CN101904819A - Method for preparing taurine particles - Google Patents

Abstract

The invention relates to a method for preparing medicinal particles by using a wet-method mixer granulator, in particular to a method for preparing taurine particles by using the wet-method mixer granulator. The method comprises: adding taurine in an amount which is 20 to 30 percent (w/w) based on the total weight of pure water and pulping quickly to obtain paste, and using the pulp with a viscosity of 300 to 400Pa.s as a binding agent in the preparation of the taurine particles by using the wet-method mixer granulator. The taurine particles are uniform in size, compact and smooth and are mainly 40 to 80 mesh spherical particles which account for 85 percent of the total particles. Compared with a method for preparing the taurine particles by spray drying, the method has the advantages that: the production process is simple; the energy consumption is low; and the obtained taurine particles are mainly 40 to 80 mesh spherical particles with high flowability.

Description

A kind of method for preparing taurine particles

Technical field

The present invention relates to prepare the method for drug particles, be specifically related to prepare the method for taurine particles with wet mixing pelletizer with wet mixing pelletizer.

Background technology

Taurine (Rine) is a kind of sulfur-bearing beta-amino acids simple in structure in the animal body, and chemical name is a 2-aminoethyl sulfonic acid, and structural formula is H ₂N-CH ₂-CH ₂-SO ₃H, odorless is acid slightly, and it is neutral that its weak solution is.Taurine has high chemical stability and low metabolic activity; extensively be present in people and the mammiferous internal organs; be one of most important aminoacid; have special pharmacological action and physiological function; but antiinflammatory, analgesia, analgesic, blood sugar lowering, keep the normal vision function, regulate nerve conduction, regulate lipid digestion and absorb, and participate in the endocrine activity, increase the heart contraction ability; improve immunocompetence, it is widely used as medicine, food and feed additive.

On medicine, with the taurine compound preparation that preparation that raw material is made has taurine sheet, taurine particles, taurine capsule, taurine eye drop and contains taurine.Present known taurine raw material is an acicular crystal, and the powdery of conventional usefulness, but its mobile poor, easily caking, poor, the unsuitable long term store of moistureproof anti-compression performance and the long-distance transport of the taurine of existing crystal formation.Its reason is taurine in transportation and storage process caking is relevant with the crystal formation and the particle size distribution of taurine, and in the production process, taurine is when crystallization is separated out from water, and particle size distribution is very wide, causes in the storage process and lumps; And owing to be subjected to the restriction of its crystal formation, its dissolubility, bad dispersibility are used inconvenience.So, change the crystal formation of taurine and crystal grain and be solve store, one of awkward feasible method, also be the problem that present many taurine producer faces.Prove after deliberation: the spherical taurine particles of 40～80 purposes is good fluidity not only, and dispersibility is also very good.

Chen Chunsong has applied for a kind of spherical particle taurine and preparation method thereof

(CN100398096C), be in blending tank, taurine to be dissolved in mix homogeneously in the pure water, make waterborne suspension, in exsiccator, carry out spray drying, the granule that makes is crossed 200 mesh sieves.Though solved the taurine agglomeration problems in this way:

1, add in the production process and used complicated spray drying device, energy consumption is bigger.

2, production institute water requirement is big, and institute's water all will be evaporated totally, and energy consumption is bigger.

3, spray drying can not guarantee that particulate size is even, can not form tight, slick and sly granule, and particularly 40～80 purpose spherical particle proportions are not high.

4, spray drying can produce a large amount of dust, though taked to collect the measure of dust, but still pollute the environment.

Summary of the invention

The objective of the invention is to solve the problem of taurine caking; a kind of particles of taurine preparation method is provided; making the gained taurine particles mainly is 40～80 purpose spherical particles; gained taurine good fluidity, prevented from caking, be convenient to transportation, the convenient storage; and simple, the suitable industrialized great production of production technology, more meet the requirement of current energy-saving and emission-reduction, low-carbon environment-friendly.

We attempt to prepare taurine particles with wet mixing pelletizer.

Because the purpose that we prepare taurine particles is to solve the taurine caking, flowability, therefore dispersion problem, prepares differently with common drug particles, does not allow to add other adjuvants, and the selection of binding agent only can be a water; The mixture of taurine, water.

By experiment, we find: water only, and can not make the taurine solid form granule, with the waterborne suspension that contains taurine, granular size is inhomogeneous, loose, and is not slick and sly, and 40～80 purpose spherical particles have only accounted for granule total amount about 50%.

We are surprised to find that: with taurine add purified water in; the consumption of taurine is 20%～30% (w/w) of total amount; stirring to pulp is to pasty state fast; viscosity is when 300～400Pas; the serosity of this moment is used for wet mixing pelletizer as binding agent and prepares taurine particles, even particle size, tight, slick and sly; mainly be 40～80 purpose spherical particles, 40～80 purpose spherical particles have accounted for 85% of granule total amount.

We find: the consumption of taurine is during greater than 30% (w/w), even viscosity at 300～400Pas, can not obtain above-mentioned spherical particle.

The reason of above-mentioned discovery is: waterborne suspension is behind stirring to pulp, and variation has taken place its physical property, as the granular size of taurine; the distribution of granule in water; with the interaction of water, all preceding different with making beating, to forming the process influence difference of spherical particle.

The spherical particle that material forms is complicated physical change process, and is relevant with many factors, specific to binding agent, with the character of binding agent, consumption, viscosity, waits closely relatedly, and this is not conspicuous.Particularly making even particle size, tight, slick and sly, mainly is 40～80 purpose spherical particles.

We also find: the serosity of taurine: powder taurine=1: 5～7, w/w

Particles of taurine preparation method of the present invention may further comprise the steps:

Proportioning: the serosity of taurine: powder taurine=1: 5～7, w/w

(1) taurine is added in the purified water, taurine is 20%～30% (w/w), starts blender then, making beating fast, and to pasty state, viscosimetric stops making beating in 300～400Pas

(2) place wet mixing pelletizer to stir for 70～90 seconds the powder taurine.

(3) serosity that will contain taurine is slowly poured in the taurine powder that is stirring, when current value stops to granulate when 1.72 peaces rise to the 1.88 peace left and right sides.

(4) taurine particles that makes is taken out through multifunctional medical cross 14 mesh sieves, and the granule after will sieving places baking oven with 70 ℃ temperature drying, treat to take out taurine particles after temperature is reduced to room temperature with testing machine.

The present invention and spray-drying process relatively have obvious effects:

1, the present invention granulates with wet mixing pelletizer, oven drying, and equipment is simple, and energy consumption is less, does not produce dust, and environment is had no adverse effects.

2, contain the serosity of 20% taurine as liquid adhesive with the present invention; join in 6 times of powder taurines; at wet mixing pelletizer granulation meter; compare with 70% waterborne suspension spray drying; use commensurability water; the grain amount that the present invention produces is about 3 times of spray-drying process amount, i.e. the power consumption of evaporation water is 1/4 of a spray-drying process, greatly reduces energy consumption.

3, granule of the present invention, even particle size, produce tight, slick and sly, mainly be 40～80 purpose spherical particles, 40～80 purpose spherical particles have accounted for 85% of granule total amount, and good fluidity is in spray-drying process, and the spray-drying process granular size is inhomogeneous, loose, and is not slick and sly, and 40～80 purpose spherical particles have only accounted for granule total amount about 50%.

Investigate through test, the granule that the present invention produces, good fluidity, prevented from caking are convenient to transportation, the convenient storage, meet the need of market.

The specific embodiment

Embodiment 1

Get taurine 200g and be added among the purified water 800mL, start blender then, making beating fast, to pasty state, viscosimetric stops making beating in 300～400Pas, standby.

Place wet mixing pelletizer to stir for 70～90 seconds 7 kilograms of powder taurines; serosity is slowly poured in the taurine powder that is stirring then; when current value stops to granulate when 1.72 peaces rise to the 1.88 peace left and right sides; the taurine particles taking-up that makes is crossed 14 mesh sieves with multifunctional medical with testing machine; granule after sieving is as for dry under 70 ℃ temperature in the baking oven; treat that temperature reduces to room temperature and take out taurine particles; prepared dry taurine particles is crossed 16 mesh sieves with multifunctional medical with testing machine, gained taurine particle size distribution such as following table (getting the 200g screening):

The order number	20-40	40-60	60-80	80-120	120-160	More than 160	Add up to
								Weight (g)	5	70	102	14	9	0	200
Percentage rate	2.5％	35％	51％	7％	4.5％	0％	100％

Embodiment 2

Get taurine 250g and be added among the purified water 750mL, start blender then, making beating fast, to pasty state, viscosimetric stops making beating in 300～400Pas, standby.

Place wet mixing pelletizer to stir for 70～90 seconds 6 kilograms of powder taurines; suspension is slowly poured in the taurine powder that is stirring then; when current value stops to granulate when 1.72 peaces rise to the 1.88 peace left and right sides; the taurine particles taking-up that makes is crossed 14 mesh sieves with multifunctional medical with testing machine; granule after sieving is as for dry under 70 ℃ temperature in the baking oven; treat that temperature reduces to room temperature and take out taurine particles; prepared dry taurine particles is crossed 16 mesh sieves with multifunctional medical with testing machine, gained taurine particle size distribution such as following table (getting the 200g screening):

The order number	20-40	40-60	60-80	80-120	120-160	More than 160	Add up to
								Weight (g)	4.2	82	92	17	4.8	0	200
Percentage rate	2.1％	41％	46％	8.5％	2.4％	0％	100％

Embodiment 3

Get taurine 300g and be added among the purified water 700mL, start blender then, making beating fast, to pasty state, viscosimetric stops making beating in 300～400Pas, standby.

Get the powder taurine and be dissolved among the purified water 300mL for 5 kilograms, make the waterborne suspension that contains taurine amount of solid 70%, standby.Draw up the grain taurine 3500g place wet mixing pelletizer to stir for 70～90 seconds; suspension is slowly poured in the taurine powder that is stirring then; when current value stops to granulate when 1.72 peaces rise to the 1.88 peace left and right sides; the taurine particles taking-up that makes is crossed 14 mesh sieves with multifunctional medical with testing machine; granule after sieving is as for dry under 70 ℃ temperature in the baking oven; treat that temperature reduces to room temperature and take out taurine particles; prepared dry taurine particles is crossed 16 mesh sieves with multifunctional medical with testing machine, gained taurine particle size distribution such as following table (getting the 200g screening):

The order number	20-40	40-60	60-80	80-120	120-160	More than 160	Add up to
								Weight (g)	4.4	80	90	17	8.6	0	200
Percentage rate	2.2％	40％	45％	8.5％	4.3％	0％	100％

Embodiment 4

The investigation of caking performance

Spray drying taurine particles and particulate taurine of the present invention are compared, and it is as follows that caking capacity is investigated experiment:

The finished product of embodiment 1 is got 100g (A), the spray drying taurine particles is got 100g (B), in the sample sack of packing into, push down with 5 kilograms of weights, placed 18 months, it is as follows to observe the caking capacity result:

A

Do not lump

Do not lump

Do not lump

Do not lump

Do not lump

Do not lump

B

Do not lump

Little caking

Little caking

Heavily lump

Heavily lump

Heavily lump

Experimental result shows: little caking appearred in the spray drying taurine particles after 14th month; heavily caking promptly appearred after 16 months; and particulate taurine of the present invention is placed after 18 months all not caking, and it has more the anti-performance of pressing of excellent protection against the tide, more helps storing and transportation.

Embodiment 5

The mobile investigation

Spray drying taurine particles and particulate taurine of the present invention are compared, and mobile investigation experiment is as follows:

The finished product of embodiment 1 is got 100g (A), the spray drying taurine particles is got 100g (B), be poured into outlet respectively in the funnel of 10mm, observe mobile situation, the result shows that the B sample is obviously slow than A sample flow velocity, and flow difficulties sees the following form:

Sample	Delivery time	Angle of rest (repose)	The outflow state
				A	8 seconds	110-120°	Quicksand like
B	10 seconds	110-120°	Quicksand like

Experimental result shows: particulate taurine of the present invention is mobile better than spray drying taurine particles.

Claims (5)

1. one kind prepares the method for taurine particles with wet mixing pelletizer, it is characterized in that:, join in the powder taurine and granulate as binding agent with the serosity that contains taurine.

2. a kind of method for preparing taurine particles according to claim 1, it is characterized in that: the serosity of taurine contains taurine 20%～30%, w/w.

3. a kind of method for preparing taurine particles according to claim 1, the viscosity of the serosity of taurine is 300～400Pas.

4. a kind of method for preparing taurine particles according to claim 1 is characterized in that: the serosity of taurine: powder taurine=1: 5～7, w/w.

5. according to claim 1,2 or 3 described a kind of methods that prepare taurine particles, may further comprise the steps:

Proportioning: the serosity of taurine: powder taurine=1: 5～7, w/w

(1) taurine is added in the purified water, taurine is 20%～30% (w/w), starts blender then, making beating fast, and to pasty state, viscosimetric stops making beating in 300～400Pas

(2) place wet mixing pelletizer to stir for 70～90 seconds the powder taurine.

(3) serosity that will contain taurine is slowly poured in the taurine powder that is stirring, when current value stops to granulate when 1.72 peaces rise to the 1.88 peace left and right sides.

(4) taurine particles that makes is taken out through multifunctional medical cross 14 mesh sieves, and the granule after will sieving places baking oven with 70 ℃ temperature drying, treat to take out taurine particles after temperature is reduced to room temperature with testing machine.