CN101889976A - Acyclovir injection and preparation method thereof - Google Patents
Acyclovir injection and preparation method thereof Download PDFInfo
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- CN101889976A CN101889976A CN2009100156235A CN200910015623A CN101889976A CN 101889976 A CN101889976 A CN 101889976A CN 2009100156235 A CN2009100156235 A CN 2009100156235A CN 200910015623 A CN200910015623 A CN 200910015623A CN 101889976 A CN101889976 A CN 101889976A
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- acyclovir
- injection
- water
- preparation
- solution
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Abstract
The invention relates to acyclovir injection which is a medical preparation of compounds and a preparation method thereof. The preparation contains acyclovir, sodium hydroxide and water for injection. The method comprises the following steps of: weighing a proper quantity of water for injection and acyclovir; adding acyclovir into water; stirring, and adding sodium hydroxide solution until the pH value of the solution is 11.0-12.0; keeping stirring until acyclovir is completely dissolved; adding activated carbon for needles, stirring for 30 minutes, stirring, adding water to full dose, filtering, encapsulating, sterilizing, lamp inspection and packing to obtain the product, wherein the volume of the carbon for needles is 0.05 percent (g/ml) of the total volume of the solution. The invention has the characteristics of simple prescription and technology, high production efficiency, strong liquid medicine stability and the like.
Description
Technical field:
The present invention relates to a kind ofly, be used for the treatment of injection of herpes simplex infections, herpes zoster, immunodeficiency person's chickenpox, acute retinal necrosis etc. and preparation method thereof, belong to field of pharmaceutical technology about containing acyclovir.
Background of invention:
Acyclovir (Acyclovir) is the synthetic class new antiviral drug of anti-biological nucleic acid, has advantages such as high selectivity, spectrum, efficient, low toxicity.
Aspect patent application, the Chinese invention patent ublic specification of application discloses name and has been called the solubilization method (application number 200510122706.6) of acyclovir in injection, wherein relate to organic solvent and surfactant, increased medical-risk virtually, for this reason, we make every effort to find the simplest a kind of method for preparing Acyclovir injection.
Summary of the invention:
The object of the present invention is to provide a kind of is a kind of injection of making of principal agent and preparation method thereof with the acyclovir.
A kind of Acyclovir injection is characterized in that adding in the principal agent acyclovir injection that an amount of PH regulator is made.
The preparation method of described Acyclovir injection is characterised in that gets 1000g water for injection and 25g acyclovir, acyclovir is joined in the water for injection, stirring down, dropping sodium solution to solution pH value is 11.0～12.0, continuing to be stirred to acyclovir dissolves fully, add the needle-use activated carbon of overall solution volume 0.05% (g/ml), stirred 30 minutes, filter, add water to full dose, filtration, embedding, sterilization, lamp inspection, packing are promptly.
The present invention has characteristics such as prescription, technology is simple, production efficiency is high, liquid medicine stability is strong.
The specific embodiment:
The present invention will be described in detail below in conjunction with example:
Acyclovir injection of the present invention and preparation method thereof is characterized in that acyclovir joins in the water for injection, regulates pH value with sodium hydroxide solution, makes stable acyclovir solution, sterilize after the packing aqueous injection.
Embodiment: in the toilet, getting proper amount of water for injection adds in the container, add the 25g acyclovir, stir, stirring down, dropping sodium solution to solution pH value is 11.0～12.0, continuing to be stirred to acyclovir dissolves fully, add the 0.5g active carbon, placed 30 minutes, filter, add water to 1000ml, filtration, embedding, sterilization, lamp inspection, packing are promptly.
Claims (4)
1. Acyclovir injection is characterized in that its liquid infusion preparation by the preparation of 9-(2-ethoxy methyl) guanine.
2. Acyclovir injection according to claim 1, wherein said liquid infusion preparation is an aqueous solution injection.
3. the preparation method of an Acyclovir injection is characterized in that preparing as follows
Get an amount of acyclovir and water for injection by following proportioning:
Acyclovir 25g water for injection 1000g
Get an amount of water for injection and acyclovir by said ratio, acyclovir is joined in the water for injection, stirring down, dropping sodium solution to solution pH value is 11.0～12.0, continuing to be stirred to acyclovir dissolves fully, add the needle-use activated carbon of overall solution volume 0.05% (g/ml), stirred 30 minutes, filter, add to the full amount of water for injection, filtration, embedding, sterilization are promptly.
4. the employed sodium hydroxide of Acyclovir injection according to claim 3 is commercially available medicinal specification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100156235A CN101889976A (en) | 2009-05-22 | 2009-05-22 | Acyclovir injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100156235A CN101889976A (en) | 2009-05-22 | 2009-05-22 | Acyclovir injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101889976A true CN101889976A (en) | 2010-11-24 |
Family
ID=43099438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100156235A Pending CN101889976A (en) | 2009-05-22 | 2009-05-22 | Acyclovir injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101889976A (en) |
-
2009
- 2009-05-22 CN CN2009100156235A patent/CN101889976A/en active Pending
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Legal Events
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20101124 |