CN101948454A - Method for preparing 2-butyl-5-nitrobenzofuran - Google Patents
Method for preparing 2-butyl-5-nitrobenzofuran Download PDFInfo
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- CN101948454A CN101948454A CN 201010501516 CN201010501516A CN101948454A CN 101948454 A CN101948454 A CN 101948454A CN 201010501516 CN201010501516 CN 201010501516 CN 201010501516 A CN201010501516 A CN 201010501516A CN 101948454 A CN101948454 A CN 101948454A
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Abstract
The invention belongs to the technical field of intermediates of a dronedarone medicament and particularly relates to a method for preparing 2-butyl-5-nitrobenzofuran which is a compound for use in the preparation of the specific dronedarone medicament for treating arrhythmia. The method comprises the following steps: reacting 2-(2-formyl-4-nitrophenoxy)hexanoic acid with anhydride ( compound of a formula II) at a reaction temperature in reaction solution and in the presence of a catalyst to form 2-butyl-5-nitrobenzofuran. The method is high in reaction yield and low in production cost and has high application value and great social and economic benefit.
Description
Technical field
The invention belongs to the technical field of medicine Dronedarone intermediate, be specially the preparation method who relates to 2-normal-butyl-5-nitrobenzofuran, this compound can be used for preparation treatment heart disorder specific medicament Dronedarone.
Background technology
Dronedarone (dronedarone hydrochloride); chemistry 2-normal-butyl-3-[4-by name (the amino propoxy-of 3-di-n-butyl) benzoyl]-5-methylsulfonyl amido cumarone; be polarization inhibitor by French company's exploitation, the clinical treatment heart disorder that is mainly used in.Its structure and feature and cardiovascular drug amiodarone are similar, and because of not containing iodine, its lipotropy is lower.It had both kept the curative effect of amiodarone, did not have the untoward reaction of amiodarone again, was the more novel drugs that substitutes of amiodarone.Along with the quickening of social process, the pressure that people bear is increasing, and the quantity of China's cardiovascular patient also constantly increases.Therefore developing Dronedarone will bring favorable economic benefit and social benefit, and its chemical structural formula is shown below:
Dronedarone
2-normal-butyl-5-nitrobenzofuran is the key intermediate of synthetic Dronedarone, and its structural formula is as follows:
Reported the method for Synthetic 2-normal-butyl-5-nitrobenzofuran among the patent WO03040120; this preparation method's processing step is: with 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid is raw material, gets 2-normal-butyl-5-nitrobenzofuran through annulation.But this method cost is higher, and productive rate is low, and productive rate is 62%.Its step is as shown in following:
In view of the pharmacy value of Dronedarone and good market outlook, seeking a kind of can be imperative with the effective ways of good yield, controllability is strong, cost is low Synthetic 2-normal-butyl-5-nitrobenzofuran.
Summary of the invention
The objective of the invention is at the problem of above-mentioned existence and the preparation method of a kind of 2-normal-butyl-5-nitrobenzofuran is provided.
The invention provides the method for a kind of 2-of preparation normal-butyl-5-nitrobenzofuran (formula I compound), may further comprise the steps:
Ⅰ
In reaction solvent, under the condition that catalyzer exists,, under temperature of reaction, react 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid and acid anhydrides (formula II compound), generate 2-normal-butyl-5-nitrobenzofuran,
Ⅱ
Wherein, R
1And R
2Represent C
1～C
4Alkyl, R
1And R
2Can be identical, also can be different.
Described acid anhydrides is one or more in diacetyl oxide, propionic anhydride, the isobutyric anhydride, is preferably diacetyl oxide.
Described catalyzer is one or more the mixture in sodium acetate, yellow soda ash, the sodium hydroxide, is preferably sodium acetate.
Described reaction solvent is one or more the mixture in formic acid, acetate, the propionic acid.
Described temperature of reaction is the reflux temperature of room temperature to solvent, is preferably the reflux temperature of solvent.
Beneficial effect of the present invention is: adopt method preparation of the present invention, the yield of reaction is higher, reaches 85.1%, the purity height of product, and HPLC purity is 98.6%, can realize efficiently, the I of large-scale production formula economically compound; And processing condition of the present invention are reasonable, and are simple to operate, and production cost is low, do not have the three wastes substantially, have bigger implementary value and economic results in society.
To the product that arrives of the present invention, detect, its data are as follows:
1H?NMR?(DMSO-d6)?δ:?0.92?(t,?3H,CH
3),?1.26?(m,?2H,C
H 2-CH
3),?1.68?(m,2H,C
H 2-CH
2-CH
3),?2.86?(m,2H,C
H 2-C＝),?7.74?(d,
?J?=?9?Hz?1H,ArH),?8.15?(dd,?
J?=?9?Hz,?
J?=?2.5?Hz?,1H,ArH),?8.49?(d,?
J?=?2.5?Hz,?1H,ArH)
Embodiment
Below by specific embodiment technical scheme of the present invention is described in detail, following embodiment is detailed explanation technical scheme of the present invention, and unrestricted the present invention.
Embodiment 1
56.3 gram 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid are joined in 300 milliliters of acetate and 300 ml acetic anhydride, add 164 gram anhydrous sodium acetates.Back flow reaction 6 hours, reaction finishes, and is cooled to room temperature, adds 1 liter of distilled water wash.Be 60-90 ℃ petroleum ether extraction then with boiling range, the gained petroleum ether solution concentrated obtain 2-normal-butyl-5-nitrobenzofuran, be yellow oily liquid 37.3 grams, yield 85.1%.HPLC purity is 98.6%.
Embodiment 2
56.3 gram 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid are joined in 300 milliliters of acetate and 300 ml acetic anhydride, add 164 gram anhydrous sodium acetates.Back flow reaction 4 hours is cooled to room temperature, stirring at normal temperature 2 hours, and reaction finishes and adds 1 liter of distilled water wash.Be 60-90 ℃ petroleum ether extraction then with boiling range, the gained petroleum ether solution concentrated obtain 2-normal-butyl-5-nitrobenzofuran, be yellow oily liquid 36.6 grams, yield 83.5%.HPLC purity is 97.4%.
Embodiment 3
56.3 gram 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid are joined in 300 milliliters of acetate, add 164 gram anhydrous sodium acetates.Be warming up to backflow, drip 300 ml acetic anhydride.Dropwise, be cooled to stirring at room reaction 12 hours, reaction finishes and adds 1 liter of distilled water wash.Be 60-90 ℃ petroleum ether extraction then with boiling range, the gained petroleum ether solution concentrated obtain 2-normal-butyl-5-nitrobenzofuran, be yellow oily liquid 34.5 grams, yield 78.6%.HPLC purity is 96.8%.
Embodiment 4
Join 56.3 gram 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid in 300 milliliters of propionic acid and 300 ml acetic anhydride in, add 164 gram anhydrous sodium acetates.Back flow reaction 6 hours, reaction finishes, and is cooled to room temperature, adds 1 liter of distilled water wash.Be 60-90 ℃ petroleum ether extraction then with boiling range, the gained petroleum ether solution concentrated obtain 2-normal-butyl-5-nitrobenzofuran, be yellow oily liquid 37.1 grams, yield 84.7%.HPLC purity is 98.3%.
Embodiment 5
56.3 gram 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid are joined in 300 milliliters of propionic acid, add 164 gram anhydrous sodium acetates.Be warming up to backflow, drip 300 ml acetic anhydride.Dropwise, be cooled to stirring at room reaction 12 hours, reaction finishes and adds 1 liter of distilled water wash.Be 60-90 ℃ petroleum ether extraction then with boiling range, the gained petroleum ether solution concentrated obtain 2-normal-butyl-5-nitrobenzofuran, be yellow oily liquid 34.6 grams, yield 79.1%.HPLC purity is 97.1%.
Claims (8)
1. the preparation method of 2-normal-butyl-5-nitrobenzofuran may further comprise the steps:
In reaction solvent, under the condition that catalyzer exists,, under temperature of reaction, react 2-(2-formyl radical-4-nitrophenoxy) n-caproic acid and acid anhydrides (formula II compound), generate 2-normal-butyl-5-nitrobenzofuran,
Wherein, R
1And R
2Represent C
1～C
4Alkyl, R
1And R
2Can be identical, also can be different.
2. preparation method according to claim 1 is characterized in that, described acid anhydrides is one or more in diacetyl oxide, propionic anhydride, the isobutyric anhydride.
3. preparation method according to claim 2 is characterized in that, described acid anhydrides is a diacetyl oxide.
4. according to the described preparation method of claim 1, it is characterized in that described catalyzer is one or more the mixture in sodium acetate, yellow soda ash, the sodium hydroxide.
5. preparation method according to claim 4 is characterized in that, described catalyzer is a sodium acetate.
6. preparation method according to claim 1 is characterized in that, described reaction solvent is one or more the mixture in formic acid, acetate, the propionic acid.
7. preparation method according to claim 1 is characterized in that, described temperature of reaction is the reflux temperature of room temperature to solvent.
8. preparation method according to claim 7 is characterized in that, described temperature of reaction is the reflux temperature of solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010501516 CN101948454A (en) | 2010-10-11 | 2010-10-11 | Method for preparing 2-butyl-5-nitrobenzofuran |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010501516 CN101948454A (en) | 2010-10-11 | 2010-10-11 | Method for preparing 2-butyl-5-nitrobenzofuran |
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|---|---|
| CN101948454A true CN101948454A (en) | 2011-01-19 |
Family
ID=43452097
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| CN 201010501516 Pending CN101948454A (en) | 2010-10-11 | 2010-10-11 | Method for preparing 2-butyl-5-nitrobenzofuran |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109053652A (en) * | 2018-09-04 | 2018-12-21 | 北京深蓝海生物医药科技有限公司 | A kind of preparation method of Amiodarone Hydrochloride intermediate |
| CN114539193A (en) * | 2022-01-20 | 2022-05-27 | 海南普利制药股份有限公司 | Preparation method of amiodarone hydrochloride intermediate |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002255954A (en) * | 2001-03-02 | 2002-09-11 | Yoshio Ishino | METHOD FOR PRODUCING 2-n-BUTYL-5-NITROBENZOFURAN |
-
2010
- 2010-10-11 CN CN 201010501516 patent/CN101948454A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002255954A (en) * | 2001-03-02 | 2002-09-11 | Yoshio Ishino | METHOD FOR PRODUCING 2-n-BUTYL-5-NITROBENZOFURAN |
Non-Patent Citations (1)
| Title |
|---|
| 《Polish J. Chem.》 20041231 H. Kwieeien Synthesis of 2-alkyl-5-nitrobenzofurans via 2-(2-formyl-4-nitrophenoxy)alkanoic acids 1865-1869 1－8 第78卷, 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109053652A (en) * | 2018-09-04 | 2018-12-21 | 北京深蓝海生物医药科技有限公司 | A kind of preparation method of Amiodarone Hydrochloride intermediate |
| CN114539193A (en) * | 2022-01-20 | 2022-05-27 | 海南普利制药股份有限公司 | Preparation method of amiodarone hydrochloride intermediate |
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Application publication date: 20110119 |