CN101897916A - Quality control method of skin-care gel - Google Patents
Quality control method of skin-care gel Download PDFInfo
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- CN101897916A CN101897916A CN2009100849968A CN200910084996A CN101897916A CN 101897916 A CN101897916 A CN 101897916A CN 2009100849968 A CN2009100849968 A CN 2009100849968A CN 200910084996 A CN200910084996 A CN 200910084996A CN 101897916 A CN101897916 A CN 101897916A
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Abstract
The invention discloses a quality control method of skin-care gel. In the method, Japanese stemona root and menthol are subjected to quality standard identification by thin layer chromatography. The quality control method of the invention can well control the quality of the skin-care gel and ensure the safety of medication.
Description
Technical field
The present invention relates to a kind of method of quality control of pharmaceutical composition, particularly a kind of quality control method of skin-care gel.
Background technology
Eczema (eczema) is a kind of common epidermis that is caused by multiple internal and external factor and the inflammatory skin disease of high dermis, and it is generally acknowledged with allergy has certain relation.Its clinical manifestation has characteristics such as symmetry, exudative, pruritus, pleomorphism and recurrent, also be a kind of allergic inflammation dermatoses with the erythra multiformity, be symmetrically distributed, violent pruritus shows effect, easily develops into the chronic feature that is repeatedly.Can betide any position of any age, but recur or aggravate the winter of being everlasting the tendency of oozing out be arranged any season, the chronic course of disease, easily outbreak repeatedly.The eczema morbidity is due to multiple factor interacts, to comprise inherited genetic factors, environmental factors, infective agent, dietary factor, medicine factor etc.In recent years, the sickness rate of eczema is in rising trend, western medical treatment, and the doctor generally can select to tie up C and add dexamethasone and some clinical medicines and combine, but medication can not surpass four days, surpasses and increases the weight of the state of an illness easily, make the state of an illness transfer general to by the part.As continuing medication, serious adverse reaction then appears possibly.Skin-care gel through being processed into, has the effect that skin moistening and itch stopping, parasite killing are deodorized by the Radix Stemonae, Herba polygoni hydropiperis, Mentholum, is used for skin prurituss such as various skin pruritus, eczema, neurodermatitis.Quality for strictness control skin-care gel is necessary to study a kind of quality control method of skin-care gel.
Summary of the invention
The object of the invention provides a kind of quality control method of skin-care gel.
The present invention is achieved by the following technical solutions:
A kind of quality control method of skin-care gel method comprises one or more in following discriminating and/or the n-butyl alcohol determination of extractives method:
Differentiate:
(1) get skin-care gel 1～10g, add 70% ethanol, 20～80ml, reflux 1 hour is put cold, add strong ammonia solution and regulate pH value to 10～11, add chloroform 10～30ml jolting again and extract, divide and get chloroform layer, evaporate to dryness, residue add methanol 0.5～2ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 0.1～1.0g, adds ethanol 10～30ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 0.5～2ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (1～10: 1～10: 0.5～1.5: 0.2～1) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 0.1～2g, add ethanol 3～10ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 1～5mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (10～30: 0.5～2) be developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 1～5g, the accurate title, decide, and adds kieselguhr 1～5g, mixes 70 ℃ of oven dry thoroughly, put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims to decide weight, after leaving standstill 1 hour, connect reflux condensing tube, be heated to boiling, and keep little and boiled 0.8～1.5 hour.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
Preferred quality control method is:
Differentiate:
(1) get skin-care gel 5g, add 70% ethanol 50ml, reflux 1 hour is put coldly, adds strong ammonia solution and regulates pH value to 10～11, adds chloroform 20ml jolting again and extracts, and divides and gets chloroform layer, and evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 0.5g, adds ethanol 20ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (4: 4: 0.8: 0.5) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 1g, add ethanol 5ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 2mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (19: 1) is developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 2g, accurate claim surely, add kieselguhr 2g, mix thoroughly, 70 ℃ of oven dry are put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims decide weight, leave standstill 1 hour after, the connection reflux condensing tube is heated to boiling, and keeps little and boiled 1 hour.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
Further specify the present invention below by experimental example but be not limited to the present invention.
Experimental example 1:
Differentiate:
(1) thin layer of the Radix Stemonae is differentiated: ammonia is regulated pH value after the alcohol hydrochloric acid reflux, extract, once on probation, and the method for chloroform extraction is developing solvent with chloroform-methanol (8: 2), and separating effect is bad.Adopted normal hexane-ethyl acetate-methanol-strong aqua ammonia (4: 4: 0.8: 0.5) be developing solvent, can differentiate (adopting the expansion effect of the silica gel G plate of manual shop to be better than precoated plate) preferably.According to formulation and technology, preparation lacks the blank sample of the Radix Stemonae, and makes blank solution according to the preparation method of need testing solution, and the expansion result shows noiseless, so list this method in quality standard.
(2) thin layer of Mentholum is differentiated: list of references, adopt dissolve with ethanol, and benzene-ethyl acetate (19: 1) is developing solvent, is contrast with the Mentholum, it is better to launch effect.According to formulation and technology, preparation lacks the blank sample of Mentholum, and makes blank solution according to the preparation method of need testing solution, and the expansion result shows noiseless, so list this method in quality standard.
Experimental example 2:
The n-butyl alcohol extractum:
Skin-care gel is processed into by three flavor medicines such as the Radix Stemonae, Herba polygoni hydropiperis, Mentholum.In view of the main component of square Chinese crude drug all is dissolved in n-butyl alcohol, therefore, we have set up the assay method of n-butyl alcohol extractum, its quality is carried out integral body control.The result is as follows:
Table 1 n-butyl alcohol determination of extractives result data table
According to the said determination result, tentative this product contains the n-butyl alcohol extractum must not be less than 8.0%.
The specific embodiment
Embodiment 1: a kind of quality control method of skin-care gel
Differentiate:
(1) get skin-care gel 1g, add 70% ethanol 20ml, reflux 1 hour is put coldly, adds strong ammonia solution and regulates pH value to 10～11, adds chloroform 10ml jolting again and extracts, and divides and gets chloroform layer, and evaporate to dryness, residue add methanol 0.5ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 0.1g, adds ethanol 10ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 0.5ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (1: 1: 0.5: 0.2) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 0.1g, add ethanol 3ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (10: 0.5) is developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 1g, accurate claim surely, add kieselguhr 1g, mix thoroughly, 70 ℃ of oven dry are put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims decide weight, leave standstill 1 hour after, the connection reflux condensing tube is heated to boiling, and keeps little and boiled 0.8 hour.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
Embodiment 2: a kind of quality control method of skin-care gel
Differentiate:
(1) get skin-care gel 10g, add 70% ethanol 80ml, reflux 1 hour is put coldly, adds strong ammonia solution and regulates pH value to 10～11, adds chloroform 30ml jolting again and extracts, and divides and gets chloroform layer, and evaporate to dryness, residue add methanol 2ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 1.0g, adds ethanol 30ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 2ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (10: 10: 1.5: 1) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 2g, add ethanol 10ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 5mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (30: 2) is developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 5g, accurate claim surely, add kieselguhr 5g, mix thoroughly, 70 ℃ of oven dry are put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims decide weight, leave standstill 1 hour after, the connection reflux condensing tube is heated to boiling, and keeps little and boiled 1.5 hours.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
Embodiment 3: a kind of quality control method of skin-care gel
Differentiate:
(1) get skin-care gel 5g, add 70% ethanol 50ml, reflux 1 hour is put coldly, adds strong ammonia solution and regulates pH value to 10～11, adds chloroform 20ml jolting again and extracts, and divides and gets chloroform layer, and evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 0.5g, adds ethanol 20ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (4: 4: 0.8: 0.5) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 1g, add ethanol 5ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 2mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (19: 1) is developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 2g, accurate claim surely, add kieselguhr 2g, mix thoroughly, 70 ℃ of oven dry are put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims decide weight, leave standstill 1 hour after, the connection reflux condensing tube is heated to boiling, and keeps little and boiled 1 hour.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
Claims (2)
1. quality control method of skin-care gel is characterized in that this method comprises one or more in following discriminating and/or the n-butyl alcohol determination of extractives method:
Differentiate:
(1) get skin-care gel 1～10g, add 70% ethanol, 20～80ml, reflux 1 hour is put cold, add strong ammonia solution and regulate pH value to 10～11, add chloroform 10～30ml jolting again and extract, divide and get chloroform layer, evaporate to dryness, residue add methanol 0.5～2ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 0.1～1.0g, adds ethanol 10～30ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 0.5～2ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (1～10: 1～10: 0.5～1.5: 0.2～1) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 0.1～2g, add ethanol 3～10ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 1～5mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (10～30: 0.5～2) be developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 1～5g, the accurate title, decide, and adds kieselguhr 1～5g, mixes 70 ℃ of oven dry thoroughly, put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims to decide weight, after leaving standstill 1 hour, connect reflux condensing tube, be heated to boiling, and keep little and boiled 0.8～1.5 hour.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
2. method of quality control according to claim 1 is characterized in that, this method is preferably as follows one or more in discriminating and/or the n-butyl alcohol determination of extractives method:
Differentiate:
(1) get skin-care gel 5g, add 70% ethanol 50ml, reflux 1 hour is put coldly, adds strong ammonia solution and regulates pH value to 10～11, adds chloroform 20ml jolting again and extracts, and divides and gets chloroform layer, and evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Radix Stemonae control medicinal material 0.5g, adds ethanol 20ml, and supersound extraction 30 minutes is put coldly, filters, and filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, in contrast medical material solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-ethyl acetate-methanol-strong aqua ammonia (4: 4: 0.8: 0.5) be developing solvent, launch, take out, dry, spray is with the improvement bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
(2) get skin-care gel 1g, add ethanol 5ml and make dissolving, centrifugal, get supernatant as need testing solution.Other gets the Mentholum reference substance, adds ethanol and makes the solution that every 1ml contains 2mg, in contrast product solution.Test according to an appendix VI of Chinese Pharmacopoeia version in 2005 B thin layer chromatography, draw above-mentioned need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (19: 1) is developing solvent, launch, take out, dry, spray is with the mixed solution of 2% vanillin sulphuric acid-ethanol (2: 8), and it is clear to be heated to the speckle colour developing at 105 ℃.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The n-butyl alcohol extractum:
Get skin-care gel 2g, accurate claim surely, add kieselguhr 2g, mix thoroughly, 70 ℃ of oven dry are put in the conical flask of 100ml, the accurate n-butyl alcohol 50ml that adds, jam-pack claims decide weight, leave standstill 1 hour after, the connection reflux condensing tube is heated to boiling, and keeps little and boiled 1 hour.Put cold after, take off conical flask, close plug claims decide weight, supplies the weight that subtracts mistake with n-butyl alcohol, shakes up, with dry filter filtration.Precision is measured filtrate 25ml, puts in the evaporating dish that is dried to constant weight, behind evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, in the dislocation exsiccator, cools off 30 minutes, accurately rapidly claims decide weight, calculating, promptly.Skin-care gel contains the n-butyl alcohol extractum must not be less than 8.0%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107976494A (en) * | 2017-11-10 | 2018-05-01 | 安徽安科余良卿药业有限公司 | The structure and its quality determining method of health skin tincture standard feature collection of illustrative plates |
| CN108426955A (en) * | 2018-03-11 | 2018-08-21 | 安徽省食品药品检验研究院 | The discrimination method of tuber of stemona genunie medicinal materials |
-
2009
- 2009-05-27 CN CN2009100849968A patent/CN101897916A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107976494A (en) * | 2017-11-10 | 2018-05-01 | 安徽安科余良卿药业有限公司 | The structure and its quality determining method of health skin tincture standard feature collection of illustrative plates |
| CN108426955A (en) * | 2018-03-11 | 2018-08-21 | 安徽省食品药品检验研究院 | The discrimination method of tuber of stemona genunie medicinal materials |
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Application publication date: 20101201 |