy (first quarter moon～January), many patients' such as pulmonary carcinoma, the esophageal carcinoma, gastric cancer, cancer of pancreas, ovarian cancer, footpath, uterus cancer, malignant lymphoma tumor body is disappeared, thereafter, part patient's row excision, its excision specimen pathological examination, cancer-free cell.This phenomenon prompting, medical treatment method by non-operation, non-radiotherapy might make patient obtain to cure fully, the present age, oncotherapy emphasized that the pattern of " first-selected operation " should not overemphasize again, so that more patient saves relevant internal organs and its function from damage, eliminate patient's human body and spiritual " incompleteness " sense, make it become real sound and healthy people, reach ideal therapeutic treatment purpose, significant to its life quality.
(4) comparative study
Anything has only contrast, just can say something.
● the present invention and existing " practical Internal Medicine-Oncology " are enumerated China authority tumour hospital and are controlled 41 routine solid tumor curative effect model cases relatively, and these hospitals have represented current international chemotherapy level, see Table shown in the 3-3:
Table 3-3 the present invention and existing " practical Internal Medicine-Oncology " are enumerated China authority tumour hospital curative effect model case relatively
Annotate: instrument treatment 1. of the present invention has been protected human body effectively, has enlarged the people's that cured the disease age, and the person's chemotherapy at advanced age about 80 years old also is safe;
2. the CR of medical treatment of the present invention leads apparently higher than the effect of Comprehensive Treatments such as matched group operation, radiotherapy, chemotherapy, statistical procedures significant difference.
● with regard to an example of the intractable tumor of human several frequently seen chemotherapy effect difference, the present invention and existing " practical Internal Medicine-Oncology " are enumerated China authority tumour hospital and are treated the effect model case and compare, and see Table 3-4:
3 grades, 4 grades intractable tumor efficiency of seven kinds of common chemotherapy effect differences of table 3-4 relatively
Annotate: 1. two groups of typical cases of case system are individual relatively routine, and therefore, processing does not take statistics;
2. matched group adopts Comprehensive Treatments such as chemotherapy, radiotherapy, operation, and average chemotherapy was 5.5 cycles, yet only 2 examples obtain the CR effect.The present invention is row operation and radiotherapy not, and chemotherapy was 2.71 cycles, all obtained the CR effect;
3. cancer of pancreas and primary hepatocarcinoma, World Health Organization (WHO) delimit and be the invalid tumor of chemotherapy, however cancer of pancreas the present invention obtains the CR effect in 1 cycle for the treatment of, and the healthy survival of serious symptom hepatocarcinoma patient is more than 10 years.
(5) curative effect of treatment tumor complication and complication
Tumour patient is because of the toxic action of its carcinous metabolite and chemotherapy, and it is impaired to cause relevant internal organs, the Chang Bingfa loss of appetite, spirit is poor, anemia, leukopenia, cancer pain, carcinous infection etc., the curative effect of the technology of the present invention reaches " tumor instrument " than " Bai Yi " and all increases.As the main toxicity observation index of chemotherapy, the technology of the present invention lift-rising blood leukocytes counting is more outstanding with numeration of leukocyte in World Health Organization (WHO).In recent years, many patients are in chemotherapy process, and leukocyte is the rising situation unexpectedly, becomes a strange thing, and " Bai Yi " reaches " tumor instrument " and do not see this phenomenon in the operating period.Part patient merges high/low blood pressure, diabetes, hepatitis B, coronary heart disease etc., and present technique all has good result.
(6) other immune correlated disease
● disease of viral infection, flu are due to the viral infection, often fall ill because of body immunity descends.This seminar part cancer patient seldom or have no interest, after finishing treatment, is but frequently caught a cold or is in the flu state in chemotherapy process.Patient thinks that this instrument is effective to catching a cold, and is in hospital once more, only goes this instrument treatment about 1 week, thereafter, but has no interest for 3～May.Clinical practice shows that present technique all has good effect to viral influenza, herpes zoster, hepatitis B etc.In view of SARS in recent years, " influenza " threaten human health, influence social order, pay much attention in the world.Present technique improves body immunity good effect, and the antagonism disease of viral infection has positive social meaning.
● connective tissue disease, lupus erythematosus are connective tissue diseases, and its morbidity is obviously relevant with immune dysfunction.Present technique treatment has reduced the consumption of hormone, eliminates its side effect, and patient does not have fat performance, and detections indexs such as erythrocyte sedimentation rate, immunoglobulin all belong to normal range, and the disease sense has been eliminated in patient's work of can normally going to work, and present technique is treated good result.
● autoimmune disease, autoimmune disease is a kind of disease that the disorder of human immune system's regulatory function causes, be because autoimmune response causes injuries of tissues and organs and corresponding function obstacle, especially liver cirrhosis and portal hypertension due to the autoimmune hepatitis, often cause serious consequence, present no effective Therapeutic Method, the present invention is exploring present technique to this sick effect.1 autoimmune disease causes end-age cirrhosis, and the severe jaundice has manually stopped gestation.The court is lived in the back, and present technique treatment first quarter moon has promoted blood leukocytes, has improved anemia and relevant organ function, has recovered body constitution.Thereafter, excised spleen, stable disease is engaged in the general housework activity in rural area.
Advantage of the present invention is: the non-operation medical treatment of combined with chemotherapy of the present invention, obviously improved the treatment for cancer effect, part patient has obtained healing, relevant internal organs and its function have been saved from damage, eliminated patient's sensual " deformity " psychology, make it become real sound and healthy people, kept normal person's mental status, for other non-operative treatment can't be obtained.
Description of drawings:
The invention will be further described below in conjunction with the accompanying drawing example:
Fig. 1 is neurocyte " action potential waveform "
Fig. 2 overall system constitutes block diagram;
Fig. 3 is system body circuit theory diagrams (treatment module circuit diagrams);
Fig. 4 is power module circuitry figure;
Fig. 5 is the I/O module circuit diagram;
Fig. 6 is the systems soft ware flow chart;
Fig. 7 is the liquid crystal panel layout;
Fig. 8 is panel on and off switch and output layout;
Fig. 9 is a machine shape.
The specific embodiment:
1. the present invention is mainly by power module, I/O module and treatment module three parts are formed, power module mainly to provide system needed+3.3V, + 5V, + 12V and+/-voltage of 100V, the I/O module mainly refers to information input of being undertaken by keyboard or touch screen and the treatment waveform that is undertaken by intelligent display, the demonstration of impedance waveform and relevant parameter, its overall system constitutes block diagram and sees Fig. 2, and system body circuit theory diagrams (treatment module circuit diagram) are seen Fig. 3.
2. hardware effort flow process; The present invention with single-chip microcomputer U1C8051F020 as CPU, related data and program all programming in the memorizer of inside.The principle and the detailed process of system works are as follows:
Beginning is provided stable+3.3V by power module ,+5V ,+12V and+/-voltage of 100V.The 220V alternating voltage forms 8V through the transformator blood pressure lowering, and the aanalogvoltage of 15V and 80V is at the direct current that interchange is become pulsation through rectifier circuit (G1, G2, G3)..After rectification circuit, insert have larger capacity electrochemical capacitor (C1, C4, C10, C11) as filter capacitor, utilize its charge-discharge characteristic, make pulsating dc voltage after the rectification become relatively galvanic current and press.Wherein the output of G3 again through Zener diode output+100V and-DC voltage of 100V, the output of G1 and G2 again by three terminal regulator MC7805T and MC7812T voltage stabilizing+5V and+12V.Wherein+5V part draws and leads up to the voltage of LM317 conversion output+3.3V.So far, the formation system is required+3.3V ,+5V ,+12V and+/-100V voltage.Physical circuit is seen accompanying drawing 4.
After the power module power supply, systematic parameters such as intensity, frequency are regulated and show by the I/O module, and show treatment waveform, human body impedance change curve and conversion time, remaining time, ambient temperature etc.A lot of work in this module are finished by software.In this module, keyboard circuit links to each other with the pin 29-36 of U1 by KEYLED, in use, realizes keyboard control function by the software processes button operation.The pin 43,44,45 of U1 is respectively applied for the MOSO that connects speech chip, MOSI, and the CS2 pin is mainly used to control voice output.Display part in the module is linked to each other with display by serial port chip U2 (MAX232) by U1, realizes real-time demonstration.The physical circuit of I/O module is seen accompanying drawing 5.
3. after the system start-up, the treatment module is exported prior foundation good tables of data and frequency meter, and the D/A converter of process U1 inside restores and is analog waveform, passes through pin 100 (DAC0) output of U1 again.The waveform of DAC0 output is through the complete treatment waveform of the final output of amplifying circuit.Amplifying circuit mainly adopts the MC4558 integrated operational amplifier to realize, waveform from DAC0 output, be input to the one-level operational amplifier through capacitor C 100 and resistance R 20, the R22 potentiometer is as feedback resistance, control the amplification of one-level amplifying circuit by the resistance of regulating R22, waveform directly enters into second amplifying circuit after one-level is amplified.Potentiometer R29 is as the feedback resistance of second amplifying circuit, the amplification of scalable second amplifying circuit, and audion (A42) and (A92) in order to the operation source of stabilizing amplifier, thus be implemented in accurate amplification under the relative voltage condition.Large power triode (A1009 and C2335) is used for the driving of amplifier out and amplifies, and final waveform is exported from OUTK, is connected to the OUTG output of relay by J8.
4.TDQH1 and TDQH2 is connected to the pin 53 and 54 (P3.1, P3.0) of U1, is respectively applied for two relays of control, control two-way output channel is to the alternately output of treatment waveform.The treatment waveform of output forms certain voltage at human body, constitutes voltage circuit with human body impedance and R47.OUTG (output of treatment waveform) also links to each other with the human body impedance Acquisition Circuit with the hot end of R47, and by the RUT1 of A/D converter AD1 and the RUX0 of AD2, the pin 18 and 19 that is connected to U1 is as input, be used to gather the human body transient voltage, calculate human body impedance by the voltage that collects and the resistance of R47, and human body impedance is shown on the display.The physical circuit of treatment module is seen accompanying drawing 3.
5. software workflow:
(1) carries out system initialization
System initialization comprises system clock, system global variables, depositor port arrangement, intervalometer, serial ports, AD module, DA module, and Wave data table (amplitude, persistent period), the initialization of frequency meter.In addition, set the position of correlated variables on indicator screen in macrodefined mode.
(2) keyboard scan
Keyboard scan is to carry out in the while of mastery routine () circulation, by setting two counting variables, carries out keyboard and disappears and tremble processing.In the process of each scanning, if button is in down state, then counting variable adds 1, and when reaching some values, it is effective to be considered as button.For strong rate, frequency, conversion time, speech selection only once simply disappears and trembles.For add-substract key, then otherwise stop disappearing and tremble, thereby realize constantly to add reducing when pressing, until unclamping.
(3) touch screen scanning
That native system adopts is the intelligent display VTK6448 of band touch screen, and the operation of all touch screens all is to be undertaken by serial ports.When touch screen was pressed, display sent data by serial ports to single-chip microcomputer U1, when unclamping, sent another group data.By processing, can judge the position of contact to data.When pressing add-substract key, start intervalometer and count, when unclamping, intervalometer stops counting, thereby calculates the time of pressing, and operates accordingly.
(4) host computer scanning
Its corresponding data is handled by PC, and the result that will handle gives single-chip microcomputer U1 and gets final product then.Such as, regulation voltage, directly import a certain magnitude of voltage and get final product.
(5) human body impedance and treatment waveform show
Single-chip microcomputer U1 is by extracting initial neurocyte " action potential " waveform data, form corresponding tables of data, in therapeutic process, D/A converter by chip integration becomes is reduced to the biological waveform of treatment with data, and makes it through the certain waveform of amplifying circuit output, act on two particular acupoint place body surfaces on the relevant meridians traveling of the human body approach, and gather voltage between two acupuncture points, and calculate the human body impedance value, at last the human body impedance value is presented on the LCD screen.
(6) temperature shows
What native system adopted is the DS18B20 temperature sensor, and monobus lin protocol is adopted in this temperature sensor, so only get final product with pin of single-chip microcomputer U1.Count by intervalometer, carry out the temperature update displayed one time every a period of time.
Software flow pattern is seen Fig. 6.
The panel layout explanation:
Accompanying drawing 7 is a LCDs, and upper left district shows neural " action potential " waveform, and the lower-left district shows human body impedance.The upper right district of LCDs, " residue treatment time " (also promptly each treatment total time) is predisposed to 32 minutes, along with treatment time passes, is that unit successively decreases gradually with " 1 minute ", finishes until treatment." conversion time " is predisposed to 8 minutes; " working strength " is predisposed to 30 volts (pulse voltages); " operating frequency " is predisposed to and is 20Hz.
The instrument working procedure:
Fig. 8 is panel " on and off switch " and " two output channels ", pushes " on and off switch ", and instrument promptly is in preheat mode; If two output loop jacks, alternately conversion (scalable) in per 4,8,16 minutes.
Fig. 7 is the liquid crystal panel layout, and the LCDs right lower quadrant is the operation control zone, finger touch " begin treatment " key, and instrument enters duty.When touching " intensity ", " frequency ", " conversion time " key, then be shown in the rectangle grey area between two lifting keys respectively, touch rises key " ∧ " or falls key " ∨ " and gives the ascending, descending adjusting.For " intensity " and " frequency ", sustained touch is fast ascending, descending (coarse adjustment) then, and point touches 1 volt of a next ascending, descending or 1Hz (fine tuning), transfers to that patient is the suitableeest to be experienced intensity and be advisable.In therapeutic process, because the patients function condition improvement, structure sensitive properties increases, and most patient often need be reduced working strength, otherwise, can not tolerate.Employed " operating frequency " is generally 20Hz, treat after 3～5 days, if DeGrain, suitable regulating frequency, its fluctuation range is 16～40Hz.Two-way output was adopted 8 minutes conversion time usually, preset.Also be according to the judgement of therapeutic effect, whether decision is adjusted, and can only put and touch the ascending, descending key, and unsustainable touch is to increase or subtract with 8 multiple, can increase to 16 minutes or be kept to conversion in 4 minutes 1 time.Each treatment is 32 minutes total time, and is unadjustable.After treatment finished, buzzer sent the sound, continued shutdown automatically in 1 minute, and also tangible " begin treatment " key can shut down immediately.Thereafter, remove and spread on the patient acupuncture point and locate each electrode, treatment finishes.
Attached: the description sequence table
| Sequence number | Title |
| Table 3-1 | The present invention reaches " apparats for treating tumor " Medical Technology index contrast table with " instrument for increasement of leucocyte " |
| Table 3-2 | The objective efficacy assessment standard of tumor (WHO) |
| Table 3-3 | The present invention and existing " practical Internal Medicine-Oncology " are enumerated China authority tumour hospital curative effect model case relatively |
| Table 3-4 | 3 grades, 4 grades intractable tumor efficiency of seven kinds of common chemotherapy effect differences relatively |
Claims (9)
1. the tumor electronic therapeutic device based on the artificial immunity technology has Fig. 2 overall system, is made up of I/O module, power module and treatment module.Comprise system body treatment modular circuit (Fig. 3), power module (Fig. 4), I/O module (Fig. 5), systems soft ware flow process (Fig. 6), liquid crystal panel layout (Fig. 7), panel on and off switch and output layout (Fig. 8), complete machine external form (Fig. 9).Its output action parameter is once excited formed " action potential " waveform of human neuronal cell line (Fig. 1), it is characterized in that the formation of neurocyte " action potential ", time sequencing according to the waveform appearance, be followed successively by a, b, c, d, five current potential wave bands of e, closely continuously, form complete neurocyte " bioelectric potential " waveform that a time excitation time presented.
2. according to the described current potential wave band of claim 1 a shown in Figure 1, b, c, d, five current potential wave bands of e are arranged, and set up the nagative potential of complete equity.It is characterized in that a wave band persistent period is 0.5ms, b wave band 1.0ms, c wave band 2.2ms, d wave band 5.3ms, e wave band 3.0m s.The amplitude of setting the main ripple b wave band of this waveform is 1 absolute unit (U), and then a wave band is 0.3U, and c is 0.4U, and d is 0.26U, and e is 0.1U.
3. constitute according to the described overall system of claim 1, Fig. 2 is arranged, constitute by treatment module, power module, I/O module.It is characterized in that functional module is independent respectively.
4. according to the described system body treatment of claim 1 modular circuit Fig. 3 is arranged, form by central processing unit and peripheral circuit thereof.It is characterized in that with U1 (C8051F020) be primary processor, comprise peripheral auxiliary circuits construction system main body circuit such as JTAG debug circuit, reference voltage circuit, reset circuit, waveform output circuit, serial port circuit, human body impedance Acquisition Circuit, waveform amplifying circuit.
5. according to the described power module of claim 1, Fig. 4 is arranged, form by power supply chip, several rectifier bridges and some additional devices of different model.It is characterized in that external power supply, the transformator transformation through rectifier bridge, diode and electric capacity rectifying and voltage-stabilizing, obtains each required DC voltage of this equipment circuit.Transfer interchange to direct current with rectifier bridge G1, G2, G3, then with power supply chip MC7805 generations+5V voltage, MC7812 generations+12V voltage, LM317 produces 3.3V voltage, usefulness 200V Zener diode generation+100V and-100V voltage.
6. according to the described I/O module of claim 1, Fig. 5 is arranged, partly constitute by sound circuit part and keyboard circuit.It is characterized in that using the ISD4003 speech chip as voice output, the key circuit design is as input.
7. according to the described systems soft ware flow process of claim 1, Fig. 6 is arranged, form by host computer procedure and program of lower computer.It is characterized in that constituting a major cycle by touch screen scanning imaging system, keyboard scan program, host computer scanning imaging system, display routine, keyboard processing subprogram, touch screen processing subprogram, instruction process subprogram.
8. according to the described liquid crystal panel layout of claim 1, Fig. 7 is arranged, form by display part and operation part.The left side that it is characterized in that screen is as the key frame that waveform shows and human body impedance shows, the right is the demonstration and the adjusting of parameters.
9. according to described panel on and off switch of claim 1 and output layout, Fig. 8 is arranged, form by power line hole and waveform output lead hole.It is characterized in that switch is positioned at the below of display screen, output interface is positioned at the both sides of on and off switch.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910023979 CN101961526B (en) | 2009-09-21 | 2009-09-21 | Tumor electronic treating device based on artificial immunological technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910023979 CN101961526B (en) | 2009-09-21 | 2009-09-21 | Tumor electronic treating device based on artificial immunological technology |
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| CN101961526A true CN101961526A (en) | 2011-02-02 |
| CN101961526B CN101961526B (en) | 2013-07-31 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107890608A (en) * | 2017-12-01 | 2018-04-10 | 王嘉浩 | Lymphocyte lift-rising instrument |
| CN110913947A (en) * | 2017-05-30 | 2020-03-24 | Gsk消费者健康有限公司 | Apparatus and method for automatically controlling transcutaneous electrical nerve stimulation based on current and forecasted weather conditions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1140612A (en) * | 1995-07-17 | 1997-01-22 | 中坚实业(深圳)有限公司 | Instrument for increasement of leucocyte |
| CN1267557A (en) * | 2000-04-07 | 2000-09-27 | 王振雄 | Tumor treating instrument |
| CN1368393A (en) * | 2001-02-08 | 2002-09-11 | 西安伟思尔医疗器械有限公司 | Bionic wave apparats for treating tumor |
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2009
- 2009-09-21 CN CN 200910023979 patent/CN101961526B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1140612A (en) * | 1995-07-17 | 1997-01-22 | 中坚实业(深圳)有限公司 | Instrument for increasement of leucocyte |
| CN1267557A (en) * | 2000-04-07 | 2000-09-27 | 王振雄 | Tumor treating instrument |
| CN1368393A (en) * | 2001-02-08 | 2002-09-11 | 西安伟思尔医疗器械有限公司 | Bionic wave apparats for treating tumor |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110913947A (en) * | 2017-05-30 | 2020-03-24 | Gsk消费者健康有限公司 | Apparatus and method for automatically controlling transcutaneous electrical nerve stimulation based on current and forecasted weather conditions |
| CN107890608A (en) * | 2017-12-01 | 2018-04-10 | 王嘉浩 | Lymphocyte lift-rising instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101961526B (en) | 2013-07-31 |
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