CN101869552B - Preparation method of chitin tablet - Google Patents
Preparation method of chitin tablet Download PDFInfo
- Publication number
- CN101869552B CN101869552B CN2009101392606A CN200910139260A CN101869552B CN 101869552 B CN101869552 B CN 101869552B CN 2009101392606 A CN2009101392606 A CN 2009101392606A CN 200910139260 A CN200910139260 A CN 200910139260A CN 101869552 B CN101869552 B CN 101869552B
- Authority
- CN
- China
- Prior art keywords
- chitin
- tablet
- mesh sieves
- dextrin
- magnesium stearate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920002101 Chitin Polymers 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 26
- 229920002472 Starch Polymers 0.000 claims abstract description 15
- 239000008107 starch Substances 0.000 claims abstract description 15
- 235000019698 starch Nutrition 0.000 claims abstract description 15
- 229920001353 Dextrin Polymers 0.000 claims abstract description 13
- 239000004375 Dextrin Substances 0.000 claims abstract description 13
- 235000019425 dextrin Nutrition 0.000 claims abstract description 13
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 13
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 13
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 13
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000008187 granular material Substances 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000007779 soft material Substances 0.000 claims abstract description 5
- 239000002002 slurry Substances 0.000 claims description 14
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 12
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 12
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 12
- 229960003943 hypromellose Drugs 0.000 claims description 12
- 239000011230 binding agent Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical group [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a preparation method of a chitin tablet. Chitin raw material is smashed and screened with a 60 mesh sieve and then 3 percent of HPMC and 6 percent of starch, which are used as adhesives, are added to prepare soft material. A 16 mesh net is used for granulating, and the obtained granules are dried, smashed and then screened through a 100 mesh sieve. A certain amount of calcium hydrophosphate, dextrin, talcum powder and magnesium stearate are added to the smashed fine powder and then are mixed evenly through a blender mixer. The tablet with certain specification is manufactured according to the requirement. The chitin prepared through the method accords with the quality requirement of the common tablet.
Description
Technical field
The present invention relates to the method for preparing of medicinal tablets, specifically, is a kind of method for preparing of chitin tablet.
Background technology
Chitin is that the occurring in nature storage capacity is only second to cellulose and the extensive a kind of biological polymer that exists.Chitin has another name called chitin, chitin, and chemistry poly-n-acetyl by name-D-glycosamine is a macromolecule polysaccharide like a kind of chemical constitution and the cellulose family.It extensively is present in the cell wall of duricrust and mushroom of insecticide, Crustacean, is one of Organic substance that storage capacity is the abundantest on the earth.In recent years, in pharmaceutically research many valued data were provided to chitin and derivant thereof, showed its in this field wide application prospect.Because aboundresources, low price, safety non-toxic and characteristics such as be widely used, development and utilization is all attached great importance in countries in the world.
The Japan scholar is through body fluid property immunity and cellular immunity evidence, and chitin has and promotes immune function, can be made into powder, granule is oral, as immunostimulant.But chitin complexation, chelating heavy metal, the interior harmful substance of adsorbate also excretes; But the activate immunity factor, the body immunologic function is improved sleep, allaying tiredness; Its alkaline matter can improve acid system, and the protection the intestines and stomach promotes the intestines and stomach rehabilitation; Can eliminate human free radical, hinder the absorption of fat, promote the conversion of cholesterol, effective blood fat reducing etc.
Existing in the market functional chitin capsule product, but since the former powder of the chitin moisture absorption very easily make functional tablet and received certain restriction.In order to meet the need of market, according to our understanding to pharmaceutics knowledge, in conjunction with the physical property of chitin, we have developed satisfactory chitin tablet, and the chitin tablet of preparation meets the pharmaceutical quality requirement of conventional tablet.
Summary of the invention
The method for preparing that the purpose of this invention is to provide a kind of chitin tablet.This method for preparing technology is simple, low cost of manufacture, has the good commercial prospect.
In order to achieve the above object, the present invention adopts following technical scheme:
After chitin raw material sieved, add binding agent, process soft material.Granulate with screen cloth then, with crushing screening behind the particle drying.In the powder for preparing, add a certain amount of excipient, use the batch mixer mix homogeneously, be pressed into the tablet of certain specification as requested, the chitin sheet of this method preparation meets the prescription of conventional tablet.
Described binding agent is hypromellose, 4% starch slurry and 6% hypromellose, 6% starch slurry and 3% the hypromellose of 10% starch slurry, 8% starch slurry, 6% starch slurry, 4% starch slurry, 2% starch slurry, 6% hypromellose, 3% hypromellose, 1% hypromellose, 8% starch slurry and 1%.Preferably 6% starch slurry and 3% hypromellose, 8% starch slurry and 1% hypromellose.Particularly preferably be 6% starch slurry and 3% hypromellose.
Described excipient is calcium lactate, calcium carbonate, calcium hydrogen phosphate, dextrin, Pulvis Talci, magnesium stearate.Preferred excipient is calcium carbonate, calcium hydrogen phosphate, dextrin, Pulvis Talci, magnesium stearate.Particularly preferably be calcium hydrogen phosphate, dextrin, Pulvis Talci, magnesium stearate.
The addition of described excipient calcium hydrogen phosphate is 10-30%.Preferably the addition of calcium hydrogen phosphate is 10-15%.The addition that particularly preferably is calcium hydrogen phosphate is 11%.
The addition of described excipient dextrin is 5-20%.Preferably the addition of dextrin is 5-8%.Particularly preferably being the dextrin addition is 5%.
The talcous addition of described excipient is 3-13%.Preferably talcous addition is 3-8%.Particularly preferably being talcous addition is 3%.
The addition of described excipient magnesium stearate is 0.5-1.5%.Preferably the addition of magnesium stearate is 0.5-0.8%.The addition that particularly preferably is magnesium stearate is 0.5%.
Described excipient calcium hydrogen phosphate, dextrin, Pulvis Talci, magnesium stearate add with pulverulence.
Described excipient calcium hydrogen phosphate, dextrin, Pulvis Talci, magnesium stearate are after the granule of preparation is pulverized 100 mesh sieves, to add.
The method for preparing of chitin of the present invention more specifically, comprises following steps:
(1) particulate preparation
Chitin raw material is crossed 60 mesh sieves, join in the grooved batch mixer.Prepare 3% hypromellose and 6% starch slurry, join in the batch mixer, stir and processed soft material in 40 minutes.Granulate with the granulator of 16 order nets then, wet granular is dry with the boiling air flow bed, obtain dried granules.
(2) preparation of tablet
Above-mentioned dried granule was pulverized 100 mesh sieves, add calcium hydrogen phosphate, dextrin, Pulvis Talci and the magnesium stearate of a certain amount of pharmaceutical grade, calcium hydrogen phosphate, dextrin, Pulvis Talci and magnesium stearate are crossed 100 mesh sieves in advance.With three-dimensional blender machine mix homogeneously, calculate the heavy back of sheet is pressed into definite shape and specification with tablet machine tablet.Through check, institute's tablet agent meets the prescription of conventional tablet.
The chitin tablet that method for preparing of the present invention obtains detects through check and analytical tool, and the disintegration of institute's tablet agent, sanitary standard etc. meet the prescription of tablet.
The present invention has characteristics such as technology is simple, production cost is low, is particularly suitable for suitability for industrialized production.
The specific embodiment
Be embodiments of the invention below, described embodiment just is used for explaining the present invention, and should not be considered to be limitation of the present invention.
Embodiment
Take by weighing chitin raw material 420g; The mixed pulp that the starch slurry of adding 6% and 3% hypromellose are formed is made binding agent, and the preparation soft material is crossed 16 mesh sieves and processed wet granular; Use oven for drying; Granule was pulverized 100 mesh sieves, added the dry powder compound mixing of the calcium hydrogen phosphate 11% of crossing 100 mesh sieves, dextrin 5%, Pulvis Talci 3%, magnesium stearate 0.5%, be pressed into 1000 with tablet machine.Through check, the chitin tablet of pressing meets the prescription of conventional tablet.
More than the method for preparing of chitin tablet provided by the present invention has been carried out detailed introduction; Used concrete example among this paper principle of the present invention and embodiment are set forth, the explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof; Simultaneously, for one of ordinary skill in the art, according to thought of the present invention, the part that on the specific embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.
Claims (1)
1. the method for preparing of a chitin tablet is characterized in that, comprises following steps:
Take by weighing chitin raw material 420g; The mixed pulp that the starch slurry of adding 6% and 3% hypromellose are formed is made binding agent, and the preparation soft material is crossed 16 mesh sieves and processed wet granular; Use oven for drying; Granule was pulverized 100 mesh sieves, added the dry powder compound mixing of the calcium hydrogen phosphate 11% of crossing 100 mesh sieves, dextrin 5%, Pulvis Talci 3%, magnesium stearate 0.5%, be pressed into 1000 with tablet machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101392606A CN101869552B (en) | 2009-04-25 | 2009-04-25 | Preparation method of chitin tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101392606A CN101869552B (en) | 2009-04-25 | 2009-04-25 | Preparation method of chitin tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101869552A CN101869552A (en) | 2010-10-27 |
| CN101869552B true CN101869552B (en) | 2012-01-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101392606A Expired - Fee Related CN101869552B (en) | 2009-04-25 | 2009-04-25 | Preparation method of chitin tablet |
Country Status (1)
| Country | Link |
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| CN (1) | CN101869552B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983707A (en) * | 2015-07-17 | 2015-10-21 | 青岛海之星生物科技有限公司 | Composite phosphoesterase and chitin compound sustained release tablet and preparation method thereof |
| CN105012943A (en) * | 2015-07-17 | 2015-11-04 | 青岛海之星生物科技有限公司 | Phosphoesterases complex and chitin compound sustained-release capsule and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004262860A (en) * | 2003-03-03 | 2004-09-24 | Fancl Corp | Chitosan-containing tablet and method for producing the same |
| CN101053409A (en) * | 2007-05-11 | 2007-10-17 | 汪昔奇 | Health care food containing natural astaxanthin |
| CN101103994A (en) * | 2006-07-13 | 2008-01-16 | 中国科学院地理科学与资源研究所 | Medicine for preventing and treating gout and hyperuricemia |
| CN101262784A (en) * | 2005-09-14 | 2008-09-10 | 金镇满 | Supplementary food composition for reducing body odor |
-
2009
- 2009-04-25 CN CN2009101392606A patent/CN101869552B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004262860A (en) * | 2003-03-03 | 2004-09-24 | Fancl Corp | Chitosan-containing tablet and method for producing the same |
| CN101262784A (en) * | 2005-09-14 | 2008-09-10 | 金镇满 | Supplementary food composition for reducing body odor |
| CN101103994A (en) * | 2006-07-13 | 2008-01-16 | 中国科学院地理科学与资源研究所 | Medicine for preventing and treating gout and hyperuricemia |
| CN101053409A (en) * | 2007-05-11 | 2007-10-17 | 汪昔奇 | Health care food containing natural astaxanthin |
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| Publication number | Publication date |
|---|---|
| CN101869552A (en) | 2010-10-27 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120125 Termination date: 20140425 |