CN101953721B - Preparation method of multilayer composite artificial vascular membrane with shape memory function - Google Patents
Preparation method of multilayer composite artificial vascular membrane with shape memory function Download PDFInfo
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- CN101953721B CN101953721B CN 201010523198 CN201010523198A CN101953721B CN 101953721 B CN101953721 B CN 101953721B CN 201010523198 CN201010523198 CN 201010523198 CN 201010523198 A CN201010523198 A CN 201010523198A CN 101953721 B CN101953721 B CN 101953721B
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Abstract
The invention relates to a multilayer composite artificial vascular membrane with a shape memory function and a preparation method thereof. The vascular membrane comprises a core layer, an inner layer and an outer layer, wherein the core layer is made of a material with a shape memory function; and the inner layer and the outer layer are polyfluortetraethylene membranes. The preparation method comprises the following steps of: using elastic fiber with the shape memory function as a base material of a textile; preparing a textile base covering membrane as the core layer of the artificial vascular membrane through a textile forming technology; carrying out mould pressing on the core layer, the inner layer and the outer layer by a mould; and preparing the integrative artificial vascular membrane. The invention has simple method and low cost and is suitable for industrialized production. The obtained vascular membrane is embedded into a body to cooperate an aorta stent, automatically releases and bursts into a branch artery by using the obvious blood pressure difference between the branch artery and a main artery after the branch artery is blocked, simplifies the whole operating process and reduces the surgery difficulty.
Description
Technical field
The invention belongs to artificial vascular membrane and preparation field thereof, particularly relate to a kind of preparation method with multilayer composite artificial vascular membrane of shape memory function.
Background technology
The method that the processing problem for branch artificial blood vessel of being out at present in section operation adopts usually has pre-windowing technology, graft original position puncture windowing technology, hybridization operation etc., and they have their own characteristics each, and its purpose is all to reduce operation wound and operating time.But betide the dissection of aorta of aortic arch and aneurysm involves important branch vessel because of it and other high risk factors make surgical intervention face great challenge, therefore await further raising, from the theory and practice meaning, reduction operating difficulty, by-pass graft simple to operate are final developing direction.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method with multilayer composite artificial vascular membrane of shape memory function, and the method is simple, and cost is low, is suitable for suitability for industrialized production; The collaborative aortic stents of gained tunica vasculose implants, exist after utilizing bifurcated artery by shutoff and between aorta obvious blood pressure difference with and shape memory function automatically discharge and charge into bifurcated artery, simplify whole operative treatment process, reduce operating difficulty.
A kind of multilayer composite artificial vascular membrane with shape memory function of the present invention, comprise: sandwich layer, internal layer and skin, the space that utilizes press moulding mode to make internal layer and outer field poly tetrafluoroethylene see through sandwich layer is bonded together, thereby reaches sandwich layer, internal layer and outer compound purpose; Described sandwich layer is for having shape memory function, and described internal layer and skin are poly tetrafluoroethylene.
Described sandwich layer, internal layer and outer field mass ratio are about 1:3.87:3.87.
Described material with shape memory function is polyester, machine silicon fiml, polyurethane etc.
Described material with shape memory function is the PTT reticulated.
Described shape memory namely utilizes the easy recovery of its " easily moulding " property and original-shape, indiscriminately ad. as one wishes moulding under certain condition, and external force is easy to again be returned to original flattened state after touching.
A kind of preparation method with multilayer composite artificial vascular membrane of shape memory function of the present invention comprises:
(1) apparatus has the material of shape memory function as the base material of fabric, by knitting molding on the model machine of small-sized circular knitting machine or by the sandwich layer of the basic overlay film of hand woven molding preparation weaving as artificial vascular membrane;
(2) with sandwich layer, internal layer, outer by mould at 200 ℃ of-250 ℃ of lower mold pressings, the integrated artificial vascular membrane that is prepared from.
The basic overlay film of described weaving is the grid with gradient Cell density structure.
The present invention utilizes branch different from the structure of film of main body, makes it to comply with the pressure of blood pressure, charges into bifurcated artery, and does not block bifurcated artery blood flow, non-internal leakage.
The present invention utilizes multidimensional weaving forming technique and surface chemical modification, the gradient elastic mesh that preparation has the shape memory structure; And have three-decker and have the branch artificial blood vessel film of shape memory function as the sandwich layer support of branch artificial blood vessel and the compound preparation of ePTFE film.
Beneficial effect
(1) preparation method of the present invention is simple, and cost is low, is suitable for suitability for industrialized production;
(2) the collaborative aortic stents of the branch artificial blood vessel of gained of the present invention implants, exist after utilizing bifurcated artery by shutoff and between aorta obvious blood pressure difference with and shape memory function automatically discharge and charge into bifurcated artery, simplify whole operative treatment process, reduce operating difficulty.
Description of drawings
Fig. 1 is the integrated structural representation of facing of the multilayer composite artificial vascular membrane of shape memory function of the present invention;
Fig. 2 is three-layer composite structure branch artificial blood vessel model schematic diagram;
Fig. 3 is branch artificial blood vessel film shape memory process schematic diagram.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1
as Fig. 1, shown in Figure 2, a kind of novel multilayer composite artificial vascular membrane with shape memory function, artificial vascular membrane is as sandwich layer and poly tetrafluoroethylene three layers of artificial vascular membrane that is composited as ectonexine by the PTT reticulated material with different densities gradient, sandwich layer because the grid modulus has gradient in the quick shape recovery capability of having of dispose procedure, therefore make the branch artificial blood vessel film have shape memory function, it can be worked in coordination with aortic stents and implant, exist after utilizing bifurcated artery by shutoff and between aorta obvious blood pressure difference with and shape memory function automatically discharge and charge into bifurcated artery, reduce operating difficulty.
The preparation method of multilayer composite artificial vascular membrane comprises:
(1) with the base material of polyester as fabric, by knitting molding on the model machine of small-sized circular knitting machine or by the sandwich layer of the basic overlay film of hand woven molding preparation weaving as artificial vascular membrane;
(2) with sandwich layer, internal layer, outer by mould 200 ℃ of lower mold pressings, the integrated artificial vascular membrane that is prepared from.
The composite vascular prosthesis film that makes, sandwich layer, internal layer and outer field mass ratio are about 1:3.87:3.87.
As shown in Figure 3, when carrying out the clinical operation operation, at first the branch artificial blood vessel film is sewn on aorta, then when implanting, the artificial vascular membrane compression is attached on aorta, utilize carrier that artificial blood vessel is delivered to lesion and will be made branch artificial blood vessel align fingers tremulous pulse, then releasing bracket, different from the structure of film of main body due to branch, make it to comply with the pressure of blood pressure, charge into bifurcated artery, and do not block the bifurcated artery blood flow, non-internal leakage.
Embodiment 2
as Fig. 1, shown in Figure 2, a kind of novel multilayer composite artificial vascular membrane with shape memory function, artificial vascular membrane is as sandwich layer and poly tetrafluoroethylene three layers of artificial vascular membrane that is composited as ectonexine by the PTT/PET twisted yarn reticulated material with different densities gradient, sandwich layer because the grid modulus has gradient in the quick shape recovery capability of having of dispose procedure, therefore make the branch artificial blood vessel film have shape memory function, it can be worked in coordination with aortic stents and implant, exist after utilizing bifurcated artery by shutoff and between aorta obvious blood pressure difference with and shape memory function automatically discharge and charge into bifurcated artery, reduce operating difficulty.
The preparation method of multilayer composite artificial vascular membrane comprises:
(1) apparatus has the material of shape memory function as the base material of fabric, and as PPT, PTT/PET etc. are by knitting molding on the model machine of small-sized circular knitting machine or by the sandwich layer of the basic overlay film of hand woven molding preparation weaving as artificial vascular membrane;
(2) with sandwich layer, internal layer, outer by mould 250 ℃ of lower mold pressings, the integrated artificial vascular membrane that is prepared from.
The composite vascular prosthesis film that makes, sandwich layer, internal layer and outer field mass ratio are about 1:3.87:3.87.
As shown in Figure 3, when carrying out the clinical operation operation, at first the branch artificial blood vessel film is sewn on aorta, then when implanting, the artificial vascular membrane compression is attached on aorta, utilize carrier that artificial blood vessel is delivered to lesion and will be made branch artificial blood vessel align fingers tremulous pulse, then releasing bracket, different from the structure of film of main body due to branch, make it to comply with the pressure of blood pressure, charge into bifurcated artery, and do not block the bifurcated artery blood flow, non-internal leakage.
Claims (5)
1. preparation method with multilayer composite artificial vascular membrane of shape memory function, described tunica vasculose comprises: sandwich layer, internal layer and skin, the space that utilizes press moulding mode to make internal layer and outer field poly tetrafluoroethylene see through sandwich layer is bonded together; Described sandwich layer is the material with shape memory function, and described internal layer and skin are poly tetrafluoroethylene, and preparation process is as follows:
(1) apparatus has the material of shape memory function as the base material of fabric, by the weaving molding or by the sandwich layer of the basic overlay film of hand woven molding preparation weaving as artificial vascular membrane;
(2) with sandwich layer, internal layer, outer by mould at 200 ℃ of-250 ℃ of lower mold pressings, the integrated artificial vascular membrane that is prepared from;
Described sandwich layer is the material with shape memory function, and described internal layer and skin are poly tetrafluoroethylene.
2. a kind of preparation method with multilayer composite artificial vascular membrane of shape memory function according to claim 1, it is characterized in that: the basic overlay film of described weaving is the grid with gradient Cell density structure.
3. a kind of preparation method with multilayer composite artificial vascular membrane of shape memory function according to claim 1, it is characterized in that: described sandwich layer, internal layer and outer field mass ratio are 1:3.87:3.87.
4. a kind of preparation method with multilayer composite artificial vascular membrane of shape memory function according to claim 1, it is characterized in that: described material with shape memory function is polyester, organosilicon membrane or polyurethane.
5. according to claim 1 or 4 described a kind of preparation methoies with multilayer composite artificial vascular membrane of shape memory function, it is characterized in that: described material with shape memory function is the PTT reticulated.
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| CN 201010523198 CN101953721B (en) | 2010-10-28 | 2010-10-28 | Preparation method of multilayer composite artificial vascular membrane with shape memory function |
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| CN 201010523198 CN101953721B (en) | 2010-10-28 | 2010-10-28 | Preparation method of multilayer composite artificial vascular membrane with shape memory function |
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| CN101953721A CN101953721A (en) | 2011-01-26 |
| CN101953721B true CN101953721B (en) | 2013-06-05 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103498308B (en) * | 2013-09-27 | 2016-01-06 | 东华大学 | A kind of tubular fiber base artificial blood vessel coating/grafting device and using method |
| WO2016205462A1 (en) * | 2015-06-19 | 2016-12-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biodegradable vascular grafts |
| CN108066047B (en) * | 2016-11-15 | 2020-06-30 | 先健科技(深圳)有限公司 | Flow-blocking membrane and implanted medical instrument |
| CN110859998A (en) * | 2019-12-18 | 2020-03-06 | 上海畅迪医疗科技有限公司 | Anti-kink artificial blood vessel and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2960586B2 (en) * | 1990-08-28 | 1999-10-06 | ミードツクス・メデイカルス・インコーポレイテツド | Anti-fraying self-holding woven artificial blood vessel and method for producing the same |
| JP2006122578A (en) * | 2004-11-01 | 2006-05-18 | Terumo Corp | Artificial blood vessel joint body and joining method |
| CN101543659A (en) * | 2007-03-28 | 2009-09-30 | 科迪斯公司 | Local vascular delivery system of probucol alone or in combination with sirolimus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS5611062A (en) * | 1979-07-10 | 1981-02-04 | Yasuharu Imai | Sheettshaped prosthetic material for medical treatment |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2960586B2 (en) * | 1990-08-28 | 1999-10-06 | ミードツクス・メデイカルス・インコーポレイテツド | Anti-fraying self-holding woven artificial blood vessel and method for producing the same |
| JP2006122578A (en) * | 2004-11-01 | 2006-05-18 | Terumo Corp | Artificial blood vessel joint body and joining method |
| CN101543659A (en) * | 2007-03-28 | 2009-09-30 | 科迪斯公司 | Local vascular delivery system of probucol alone or in combination with sirolimus |
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