CN101889963B - Microemulsion composition and preparation method thereof - Google Patents
Microemulsion composition and preparation method thereof Download PDFInfo
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- CN101889963B CN101889963B CN2010102456468A CN201010245646A CN101889963B CN 101889963 B CN101889963 B CN 101889963B CN 2010102456468 A CN2010102456468 A CN 2010102456468A CN 201010245646 A CN201010245646 A CN 201010245646A CN 101889963 B CN101889963 B CN 101889963B
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Abstract
The invention relates to a microemulsion composition and a preparation method thereof. The microemulsion composition comprises the following components in percentage by weight: 10 to 20 percent of component A, 15 to 30 percent of component B and 50 to 70 percent of component C, wherein the component A comprises the following components in part by weight: 1.5 to 3 parts of non-ionic emulsifier, 0.5 to 1.5 parts of cetyl alcohol ether-6, 1.0 to 2.5 parts of stearyl ether-21, 5 to 10 parts of liquid paraffin and 2 to 8 parts of octyl palmitate or butyrospermum parkii; the non-ionic emulsifier is lecithin, polyglyceryl fatty acid ester or a mixture thereof; the component B is deionized water; and the component C comprises glycerol and deionized water in a weight ratio of 1:3-7. The microemulsion composition provided by the invention has the liquid drops much smaller than those of an emulsion, is stable and favorable for skin penetration, promotes the exertion of effective substances, and can be widely applied to the cosmetics industry.
Description
Technical field
The present invention relates to a kind of microemulsion composition and preparation method thereof, this microemulsion composition is applicable to cosmetic industry.
Background technology
The active ingredient of cosmetics determines its effect, and still, any cosmetics all will be by the suitable due effect of carrier competence exertion.That is to say, the composition of this cosmetic base and character, directly influence its active ingredient release, penetrate, absorb.Therefore, even same prescription, the different effects that solvent produced also differ widely.
Human body skin mainly absorbs external substance by three approach: 1. enter through hair follicle, sebum glandular orifice and pore; 2. directly passing the horn cell film enters; 3. enter through the horn cell gap.General cosmetics emulsion droplet is between the 1-10 micron, and the product active ingredient can't the skin permeation the inside, thereby can't bring into play the effect of effective ingredient.
For improving the mobility of cosmetics in human body skin, people have developed the cosmetic formulations that has more lipophilic emulsion-type, microemulsion type again.The most general known method is that fat-soluble, pure dissolubility active ingredient is dissolved in oils or organic solvent, adds at least a emulsifying agent so that help this material solubilising in oil, in the water or in the oil-water mixture, from and form Emulsion, microemulsion preparation etc.The Emulsion that this method forms belongs to the heterogeneous system of thermodynamic instability, because the influence of dispersion and external condition, usually causes emulsion creaming, flocculation, phase inversion easily or becomes sour; Though the microemulsion that this method forms can form thermodynamic stable system, and appearance transparent is similar to true solution, and emulsifier content generally can be up to 15～30%.Obviously, emulsifying agent plays a part very crucial to the success or not of the emulsifying of Emulsion, microemulsion preparation or microemulsified, so the greatest drawback of this class preparation just is to have to use a large amount of emulsifying agents.Though these emulsifying agents are the emulsive oily material effectively, can make the active ingredient solubilising, preparation potentiation, stable, anticorrosion, but, exist the problem of little poison in use, need also to be clear that these emulsifying agents also are the materials that appends in the cosmetics, no matter from manufacturing cost, still healthy aspect is seen, is not desired.
Summary of the invention
The purpose of this invention is to provide a kind of microemulsion composition, this microemulsion composition can help transdermal penetration, promotes the performance of effect material.
For achieving the above object, the invention provides a kind of microemulsion composition, this microemulsion composition comprises the component of the following meter of percent by weight:
Component A 10～20%;
B component 15～30%;
Component C 50～70%;
Described component A comprises meter by weight:
1.5～3 parts of nonionic emulsifiers;
Spermaceti alcohol ether-6 0.5～1.5 part;
Stearic alcohol ether-21 1.0～2.5 part;
5～10 parts of liquid paraffin;
2～8 parts of iso-octyl palmitate or Butyrospermum fruit oil;
Described nonionic emulsifier is selected lecithin, polyglyceryl fatty acid ester or the mixture of the two; Further, described polyglyceryl fatty acid ester is selected the different hard fatty acid ester of polyglycereol-3-.
Described spermaceti alcohol ether-6 and stearic alcohol ether-the 21st play the effect of auxiliary nonionic emulsifier, make that the microemulsion that forms is more stable, are not subject to the influence of external environment.
The oils and fats that component A selects must dissolve each other, can be good at dissolving each other as liquid paraffin and iso-octyl palmitate or Butyrospermum fruit oil, immiscible oils and fats can reduce emulsifying effectiveness, and oil phase has bigger molecular weight and lower dipole-dipole force, makes that the microemulsion that forms is more stable.
Described B component is a deionized water;
Described component C comprises glycerol and deionized water, and wherein, the ratio of glycerol and deionized water is 1: 3～7 by weight.
Further, described microemulsion composition comprises the component of the following meter of percent by weight:
Component A 15%;
B component 25%;
Component C 60%.
Above-mentioned microemulsion composition, wherein, the glycerol that component C comprises and the ratio of deionized water are 1: 5 by weight.
Further, microemulsion composition of the present invention also comprises the component D of percent meter 0.1～1% by weight; This component D comprises essence and antiseptic, and wherein, the ratio of essence and antiseptic is 1: 2～5 by weight.
Above-mentioned microemulsion composition, wherein, among the described component D, the ratio of essence and antiseptic is 1: 4 by weight; Described antiseptic is selected germall-C.
The present invention also provides the preparation method of microemulsion composition, and it comprises following concrete steps:
Step 1, A to 75 ℃～100 ℃ of heat contents stir; Simultaneously, heat contents is B to 75 ℃～100 ℃;
Step 2 stirs down, and B component is slowly splashed among the component A, stops heating when having observed tangible blue light; When dispersed emulsified particles size during near optical wavelength (400-770nm), light can produce diffraction, and solution system has shown as blue light between transparent and translucent; Emulsifying temperature will be higher than phase inversion temperature more than 10 degrees centigrade, does not occur otherwise may there be blue light;
Step 3, the solution in the cooling step 2 is reduced to 35 ℃～45 ℃ up to temperature, adds component C, stirs, and obtains microemulsion composition.
The preparation method of above-mentioned microemulsion composition wherein, also comprises:
Step 4 further with the solution cool to room temperature in the step 3, adds component D, and stirring to obtain microemulsion composition.
Microemulsion is in the presence of one or more relatively large amphiphilic compounds, the isotropic transparent colloidal dispersion system of two kinds of not miscible spontaneous formation of liquid.Used amphiphilic species is a kind of to be the surfactant that suits, and the polar organic matter that another kind is generally medium chain often is called cosurfactant.Two kinds of not miscible liquid are a kind of to be water, and another kind is generally polar organic matter and is generally oil.Microemulsion dispersed phase drop size generally between 10-100nm, is roughly handed between group and macromole and the common hydrophobic colloid granule, much smaller than emulsion drop size between surfactant.When forming microemulsion with non-ionic surface active agent, often do not need to add cosurfactant, this system is a ternary system.Microemulsion remedies the blank in emulsifying field between solubilising and emulsifying, help transdermal penetration, can promote the performance of effect material.Microemulsified is that drop is distributed to nanometer level, and reaches stable a kind of special emulsifying technology, usefulness be the skilful power (not needing homogenizing) that reduces interfacial tension, but not the rough power of external energy, product presents special blue light effect after the emulsifying.
The condition that microemulsion forms: suitable emulsifying agent is corresponding with oils and fats; Suitable temperature (being higher than more than the PIT10 degree); Bigger energy input is embodied as, and in the time of near phase inversion point, provide stronger mechanical agitation energy; And enough emulsifying agent consumptions.
In general, in the cosmetics there be by the influence factor of skin absorbs the effect material: the availability influence factor; Working substance concentration in the substrate; Use amount on the unit skin area; Transmitance; Time of staying and in the stability (free radical resisting and resistance to enzymolysis effect) of skin in the time of staying.
And the microemulsion composition drop that the present invention forms is much smaller than the emulsion drop, disperses more evenly, and the influence of environment is little, more stable to external world, so, can help transdermal penetration as solvent, the performance of promotion effect material.
The specific embodiment
Below in conjunction with embodiment technical scheme of the present invention is further described.
Embodiment 1
According to the form below takes by weighing raw material:
Step 1, A to 75 ℃ of heat contents stirs; Simultaneously, heat contents is B to 75 ℃;
Step 2 stirs down, and B component is slowly splashed among the component A, stops heating when having observed tangible blue light;
Step 3, the solution in the cooling step 2 is reduced to 35 ℃ up to temperature, adds component C, stirs, and obtains microemulsion composition.
Embodiment 2
According to the form below takes by weighing raw material:
Step 1, A to 85 ℃ of heat contents stirs; Simultaneously, heat contents is B to 85 ℃;
Step 2 stirs down, and B component is slowly splashed among the component A, stops heating when having observed tangible blue light;
Step 3, the solution in the cooling step 2 is reduced to 40 ℃ up to temperature, adds component C, stirs, and obtains microemulsion composition;
Step 4 further with the solution cool to room temperature in the step 3, adds component D, and stirring to obtain microemulsion composition.
Embodiment 3
According to the form below takes by weighing raw material:
Step 1, A to 80 ℃ of heat contents stirs; Simultaneously, heat contents is B to 80 ℃;
Step 2 stirs down, and B component is slowly splashed among the component A, stops heating when having observed tangible blue light;
Step 3, the solution in the cooling step 2 is reduced to 45 ℃ up to temperature, adds component C, stirs, and obtains microemulsion composition;
Step 4 further with the solution cool to room temperature in the step 3, adds component D, and stirring to obtain microemulsion composition.
The present invention adopts nonionic emulsifier, selects suitable oils and fats, and the microemulsion composition drop of formation disperses more even much smaller than the emulsion drop, and the influence of environment is little, more stable to external world, so, can help transdermal penetration as solvent, promote the performance of effect material.
Although content of the present invention has been done detailed introduction by above preferred embodiment, will be appreciated that above-mentioned description should not be considered to limitation of the present invention.After those skilled in the art have read foregoing, for multiple modification of the present invention with to substitute all will be conspicuous.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (9)
1. a microemulsion composition is characterized in that, this microemulsion composition comprises the component of the following meter of percent by weight:
Component A 10～20%;
B component 15～30%;
Component C 50～70%;
Described component A comprises meter by weight:
1.5～3 parts of nonionic emulsifiers;
Spermaceti alcohol ether-6 0.5～1.5 part;
Stearic alcohol ether-21 1.0～2.5 part;
5～10 parts of liquid paraffin;
2～8 parts of iso-octyl palmitate or Butyrospermum fruit oil;
Described nonionic emulsifier is selected the mixture of lecithin, polyglyceryl fatty acid ester;
Described B component is a deionized water;
Described component C comprises glycerol and deionized water, and wherein, the ratio of glycerol and deionized water is 1: 3～7 by weight.
2. microemulsion composition as claimed in claim 1 is characterized in that, described polyglyceryl fatty acid ester is selected the different hard fatty acid ester of polyglycereol-3-.
3. microemulsion composition as claimed in claim 1 is characterized in that, this microemulsion composition comprises the component of the following meter of percent by weight:
Component A 15%;
B component 25%;
Component C 60%.
4. microemulsion composition as claimed in claim 1 is characterized in that, among the described component C, the ratio of glycerol and deionized water is 1: 5 by weight.
5. microemulsion composition as claimed in claim 1 is characterized in that, described microemulsion composition also comprises the component D of percent meter 0.1～1% by weight; This component D comprises essence and antiseptic, and wherein, the ratio of essence and antiseptic is 1: 2～5 by weight.
6. microemulsion composition as claimed in claim 5 is characterized in that, among the described component D, the ratio of essence and antiseptic is 1: 4 by weight.
7. microemulsion composition as claimed in claim 5 is characterized in that, described antiseptic is selected germall-C.
8. the preparation method of a microemulsion composition according to claim 1 is characterized in that, this method comprises following concrete steps:
Step 1, A to 75 ℃～80 ℃ of heat contents stir; Simultaneously, heat contents is B to 75 ℃～80 ℃;
Step 2 stirs down, and B component is slowly splashed among the component A, stops heating when having observed tangible blue light;
Step 3, the solution in the cooling step 2 is reduced to 35 ℃～45 ℃ up to temperature, adds component C, stirs, and obtains microemulsion composition.
9. the preparation method of microemulsion composition as claimed in claim 8 is characterized in that, this method comprises following concrete steps:
Step 4 further with the solution cool to room temperature in the step 3, adds component D, and stirring to obtain microemulsion composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102456468A CN101889963B (en) | 2010-08-05 | 2010-08-05 | Microemulsion composition and preparation method thereof |
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| CN2010102456468A CN101889963B (en) | 2010-08-05 | 2010-08-05 | Microemulsion composition and preparation method thereof |
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| CN101889963A CN101889963A (en) | 2010-11-24 |
| CN101889963B true CN101889963B (en) | 2011-09-28 |
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| JP2018087149A (en) * | 2016-11-28 | 2018-06-07 | ロレアル | Composition in the form of nano- or micro-emulsion |
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| CN1241536C (en) * | 2001-08-13 | 2006-02-15 | 日清奥利友集团株式会社 | Humectant and cosmetics and external prepan. contg. same |
| JP2003212747A (en) * | 2002-01-15 | 2003-07-30 | Nisshin Oillio Ltd | Water-in-oil emulsified skin preparation for external use |
| CN1331459C (en) * | 2003-01-31 | 2007-08-15 | 宝洁公司 | Skin care composition comprising first and second emulsions |
| AU2005206084A1 (en) * | 2004-01-09 | 2005-08-04 | Wyeth | Microemulsions for pharmaceutical compositions |
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