CN101940746A - Jinji blood stasis eliminating pills and preparation method thereof - Google Patents
Jinji blood stasis eliminating pills and preparation method thereof Download PDFInfo
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- CN101940746A CN101940746A CN 201010281342 CN201010281342A CN101940746A CN 101940746 A CN101940746 A CN 101940746A CN 201010281342 CN201010281342 CN 201010281342 CN 201010281342 A CN201010281342 A CN 201010281342A CN 101940746 A CN101940746 A CN 101940746A
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Abstract
The invention discloses traditional Chinese medicine Jinji blood stasis eliminating pills for treating a chronic pelvic inflammatory disease and a preparation method thereof. The Jinji blood stasis eliminating pill has effectively improved active components of medicaments and the advantages of less taking dosage, convenient taking and obvious curative effect. The preparation method is characterized by comprising the following steps of: with honeysuckle, baical skullcap root, dandelion, Chinese violet, Chinese honeylocust spine, common peony root, suberect spatholobus stem, common burreed rhizome, szechuan lovage rhizome, nutgrass galingale rhizome (vinegar), corydalis tuber (vinegar) and cowherb seed (frying) as raw materials, processing the raw materials by methods of ultrasonic extraction, concentration, drying, pulverization, and the like; and with polyethylene glycol-4,000 as an aqueous solution solid substrate and liquid paraffin as cooling liquid, uniformly mixing according to the ratio of the medicaments to the substrate of 1:3 to obtain the pills.
Description
(1) technical field
The present invention relates to the field of Chinese medicines, specifically, relate to a kind of medicine Jinji blood stasis removing drop pill for the treatment of chronic pelvic inflammatory disease and preparation method thereof.
(2) background technology
Jinji blood stasis removing pellet is used for card and belongs to damp-heat accumulation, the treatment of qi stagnation and blood stasis type women's chronic pelvic inflammatory disease, the active component that adopts common decoction and alcohol sedimentation technique to extract medicine forms with pharmaceutically acceptable excipient and adjuvant processing and preparing again, have that active ingredient extracts not exclusively, taking dose is big, take inconvenience, deficiencies such as easy deliquescence.
(3) summary of the invention
For overcoming the deficiency that Jinji blood stasis removing pellet exists, the invention provides that a kind of active ingredient extracts fully, taking dose is little, taking convenience, stay-in-grade Jinji blood stasis removing drop pill.
The Jinji blood stasis removing drop pill is by following method preparation:
Extracting honeysuckle 200g, Radix Scutellariae 200g, Herba Taraxaci 150g, Herba Violae 100g, Spina Gleditsiae 150g, Radix Paeoniae Rubra 150g, Caulis Spatholobi 200g, rhizoma sparganic 100g, Rhizoma Chuanxiong 100g, Rhizoma Cyperi (vinegar) 100g, Rhizoma Corydalis (vinegar) 100g, Semen Vaccariae (stir-fry) 100g, add the water that is equivalent to 8～10 times of amounts of medical material, 40～60 ℃ of supersound extraction, filter, filtering residue is with 40～60 ℃ of supersound process of 70～80% ethanol, filter, twice filtrate is merged, and 70～80 ℃ are condensed into extractum, drying and crushing, cross 100 mesh sieves, press 1: 3 mixing of medicine and substrate, 70～90 ℃ of control temperature of charge, 2～20 ℃ of condensation temperatures, drip apart from 2.0～4.0cm, drip 30～100 droplets/minute of speed, splash in the liquid coolant, take out after drop pill is shaped, surface cool liquid is removed in suction, is drying to obtain.
The Chinese crude drug source that above-mentioned embodiment is mentioned is as follows:
Flos Lonicerae: be caprifoliaceae plant dry flower or the first flower of opening of band of Radix Ophiopogonis.Heat-clearing and toxic substances removing is arranged, the effect of wind-heat dissipating.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae.Heat clearing and damp drying is arranged, the effect of eliminating fire and detoxication.
Herba Taraxaci: for feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herbs of several plants together.Heat-clearing and toxic substances removing is arranged, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome is used for jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Herba Violae: be the dry herb of Violaceae Chinese violet.The effect that heat-clearing and toxic substances removing is arranged.
Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia.The detumescence poison holding is arranged, the effect of evacuation of pus.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Clearing away heat and cooling blood is arranged, and the effect of eliminating stasis to stop pain is used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache.
Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus.Be used for menoxenia; Dysmenorrhea; Amenorrhea.
Rhizoma sparganic: be the dry tuber of Sparganiaceae plant rhizoma scirpi.The removing blood stasis circulation of qi promoting is arranged, removing food stagnancy analgesic effect.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong.Blood-activating and qi-promoting is arranged, the effect of wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache.
Rhizoma Cyperi (vinegar): be the process of preparing Chinese medicine processed goods of Rhizoma Cyperi.Promoting QI circulation for relieving depression are arranged, the effect of menstruction regulating and pain relieving.
Rhizoma Corydalis (vinegar): be the process of preparing Chinese medicine processed goods of Rhizoma Corydalis.Invigorate blood circulation promoting the circulation of QI, analgesic effect.
Semen Vaccariae (stir-fry): be the process of preparing Chinese medicine processed goods of Semen Vaccariae.The effect that promoting blood circulation to restore menstrual flow is arranged.
The used crude drug of Jinji blood stasis removing drop pill all can be bought from common pharmacy and obtain, and its specification meets national medical standard.
(4) specific embodiment
The following example only is used to illustrate the present invention, rather than the restriction we are bright by any way.
Specific embodiments of the invention 1
Extracting honeysuckle 200g, Radix Scutellariae 200g, Herba Taraxaci 150g, Herba Violae 100g, Spina Gleditsiae 150g, Radix Paeoniae Rubra 150g, Caulis Spatholobi 200g, rhizoma sparganic 100g, Rhizoma Chuanxiong 100g, Rhizoma Cyperi (vinegar) 100g, Rhizoma Corydalis (vinegar) 100g, Semen Vaccariae (stir-fry) 100g, the water that adds 8 times of amounts of crude drug, 40 ℃ of supersound extraction 1 hour, filter, filtering residue was with 40 ℃ of supersound process of 70% ethanol 1 hour, filter, twice filtrate is merged, and 70 ℃ are condensed into extractum, drying and crushing, cross 100 mesh sieves, press 1: 3 mixing of medicine and Macrogol 4000,70 ℃ of control temperature of charge, 2 ℃ of condensation temperatures, drip apart from 2.0cm, drip 30 droplets/minute of speed, splash in the liquid paraffin, take out after drop pill is shaped, surface cool liquid is removed in suction, is drying to obtain 200 gram drop pill.
Specific embodiments of the invention 2
Extracting honeysuckle 200g, Radix Scutellariae 200g, Herba Taraxaci 150g, Herba Violae 100g, Spina Gleditsiae 150g, Radix Paeoniae Rubra 150g, Caulis Spatholobi 200g, rhizoma sparganic 100g, Rhizoma Chuanxiong 100g, Rhizoma Cyperi (vinegar) 100g, Rhizoma Corydalis (vinegar) 100g, Semen Vaccariae (stir-fry) 100g, the water that adds 10 times of amounts of crude drug, 60 ℃ of supersound extraction 1 hour, filter, filtering residue was with 60 ℃ of supersound process of 80% ethanol 1 hour, filter, twice filtrate is merged, and 80 ℃ are condensed into extractum, drying and crushing, cross 100 mesh sieves, press 1: 3 mixing of medicine and Macrogol 4000,90 ℃ of control temperature of charge, 20 ℃ of condensation temperatures, drip apart from 4.0cm, drip 100 droplets/minute of speed, splash in the liquid paraffin, take out after drop pill is shaped, surface cool liquid is removed in suction, is drying to obtain 200 gram drop pill.
The most preferred specific embodiment 3 of the present invention
Extracting honeysuckle 200g, Radix Scutellariae 200g, Herba Taraxaci 150g, Herba Violae 100g, Spina Gleditsiae 150g, Radix Paeoniae Rubra 150g, Caulis Spatholobi 200g, rhizoma sparganic 100g, Rhizoma Chuanxiong 100g, Rhizoma Cyperi (vinegar) 100g, Rhizoma Corydalis (vinegar) 100g, Semen Vaccariae (stir-fry) 100g, the water that adds 10 times of amounts of crude drug, 50 ℃ of supersound extraction 1 hour, filter, filtering residue was with 50 ℃ of supersound process of 80% ethanol 1 hour, filter, twice filtrate is merged, and 80 ℃ are condensed into extractum, drying and crushing, cross 100 mesh sieves, press 1: 3 mixing of medicine and Macrogol 4000,80 ℃ of control temperature of charge, 10 ℃ of condensation temperatures, drip apart from 3.0cm, drip 30 droplets/minute of speed, splash in the liquid paraffin, take out after drop pill is shaped, surface cool liquid is removed in suction, is drying to obtain 200 gram drop pill.
The method of inspection of one Jinji blood stasis removing drop pill embodiment:
(1) Radix Scutellariae, Flos Lonicerae discrimination method in the side: get this product 1g, add water 50ml, put hot bath and make dissolving, use n-butanol extraction 2 times, each 20ml merges n-butyl alcohol liquid, and water bath method, residue add 2ml methanol makes dissolving, as need testing solution.Other gets baicalin reference substance, chlorogenic acid reference substance, adds methanol respectively and makes the solution that every 1ml contains 0.1mg, in contrast product solution.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test, draw each 2 μ l of above-mentioned three kinds of solution, put respectively on same polyamide film, be developing solvent with acetic acid, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(2) Radix Paeoniae discrimination method in the side: get the peoniflorin reference substance, add ethanol and make the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw reference substance solution and discriminating (1) item each 10 μ l of need testing solution down, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with chloroform-ethyl acetate-methanol-formic acid (40: 15: 10: 0.2) be developing solvent, launch, take out, dry, spray is with 5% vanillin sulfuric acid solution, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show identical bluish violet speckle.
(3) Rhizoma Corydalis discrimination method in the side: get this product 1g, porphyrize adds methanol 50ml supersound process 30 minutes, filter, filtrate evaporate to dryness, residue add water makes dissolving, adds ammonia solution and transfers to alkalescence, ether extraction 3 times, each 15ml, merge extractive liquid,, evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets the tetrahydropalmatine reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw above-mentioned need testing solution 10 μ l, reference substance solution 1 μ l respectively, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with cyclohexane extraction-chloroform-methanol (10: 6: 1) is developing solvent, launch, take out, dry, after putting in the iodine vapor the smoked several seconds, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(4) Rhizoma Chuanxiong discrimination method in the side: get this product 2g, add water 50ml, regulate pH value to 2 ~ 3 with dilute hydrochloric acid, hot bath makes dissolving, put cold, with ether extraction 3 times, each 20ml merges ether solution, extracts 3 times with 2% sodium carbonate liquor, each 15ml divides and gets alkali liquor, adds hydrochloric acid and regulates pH value to 2 ~ 3, add diethyl ether and extract 3 times, each 15ml merges ether solution, volatilize, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets the ferulic acid reference substance and adds methanol and make the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 5 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with benzene-glacial acetic acid-methanol (30: 1: 3) is developing solvent, launch, take out, dry, under ultra-violet lamp (365nm), inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(5) determination of chlorogenic acid in the side:
Measure according to high performance liquid chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 D).
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filler; With acetonitrile-0.4% phosphoric acid solution (13: 87) is mobile phase; The detection wavelength is 327nm.Number of theoretical plate calculates by the chlorogenic acid peak should be not less than 1000.
The preparation of reference substance solution: it is an amount of that precision takes by weighing the chlorogenic acid reference substance, puts in the brown measuring bottle, adds 50% methanol and make the solution that every 1ml contains 40 μ g, promptly gets (preserving below 10 ℃).
The preparation of need testing solution: get this product, porphyrize, precision takes by weighing 1g, put in the tool plug conical flask, add 50% methanol 30ml, supersound extraction 25 minutes, filter, residue is with 50% methanol wash 3 times, 5ml at every turn, filter, merging filtrate quantitatively shifts in the 100ml measuring bottle, adds 50% methanol and is diluted to scale, shake up, promptly.Algoscopy: accurate need testing solution and each 10 μ l of reference substance solution of drawing, inject chromatograph of liquid respectively, measure, calculate, promptly.
The every gram of this product contains chlorogenic acid (C
16H
18O
9) must not be less than 0.4mg.
The clinical observation on the therapeutic effect test of two Jinji blood stasis removing drop pill treatment chronic pelvic inflammatory disease
(1) physical data
Statistics outpatient service and inpatient accept undergoing chronic pelvic inflammation 224 examples altogether for medical treatment, and the patient all has symptoms such as in various degree leucorrhea abnormal, adhesion.28～65 years old age wherein, 38 years old mean age.The employing Jinji blood stasis removing pellet is a matched group.
(2) efficacy assessment standard
Cure: clinical symptom disappearance, leucorrhea is normal, and adhesion disappears.Produce effects: clinical symptoms disappears substantially, and leucorrhea is normal substantially, and adhesion has significant improvement.Effectively: clinical symptoms takes a turn for the better, and leucorrhea and adhesion symptom have improvement to a certain degree.Invalid: clinical symptoms does not have improvement, and leucorrhea and adhesion symptom do not have improvement.
(3) clinical observation result
The clinical observation on the therapeutic effect comparative test result of treatment undergoing chronic pelvic inflammation
Above-mentioned clinical observation on the therapeutic effect result shows, the Jinji blood stasis removing drop pill can more effectively improve patient's symptoms such as leucorrhea abnormal, adhesion under the same conditions with respect to Jinji blood stasis removing pellet when treatment chronic pelvic inflammatory disease symptom.
The viewing test of three Jinji blood stasis removing drop pill chlorogenic acid contents, dose, stability
The employing Jinji blood stasis removing pellet is a matched group.
Above-mentioned observation shows that the Jinji blood stasis removing drop pill has active ingredient with respect to Jinji blood stasis removing pellet and extracts complete, remarkable advantages such as taking dose is little, steady quality when treatment chronic pelvic inflammatory disease symptom.
The Jinji blood stasis removing drop pill is compared active ingredient with Jinji blood stasis removing pellet and is significantly improved, and medicine forms solid dispersion under quenching conditions, exists with atomic little crystal grain, and dissolution rate is fast, the bioavailability height, and taking dose is little, taking convenience, mouthfeel is good.
Claims (2)
1. Chinese medicine for the treatment of women's chronic pelvic inflammation, it is characterized in that extracting honeysuckle 200g, Radix Scutellariae 200g, Herba Taraxaci 150g, Herba Violae 100g, Spina Gleditsiae 150g, Radix Paeoniae Rubra 150g, Caulis Spatholobi 200g, rhizoma sparganic 100g, Rhizoma Chuanxiong 100g, Rhizoma Cyperi (vinegar) 100g, Rhizoma Corydalis (vinegar) 100g, Semen Vaccariae (stir-fry) 100g, add 40～60 ℃ of supersound extraction of 8～10 times of water, filter, filtering residue is with 40～60 ℃ of supersound extraction of 70～80% ethanol, filter, merging filtrate, 70～80 ℃ are condensed into extractum, dry, pulverize, add pharmaceutically acceptable substrate, 70～90 ℃ of control temperature of charge, 2～20 ℃ of condensation temperatures, drip apart from 2.0～4.0cm, drip 30～100 droplets/minute of speed and make drop pill.
2. according to the preparation method of the described medicine of claim 1, it is characterized in that the substrate that adopts is Polyethylene Glycol, liquid coolant is a liquid paraffin.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973731A (en) * | 2011-09-05 | 2013-03-20 | 王成光 | Pelvic inflammatory disease and dysmenorrheal treatment liquid agent and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1891285A (en) * | 2005-07-08 | 2007-01-10 | 仁和（集团）发展有限公司 | Chinese medicine composition, and its preparing method and quality control method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1891285A (en) * | 2005-07-08 | 2007-01-10 | 仁和（集团）发展有限公司 | Chinese medicine composition, and its preparing method and quality control method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973731A (en) * | 2011-09-05 | 2013-03-20 | 王成光 | Pelvic inflammatory disease and dysmenorrheal treatment liquid agent and preparation method thereof |
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