CN101953903B - Mouthwash for treating gingivitis of children and preparation method thereof - Google Patents
Mouthwash for treating gingivitis of children and preparation method thereof Download PDFInfo
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- CN101953903B CN101953903B CN2010102789413A CN201010278941A CN101953903B CN 101953903 B CN101953903 B CN 101953903B CN 2010102789413 A CN2010102789413 A CN 2010102789413A CN 201010278941 A CN201010278941 A CN 201010278941A CN 101953903 B CN101953903 B CN 101953903B
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- radix
- rhizoma
- gingivitis
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- 208000007565 gingivitis Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000002324 mouth wash Substances 0.000 title abstract 5
- 229940051866 mouthwash Drugs 0.000 title abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 4
- 230000000366 juvenile effect Effects 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 241000206501 Actaea <angiosperm> Species 0.000 claims description 2
- 241000555682 Forsythia x intermedia Species 0.000 claims description 2
- 241000245240 Lonicera Species 0.000 claims description 2
- 235000014435 Mentha Nutrition 0.000 claims description 2
- 241001072983 Mentha Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000906579 Actaea cimicifuga Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000576429 Forsythia suspensa Species 0.000 abstract 1
- 241000212322 Levisticum officinale Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 241000266847 Mephitidae Species 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 235000005301 cimicifuga racemosa Nutrition 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 6
- 210000004195 gingiva Anatomy 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- 208000024283 Gingival haemorrhages Diseases 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 206010018275 Gingival atrophy Diseases 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to mouthwash for treating gingivitis of children. The mouthwash is prepared from the following substances in part by weight: 10 to 20 parts of rhubarb, 5 to 15 parts of weeping forsythia, 1 to 5 parts of Chinese gall, 3 to 8 parts of angelica dahurica, 1 to 5 parts of mint, 5 to 10 parts of honeysuckle flower, 5 to 10 parts of liquoric root, 3 to 8 parts of lightyellow sophora root, 5 to 10 parts of szechuan lovage rhizome, 10 to 20 parts of skunk bugbane and 50 to 100 parts of water. The invention also relates to a method for preparing the mouthwash. The mouthwash for treating the gingivitis of the children has the characteristics of low cost, easy preparation, small toxic or side effect and remarkable curative effect.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to collutory of a kind of juvenile's of treatment gingivitis and preparation method thereof.
Background technology
Child's gingivitis is a kind of chronic inflammatory disease in oral cavity, and its symptom is that gingiva is easily hemorrhage, especially to brush teeth the back obviously.Can cause gingival atrophy late period, and odontoseisis early takes off.This disease is a first-selection with antibiotic amoxicillin and metronidazole treatment generally, and must regularly remove dental calculus and dental plaque.But, and don't should use antibiotic repeatedly with easily outbreak repeatedly of this method treatment.And since children physique a little less than, too early use antibiotics damages the child easily.Therefore, press for the medicament of seeking a kind of juvenile's of treatment gingivitis.
Summary of the invention
The collutory that the purpose of this invention is to provide a kind of juvenile's of treatment gingivitis.
The present invention also aims to provide the preparation method of the collutory of this treatment juvenile gingivitis.
In order to realize purpose of the present invention, the invention provides a kind of collutory of the juvenile's of treatment gingivitis, it is to be made by following materials by weight: Radix Et Rhizoma Rhei 10-20 part, Fructus Forsythiae 5-15 part, Galla Chinensis 1-5 part, Radix Angelicae Dahuricae 3-8 part, Herba Menthae 1-5 part, Flos Lonicerae 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Sophorae Flavescentis 3-8 part, Rhizoma Chuanxiong 5-10 part, Rhizoma Cimicifugae 10-20 part and water 50-100 part.
Preferably, the collutory of treatment of the present invention juvenile gingivitis is to be made by following materials by weight: 80 parts in 15 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Forsythiaes, 5 parts of Galla Chinensiss, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Menthaes, 8 parts of Flos Loniceraes, 5 parts in Radix Glycyrrhizae, 8 parts of Radix Sophorae Flavescentiss, 10 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Cimicifugaes and water.
The present invention also provides a kind of preparation method of collutory of the juvenile's of treatment gingivitis, this method comprises: take by weighing Radix Et Rhizoma Rhei 150 grams, Fructus Forsythiae 100 grams, Galla Chinensis 50 grams, the Radix Angelicae Dahuricae 50 grams, Herba Menthae 50 grams, Flos Lonicerae 80 grams, Radix Glycyrrhizae 50 grams, Radix Sophorae Flavescentis 80 grams, Rhizoma Chuanxiong 100 grams, Rhizoma Cimicifugae 150 grams and water 800 grams, place in the flask of sealing, heating is 5 hours under 50 ℃ water-bath, filter, collect filtrate promptly.
The collutory of treatment juvenile gingivitis of the present invention has the advantages that cost is low, preparation is easy, toxic and side effects is little, curative effect is showing.
The specific embodiment
Embodiment 1:
Take by weighing Radix Et Rhizoma Rhei 150 grams, Fructus Forsythiae 100 grams, Galla Chinensis 50 grams, the Radix Angelicae Dahuricae 50 grams, Herba Menthae 50 grams, Flos Lonicerae 80 grams, Radix Glycyrrhizae 50 grams, Radix Sophorae Flavescentis 80 grams, Rhizoma Chuanxiong 100 grams, Rhizoma Cimicifugae 150 grams and water 800 grams, place in the flask of sealing, heating is 5 hours under 50 ℃ water-bath, filter, collect filtrate, sterilizing promptly.
Experimental example
Physical data:
Infant 30 examples, male's 18 examples, women's 12 examples, minimum 4 years old of age, maximum 10 years old.On inspection, the symptom of infant is simple red swelling of gingiva, kermesinus, gingival sulcus intensification, gingival sulcus pyorrhea, the rotten to the corn and gingiva severe haemorrhage of gum edge, gingiva congestion and edema.Whole cases persons that do not have the odontoseisis.All do not have before the prescription on individual diagnosis and take any antibiotic medicine.
Therapeutic scheme
Use the collutory of embodiment 1 preparation to treat, use 20ml to gargle at every turn.Every day 3 times.Used for 1 week continuously.
Criterion of therapeutical effect
Produce effects: gingival hemorrhage stops after medication 1-3 days, and the gingiva congestion and edema disappears substantially, halitosis disappears.Effectively: gingival hemorrhage stops after medication 3-7 days, and redness disappears substantially, and halitosis obviously alleviates or disappears.Invalid: medication after 7 days symptom do not have obvious improvement.
Therapeutic outcome
After using for 1 week continuously, produce effects 25 examples in the 30 routine infants, effective 5 examples, total effective rate 100%.
Untoward reaction
In therapeutic process, do not find tangible untoward reaction.
Claims (3)
1. a collutory for the treatment of juvenile's gingivitis is characterized in that it is to be made by following materials by weight: Radix Et Rhizoma Rhei 10-20 part, Fructus Forsythiae 5-15 part, Galla Chinensis 1-5 part, Radix Angelicae Dahuricae 3-8 part, Herba Menthae 1-5 part, Flos Lonicerae 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Sophorae Flavescentis 3-8 part, Rhizoma Chuanxiong 5-10 part, Rhizoma Cimicifugae 10-20 part and water 50-100 part.
2. the collutory of treatment according to claim 1 juvenile gingivitis is characterized in that it is to be made by following materials by weight: 80 parts in 15 parts of Radix Et Rhizoma Rhei, 10 parts of Fructus Forsythiaes, 5 parts of Galla Chinensiss, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Menthaes, 8 parts of Flos Loniceraes, 5 parts in Radix Glycyrrhizae, 8 parts of Radix Sophorae Flavescentiss, 10 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Cimicifugaes and water.
3. preparation method for the treatment of the collutory of juvenile's gingivitis, this method comprises: take by weighing Radix Et Rhizoma Rhei 150 grams, Fructus Forsythiae 100 grams, Galla Chinensis 50 grams, the Radix Angelicae Dahuricae 50 grams, Herba Menthae 50 grams, Flos Lonicerae 80 grams, Radix Glycyrrhizae 50 grams, Radix Sophorae Flavescentis 80 grams, Rhizoma Chuanxiong 100 grams, Rhizoma Cimicifugae 150 grams and water 800 grams, place in the flask of sealing, heating is 5 hours under 50 ℃ water-bath, filter, collect filtrate promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102789413A CN101953903B (en) | 2010-09-13 | 2010-09-13 | Mouthwash for treating gingivitis of children and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102789413A CN101953903B (en) | 2010-09-13 | 2010-09-13 | Mouthwash for treating gingivitis of children and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101953903A CN101953903A (en) | 2011-01-26 |
| CN101953903B true CN101953903B (en) | 2011-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102789413A Expired - Fee Related CN101953903B (en) | 2010-09-13 | 2010-09-13 | Mouthwash for treating gingivitis of children and preparation method thereof |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579938B (en) * | 2012-03-22 | 2013-11-13 | 吴文 | Spray for curing gingivitis |
| CN103536875B (en) * | 2012-12-06 | 2015-06-10 | 魏丽 | Preparation method of drug for treating Children's gingivitis |
| CN104306286A (en) * | 2014-09-26 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Herbal multiple-effect mouthwash and preparation method thereof |
| CN104367682A (en) * | 2014-11-14 | 2015-02-25 | 孙丰卿 | Traditional Chinese medicinal composition for treating chronic gingivitis and gargle of traditional Chinese medicinal composition |
| CN107041904A (en) * | 2017-03-27 | 2017-08-15 | 浙江中医药大学 | A kind of Chinese traditional medicine composition mouthwashes with antibacterial action |
| CN107308081A (en) * | 2017-07-11 | 2017-11-03 | 景雷 | A kind of strong bactericidal mouthwash |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744939A (en) * | 2010-01-31 | 2010-06-23 | 张敏洁 | Chinese medicinal herb compound and preparation method with health care effect for preventing mouth disease |
| CN101816732B (en) * | 2010-04-26 | 2012-06-20 | 董立亭 | Chinese medicinal decoction for treating toothache |
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- 2010-09-13 CN CN2010102789413A patent/CN101953903B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN101953903A (en) | 2011-01-26 |
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| C14 | Grant of patent or utility model | ||
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Owner name: TIANJIANG PHARMACEUTICAL INDUSTRY CO., LTD., JIANG Free format text: FORMER OWNER: YANG YALI Effective date: 20130701 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Free format text: CORRECT: ADDRESS; FROM: 272100 JINING, SHANDONG PROVINCE TO: 214400 WUXI, JIANGSU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130701 Address after: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee after: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin Address before: 272100 children's Dental Department of Jining Stomatological Hospital of Shandong Province Patentee before: Yang Yali |
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| TR01 | Transfer of patent right |
Effective date of registration: 20170619 Address after: 037000 No. 2, building 2, Cang Cang street, Datong City, Shanxi Province, No. 15 Patentee after: Hu Jianli Address before: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee before: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin |
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| CP02 | Change in the address of a patent holder |
Address after: No. 6, Yongsheng street, Tian Zhuang Town, Pingdu City, Qingdao, Shandong Patentee after: Hu Jianli Address before: 037000 No. 2, building 2, Cang Cang street, Datong City, Shanxi Province, No. 15 Patentee before: Hu Jianli |
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| CP02 | Change in the address of a patent holder | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110831 Termination date: 20180913 |
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| CF01 | Termination of patent right due to non-payment of annual fee |