CN101857647B - Method for preparing floating konjac glucomannan (KGM) and application - Google Patents
Method for preparing floating konjac glucomannan (KGM) and application Download PDFInfo
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Abstract
The invention discloses a method for preparing floating konjac glucomannan (KGM) and application, belongs to the field of biomedical polymer materials, and aims at the problem that an ideal floating framework material does not exist. The method for preparing the floating KGM comprises the following steps of: dissolving konjac flour in distilled water, and then stirring the mixture to prepare a sol; centrifuging and demixing the sol, adding ethanol into a supernatant, ensuring that the ethanol content of the supernatant reaches 30 to 50 percent, and then standing the mixture to obtain a precipitate; separating the precipitate, reacting the precipitate with the ethanol until starch color reaction does not appear to obtain the KGM; after baking the KGM or performing freeze drying on the KGM, crushing and screening the KGM to obtain the floating KGM. The floating KGM can be used as a floating framework material and applied to the fields of biochemistry, pharmacy and the like. A cross-linking agent is not used in the floating KGM, and the floating KGM is swelled but not dissolved in aqueous solution, so that the floating KGM has the advantages of stable performance, high biocompatibility, abundant raw material sources, and simple preparation process.
Description
Technical field
The present invention relates to a kind of preparation method and purposes of floating konjac glucomannan (KGM), belong to field of biomedical polymer materials.
Background technology
Sustained release is that active substance and base material (generally being macromolecular material) are combined or mix to make active substance pass through diffusion way in the regular hour; Be discharged into the technology in the environment with a certain speed; This technology has great importance in fields such as medical science, pharmacy, biological chemistry, agricultural, environmental protection, more and more attracts people's extensive concern.In control release technic, base material is the focus of scientists study always, and it is simple to hope to search out preparation, and stable performance is cheap, the base material that the source is abundant.
Novel drug delivery system is one of main direction of preparation development always.Along with the continuous listing of controlled slow-release preparation, medical scholars find that this type preparation has two significant disadvantages in recent years: the one, and the resistance problem appears in long-time stable blood concentration easily; The 2nd, the medicine time average that effective absorption site stops in gi tract is 6 hours, and processing controlled slow-release preparation for the medicine in those narrow absorption windows does not then have clinical meaning; But the stomach floating preparation that on the controlled slow-release preparation basis, develops can remedy the limitation of general controlled slow-release preparation to narrow absorption window medicine.
According to the floating medicine-feeding technology of stomach of principle of hydrodynamics design mainly is that the character of low density and suction back density step-down through auxiliary material reaches and swims in stomach bottom; Do not receive the influence of peristole; Swim in gastric content top for a long time; Constantly discharge medicine, drug absorption is increased, improve bioavailability of medicament.The most frequently used auxiliary material of gastric floating tablet has hypromellose, and stearyl alcohol etc. float ability in order to improve rising of floating tablet in some cases, add a small amount of effervescent.Owing to select the scope of auxiliary material little, therefore up to the present, only have only tens kind listings in the world, the exploitation of proper auxiliary materials is the bottleneck of this formulation development of restriction.
The konjaku main product is in China middle and south, be rich in its stem tuber Rhizoma amorphophalli glucomannan (Konjac Glucomannan, KGM), this is a kind of HMW, nontoxic nonionic polysaccharide is used as heath food for a long time in China.In recent years, the researchist has done a lot of researchs to its structure and character, and the result finds to comprise in the konjak portuguese gansu polyose glycan molecule glucose and seminose; With β-1, the 4-glycosidic link connects, and the ratio of seminose and glucose is 1.6: 1; Simultaneously on seminose C-3 position, have the short-chain branch structure, approximately on per 32 saccharide residues 3 left and right sides side chains are arranged, side chain has only several residue length; And on the C-6 position, have acetyl group, and there is 1 ethanoyl on per approximately 19 saccharide residues, combine with the mode of ester.In addition, find that it has many good properties, for example strong water-absorbent, thickening property, gelation, biocompatibility, biodegradability etc., thereby be used to the sustained release and the enzyme immobilization of active substance, be applicable to fields such as biological chemistry, pharmacy.
Summary of the invention
One of the object of the invention is to the problem that lacks desirable floatability framework material, especially to lacking desirable floatability framework material in the auxiliary material of floating preparation, the problem of the application of restriction floating in stomach preparation; A kind of preparation method of floating konjac glucomannan (KGM) is provided; Two of the object of the invention provides the purposes with a kind of floating konjac glucomannan (KGM), and described floating konjac glucomannan (KGM) can be applied to fields such as biological chemistry, pharmacy as the floatability framework material; Be preferably used as the active ingredient carriers material; The release of control active substance in liquid, preferred, as the floatability framework material of floating in stomach preparation.Floating konjac glucomannan (KGM) of the present invention does not use any linking agent, and swelling is to a certain degree arranged in the aqueous solution but do not dissolve, stable performance, good biocompatibility, raw material sources are abundant, preparation technology is simple.
The objective of the invention is to realize through following technical proposals.
A kind of preparation method of floating konjac glucomannan (KGM) comprises the steps:
(1) take by weighing Rhizoma amorphophalli powder and be dissolved in the zero(ppm) water, stirring at room 1～10 hour is processed the colloidal sol that concentration is 0.1g/100ml～10g/100ml;
(2) said colloidal sol is centrifugal to layering, its at the middle and upper levels liquid under whipped state, add 50%～95% ethanol, make upper strata liquid contain alcohol amount and reach 30%～50%, placing after 2～24 hours must throw out;
(3) separate said throw out, with throw out repeatedly with 50%～95% Ethanol Treatment till the reaction of no starch coloration, obtain Rhizoma amorphophalli glucomannan;
(4) Rhizoma amorphophalli glucomannan is obtained a kind of floating konjac glucomannan (KGM) of the present invention in 40 ℃～120 ℃ bakings 1～12 hour or lyophilize after 1～10 day.
Wherein, said Rhizoma amorphophalli powder is meant konjaku powder or konjak gum, and the molecular weight that said floating konjac glucomannan (KGM) makes for the preparation method by said floating konjac glucomannan (KGM) is 50,000～3,000,000 Rhizoma amorphophalli glucomannan.
Said floating konjac glucomannan (KGM) through pulverizing, crossing 80～200 mesh sieves, can be made the floating konjac glucomannan (KGM) as the floatability framework material of floating in stomach preparation.
A kind of purposes of floating konjac glucomannan (KGM); Floating konjac glucomannan (KGM) of the present invention can be used as the floatability framework material; Be applied to fields such as biological chemistry, pharmacy, be preferably used as the active ingredient carriers material, the release of control active substance in liquid; Preferred, as the floatability framework material of floating in stomach preparation.
Beneficial effect:
1. raw material is a Rhizoma amorphophalli powder, and the source is abundant, and is nontoxic, can complete biodegradable.
2. adjustment preparation condition parameter can make the floating konjac glucomannan (KGM) of different flotation properties.
3. technology is simple, does not need expensive equipment and reagent, is to be grasped by those skilled in the art easily, helps preserving the biocompatibility of material, is beneficial to environment protection.
4. a kind of floatability framework material of novel stomach floating preparation is provided, has improved the bioavailability of stomach floating preparation, increased the kind of stomach floating preparation, be beneficial to applying of promotion stomach floating preparation.
Description of drawings
Fig. 1 is the floating kinetic curve of the gastric floating tablet of the floating konjac glucomannan (KGM) that contains respectively (KGM) 40%, 50% of embodiment 1 preparation and 60%.
Fig. 2 is the floating kinetic curve of the gastric floating tablet that contains floating konjac glucomannan (KGM) (KGM) 30%, 50% and 60% respectively of embodiment 2 preparations.
Fig. 3 is the floating kinetic curve of the gastric floating tablet that contains floating konjac glucomannan (KGM) (KGM) 40%, 50% and 60% respectively of embodiment 3 preparations.
Fig. 4 is the floating kinetic curve of the gastric floating tablet that contains floating konjac glucomannan (KGM) (KGM) 30%, 50% and 60% respectively of embodiment 4 preparations.
Fig. 5 is the floating kinetic curve of the gastric floating tablet that contains floating konjac glucomannan (KGM) (KGM) 40%, 50% and 60% respectively of embodiment 5 preparations
Fig. 6 is the floating kinetic curve of the gastric floating tablet that contains floating konjac glucomannan (KGM) (KGM) 30%, 40% and 50% respectively of embodiment 6 preparations.
Fig. 7 is the floating kinetic curve of the gastric floating tablet that contains floating konjac glucomannan (KGM) (KGM) 40%, 50% and 60% respectively of embodiment 7 preparations.
Fig. 8 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 1 preparation.
Fig. 9 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 2 preparations.
Figure 10 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 3 preparations.
Figure 11 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 4 preparations.
Figure 12 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 5 preparations.
Figure 13 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 6 preparations.
Figure 14 is the lasting flotation time of the gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of embodiment 7 preparations.
Figure 15 is the cumulative release of the metronidazole gastric floating tablet that contains different content floating konjac glucomannan (KGM) (KGM) of the embodiment 4 preparation line of writing music.
Embodiment
In order to prove absolutely the mode of characteristic of the present invention and embodiment of the present invention, provide embodiment below.
SGF in following examples is meant: the HCl solution of pH=1.2, used ethanol is industrial alcohol among the embodiment.
Embodiment 1
Take by weighing Rhizoma amorphophalli powder 16 grams and be dissolved in 16000 ml distilled waters, stirring at room 6 hours makes into even colloidal sol; Said colloidal sol is centrifugal to layering, and wherein, upper strata liquid adds 95% ethanol under whipped state makes upper strata liquid contain alcohol amount to reach 50%, and placing after 24 hours must throw out; Sediment separate out is used 50%. Ethanol Treatment 5 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; With the Rhizoma amorphophalli glucomannan of gained in 40 ℃ of bakings drying, pulverizing in 12 hours, cross 100 mesh sieves, obtain said a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 1 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 40%, 50% of containing embodiment 1 preparation and 60%; Article 3, curve all presented steady tendency after 5 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the gastric floating tablet floating force also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 1 preparation of curve representation shown in Figure 8; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 8 hours for 35% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 12.5 hours for 40% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 14 hours for 45% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 18 hours for 50% gastric floating tablet; Curve is in rising trend, and along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 40% can form good gel coat, and the phenomenon of floating tablet disintegration can not take place, and can be implemented in directly to rise in the SGF to float, and can continue floating more than 12 hours.
Take by weighing Rhizoma amorphophalli powder 180 grams and be dissolved in 3000 ml distilled waters, stirring at room 1 hour makes into even colloidal sol; Said colloidal sol is centrifugal to layering, and wherein, upper strata liquid adds 50% ethanol under whipped state makes upper strata liquid contain alcohol amount to reach 30%, and placing after 16 hours must throw out; Sediment separate out is used 50% Ethanol Treatment 5 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; With the Rhizoma amorphophalli glucomannan of gained in 120 ℃ of bakings drying, pulverizing in 1 hour, cross 200 mesh sieves, obtain a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 2 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 30%, 50% of containing embodiment 2 preparation and 60%; Article 3, curve all presented steady tendency after 4 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, gastric floating tablet buoyancy also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 2 preparations of curve representation shown in Figure 9; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 5 hours for 20% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 30% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 32% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 35% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content be 44% gastric floating tablet to continue the flotation time be 30 hours, floating konjac glucomannan (KGM) (KGM) content be 50% gastric floating tablet to continue the flotation time be 30 hours, curve is in rising trend; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 30% can form good gel coat, and the phenomenon of floating tablet disintegration can not take place, and can be implemented in directly to rise in the SGF to float, and can continue floating more than 24 hours.
Embodiment 3
Take by weighing Rhizoma amorphophalli powder 100 grams and be dissolved in 1000 ml distilled waters, stirring at room 10 hours makes into even colloidal sol; Said colloidal sol is centrifugal to layering, and wherein, upper strata liquid adds 60% ethanol under whipped state makes upper strata liquid contain alcohol amount to reach 40%, and placing after 2 hours must throw out; Sediment separate out is used 60% Ethanol Treatment 6 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; With the Rhizoma amorphophalli glucomannan of gained in 70 ℃ of bakings drying, pulverizing in 5 hours, cross 100 mesh sieves, obtain a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 3 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 40%, 50% of containing embodiment 3 preparation and 60%; Article 3, curve all presented steady tendency after 5 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, gastric floating tablet buoyancy also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 3 preparations of curve representation shown in Figure 10; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 20 hours for 32% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 20 hours for 37% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 42% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 26 hours for 47% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content be 52% gastric floating tablet to continue the flotation time be 30 hours, floating konjac glucomannan (KGM) (KGM) content be 57% gastric floating tablet to continue the flotation time be 34 hours, curve is in rising trend; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 40% can form good gel coat, and the phenomenon of floating tablet disintegration can not take place, and can be implemented in directly to rise in the SGF to float, and can continue floating more than 24 hours.
Take by weighing Rhizoma amorphophalli powder 12 grams and be dissolved in 12000 ml distilled waters, stirring at room 8 hours makes into even colloidal sol; Said colloidal sol is centrifugal to layering, and wherein, upper strata liquid adds 85% ethanol under whipped state makes upper strata liquid contain alcohol amount to reach 30%, and placing after 16 hours must throw out; Sediment separate out is used 60% Ethanol Treatment 4 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; 100 mesh sieves are pulverized, crossed to the Rhizoma amorphophalli glucomannan lyophilize of gained after 3 days,, can said a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 4 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 30%, 50% of containing embodiment 4 preparation and 60%; Article 3, curve all presented steady tendency after 4 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, gastric floating tablet buoyancy also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 4 preparations of curve representation shown in Figure 11; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 20 hours for 32% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 20 hours for 37% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 42% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 26 hours for 47% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content be 52% gastric floating tablet to continue the flotation time be 30 hours, floating konjac glucomannan (KGM) (KGM) content be 57% gastric floating tablet to continue the flotation time be 34 hours, curve is in rising trend; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Can find out by Figure 15; In the identical time; Accumulation release degree size sequence is: the gastric floating tablet of gastric floating tablet＜floating konjac glucomannan (KGM) (KGM) content 70% of gastric floating tablet＜floating konjac glucomannan (KGM) (KGM) content 60% of gastric floating tablet＜floating konjac glucomannan (KGM) (KGM) content 55% of floating konjac glucomannan (KGM) (KGM) content 30%, explain that the increase gastric floating tablet rate of releasing drug along with said floating konjac glucomannan (KGM) content reduces.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 30% can form good gel coat; Realize slow release effect; The phenomenon of floating tablet disintegration can not take place; Can be implemented in the SGF directly to rise and float, and can continue floatingly more than 24 hours, realize good slow release effect simultaneously.
Take by weighing Rhizoma amorphophalli powder 25 grams and be dissolved in 5000 ml distilled waters, stirring at room 2 hours makes into even colloidal sol; Said colloidal sol is centrifugal to layering, and wherein, upper strata liquid adds 75% ethanol under whipped state makes upper strata liquid contain alcohol amount to reach 50%, and placing after 24 hours must throw out; Sediment separate out is used 50% Ethanol Treatment 7 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; 200 mesh sieves are pulverized, crossed to the Rhizoma amorphophalli glucomannan lyophilize of gained after 1 day,, can a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 5 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 40%, 50% of containing embodiment 5 preparation and 60%; Article 3, curve all presented steady tendency after 4 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, gastric floating tablet buoyancy also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 5 preparations of curve representation shown in Figure 12; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 9 hours for 35% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 12 hours for 40% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 15 hours for 45% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 17.5 hours for 50% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content be 55% gastric floating tablet to continue the flotation time be 23.5 hours, floating konjac glucomannan (KGM) (KGM) content be 60% gastric floating tablet to continue the flotation time be 25 hours, curve is in rising trend; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 40% can form good gel coat, and the phenomenon of floating tablet disintegration can not take place, and can be implemented in directly to rise in the SGF to float, and can continue floating more than 12 hours.
Take by weighing Rhizoma amorphophalli powder 150 grams and be dissolved in 3000 ml distilled waters, stirring at room 10 hours makes into even colloidal sol; Said colloidal sol is centrifugal to layering, and wherein, upper strata liquid adds 50% ethanol under whipped state makes upper strata liquid contain alcohol amount to reach 30%, and placing after 2 hours must throw out; Sediment separate out is used 60% Ethanol Treatment 7 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; 100 mesh sieves are pulverized, crossed to the Rhizoma amorphophalli glucomannan lyophilize of gained after 10 days,, can a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 6 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 30%, 40% of containing embodiment 6 preparation and 50%; Article 3, curve all presented steady tendency after 4 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, gastric floating tablet buoyancy also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 6 preparations of curve representation shown in Figure 13; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 7 hours for 20% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 30% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 32% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 26 hours for 35% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content be 44% gastric floating tablet to continue the flotation time be 30 hours, floating konjac glucomannan (KGM) (KGM) content be 50% gastric floating tablet to continue the flotation time be 32 hours, curve is in rising trend; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 30% can form good gel coat, and the phenomenon of floating tablet disintegration can not take place, and can be implemented in directly to rise in the SGF to float, and can continue floating more than 24 hours.
Embodiment 7
Take by weighing Rhizoma amorphophalli powder 80 grams and be dissolved in 800 ml distilled waters, stirring at room 5 hours makes into even colloidal sol; Said colloidal sol is centrifugal to layering, its at the middle and upper levels liquid under whipped state, add 65% ethanol and make upper strata liquid contain alcohol amount to reach 40%, placing after 10 hours must throw out; Sediment separate out is used 65% Ethanol Treatment 4 times repeatedly with throw out, till no starch coloration reaction, obtains Rhizoma amorphophalli glucomannan; 100 mesh sieves are pulverized, crossed to the Rhizoma amorphophalli glucomannan lyophilize of gained after 6 days,, can a kind of floating konjac glucomannan (KGM) of the present invention.3 curves shown in Figure 7 are respectively the floating kinetic curve of the gastric floating tablet of a kind of floating konjac glucomannan (KGM) (KGM) 40%, 50% of containing embodiment 7 preparation and 60%; Article 3, curve all presented steady tendency after 4 hours; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, gastric floating tablet buoyancy also increases; The lasting flotation time of a kind of floating konjac glucomannan (KGM) (KGM) gastric floating tablet that contains embodiment 7 preparations of curve representation shown in Figure 14; This curve display floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 20 hours for 32% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 21 hours for 37% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 24 hours for 36%～42% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content is that to continue the flotation time be 26 hours for 47% gastric floating tablet; Floating konjac glucomannan (KGM) (KGM) content be 52% gastric floating tablet to continue the flotation time be 32 hours, floating konjac glucomannan (KGM) (KGM) content be 57% gastric floating tablet to continue the flotation time be 34 hours, curve is in rising trend; Along with the increase of floating konjac glucomannan (KGM) (KGM) content, the lasting flotation time of gastric floating tablet also prolongs.
Said floating konjac glucomannan (KGM) content is that the gastric floating tablet more than 40% can form good gel coat, and the phenomenon of floating tablet disintegration can not take place, and can be implemented in directly to rise in the SGF to float, and can continue floating more than 24 hours.
The present invention includes but be not limited to above embodiment, every any replacement or local improvement of being equal to of under spirit of the present invention and principle, carrying out all will be regarded as within protection scope of the present invention.
Claims (3)
1. the preparation method of a floating konjac glucomannan (KGM), it is characterized in that: the preparation method comprises the steps:
(1) take by weighing Rhizoma amorphophalli powder and be dissolved in the zero(ppm) water, stirring at room 1～10 hour is processed the colloidal sol that concentration is 0.1g/100ml～10g/100ml;
(2) said colloidal sol is centrifugal to layering, its at the middle and upper levels liquid under whipped state, add 50%～95% ethanol, make upper strata liquid contain alcohol amount and reach 30%～50%, placing after 2～24 hours must throw out;
(3) separate said throw out, throw out is used 50%～95% ethanol repeatedly, handle till no starch coloration reaction, obtain Rhizoma amorphophalli glucomannan;
(4) Rhizoma amorphophalli glucomannan after 1～10 day, is obtained a kind of floating konjac glucomannan (KGM) of the present invention in 40 ℃～120 ℃ bakings 1～12 hour or lyophilize;
Wherein, said Rhizoma amorphophalli powder is meant konjaku powder or konjak gum.
2. the preparation method of a kind of floating konjac glucomannan (KGM) according to claim 1; It is characterized in that: said floating konjac glucomannan (KGM) through pulverizing, crossing 80～200 mesh sieves, can be made the floating konjac glucomannan (KGM) as the floatability framework material of floating in stomach preparation.
3. the preparation method of a kind of floating konjac glucomannan (KGM) according to claim 1 and 2, it is characterized in that: the molecular weight of said floating konjac glucomannan (KGM) is 50,000～3,000,000.
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| CN102863550B (en) * | 2012-10-25 | 2014-06-18 | 西南大学 | Preparation method of octylene succinic acid konjac glucomannan ester |
| CN103360507B (en) * | 2013-06-18 | 2015-12-02 | 昭通市三艾有机魔芋发展有限责任公司 | A kind of Konjac glucomannan separation method and device thereof |
| CN109097351A (en) * | 2018-08-01 | 2018-12-28 | 浙江海洋大学 | A kind of preparation method of the novel immobilised enzymes for oil spilling reparation |
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Non-Patent Citations (3)
| Title |
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| Han-Wen Yeh等.漂浮缓释高分子材料KGM制备.《2009年全国高分子学术论文报告会论文集》.2009,F-P-037. * |
| S.A. Jaeon,et al.The isolation and characterization of a water extract of konjac flour gum.《Carbohydrate Polymers》.1993,第20卷(第1期),第35-41页. * |
| 张升晖等.魔芋葡甘露聚糖纯化及性能研究.《食品科学》.2005,第26卷(第9期),第275-277页. * |
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