CN101897671B - Xylitol micro pill preparations and preparation method thereof - Google Patents
Xylitol micro pill preparations and preparation method thereof Download PDFInfo
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- CN101897671B CN101897671B CN2009100986560A CN200910098656A CN101897671B CN 101897671 B CN101897671 B CN 101897671B CN 2009100986560 A CN2009100986560 A CN 2009100986560A CN 200910098656 A CN200910098656 A CN 200910098656A CN 101897671 B CN101897671 B CN 101897671B
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- xylitol
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Abstract
The invention relates to xylitol micro pill preparations and a preparation method thereof. The preparations are the micro pills and comprise the following components in percentage by weight: 75 to 90 percent of xylitol, 1 to 10 percent of adhesive, 1 to 10 percent of coating substance, 1 to 5 percent of plasticizer, 0.5 to 2 percent of antisticking agent and a proper amount of solvent. In the xylitol micro pill preparations, the micro pills are prepared from the xylitol, so that the moisture absorption and deliquesce of the xylitol is effectively avoided, and meanwhile, when the micro pills are chewed, the micro pills can also be bit through, and the taste is not influenced; the micro pills have the effect of sustained release, so that the taking times are reduced, and compliance is intensified; the micro pills are not fractured, and the sweet taste is controlled, so that people who do not like the sweet taste can take the micro pills conveniently; and the stability of the prepared xylitol micro pills is high, and deterioration caused by the moisture absorption of the xylitol can be avoided.
Description
Technical field
The present invention relates to a kind of Xylitol micro pill preparations and preparation method thereof.
Background technology
Xylitol is a kind of pentabasis alcohol, is the glycometabolic normal intermediate of human body, and the major function of xylitol comprises: 1, diabetes patient's sweeting agent, supplementary and auxiliary therapeutical agent; 2, prevent and treat dental caries; 3, prevention of otitis media and pulmonary infection; 4, bacillus bifidus proliferation function can be regulated function of intestinal canal; 5, improve liver function etc.It is thus clear that being widely used of xylitol, market prospect is wide.
But xylitol draws moist strong, in the Related product production process, causes adhesion easily, influences technological operation, and storing easily, caking goes bad.Xylitol is excessive at some health field application dose, and the once edible soapy feeling that too much causes is repeatedly edible cumbersome again, and forgets easily.Also have the part crowd to dislike the thing of edible sweet taste.
Summary of the invention
The object of the present invention is to provide a kind of Xylitol micro pill preparations with the moisture absorption, taste masking and slow releasing function.
Another object of the present invention is to provide a kind of method for preparing of Xylitol micro pill preparations.
In order to realize the foregoing invention purpose, the present invention adopts following technical scheme:
A kind of Xylitol micro pill preparations comprises the main component xylitol, and said preparation is a micropill, comprises following components in part by weight:
Xylitol 75%～90% binding agent 1%～10%
Coating material 1%～10% plasticizer 1%～5%
Antiplastering aid 0.5%～2% solvent is an amount of
Described binding agent is PVPk30, hypromellose, one or more mixing in the acrylic resin.
Described coating material is one or more mixing in acrylic resin, sodium alginate, hypromellose, the hyprolose.
Described plasticizer is a kind of or its mixing in triethyl citrate, the diethyl phthalate.
Described antiplastering aid is one or more mixing in Pulvis Talci, micropowder silica gel, the magnesium stearate.
Described solvent is one or more mixing in water, ethanol, the isopropyl alcohol.
The present invention also provides a kind of method for preparing of Xylitol micro pill preparations, and this method at first is prepared into the micropill shape with xylitol, wraps coatings on its surface then and obtains.
As of the present invention preferred, this method comprises the steps:
(1) xylosic alcohol powder is broken into Powdered; Cross 300～500 mesh sieves; Then with the part xylitol powder as for doing centrifugal rolling in the centrifugal granulator coating machine, addition is the minimum inventory of centrifugal granulator coating machine, spray adhesive; Powder self becomes ball under the action of the centrifugal, constantly sprays xylitol powder simultaneously and makes piller surface attachment xylitol powder and grow up gradually and obtain the xylitol piller;
(2) the xylitol piller is dry;
(3) coating material, plasticizer and antiplastering aid are dissolved in solvent and obtain coating solution; With dried piller as for doing centrifugal rolling in the centrifugal granulator coating machine; Spray coating solution, dry simultaneously just at the piller of coating, make its be in constantly by bag with and inadherent state; Use up to coating solution, obtain the Xylitol micro pill behind the coating;
(4) Xylitol micro pill behind the coating is drying to obtain.
A kind of Xylitol micro pill preparations of the present invention, because xylitol is prepared into micropill, effectively having stoped xylitol is moisture absorption and deliquescence, micropill micropill when being chewed also can be broken by the teeth simultaneously, does not influence taste; Because micropill has slow-release function, has reduced and has taken number of times, has strengthened compliance; Micropill does not break, and sweet taste is controlled, and the crowd of being convenient to dislike sweet taste takes; The Xylitol micro pill good stability for preparing can not occur because that the hygroscopicity of xylitol causes is rotten.
The specific embodiment
Through embodiment the present invention is done further explanation below.
Embodiment 1: present embodiment adopts following material:
Art sugar alcohol 2000g hypromellose 110g acrylic resin 100g
Triethyl citrate 15g magnesium stearate 7.3g 75% ethanol 2500ml
Method for preparing: (1) is broken into xylosic alcohol powder Powdered; Cross 400 mesh sieves; Then with the 1000g xylitol powder as for doing centrifugal rolling in the centrifugal granulator coating machine; Spray adhesive, powder self become ball under the action of the centrifugal, constantly spray remaining xylitol powder simultaneously and make piller surface attachment xylitol powder and grow up gradually and obtain the xylitol piller;
(2) the xylitol piller is dry;
(3) hypromellose, acrylic resin, triethyl citrate, magnesium stearate are dissolved in 75% ethanol and obtain coating solution; With dried piller as for doing centrifugal rolling in the centrifugal granulator coating machine; Spray coating solution, dry simultaneously just at the piller of coating, make its be in constantly by bag with and inadherent state; Use up to coating solution, obtain the Xylitol micro pill behind the coating;
(4) Xylitol micro pill behind the coating is drying to obtain.
A kind of Xylitol micro pill preparations that present embodiment obtains, because xylitol is prepared into micropill, effectively having stoped xylitol is moisture absorption and deliquescence, micropill micropill when being chewed also can be broken by the teeth simultaneously, does not influence taste; Because micropill has slow-release function, has reduced and has taken number of times, has strengthened compliance; Micropill does not break, and sweet taste is controlled, and the crowd of being convenient to dislike sweet taste takes; The Xylitol micro pill good stability for preparing can not occur because that the hygroscopicity of xylitol causes is rotten.
Embodiment 2: present embodiment adopts following material:
Xylitol 2000g PVPk30 200g sodium alginate 100g
Diethyl phthalate 20g Pulvis Talci 6g 75% ethanol 3000ml
Method for preparing is identical with embodiment 1.
Embodiment 3: present embodiment adopts following material:
Xylitol 2000g PVPk30 150g hypromellose 40
Sodium alginate 80g hyprolose 20g diethyl phthalate 20g
Pulvis Talci 6g 75% ethanol 3000ml
Method for preparing is identical with embodiment 1.
Claims (1)
1. an Xylitol micro pill preparations is characterized in that adopting following material to prepare: xylitol 2000g, hypromellose 110g, acrylic resin 100g, triethyl citrate 15g, magnesium stearate 7.3g, 75% ethanol 2500ml; Adopted the method for being prepared as follows:
(1) xylosic alcohol powder is broken into Powdered; Cross 400 mesh sieves; Place centrifugal granulator coating machine to do centrifugal rolling the 1000g xylitol powder then; Spray adhesive, powder become ball under the action of the centrifugal, spray simultaneously constantly remaining xylitol powder and make piller surface attachment xylitol powder and grow up gradually and obtain the xylitol piller;
(2) the xylitol piller is dry;
(3) hypromellose, acrylic resin, triethyl citrate, magnesium stearate are dissolved in 75% ethanol and obtain coating solution; Place centrifugal granulator coating machine to do centrifugal rolling dried xylitol piller; Spray coating solution, dry simultaneously just at the piller of coating, it is in constantly by bag and inadherent state; Use up to coating solution, obtain the Xylitol micro pill behind the coating;
(4) Xylitol micro pill that obtains is drying to obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100986560A CN101897671B (en) | 2009-05-25 | 2009-05-25 | Xylitol micro pill preparations and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100986560A CN101897671B (en) | 2009-05-25 | 2009-05-25 | Xylitol micro pill preparations and preparation method thereof |
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| CN101897671A CN101897671A (en) | 2010-12-01 |
| CN101897671B true CN101897671B (en) | 2012-11-14 |
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| CN2009100986560A Active CN101897671B (en) | 2009-05-25 | 2009-05-25 | Xylitol micro pill preparations and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579398A (en) * | 2004-05-14 | 2005-02-16 | 许宏昌 | Xylosic alcohol nicotine tablet and its preparation method |
| CN1582703A (en) * | 2004-05-28 | 2005-02-23 | 许宏昌 | Xylitol pellets composition and preparation thereof |
| CN1686089A (en) * | 2005-05-08 | 2005-10-26 | 赵力 | Xylitol granule capable of directly being pressed into tablet and its preparation method |
| CN1732905A (en) * | 2004-08-09 | 2006-02-15 | 赵力 | Directly tabletting xylitol powder and its production method |
-
2009
- 2009-05-25 CN CN2009100986560A patent/CN101897671B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579398A (en) * | 2004-05-14 | 2005-02-16 | 许宏昌 | Xylosic alcohol nicotine tablet and its preparation method |
| CN1582703A (en) * | 2004-05-28 | 2005-02-23 | 许宏昌 | Xylitol pellets composition and preparation thereof |
| CN1732905A (en) * | 2004-08-09 | 2006-02-15 | 赵力 | Directly tabletting xylitol powder and its production method |
| CN1686089A (en) * | 2005-05-08 | 2005-10-26 | 赵力 | Xylitol granule capable of directly being pressed into tablet and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 张志荣.微丸.《药剂学》.高等教育出版社,2007,(第1版),479-483. * |
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| CN101897671A (en) | 2010-12-01 |
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Owner name: ZHEJIANG POLY PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: FAN MINHUA Effective date: 20150819 Owner name: HAINAN PLOY PHARMACEUTICAL CO., LTD. Effective date: 20150819 |
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Effective date of registration: 20150819 Address after: 310009, Hangzhou, Zhejiang province Binjiang District Road, No. 1509, wing Heng building, 10 floor Patentee after: Zhejiang Poly Pharmaceutical Co., Ltd. Patentee after: Hainan Puli Pharmacy stock Co., Ltd Address before: 310002 20-3-301, Zhongda village, Shangcheng District, Zhejiang, Hangzhou Patentee before: Fan Minhua |