CN101940318B - Soft capsule with functions of relieving cough, anti-inflammation and reducing blood lipid and preparation method thereof - Google Patents
Soft capsule with functions of relieving cough, anti-inflammation and reducing blood lipid and preparation method thereof Download PDFInfo
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- CN101940318B CN101940318B CN2010102166910A CN201010216691A CN101940318B CN 101940318 B CN101940318 B CN 101940318B CN 2010102166910 A CN2010102166910 A CN 2010102166910A CN 201010216691 A CN201010216691 A CN 201010216691A CN 101940318 B CN101940318 B CN 101940318B
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Abstract
The invention relates to a soft capsule with functions of relieving cough, resisting inflammation and reducing blood lipid and a preparation method thereof, and the method comprises the following steps: schisandra chinensis fruit and pumpkin seeds are respectively smashed to 40-60 meshes and put to a CO2 supercritical extraction device, and extraction is carried out for 2.5-3 hours at 35MPa at 40-45DEG C with the speed of 1-2L/min, thus obtaining CO2 supercritical extracts of schisandra chinensis and evening primrose; and then 48-53 parts of the CO2 supercritical extract of schisandra chinensis, 46-52 parts of the CO2 supercritical extract of the pumpkin seeds and 1.0 part of vitamin E are put to a mixing tank in parts by weight to be stirred and mixed well, and then the materials are put to a soft capsule packer to be pelleted. The formulation type is advanced, which can ensure active ingredients to have durable effect; the impurity content is low, and the content of the active ingredients is high; the active ingredients are easy to absorb; CO2 is used as the extraction solvent, no organic solvent remains, and the edible use is safer; and the soft capsule is a natural food with health care functions.
Description
Technical field
The present invention relates to a kind of soft capsule and preparation method with antibechic, anti-inflammatory and hypolipemic function, to the north of magnolia vine fruit oil and pumpkin seed oil be that feedstock production forms, belong to the health food production technical field.
Background technology:
Magnolia vine fruit oil is that the seed of magnoliaceae schisandra (FructusSchisandraeChinensis) is through squeezing or extract the fat-soluble part obtain.Modern study proves: magnolia vine fruit oil has the help the five internal organs, nourshing kidney benefit lung, effects such as astringe yin receipts sweat, convergence are taken the photograph admittedly, antitoxic heart-soothing and sedative; Can nurse one's health cental system neural excited process and process of inhibition, make it to tend to balance, improve intellection ability, operating efficiency.
The fruit of Chinese magnoliavine is used for treatments such as hepatitis and neurasthenia clinically and all receives better therapeutic effect, so fruit of Chinese magnoliavine consumption is very big, and the raw material that is used for the fruit of Chinese magnoliavine preparation every year can reach tons up to a hundred.But these preparations have only been used the ethanol extract of the fruit of Chinese magnoliavine, and the dregs of a decoction are generally thrown away as refuse, and throw away the part the highest part of liposoluble constituent content just, very unfortunately.
Pumpkin seed oil is that the seed of annual liana pumpkin Cucurbitamoschata (Duch..) poiret of overgrowing of Curcurbitaceae is through squeezing or extract the fat-soluble part obtain.Be pumpkin seeds oil again, pumpkin seed oil.
Summary of the invention:
The present invention provides a kind of soft capsule with antibechic, anti-inflammatory and hypolipemic function, has good antibechic anti-inflammatory and effect for reducing blood fat.
The present invention also provides above-mentioned preparation of soft capsule method, is applicable to suitability for industrialized production.
The present invention has the soft capsule of antibechic, anti-inflammatory and hypolipemic function, is made up of following raw material by weight:
Magnolia vine fruit oil: 48～53, pumpkin seed oil: 46～52, vitamin E: 1.0.
Its preparation method:
Residue after fruit of Chinese magnoliavine seed or the extraction is crushed to 40 orders～60 orders, puts into CO
2In the supercritical extraction unit, with 35MPa pressure; 40 ℃ of extraction temperature; 2L/min; Extract and obtained fruit of Chinese magnoliavine CO in 3 hours
2Supercritical extract.Or fruit of Chinese magnoliavine seed do not pulverized in the direct adding LQ95 type squeezer, with 40～42 rev/mins, machine presses and obtains magnolia vine fruit oil.
Pumpkin seeds are crushed to 40 orders～60 orders, put into CO
2In the supercritical extraction unit, with 35MPa pressure; 45 ℃ of extraction temperature, 35 ℃ of separation temperatures; 1L/min; Extract and obtained pumpkin seeds CO in 2.5 hours
2Supercritical extract; Or pumpkin seeds are not pulverized in the direct adding LQ95 type squeezer, with 43～45 rev/mins, machine presses and obtains pumpkin seed oil.
With fruit of Chinese magnoliavine CO
2Supercritical extract, pumpkin seeds CO
2Supercritical extract and vitamin E are put into material-compound tank in proportion and are mixed, and send into soft capsule packing machine pelleting.
Show that with experiment soft capsule of the present invention has the effect of antibechic below:
1 material
1.1 medicine and reagent
Soft capsule of the present invention, our unit makes; Ammoniacal liquor, analyze pure, Tianjin recovery development in science and technology Co., Ltd, lot number 080613; TANKEJING, Baishan City Changbaishan Pharmaceutical Co., Ltd, lot number 090514;
1.2 animal used as test
60 of cavys, body weight 270.52 ± 20.31g, male and female half and half are available from Jilin University's Experimental Animal Center.
2. method
Animal used as test is divided into five groups at random; Every group 12, be respectively blank group (purified water), positive controls (10mg/ (kg*d) TANKEJING), high dose group (20mg/ (kg*d) the present invention), middle dose groups (10mg/ (kg*d) the present invention), low dose group (5mg/ (kg*d) the present invention); Administering mode is for irritating stomach.
Administration every day 1 time, 5d after the last administration, accepts ammoniacal liquor respectively and quantitatively sprays continuously, and the incubation period of cough appears in the record cavy, and the cough number of times in the 2min.The result carries out the t check, and the result sees table 1.
3. result and analysis
Table 1 the present invention brings out the influence of cough cavy to ammoniacal liquor
Annotate with control group and compare,
*P＜0.01,
*P＜0.05
The result shows that Chinese seed oil, 3 dose groups of pumpkin seed oil soft capsule and TANKEJING group compare with control group respectively, all can obviously prolong ammoniacal liquor and draw the time that cough takes place cavy of coughing, and reduces the cough number of times, and pointing out has antitussive action preferably.
With the experiment of reducing blood lipid pharmacology, prove that the present invention has effect for reducing blood fat below.
1. material
1.1 medicine and reagent
Soft capsule of the present invention, modeling emulsion makes by our unit; Blood fat recovery capsule, the Beijing WBL Peking University Biotech Co., Ltd;
1.2 animal used as test
72 of mouse, body weight body weight 22.13 ± 2.56g, male and female half and half are available from Jilin University's Experimental Animal Center.
2. method
Animal used as test is divided into 6 groups at random; Every group 12; Be respectively blank group (physiological saline), model group (physiological saline), positive controls (1.0g/ (kg*d) blood fat health), high dose group (40mg/ (kg*d) the present invention), middle dose groups (20mg/ (kg*d) the present invention), low dose group (10mg/ (kg*d) the present invention); Administering mode is for irritating stomach.
Except that the normal control group, all the other 6 groups of every mornings irritate stomach and only give modeling emulsion 0.5ml/, and the normal control group gives isopyknic physiological saline; Every afternoon, each administration group was distinguished gastric infusion, continuous 15d, and after the last administration, fasting 12h, the arteria carotis blood sampling, separation of serum is subsequent use.
Full automatic biochemical apparatus is measured the content of serum total cholesterol (TC), triglycerides (TG), HDL-C (HDL-C).The result carries out the t check, and the result sees table 1.
3. result and analysis
Table 1 the present invention is to inducing the influence of high blood lipid model mouse blood index
High dose group is compared with positive controls on serum total cholesterol (TC) content, triglycerides (TG) content, three indexs of HDL-C (HDL-C) content and is not had a conspicuousness (P＞0.05), compares difference extremely significantly (P＜0.01) with model group.In dose groups on three indexs, compare the significance of difference (P＜0.05) with positive controls, but compare difference same significantly (P＜0.05) with model group.Low dose group on three indexs with positive controls difference extremely significantly (P＜0.01), compare difference with model group and do not have a conspicuousness (P＞0.05).
The result:
Soft capsule high dose of the present invention, middle dosage have certain effect to reducing the blood blood fat, and exist certain dose relationship.
Good effect of the present invention is: magnolia vine fruit oil, pumpkin seed oil and vitamin E are processed compound formulation, have synergy, its antibechic, anti-inflammatory and reducing blood lipid obviously strengthen than the resultant action of the independent effect of above-mentioned each raw material to some extent.It is isolated with active ingredient and air to process capsule preparations, avoids the destruction of light to photoactive substance simultaneously, prevent the oxidation of content active ingredient and lose and render a service or contaminated, enhanced stability, guarantee its active ingredient render a service lasting.
The specific embodiment:
Embodiment 1:
Residue after fruit of Chinese magnoliavine seed or the extraction is crushed to 40 orders～60 orders, puts into CO
2In the supercritical extraction unit, with 35MPa pressure; 40 ℃ of extraction temperature; 2L/min; Extract and obtained fruit of Chinese magnoliavine CO in 3 hours
2Supercritical extract.
Pumpkin seeds are crushed to 40 orders～60 orders, put into CO
2In the supercritical extraction unit, with 35MPa pressure; 45 ℃ of extraction temperature, 35 ℃ of separation temperatures; 1L/min; Extract and obtained pumpkin seeds CO in 2.5 hours
2Supercritical extract.
With fruit of Chinese magnoliavine CO
2Supercritical extract is 53kg, pumpkin seeds CO
2Supercritical extract is that 46kg and vitamin E are that 1.0kg puts into material-compound tank and mixes, and sends into soft capsule packing machine pelleting.
Embodiment 2:
Fruit of Chinese magnoliavine seed is not pulverized in the direct adding LQ95 type squeezer, and with 40～42 rev/mins, machine presses and obtains magnolia vine fruit oil.
Pumpkin seeds are not pulverized in the direct adding LQ95 type squeezer, and with 43～45 rev/mins, machine presses and obtains pumpkin seed oil.
With magnolia vine fruit oil is that 50kg, pumpkin seed oil are that 50kg and vitamin E are that 1.0kg puts into material-compound tank and mixes, and sends into soft capsule packing machine pelleting.
Embodiment 3:
Schisandra fruit is crushed to 40 orders～60 orders, puts into CO
2In the supercritical extraction unit, with 35MPa pressure; 40 ℃ of extraction temperature; 2L/min; Extract and obtained fruit of Chinese magnoliavine CO in 3 hours
2Supercritical extract.
Pumpkin seeds are crushed to 40 orders～60 orders, put into CO
2In the supercritical extraction unit, with 35MPa pressure; 45 ℃ of extraction temperature, 35 ℃ of separation temperatures; 1L/min; Extract and obtained pumpkin seeds CO in 2.5 hours
2Supercritical extract.
With fruit of Chinese magnoliavine CO
2Supercritical extract is 48kg, pumpkin seeds CO
2Supercritical extract is that 52kg and vitamin E are that 1.0kg puts into material-compound tank in proportion and mixes, and sends into soft capsule packing machine pelleting.
Claims (1)
1. soft capsule with antibechic, anti-inflammatory and hypolipemic function is to be processed by following raw material by weight:
Magnolia vine fruit oil: 48～53, pumpkin seed oil: 46～52, vitamin E: 1.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102166910A CN101940318B (en) | 2010-07-05 | 2010-07-05 | Soft capsule with functions of relieving cough, anti-inflammation and reducing blood lipid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102166910A CN101940318B (en) | 2010-07-05 | 2010-07-05 | Soft capsule with functions of relieving cough, anti-inflammation and reducing blood lipid and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101940318A CN101940318A (en) | 2011-01-12 |
| CN101940318B true CN101940318B (en) | 2012-09-05 |
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| CN2010102166910A Expired - Fee Related CN101940318B (en) | 2010-07-05 | 2010-07-05 | Soft capsule with functions of relieving cough, anti-inflammation and reducing blood lipid and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102154056B (en) * | 2011-03-18 | 2012-09-05 | 刘东波 | Method for extracting cushaw seed oil from cushaw seeds |
| WO2022017417A1 (en) * | 2020-07-22 | 2022-01-27 | 湖南诺茗心生物工程有限公司 | Use of composite volatile oil for reducing sleep disorders |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1781523A (en) * | 2004-12-01 | 2006-06-07 | 赵景辉 | Schisandra chinensis soft capsule |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1781523A (en) * | 2004-12-01 | 2006-06-07 | 赵景辉 | Schisandra chinensis soft capsule |
Non-Patent Citations (6)
| Title |
|---|
| 吴国欣等.GCMS法分析南瓜籽油脂肪酸组成.《中草药》.2003,第34卷(第12期), * |
| 周泉城等.维生素E对小鼠高血脂预防作用研究.《中国粮油学报》.2005,第20卷(第3期), * |
| 张彩丽等.五味子研究进展.《保定师范专科学校学报》.2004,第17卷(第4期), * |
| 牛广财等.南瓜籽油超临界CO2流体萃取及其脂肪酸成分分析.《中国粮油学报》.2010,第25卷(第4期), * |
| 王传蓉等.维生素E的免疫研究进展.《中国畜牧兽医》.2008,第35卷(第8期), * |
| 白延斌等.五味子对去卵巢肥胖大鼠体重及血脂等的影响.《实用医学杂志》.2007,第23卷(第13期), * |
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