CN101953818A - Intranasal administration encapsulated based on polyelectrolyte capsule - Google Patents
Intranasal administration encapsulated based on polyelectrolyte capsule Download PDFInfo
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- CN101953818A CN101953818A CN200910162027XA CN200910162027A CN101953818A CN 101953818 A CN101953818 A CN 101953818A CN 200910162027X A CN200910162027X A CN 200910162027XA CN 200910162027 A CN200910162027 A CN 200910162027A CN 101953818 A CN101953818 A CN 101953818A
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- capsule
- spraying
- nasal
- packed
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Abstract
A micron and nanometer encapsulated technology synthesized by step-by-step shells can be applied for intranasal and pulmonary administration. Liquid, gas or solid encapsulation can form an aerosol in spray treatment. Different shell compositions create stability, compatibility, and degradation and releasing attributes. A plurality of substances comprising the compound widely used for intranasal administration can be encapsulated, or are administrated through spray capsules.
Description
Detailed description of the invention
1. at present, the encapsulation technology based on the multilayer polyelectrolyte capsule has developed into the stage that a lot of molecules can both be packed.Capsule can be made by various electric charge polymers and comprise synthesized polymer body and biocompatible, natural and biodegradable polymer, and protein for example,
OligopeptideAnd polysaccharide.Capsule can be made all size, mainly from 100 nanometers to 20 micron and bigger.The inside of capsule is the aqueous packed raw material that is dissolved in blister cavities that comprises, packed liquid oil base emulsion drop, solid (packed micron and nanocrystal) or packed gaseous state.
2. spraying can be applied to water pocket and suspends and make the aerosol that contains capsule.The complete number of plies that depends on polyeletrolyte of capsule, in fact nozzle can be passed through less than 5 microns capsule in pressurization back in spraying, and can encapsulating material is saved intactly, can not break.Also can be processed into standard less than 10 microns liquid medicine bags, conventional spraying.With the shell of respective thickness above 10 nanometers, packed material can not leak.More the encapsulation oil droplet capsule of giant must remain on below 0.5 micron, keeps the complete of them man-hour to add in spraying.For the encapsulation emulsion drop, size restrictions is less than 0.5 micron, otherwise dripping of pressurized can be crushed to littler dripping, and the polymerization shell is not designed to bear more large scale.
3. wanting solids packed and that spraying is subsequently handled can be the nanocrystal of medicine or the polymer particles that the medicine molecule is housed.Encapsulating material is deposited in the capsule in the time of also can being spraying, thereby realizes administration in the capsule.
More 4. can use the common drug and the having of above method encapsulation by nasal-cavity administration:
-beclometasone dipropionate monohydrate;
-flunisolide;
-fluticasone pine furoate;
-Mo Meitasong furoate;
-FLUTICASONE PROPIONATE;
5. polymer shell is synthetic can be designed to finish with the next item down or several standards:
I) be degradable, if make for example polysaccharide or peptide with the degradable biological high polymer.Degradation rate is to be controlled by the kind/stability and the deposited layers of use polymer.When the shell of medicine arrives pulmonary and is degraded, packaged medicine just has been released.
Ii) polymer shell can be used for the cell storage.One or more active substances can be synthesized in the multilamellar capsule.Active substance is incorporated into when encapsulating material arrives medicine-feeding part can provide combined effect.This comprises antioxidant substance.Advantage is to store for a long time in having realized, capsule can be by the freezing life-span that increases shell.
The outermost layer that capsular adhesion is provided that iii) has the function group when sucking can be regulated the adhesion attribute of capsule.
6. in order to meet the requirement of nasal-cavity administration, the size that the design example by spraying such as the variation of nozzle diameter or applying pressure can be regulated capsule.The capsule upper dimension bound can be adjusted by changing nozzle.
Claims (14)
1. use the method that realizes spraying capsule suspension nasal-cavity administration by synthetic micron of multi step format shell and nanometer encapsulation technology.
2. according to the method described in the claim 1, wherein, synthetic can being conditioned of softgel shell provides real-time control degradation.
3. according to the method described in the claim 1, wherein, softgel shell is synthetic can be conditioned provide in storage for a long time.
4. according to the method described in the claim 1, wherein, the top layer that is capped cell is designed to provide in lung or on other organ the pulmonary administration capsular adhesion of necessity.
5. according to the method described in the claim 1, wherein, be used for the encapsulating material form that the capsule of nasal-cavity administration loads and comprise gas, liquid (oil or water), or solid.
6. according to the method described in the claim 1, wherein, single capsule can encapsulate a plurality of compositions.
7. according to the method described in the claim 1, wherein, the nozzle diameter of aerosol apparatus can be conditioned the capsule that makes required size and can completely pass through in pressurization and course of injection.
8. according to the method described in the claim 1, wherein, medication crystalline solid and noncrystal are made solids and are realized the spraying nasal-cavity administration.
9. according to the method described in the claim 1, wherein, capsule solution evaporation when spraying, micromolecule is deposited and enters in the capsule.
10. according to the method described in the claim 1, wherein, beclometasone dipropionate monohydrate is packed medicament.
11. according to the method described in the claim 1, wherein, flunisolide is packed medicament.
12. according to the method described in the claim 1, wherein, fluticasone pine furoate is packed medicament.
13. according to the method described in the claim 1, wherein, the Mo Meitasong furoate is packed medicament.
14. according to the method described in the claim 1, wherein, FLUTICASONE PROPIONATE is packed medicament.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22667009P | 2009-07-17 | 2009-07-17 | |
| US61/226670 | 2009-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101953818A true CN101953818A (en) | 2011-01-26 |
Family
ID=43481578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910162027XA Pending CN101953818A (en) | 2009-07-17 | 2009-08-07 | Intranasal administration encapsulated based on polyelectrolyte capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101953818A (en) |
-
2009
- 2009-08-07 CN CN200910162027XA patent/CN101953818A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110126 |