CN101904864B - Application of silicone oil in preparing allergen retarder - Google Patents
Application of silicone oil in preparing allergen retarder Download PDFInfo
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Abstract
The invention relates to an application of silicone oil in preparing an allergen retarder. Silicone oil can be smeared on the inner wall of the nasal cavity to stick allergens in the air to inhibit the allergic reaction, thereby performing the functions of preventing and relieving the allergic rhinitis. The inventor discovers that when the silicone oil is used before the stage of attack of the seasonal allergic rhinitis, the attack of the seasonal allergic rhinitis can be effectively prevented; after the attack of the seasonal allergic rhinitis, a patient continuously uses the silicone oil for two weeks, and then, the attack degree of the seasonal allergic rhinitis can be effectively relieved; and for perennial allergic rhinitis, the patient continuously uses the silicone oil for two weeks, and then, the attack degree of the perennial allergic rhinitis can also be effectively relieved.
Description
Technical field
The present invention relates to the new purposes of a kind of medical treatment of silicone oil.Silicone oil (English Silicones) can obviously prevent and alleviate the generation of allergic rhinitis through sticking together the effect of inhalant allergens.
Background technology
Allergic rhinitis (Allergic Rhinitis, AR) by anaphylactogen excite, by the nose inflammatory diseases of IgE mediation, comprise seasonal allergic rhinitis and catarrhus perennialis.Allergic rhinitis over nearly 30 years in the world prevalence be obvious ascendant trend, development has prevention and the generation of control allergic rhinitis and the allergen blocker of outbreak, has the important clinical meaning.Most important exopathogenic factor of allergic rhinitis is exactly an anaphylactogen; Anaphylactogen can combine with IgE; Water soluble protein or glycoprotein with sensitization or potential sensitization activity, molecular weight 5～70Kda generally includes pollen, animal skin, fungus and the food etc. of natural origin.Can the per nasal suction cause the anaphylactogen of allergic rhinitis to comprise: pollen, dust, demodicid mite, fungus, animal scurf and poultry feather etc.Anaphylactogen is the essential condition that causes allergic rhinitis, if blocked allergenic contact, just has been equivalent to eliminate the probability that allergic rhinitis takes place.The former patient who causes allergic rhinitis to take place of contact allergy if can reduce contacting of nasal cavity and more anaphylactogens, can alleviate the attack degree of allergic rhinitis.
Nontoxic, colourless, tasteless, no sensitization of skin property that silicone oil has, biologically inert and advantages such as good biocompatibility and anti-extreme temperature are widely used in biomedicine field.Do not see so far and utilize its adhesive properties, be applied to prevent and alleviate the research report of allergic rhinitis, do not see the patent report of external this aspect yet.
Summary of the invention
The present invention relates to the new purposes of a kind of medical treatment of silicone oil.
Silicone oil (English Silicones) can obviously prevent and alleviate the generation of allergic rhinitis through the effect of sticking together.Through method of the present invention, adopt suitable method for using, can block or reduce anaphylactogen and get into nasal cavity, thereby block or alleviate the anaphylactoid generation and the order of severity.If can promote, good economic benefits and social benefit will be arranged.
Therefore the invention provides the new purposes of silicone oil, that is, and the application of silicone oil in the preparation allergen retarder.
Wherein, described allergen retarder comprises the medicine of treatment of allergic rhinitis; The medicine that also comprises Polyglucan property rhinitis; Also comprise the medical apparatus and instruments or the preparation that stick together inhalant allergens; And, comprise the food, beverage and the health product that prevent and/or treat allergic rhinitis.
Applicant of the present invention finds, stage of attack is last to begin the back up to stage of attack and give the seasonal allergic rhinitis patient one week and use silicone oil, can effectively prevent the outbreak of seasonal allergic rhinitis.After the seasonal allergic rhinitis outbreak, the patient uses 2 weeks of silicone oil continuously, can effectively alleviate the attack degree of seasonal allergic rhinitis.Catarrhus perennialis, patient use 2 weeks of silicone oil continuously, can effectively alleviate catarrhus perennialis's attack degree.
In the present invention, term " allergic rhinitis " be meant excite by anaphylactogen, by the nose inflammatory diseases of IgE mediation, comprise seasonal allergic rhinitis and catarrhus perennialis.Seasonal allergic rhinitis (claiming pollinosis or pollinosis again) is caused by seasonal sensitinogen, only in fixedly morbidity in season, has no symptom outside season.Perennial rhinitis then all can be fallen ill any time within 1 year.
The invention provides the new medical use of silicone oil, that is, use sticking together of silicone oil and be used as additive or adjuvant, it is prepared into effect is the application of treating, preventing, alleviate medicine, food, beverage and the health product aspect of allergic rhinitis.
The application of silicone oil of the present invention in the preparation allergen retarder, wherein silicone oil has structure:
n＝300-5000。
The silicone oil that the present invention was directed against is the silicone oil with said structure formula; Its relative molecular mass about 20000～400000; Conventional parameter according to silicone oil in the industry; Generally divide the silicone oil of different grades with average viscosity, the above-mentioned silicone oil of the present invention is the silicone oil of average viscosity 1000～1000000cSt.
In a preferred embodiment of the invention, the preferred n=1400-1600 of described silicone oil, its relative molecular mass is about 100000～120000, average viscosity 40000～80000cSt.
Above-mentioned cSt (centistoke) is dynamic viscosity unit: 1cSt=1mm
2/ S; The most preferred viscosity of the sample that the present invention experimentizes is the methyl-silicone oil of 60000cSt, its degree of polymerization formula: n=M/74, and wherein M is a relative molecular mass.
Allergic rhinitis described in the present invention especially refers to seasonal allergic rhinitis and/or catarrhus perennialis.
Give an example several representative instance in numerous experimental examples of the present invention further sets forth the effect that the specific embodiments of silicone oil (below be called these article) is brought:
One: silicone oil sticks together anaphylactogen, and the prevention seasonal allergic rhinitis is had an effect.
1. material and method
Choose 10 patients that several years seasonal allergic rhinitis history of past illness was once arranged under voluntary fully prerequisite, last in the seasonal allergic rhinitis outbreak to two weeks using these article, begin one week of back until stage of attack.
Method for using: every day is with these article 0.2cm
3(Semen Glycines size) is applied in nasal vestibule, checks aspect following two before these article of use and after one week of stage of attack to compare:
VAS scoring: visual analogue scales (visual analogue scale; VAS) scoring and standardized questionnaire investigation; Rhinocnesmus, left side nasal obstruction, right side nasal obstruction, sneeze, clear water tears are marked respectively; (visual analog scale VAS) goes up sniffle is carried out self evaluation at the vision gage of a 10cm.
The twang reflection results relatively
Twang reflection measurement method (acoustic rhinometry) is a kind of objective determination method of utilizing the principle assessment nasal airways of acoustic reflection; It can be through the minimum sectional area of describing nasal cavity and the true aeration status that the nasal cavity volume reflects nasal cavity; Wherein (minimum crosssectional area MCA) is the objective indicator that can reflect the nasal cavity degree of opening of generally acknowledging at present to the nasal cavity minimum sectional area.
Table 1. seasonal allergic rhinitis forward and backward sniffle VAS value of stage of attack is (n=10) relatively
Table 2. seasonal allergic rhinitis forward and backward twang reflex of stage of attack MCA value as a result compares (n=10)
2. result
Seasonal allergic rhinitis is to have the anaphylactogen that characteristic appears in seasonality by pollen etc. to cause that seasonal allergic rhinitis patient began before stage of attack to smear these article of use at the nasal vestibule position, can effectively stick together inhalant allergens such as pollen.Through stoping contacting of anaphylactogen and nasal membrane, thus the outbreak of effective Polyglucan property rhinitis.
The patient continues to use these article before the seasonal allergic rhinitis outbreak with after getting into stage of attack, the VAS scoring is though sniffles such as rhinocnesmus, bilateral nasal obstruction, sneeze and clear water tears increase to some extent; But with compare and do not have notable difference before the outbreak; P＞0.05, not statistically significant is seen table 1.The twang reflex, the MCA value has minimizing slightly, but with outbreak before compare and do not have notable difference, p＞0.05, not statistically significant is seen table 2.Like this, visible from subjective and objective two kinds of indexs, use these article can effectively prevent the outbreak of seasonal allergic rhinitis.
Two: silicone oil sticks together anaphylactogen, alleviates the effect of seasonal allergic rhinitis.
1. material and method
Choose 10 and be in seasonal allergic rhinitis stage of attack patient under voluntary fully prerequisite, do not use any medicine or antianaphylactic treatment method in two weeks, use these article.Method for using: every day is with these article 0.2cm
3(Semen Glycines size) is applied in nasal vestibule, before these article of use, reaches these article of use and carries out sniffle VAS scoring and twang reflex after 2 weeks.
Table 3. seasonal allergic rhinitis stage of attack
Reach these article of use 2 all backs sniffle VAS values relatively (n=10) before these article of use
*: p＜0.01, the seasonal allergic rhinitis stage of attack use before these article and these article of use 2 all after sniffle VAS values utmost point significant difference is relatively arranged.
*: p＜0.05, the seasonal allergic rhinitis stage of attack use before these article and these article of use 2 all after sniffle VAS values significant difference is relatively arranged.
Table 4. seasonal allergic rhinitis stage of attack
Before these article of use and 2 week of these article of use back twang reflexs as a result the MCA value compare (n=10)
*: p＜0.05, the seasonal allergic rhinitis stage of attack use before these article and these article of use 2 all after MCA significant difference is relatively arranged.
2. result
Seasonal allergic rhinitis is to have the anaphylactogen that characteristic appears in seasonality by pollen etc. to cause; Seasonal allergic rhinitis patient stage of attack; Smear these article of use at the nasal vestibule position and can effectively stick together inhalant allergens such as pollen; The minimizing anaphylactogen contacts with nasal membrane, thereby effectively alleviates the attack degree of allergic rhinitis.
The patient is seasonal allergic rhinitis continuous the use these 2 weeks of article of stage of attack, and VAS marks, and sniffles such as rhinocnesmus, sneeze and clear water tears all significantly descend; With use these article before compared utmost point notable difference; P＜0.01, bilateral nasal obstruction also have clear improvement, and compare before these article of use that there were significant differences; Table 3 is seen in p＜0.05.The twang reflex, the MCA value with use these article before compared obvious increase, table 4 is seen in p＜0.05.Like this, visible from subjective and objective two kinds of indexs, use these article can effectively alleviate the attack degree of seasonal allergic rhinitis.
Three: silicone oil sticks together anaphylactogen, alleviates catarrhus perennialis's effect.
1. material and method
Choose 10 catarrhus perennialis patients under voluntary prerequisite, do not use any medicine or antianaphylactic treatment method in two weeks, use these article.Method: every day is with these article 0.2cm
3Be applied in nasal vestibule, before these article of use, reach these article of use and carry out sniffle VAS scoring and twang reflex after 2 weeks.
The long-term allergic rhinitis of table 5. reaches these article of use 2 all backs sniffle VAS values relatively (n=10) before using these article
*: p＜0.01, the catarrhus perennialis uses before these article and these article of use 2 all backs sniffle VAS values relatively have utmost point significant difference.
*: p＜0.05, the catarrhus perennialis uses before these article and these article of use 2 all backs sniffle VAS values relatively have significant difference.
Table 6. catarrhus perennialis use before these article and 2 week of these article of use back twang reflexs as a result the MCA value compare (n=10)
*: p＜0.05, the seasonal allergic rhinitis stage of attack use before these article and these article of use 2 all after sniffle VAS values significant difference is relatively arranged.
2. result
Allergic rhinitis is caused by multiple anaphylactogen throughout the year, smears these article of use at the nasal vestibule position, can effectively stick together inhalant allergens, and the minimizing anaphylactogen contacts with nasal membrane, thereby effectively alleviates the attack degree of allergic rhinitis.
Catarrhus perennialis patient uses 2 weeks of these article continuously, the VAS scoring, and sniffles such as rhinocnesmus, bilateral nasal obstruction and sneeze all significantly descend; With use these article before compared notable difference, extremely obviously minimizing has been compared before clear water tears and these article of use in p＜0.05; Table 5 is seen in p＜0.01.The twang reflex, the MCA value with use these article before compared obvious increase, table 6 is seen in p＜0.05.Visible from subjective and objective two kinds of indexs, use these article can effectively alleviate catarrhus perennialis's attack degree.
In sum, the present invention mainly provides the new purposes of a kind of silicone oil as allergen retarder, that is, it prevents and/or treats the application in the medicine of allergic rhinitis at preparation application, especially silicone oil in the allergen retarder in preparation.
Specific embodiments
Silicone oil in embodiment 1. present embodiments is the chemical compound with structure:
N=300-500, relative molecular mass is about 20000～40000, the about 600～1000cSt of average viscosity;
Choose 10 patients that several years seasonal allergic rhinitis history of past illness was once arranged, last in the seasonal allergic rhinitis outbreak to two weeks using these article, begin one week of back until stage of attack.
Method for using: every day is with these article 0.2cm
3Be applied in nasal vestibule, check aspect following two before these article of use and after one week of stage of attack to compare:
VAS scoring: visual analogue scales (visual analogue scale; VAS) scoring and standardized questionnaire investigation; Rhinocnesmus, left side nasal obstruction, right side nasal obstruction, sneeze, clear water tears are marked respectively; (visual analog scale VAS) goes up sniffle is carried out self evaluation at the vision gage of a 10cm.
The twang reflection results compares:
Twang reflection measurement method (acoustic rhinometry) is a kind of objective determination method of utilizing the principle assessment nasal airways of acoustic reflection; It can be through the minimum sectional area of describing nasal cavity and the true aeration status that the nasal cavity volume reflects nasal cavity; Wherein (minimum crosssectional area MCA) is the objective indicator that can reflect the nasal cavity degree of opening of generally acknowledging at present to the nasal cavity minimum sectional area.
Experimental data is close with the data of above-mentioned table 1 and table 2, therefore omits here.The patient continues to use these article before the seasonal allergic rhinitis outbreak with after getting into stage of attack, the VAS scoring is though sniffles such as rhinocnesmus, bilateral nasal obstruction, sneeze and clear water tears increase to some extent; But with compare and do not have notable difference before the outbreak; P＞0.05, not statistically significant is seen table 1.The twang reflex, the MCA value has minimizing slightly, but with outbreak before compare and do not have notable difference, p＞0.05, not statistically significant.Thus it is clear that, use these article can effectively prevent the outbreak of seasonal allergic rhinitis.
Explain: the silicone oil of present embodiment can stick together anaphylactogen, can prevent seasonal allergic rhinitis to have an effect.
Silicone oil in embodiment 2. present embodiments is the chemical compound with structure:
N=1000-1300, relative molecular mass is about 60000～100000, the about 10000～40000cSt of average viscosity.
Choose 10 and be in seasonal allergic rhinitis stage of attack patient, do not use any medicine or antianaphylactic treatment method in two weeks, use these article.
Method for using: every day is with these article 0.2cm
3Be applied in nasal vestibule, before these article of use, reach these article of use and carry out sniffle VAS scoring and twang reflex after 2 weeks.
Experimental result data is close with the data of above-mentioned table 3 and table 4, therefore omits here.
Seasonal allergic rhinitis is to have the anaphylactogen that characteristic appears in seasonality by pollen etc. to cause; Seasonal allergic rhinitis patient stage of attack; Smear these article of use at the nasal vestibule position; Can effectively stick together inhalant allergens such as pollen, the minimizing anaphylactogen contacts with nasal membrane, thereby effectively alleviates the attack degree of allergic rhinitis.
The patient is seasonal allergic rhinitis continuous the use these 2 weeks of article of stage of attack; VAS scoring, sniffles such as rhinocnesmus, sneeze and clear water tears all significantly descend, and have compared utmost point notable difference before these article of use; P＜0.01; Bilateral nasal obstruction also has clear improvement, and compares before these article of use that there were significant differences, p＜0.05.The twang reflex, the MCA value with use these article before compared obvious increase, p＜0.05.Thus it is clear that, use these article can effectively alleviate the attack degree of seasonal allergic rhinitis.
Explain: the silicone oil of present embodiment can stick together anaphylactogen, can alleviate the effect of seasonal allergic rhinitis.
Silicone oil in embodiment 3. present embodiments is the chemical compound with structure:
N=3000-5000, relative molecular mass 200000～400000, average viscosity 300000～1000000cSt;
1. material and method
Choose 10 catarrhus perennialis patients under voluntary fully prerequisite, do not use any medicine or antianaphylactic treatment method in two weeks, use these article.
Method for using: every day is with these article 0.2cm
3(Semen Glycines size) is applied in nasal vestibule, before these article of use, reaches these article of use and carries out sniffle VAS scoring and twang reflex after 2 weeks.
Experimental result data is close with the data of above-mentioned table 5 and table 6, therefore omits here.
Allergic rhinitis is caused by multiple anaphylactogen throughout the year, smears these article of use at the nasal vestibule position, can effectively stick together inhalant allergens, and the minimizing anaphylactogen contacts with nasal membrane, thereby effectively alleviates the attack degree of allergic rhinitis.
Catarrhus perennialis patient uses 2 weeks of these article continuously, the VAS scoring, and sniffles such as rhinocnesmus, bilateral nasal obstruction and sneeze all significantly descend; With use these article before compared notable difference; P＜0.05, the clear water tears with use these article before compared extremely obviously minimizing, p＜0.01.The twang reflex, the MCA value with use these article before compared obvious increase, p＜0.05.Like this, visible from subjective and objective two kinds of indexs, use these article can effectively alleviate catarrhus perennialis's attack degree.
Explain: the silicone oil of present embodiment can stick together anaphylactogen, can alleviate catarrhus perennialis's effect.
Silicone oil in embodiment 4. present embodiments is the chemical compound with structure:
N=1300-2000, relative molecular mass 100000～200000, the about 30000～300000cSt of average viscosity;
Choose 10 patients that several years seasonal allergic rhinitis history of past illness was once arranged, last in the seasonal allergic rhinitis outbreak to two weeks using these article, begin one week of back until stage of attack.
Method for using: every day is with these article 0.2cm
3Be applied in nasal vestibule, check aspect following two before these article of use and after one week of stage of attack to compare:
VAS scoring: visual analogue scales (visual analogue scale; VAS) scoring and standardized questionnaire investigation; Rhinocnesmus, left side nasal obstruction, right side nasal obstruction, sneeze, clear water tears are marked respectively; (visual analog scale VAS) goes up sniffle is carried out self evaluation at the vision gage of a 10cm.
Experimental data is close with the data of embodiment 1, therefore slightly.The patient continues to use these article before the seasonal allergic rhinitis outbreak with after getting into stage of attack, the VAS scoring is though sniffles such as rhinocnesmus, bilateral nasal obstruction, sneeze and clear water tears increase to some extent; But with compare and do not have notable difference before the outbreak; P＞0.05, not statistically significant is seen table 1.The twang reflex, the MCA value has minimizing slightly, but with outbreak before compare and do not have notable difference, p＞0.05, not statistically significant.It is thus clear that these article can effectively prevent the outbreak of seasonal allergic rhinitis.
Explain: the silicone oil of present embodiment can stick together anaphylactogen, can prevent seasonal allergic rhinitis to have an effect.
Silicone oil in embodiment 5. present embodiments is the chemical compound with structure:
N=1400-1600, relative molecular mass is about 100000～120000, average viscosity 40000～80000cSt.
Choose 10 and be in seasonal allergic rhinitis stage of attack patient, do not use any medicine or antianaphylactic treatment method in two weeks.
Method for using: every day is with these article 0.2cm
3Be applied in nasal vestibule, before these article of use, reach these article of use and carry out sniffle VAS scoring and twang reflex after 2 weeks.
Experimental data is close with the data of embodiment 2, therefore slightly.The patient is seasonal allergic rhinitis continuous the use these 2 weeks of article of stage of attack; VAS scoring, sniffles such as rhinocnesmus, sneeze and clear water tears all significantly descend, and have compared utmost point notable difference before these article of use; P＜0.01; Bilateral nasal obstruction also has clear improvement, and compares before these article of use that there were significant differences, p＜0.05.The twang reflex, the MCA value with use these article before compared obvious increase, p＜0.05.It is thus clear that these article can effectively alleviate the attack degree of seasonal allergic rhinitis.Explain: the silicone oil of present embodiment can stick together anaphylactogen, can alleviate the effect of seasonal allergic rhinitis.
Silicone oil in embodiment 6. present embodiments is the chemical compound with structure:
N=1400-1600, the about 60000cSt of average viscosity.
1. material and method
Choose 10 catarrhus perennialis patients under voluntary fully prerequisite, do not use any medicine or antianaphylactic treatment method in two weeks, use these article.
Method for using: every day is with these article 0.2cm
3(Semen Glycines size) is applied in nasal vestibule, before these article of use, reaches these article of use and carries out sniffle VAS scoring and twang reflex after 2 weeks.
Experimental result data is close with the data of embodiment 3, therefore slightly.
Catarrhus perennialis patient uses 2 weeks of these article continuously, the VAS scoring, and sniffles such as rhinocnesmus, bilateral nasal obstruction and sneeze all significantly descend; With use these article before compared notable difference; P＜0.05, the clear water tears with use these article before compared extremely obviously minimizing, p＜0.01.The twang reflex, the MCA value with use these article before compared obvious increase, p＜0.05.It is thus clear that these article can effectively alleviate catarrhus perennialis's attack degree.
Explain: the silicone oil of present embodiment can stick together anaphylactogen, can alleviate catarrhus perennialis's effect.
Embodiment 7
Silicone oil in the present embodiment is the chemical compound with structure:
N=1400-1600, the about 60000cSt of average viscosity.
1. material and method
Choose 20 seasonalities or catarrhus perennialis patient under voluntary fully prerequisite, do not use any medicine or antianaphylactic treatment method in two weeks, use these article.
Method for using: every day is with these article 0.2cm
3(Semen Glycines size) is applied in nasal vestibule, before these article of use, reaches these article of use and carries out asal resistance meter (Rhinomanometry) inspection after 2 weeks.
The import like product that a kind of " safe this pollen barrier " by name only arranged in the market; (original text is seen Arch Otolaryngol Head Neck Surg to unite the clinical trial of carrying out through Frankfurt, Germany otorhinolaryngology hospital, Berlin, Germany Charite university's department of otorhinolaryngology and Russian Federation's research establishment immune Research; 2004:130:979-984); After using " safe this pollen barrier ", use the asal resistance instrumentation and decide respiratory air flow speed, receive sensitization than the patient and excite back mensuration respiratory air flow speed to improve 20%; The two has compared utmost point significance meaning, P＜0.01.The patient uses the asal resistance instrumentation respectively and decides respiratory air flow speed behind sensitization morbidity back and these article of use, the respiratory air flow speed of using these article back to measure improves 38%, and the two is compared also has utmost point significant difference, p＜0.01.
The asal resistance instrumentation uses before and after these article or safe this pollen barrier surely, the change of respiratory air flow speed
Explain: the silicone oil of present embodiment can stick together anaphylactogen, can alleviate seasonality or catarrhus perennialis's effect, and has stronger effect than similar imported product.
More than be intended to further specify the present invention, scope of the present invention do not limited.Those skilled in the art can not depart from the improvement and the variation of category of the present invention and spirit to embodiment disclosed herein.
Claims (4)
1. the application of silicone oil in the preparation allergen retarder, described allergen retarder is the preparation that sticks together inhalant allergens that is applied topically to the nasal vestibule position; Wherein, described silicone oil has structure:
n＝300-5000。
2. application as claimed in claim 1, wherein, the relative molecular mass of described silicone oil is 20000～400000.
3. application as claimed in claim 1, wherein, the average viscosity of described silicone oil is 1000～1000000cSt.
4. each described application of claim 1 to 3, wherein, described anaphylactogen blocker can be used for prevention or treatment seasonal allergic rhinitis and/or catarrhus perennialis.
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