CN101940575A - Cefditoren pivoxil solid preparation and preparation method thereof - Google Patents
Cefditoren pivoxil solid preparation and preparation method thereof Download PDFInfo
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- CN101940575A CN101940575A CN2010105181556A CN201010518155A CN101940575A CN 101940575 A CN101940575 A CN 101940575A CN 2010105181556 A CN2010105181556 A CN 2010105181556A CN 201010518155 A CN201010518155 A CN 201010518155A CN 101940575 A CN101940575 A CN 101940575A
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Abstract
The invention relates to a cefditoren pivoxil solid preparation and a preparation method thereof, the preparation contains cefditoren pivoxil nano microcapsule and pharmaceutical adjuvant, wherein the nano microcapsule is prepared from cefditoren pivoxil and a carrier material according to the weight ratio of 4-8:1, and the carrier material is a combination of xanthan gum, silk fibroin and superfine silica gel powder based on a weight ratio of 1.5-4.5:1:1. By using the solid preparation and the preparation method thereof, an entrapment rate higher than 95% can be achieved, thereby avoiding burst release of the medicament, reducing the untoward effects and improving the compliance of patients.
Description
Technical field
The present invention relates to a kind of solid preparation and preparation method thereof, relate in particular to a kind of Cefditoren pivoxil Cephalosporins solid preparation and preparation method thereof, belong to medical technical field.
Background technology
Cefditoren pivoxil Cephalosporins, chemistry is by name: (-)-(6R, 7R)-2,2-dimethyl propylene acyl-oxygen methyl 7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyl group imido acetylamino]-3-[(Z)-and 2-(4-methyl-5-thiazole base) vinyl]-8-oxo-5-thia-1-azabicyclic [4,2,0] oct-2-ene-2-carboxylate, its structure is as follows:
Cefditoren pivoxil Cephalosporins is researched and developed by Japanese MingZhi fruit Co., Ltd, goes on the market in Japan first on April 1st, 1994.Its mechanism of action is synthetic for suppressing bacteria cell wall, with the affinity height of various antibacterial penicillin-binding proteins (PBP), and the effect of performance bactericidal properties.This product at the approval indication of Japan is: treat various infection diseases such as respiratory tract, skin infection, urinary tract infection etc.
The Cefditoren pivoxil Cephalosporins untoward reaction has, anaphylaxis: erythra, pruritus, urticaria and heating etc.; Digestive system: feel sick vomiting, diarrhoea etc.; Blood system: hypereosinophilic syndrome, leukopenia etc.; Renal function: accidental BUN and serum creatinine rise; Liver function: GOT appears sometimes, GPT, Al-P rises.In addition, the Cefditoren pivoxil Cephalosporins life-time service can cause the undue growth of non-sensibility microorganism, changes normal intestinal flora, brings out superinfection, especially pseudomembranous colitis.Therefore suffer from gastroenteropathy, especially enteritis patient Ying Shen Cefditoren pivoxil Cephalosporins.
In view of the clinical practice of Cefditoren pivoxil Cephalosporins is extensive, research and development Cefditoren pivoxil Cephalosporins new formulation improves patient's compliance, reduces even stops untoward reaction, improves clinical safety in utilization, is the more urgent demand of Cefditoren pivoxil Cephalosporins clinical practice.
Summary of the invention
Technical problem to be solved by this invention is the defective that overcomes prior art, provide a kind of Cefditoren pivoxil Cephalosporins solid preparation, said preparation to have can significantly promote drug compliance, reduce characteristics such as untoward reaction.In addition, the present invention also will provide the preparation method of said preparation.
Problem of the present invention is realized by following technical scheme:
A kind of Cefditoren pivoxil Cephalosporins solid preparation, contain Cefditoren pivoxil Cephalosporins nano-microcapsule and pharmaceutic adjuvant in the said preparation, described nano-microcapsule is that 4～8:1 makes by Cefditoren pivoxil Cephalosporins and carrier material with ratio of weight and number, described carrier material is xanthan gum-fibroin albumen-micropowder silica gel compositions, and wherein the ratio of weight and number of xanthan gum, fibroin albumen and micropowder silica gel is 1.5～4.5:1:1.
Above-mentioned Cefditoren pivoxil Cephalosporins solid preparation, the ratio of weight and number of described xanthan gum, fibroin albumen and micropowder silica gel are 4.2:1:1.
Above-mentioned Cefditoren pivoxil Cephalosporins solid preparation, described pharmaceutic adjuvant are diluent, disintegrating agent, adhesive, lubricant and fluidizer.
Above-mentioned Cefditoren pivoxil Cephalosporins solid preparation, the dosage form of described Cefditoren pivoxil Cephalosporins solid preparation are tablet, capsule, dry suspension or granule.
A kind of method for preparing above-mentioned Cefditoren pivoxil Cephalosporins solid preparation, it carries out as follows:
A stirs fusion and insulation after ratio is mixed by weight with fibroin albumen with xanthan gum under 55～60 ℃ of conditions, slowly add micropowder silica gel while stirring, and micropowder silica gel is uniformly dispersed, compositions is standby;
B is that the ratio of 3:1:8 makes microemulsion according to propoxylation methyl glucoside weight, isobutanol volume, ethyl acetate volume ratio, adds Cefditoren pivoxil Cephalosporins in emulsion, places 40～60 ℃ of water-baths;
C adds the steps A resulting composition in microemulsion, be stirred to evenly, and as reactant liquor, the pH value of regulating this reactant liquor with the NaOH solution of mass concentration 10% is 8.0～10.0, adds an amount of methanol with this solution, isothermal reaction 1～2 hour;
D is cooled to 0 ℃ with reactant liquor, and the glutaraldehyde that adds 0.08～0.125 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 40～60 ℃ again, and adding glacial acetic acid to the value of pH is 2.0～4.0, obtains suspension;
Treat after E is static that sedimentation is complete, the supernatant that inclines filters, and washes with water to no aldehyde flavor, drains, promptly.
The above-mentioned method for preparing the Cefditoren pivoxil Cephalosporins solid preparation, the temperature that stirs fusion and insulation in the described steps A is 57 ℃;
Bath temperature is 50 ℃ among the described step B;
The pH value of reactant liquor is 9.0 among the described step C; Isothermal reaction 1.5 hours;
The glutaraldehyde consumption is 0.1 times of reactant liquor volume among the described step D, slowly is warming up to 50 ℃, and the glacial acetic acid adjust pH is 3.0.
Cefditoren pivoxil Cephalosporins solid preparation provided by the present invention is a lapping with xanthan gum-fibroin albumen-micropowder silica gel compositions, usage ratio, melt temperature, insulation measure and various factors by investigating xanthan gum-fibroin albumen-micropowder silica gel is to the influence of preparation, determined preparation condition: the ratio of weight and number of xanthan gum, fibroin albumen and micropowder silica gel is 1.5～4.5:1:1, and 55～60 ℃ of melt temperatures also are incubated standby; The complex coacervation pH value is 8.0～10.0; The complex coacervation time is 1～2 hour; The amount of cross-linking agent is 0.08～0.125 times of a reactant liquor volume; Crosslinking time is 30 minutes.Especially the ratio of weight and number when xanthan gum, fibroin albumen and micropowder silica gel is 4.2:1:1, and 57 ℃ of melt temperatures also are incubated standby; The complex coacervation pH value is 9.0; The complex coacervation time is 1.5 hours; The amount of cross-linking agent is 0.1 times of a reactant liquor volume; When crosslinking time was 30 minutes, envelop rate reached more than 95% especially.Avoid medicine to dash forward and released, reduced untoward reaction, improved patient's compliance.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment.
The preparation of the solid preparation of embodiment 1 Cefditoren pivoxil Cephalosporins
(1) with after xanthan gum 15g, the fibroin albumen 10g mixing, stir fusion and insulation under 55 ℃ of conditions, slowly add micropowder silica gel 10g while stirring, micropowder silica gel is uniformly dispersed, it is standby to get compositions;
(2) make microemulsion with propoxylation methyl glucoside 15g, isobutanol 5ml, ethyl acetate 40ml, in emulsion, add Cefditoren pivoxil Cephalosporins 140g, place 40 ℃ of water-baths;
(3) compositions of the middle gained of adding (1) in microemulsion is stirred to evenly, and as reactant liquor, the pH value of regulating this reactant liquor with 10% NaOH solution is 8.0, adds an amount of methanol with this solution, isothermal reaction 1 hour;
(4) reactant liquor is cooled to 0 ℃, the glutaraldehyde that adds 0.08 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 40 ℃ again, and adding glacial acetic acid to pH value is 2.0, obtains suspension;
(5) treat that sedimentation is complete after static, the supernatant that inclines filters, and washes with water to no aldehyde and distinguishes the flavor of, and drains, promptly.
The preparation of the solid preparation of embodiment 2 Cefditoren pivoxil Cephalosporins
(1) with after xanthan gum 45g, the fibroin albumen 10g mixing, stir fusion and insulation under 60 ℃ of conditions, slowly add micropowder silica gel 10g while stirring, micropowder silica gel is uniformly dispersed, it is standby to get compositions;
(2) make microemulsion with propoxylation methyl glucoside 120g, isobutanol 40ml, ethyl acetate 320ml, in emulsion, add Cefditoren pivoxil Cephalosporins 520g, place 60 ℃ of water-baths;
(3) compositions of adding (1) gained in microemulsion is stirred to evenly, and as reactant liquor, the pH value of regulating this reactant liquor with 10% NaOH solution is 10.0, adds an amount of methanol with this solution, isothermal reaction 2 hours;
(4) reactant liquor is cooled to 0 ℃, the glutaraldehyde that adds 0.125 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 60 ℃ again, and adding glacial acetic acid to pH value is 4.0, obtains suspension;
(5) treat that sedimentation is complete after static, the supernatant that inclines filters, and washes with water to no aldehyde and distinguishes the flavor of, and drains, promptly.
The preparation of the solid preparation of embodiment 3 Cefditoren pivoxil Cephalosporins
(1) with after xanthan gum 25g, the fibroin albumen 10g mixing, stir fusion and insulation under 58 ℃ of conditions, slowly add micropowder silica gel 10g while stirring, micropowder silica gel is uniformly dispersed, it is standby to get compositions;
(2) make microemulsion with propoxylation methyl glucoside 60g, isobutanol 20ml, ethyl acetate 160ml and in emulsion, add Cefditoren pivoxil Cephalosporins 270g, place 50 ℃ of water-baths;
(3) add (1) resulting composition in microemulsion, be stirred to evenly, as reactant liquor, the pH value of regulating this reactant liquor with 10% NaOH solution is 9.0, adds an amount of methanol with this solution, isothermal reaction 1.5 hours;
(4) reactant liquor is cooled to 0 ℃, the glutaraldehyde that adds 0.1 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 50 ℃ again, and adding glacial acetic acid to pH value is 3.0, obtains suspension;
(5) treat that sedimentation is complete after static, the supernatant that inclines filters, and washes with water to no aldehyde and distinguishes the flavor of, and drains, promptly.
The Cefditoren pivoxil Cephalosporins nano-microcapsule of gained among above-mentioned 1～3 embodiment is made granule, dry suspension or tabletting by dry method or wet granulation and pharmaceutic adjuvant mix homogeneously such as diluent, disintegrating agent, adhesive, lubricant and fluidizer or incapsulate.
The preparation of the dried mixed suspension preparation of embodiment 4 Cefditoren pivoxil Cephalosporins
(1) with after xanthan gum 42g, the fibroin albumen 10g mixing, stir fusion and insulation under 56 ℃ of conditions, slowly add micropowder silica gel 10g while stirring, micropowder silica gel is uniformly dispersed, it is standby to get compositions;
(2) make microemulsion with propoxylation methyl glucoside 90g, isobutanol 30ml, ethyl acetate 240ml, in emulsion, add Cefditoren pivoxil Cephalosporins 372g, place 60 ℃ of water-baths;
(3) add (1) resulting composition in microemulsion, be stirred to evenly, as reactant liquor, the pH value of regulating this reactant liquor with 10% NaOH solution is 10.0, adds an amount of methanol with this solution, isothermal reaction 2 hours;
(4) reactant liquor is cooled to 0 ℃, the glutaraldehyde that adds 0.125 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 60 ℃ again, and adding glacial acetic acid to pH value is 4.0, obtains suspension;
(5) treat that sedimentation is complete after static, the supernatant that inclines filters, and washes with water to no aldehyde and distinguishes the flavor of, and drains, and is standby;
(6) sodium carbonate is crossed 80 mesh sieves, got (d) gained precipitum, 4g microcrystalline Cellulose, 1g sodium carbonate, put into high speed granulator, do and mixed 1 minute, add 11g 20% arabic gum aqueous solution, stirred discharging 5 minutes, 18 order nylon mesh are granulated, airpillow-dry, 65 ℃ of inlet temperature, 38.5 ℃ of drop temperatures, pellet moisture is 3.68%, 16 order iron wire sieve granulate; Granule is crossed 40 mesh sieves sieve fine powder, get coarse granule;
(7) Icing Sugar is crossed 100 mesh sieves, taken by weighing the 0.05g lemon yellow and add in the 1.5g1%HPMC solution and stir, take by weighing 20g Icing Sugar, 8g mannitol, the sweet high speed granulator of putting into of 0.5g A Siba, do and mixed 1 minute, pour the 1%HPMC solution that adds lemon yellow into stir about 5 minutes, 150 rev/mins of mixing speeds, 18 order nylon mesh are granulated, airpillow-dry, 65 ℃ of inlet temperature, drop temperature is controlled at 30 ℃-40 ℃, 16 order iron wire sieve granulate, discharging;
(8) measure medicine-containing particle content, the mixed of press 2:1 with sugared granule is even, is up to the standards, pack, specification be 1.5g/ bag (in Cefditoren pivoxil Cephalosporins) promptly.
The preparation of embodiment 5 Cefditoren pivoxil Cephalosporins tablets, external stripping and clinical adverse situation
One, the preparation of Cefditoren pivoxil Cephalosporins tablet
(1) with after xanthan gum 42g, the fibroin albumen 10g mixing, stir fusion and insulation under 57 ℃ of conditions, slowly add micropowder silica gel 10g while stirring, micropowder silica gel is uniformly dispersed, it is standby to get compositions;
(2) make microemulsion with propoxylation methyl glucoside 30g, isobutanol 10ml, ethyl acetate 80ml, in emulsion, add Cefditoren pivoxil Cephalosporins 372g, place 50 ℃ of water-baths;
(3) compositions of the middle gained of adding (1) in microemulsion is stirred to evenly, and as reactant liquor, the pH value of regulating this reactant liquor with 10% NaOH solution is 9.0, adds an amount of methanol with this solution, isothermal reaction 1.5 hours;
(4) reactant liquor is cooled to 0 ℃, the glutaraldehyde that adds 0.1 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 50 ℃ again, and adding glacial acetic acid to pH value is 3.0, obtains suspension;
(5) treat that sedimentation is complete after static, the supernatant that inclines filters, and washes with water to no aldehyde and distinguishes the flavor of, and drains, and is standby.
(6) get gained precipitum Cefditoren pivoxil Cephalosporins meter 300g and hydrogenated vegetable oil 35g, carboxymethyl starch sodium 22g and micropowder silica gel 5g in the step (4), tabletting gets the tablet that the Cefditoren pivoxil Cephalosporins specification is the 100mg/ sheet.
Two, the external stripping of Cefditoren pivoxil Cephalosporins tablet
Dissolution medium is that 100r/min, temperature are 37.0 ℃ ± 0.5 ℃ for pH6.80 phosphate buffer 900 ml, the rotating speed of handling through the degassing, respectively at sampling 5 ml behind 5,15,30,45,60,120,240,360 and 480 min, with little lonely L membrane filtration, and benefit man equivalent medium, get filtrate and measure it, find c (m1), calculate accumulation stripping percentage rate by the standard curve regression equation at wavelength 321 nm places, and with commercially available Cefditoren pivoxil Cephalosporins tablet in contrast, see Table 1.
The result shows, compares with the Cefditoren pivoxil Cephalosporins ordinary tablet, and Cefditoren pivoxil Cephalosporins tablet of the present invention has tangible slow releasing function, has reduced toxic and side effects, has improved patient's compliance.
Three, Cefditoren pivoxil Cephalosporins tablet clinical research untoward reaction situation of the present invention
142 routine patients, wherein there are 18 examples to suffer from enteritis, participated in the clinical research of this product, be equally divided into test group and matched group at random, wherein test group is taken Cefditoren pivoxil Cephalosporins tablet of the present invention, matched group is taken commercially available Cefditoren pivoxil Cephalosporins conventional tablet, specification is the 100mg/ sheet, takes twice every day, each a slice, took continuously 7 days, and saw Table 2.
Because preparation of the present invention has tangible slow releasing function, having avoided medicine to dash forward releases, and then reduced toxic and side effects, improved patient's compliance, compare with commercially available common Cefditoren pivoxil Cephalosporins preparation and to have avoided gastrointestinal reaction, anaphylaxis, the generation of untoward reaction such as blood system, kidney, and to enteritis patient's not influence of intestinal microbial population normal condition, avoid superinfection, therefore had significant technological progress.
Obviously, the foregoing description only is for clearly demonstrating the example that the present invention enumerates among the present invention, and is not to be qualification to protection domain of the present invention.The variation of other form of making on the basis of the above still is among protection scope of the present invention.
Claims (6)
1. Cefditoren pivoxil Cephalosporins solid preparation, it is characterized in that, contain Cefditoren pivoxil Cephalosporins nano-microcapsule and pharmaceutic adjuvant in the said preparation, described nano-microcapsule is that 4～8:1 makes by Cefditoren pivoxil Cephalosporins and carrier material with ratio of weight and number, described carrier material is xanthan gum-fibroin albumen-micropowder silica gel compositions, and wherein the ratio of weight and number of xanthan gum, fibroin albumen and micropowder silica gel is 1.5～4.5:1:1.
2. solid preparation according to claim 1 is characterized in that, the ratio of weight and number of described xanthan gum, fibroin albumen and micropowder silica gel is 4.2:1:1.
3. solid preparation according to claim 2 is characterized in that, described pharmaceutic adjuvant is diluent, disintegrating agent, adhesive, lubricant and fluidizer.
4. solid preparation according to claim 3 is characterized in that, the dosage form of described Cefditoren pivoxil Cephalosporins solid preparation is tablet, capsule, dry suspension or granule.
5. method for preparing as claim 1,2,3 or 4 described solid preparations is characterized in that it carries out as follows:
A. after ratio is mixed by weight with fibroin albumen with xanthan gum, stir fusion and insulation under 55～60 ℃ of conditions, slowly add micropowder silica gel while stirring, micropowder silica gel is uniformly dispersed, it is standby to get compositions;
B. be that the ratio of 3:1:8 makes microemulsion according to propoxylation methyl glucoside weight, isobutanol volume, ethyl acetate volume ratio, in emulsion, add Cefditoren pivoxil Cephalosporins, place 40～60 ℃ of water-baths;
C. add the steps A resulting composition in microemulsion, be stirred to evenly, as reactant liquor, the pH value of regulating this reactant liquor with the NaOH solution of mass concentration 10% is 8.0～10.0, adds an amount of methanol with this solution, isothermal reaction 1～2 hour;
D. reactant liquor is cooled to 0 ℃, the glutaraldehyde that adds 0.08～0.125 times of reactant liquor volume continues to stir 30 minutes, slowly is warming up to 40～60 ℃ again, and adding glacial acetic acid to the value of pH is 2.0～4.0, obtains suspension;
E. treat after static that sedimentation is complete, the supernatant that inclines filters, and washes with water to no aldehyde flavor, drains, promptly.
6. the preparation method of solid preparation according to claim 5 is characterized in that:
The temperature that stirs fusion and insulation in the described steps A is 57 ℃;
Bath temperature is 50 ℃ among the described step B;
The pH value of reactant liquor is 9.0 among the described step C; Isothermal reaction 1.5 hours;
The glutaraldehyde consumption is 0.1 times of reactant liquor volume among the described step D, slowly is warming up to 50 ℃, and the glacial acetic acid adjust pH is 3.0.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716098A (en) * | 2012-06-29 | 2012-10-10 | 海南美大制药有限公司 | Cefditoren pivoxil liposome solid preparation |
| CN105663058A (en) * | 2016-02-01 | 2016-06-15 | 济南康和医药科技有限公司 | Cefditoren pivoxil nanoparticle pharmaceutical preparation and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537005A (en) * | 2001-04-26 | 2004-10-13 | �����Ƹ���ʽ���� | Amorphous cefditoren pivoxil composition and process for producing the same |
| CN1694709A (en) * | 2002-10-02 | 2005-11-09 | 明治制果株式会社 | Antibacterial medicinal composition of enhanced oral absorptivity |
| CN1863535A (en) * | 2003-10-08 | 2006-11-15 | 明治制果株式会社 | Noncrystalline antibacterial composition containing cefditoren pivoxil |
-
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- 2010-10-25 CN CN2010105181556A patent/CN101940575B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537005A (en) * | 2001-04-26 | 2004-10-13 | �����Ƹ���ʽ���� | Amorphous cefditoren pivoxil composition and process for producing the same |
| CN1694709A (en) * | 2002-10-02 | 2005-11-09 | 明治制果株式会社 | Antibacterial medicinal composition of enhanced oral absorptivity |
| CN1863535A (en) * | 2003-10-08 | 2006-11-15 | 明治制果株式会社 | Noncrystalline antibacterial composition containing cefditoren pivoxil |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716098A (en) * | 2012-06-29 | 2012-10-10 | 海南美大制药有限公司 | Cefditoren pivoxil liposome solid preparation |
| CN102716098B (en) * | 2012-06-29 | 2014-01-15 | 海南美大制药有限公司 | Cefditoren pivoxil liposome solid preparation |
| CN105663058A (en) * | 2016-02-01 | 2016-06-15 | 济南康和医药科技有限公司 | Cefditoren pivoxil nanoparticle pharmaceutical preparation and preparation method |
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