CN101869552B - Preparation method of chitin tablet - Google Patents

Abstract

The invention relates to a preparation method of chitin tablets. The preparation method is to crush the chitin raw material through a 60-mesh sieve, add 3% hypromellose and 6% starch slurry as a binder to make a soft material, and then use a 16-mesh net to granulate and dry the granules , and then crush the particles through a 100-mesh sieve. Add a certain amount of calcium hydrogen phosphate, dextrin, talcum powder and magnesium stearate to the pulverized fine powder, mix evenly with a mixer, and press into tablets of certain specifications according to requirements. The chitin tablets prepared by this method It meets the quality requirements of ordinary tablets.

Description

A kind of preparation method of chitin tablet

technical field

The invention relates to a preparation method of a medicinal tablet, in particular to a preparation method of a chitin tablet.

Background technique

Chitin is a kind of biopolymer widely existing in nature after storage capacity of cellulose. Chitin, also known as chitin and chitin, is chemically called poly-N-acetyl-D-glucosamine, and is a polymer polysaccharide with a chemical structure similar to cellulose. It is widely found in the hard shells of insects and crustaceans and the cell walls of fungi, and is one of the most abundant organic substances stored on the earth. In recent years, the research on chitin and its derivatives in medicine has provided a lot of valuable information, showing its broad application prospects in this field. Due to the characteristics of abundant resources, cheap price, safety and non-toxicity and wide application, all countries in the world attach great importance to the development and utilization.

Japanese scholars have proved by humoral immunity and cellular immunity tests that chitin has the function of promoting immunity, and it can be made into powder or granule orally as an immune enhancer. Chitin can complex and chelate heavy metals, absorb harmful substances in the body and excrete them; it can activate immune factors, strengthen the immune function of the human body, improve sleep, and eliminate fatigue; its alkaline substances can improve the acid system, protect the stomach, and promote the recovery of the stomach; It can eliminate free radicals in the human body, hinder the absorption of fat, promote the conversion of cholesterol, and effectively reduce blood lipids.

At present, there are functional chitin capsule products on the market, but because chitin raw powder is very easy to absorb moisture, it is limited to make functional tablets. In order to meet the market demand, based on our understanding of pharmacy knowledge and combined with the physical properties of chitin, we have developed chitin tablets that meet the requirements, and the prepared chitin tablets meet the pharmaceutical quality requirements of ordinary tablets.

Contents of the invention

The purpose of this invention is to provide a kind of preparation method of chitin tablet. The preparation method has simple process, low manufacturing cost and good commercial prospect.

In order to achieve the above object, the present invention adopts the following technical solutions:

After the chitin raw material is sieved, a binder is added to make a soft material. The granules are then granulated with a sieve, the granules are dried and crushed and sieved. A certain amount of excipient is added to the prepared powder, mixed evenly with a mixer, and pressed into tablets with certain specifications according to requirements. The chitin tablets prepared by this method meet the quality requirements of ordinary tablets.

Described binder is 10% starch slurry, 8% starch slurry, 6% starch slurry, 4% starch slurry, 2% starch slurry, 6% hypromellose, 3% hydroxypropyl methylcellulose Promellose, 1% hypromellose, 8% starch slurry and 1% hypromellose, 4% starch slurry and 6% hypromellose, 6% starch slurry and 3% hypromellose. Preferred are 6% starch slurry and 3% hypromellose, 8% starch slurry and 1% hypromellose. Especially preferred is 6% starch slurry and 3% hypromellose.

The excipients are calcium lactate, calcium carbonate, calcium hydrogen phosphate, dextrin, talcum powder and magnesium stearate. Preferred excipients are calcium carbonate, calcium hydrogen phosphate, dextrin, talc, magnesium stearate. Particularly preferred are calcium hydrogen phosphate, dextrin, talc, magnesium stearate.

The added amount of the excipient calcium hydrogen phosphate is 10-30%. Preferably the addition of calcium hydrogen phosphate is 10-15%. It is particularly preferred that the addition of calcium hydrogen phosphate is 11%.

The added amount of the excipient dextrin is 5-20%. Preferably, the added amount of dextrin is 5-8%. It is particularly preferred that the added amount of dextrin is 5%.

The added amount of the excipient talcum powder is 3-13%. Preferably, the added amount of talcum powder is 3-8%. Particularly preferred is the addition of talc in an amount of 3%.

The added amount of the excipient magnesium stearate is 0.5-1.5%. Preferably, the added amount of magnesium stearate is 0.5-0.8%. It is particularly preferred that the added amount of magnesium stearate is 0.5%.

The excipients calcium hydrogen phosphate, dextrin, talcum powder and magnesium stearate are added in powder state.

The excipients calcium hydrogen phosphate, dextrin, talcum powder and magnesium stearate are added after the prepared granules are crushed through a 100-mesh sieve.

The preparation method of chitin of the present invention, more specifically, comprises the following steps:

(1) Preparation of particles

Pass the chitin raw material through a 60-mesh sieve and add it to the tank mixer. Prepare 3% hypromellose and 6% starch slurry, add in the mixer, stir for 40 minutes to make soft material. Then use a granulator with a 16-mesh mesh to granulate, and dry the wet granules with a boiling air-flow bed to obtain dry granules.

(2) Preparation of tablets

The above-mentioned dry granules are crushed through a 100-mesh sieve, and a certain amount of pharmaceutical grade calcium hydrogen phosphate, dextrin, talcum powder and magnesium stearate is added, and the calcium hydrogen phosphate, dextrin, talc powder and magnesium stearate are passed through 100 mesh sieve. Mix evenly with a three-dimensional mixer, calculate the weight of the tablet, and press it into a tablet of a certain shape and specification with a tablet press. After inspection, the compressed tablets meet the quality requirements of ordinary tablets.

The chitin tablet obtained by the preparation method of the present invention is tested by inspection and analysis instruments, and the disintegration degree, hygienic standard and the like of the compressed tablet meet the quality requirements of the tablet.

The invention has the characteristics of simple process and low production cost, and is especially suitable for industrialized production.

Detailed ways

The following are examples of the present invention, which are only used to illustrate the present invention, and should not be regarded as limiting the present invention.

Example

Weigh 420g of chitin raw material, add 6% starch slurry and 3% hypromellose mixed slurry as binder, prepare soft material, pass through 16 mesh sieves to make wet granules, dry in an oven, and The granules are crushed through a 100-mesh sieve, added with 11% calcium hydrogen phosphate, 5% dextrin, 3% talcum powder, and 0.5% magnesium stearate dry powder additives that have passed through a 100-mesh sieve, mixed evenly, and pressed into a tablet. 1000 pieces. After inspection, the pressed chitin tablets meet the quality requirements of ordinary tablets.

The preparation method of the chitin tablet provided by the present invention has been described in detail above, and the principle and implementation of the present invention have been explained by using specific examples in this paper. The description of the above examples is only used to help understand the method of the present invention and its core idea; at the same time, for those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation and scope of application. limits.

Claims (1)

1. the method for preparing of a chitin tablet is characterized in that, comprises following steps:

Take by weighing chitin raw material 420g; The mixed pulp that the starch slurry of adding 6% and 3% hypromellose are formed is made binding agent, and the preparation soft material is crossed 16 mesh sieves and processed wet granular; Use oven for drying; Granule was pulverized 100 mesh sieves, added the dry powder compound mixing of the calcium hydrogen phosphate 11% of crossing 100 mesh sieves, dextrin 5%, Pulvis Talci 3%, magnesium stearate 0.5%, be pressed into 1000 with tablet machine.