CN101852759A - Contrasting fluid deciding effectiveness of electrochemical sensing system and method thereof - Google Patents
Contrasting fluid deciding effectiveness of electrochemical sensing system and method thereof Download PDFInfo
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- CN101852759A CN101852759A CN200910129928A CN200910129928A CN101852759A CN 101852759 A CN101852759 A CN 101852759A CN 200910129928 A CN200910129928 A CN 200910129928A CN 200910129928 A CN200910129928 A CN 200910129928A CN 101852759 A CN101852759 A CN 101852759A
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Abstract
The invention discloses contrasting fluid deciding the effectiveness of an electrochemical sensing system and a using method thereof. The electrochemical sensing system is applicable to measuring the concentration of an object to be measured in a body fluid sample. The contrasting fluid contains the object to be measured with the known concentration and an alcohol regulator. The contrasting fluid can produce a current signal in the electrochemical sensing system with the qualified effectiveness, and the measurement concentration which corresponds to the current signal is lower than the known concentration.
Description
Technical field
The present invention relates to a kind of contrasting fluid and using method thereof that determines effectiveness of electrochemical sensing system, particularly measure the contrasting fluid and the using method thereof of the electrochemical sensing system of testing concentration in the body fluid.
Background technology
Known electrochemical sensing system uses a kind of standard solution really to imitate as system effectiveness, and this solution is commonly referred to as contrasting fluid (control solution) or claims titer (standard solution).For example, whether type blood sugar sensor-based system is in normal condition for user's test macro (comprising test pieces and tester), to be sure of follow-up test result promptly with the contrasting fluid at home.Therefore, contrasting fluid's quality whether the stable relation usefulness of sensor-based system can correctly be judged.This class contrasting fluid's the quality of production, its preparation accuracy and resistance tocrocking also are the emphasis of development.
The contrasting fluid of general no blood cell, its physical property and determinand content obviously differ from blood, so that response intensity is apparently higher than whole blood.Known galvanochemistry blood sugar sensor-based system contrasting fluid, determinand is about in the measurement concentration of sensor-based system between 1.2 to 2.5 times of determinand actual concentrations.For example, the actual concentrations of determinand glucose is applied to sensor-based system with this contrasting fluid when rising between 120 milligrams/deciliter for 30 milligrams/minute, and the measurement concentration range that its usefulness is qualified rises between 250 milligrams of/deciliter scopes about 50 milligrams/minute.
Yet the actual concentrations of contained determinand glucose may be subjected to the influence of environment and changes among the contrasting fluid.For example because of user's careless manipulation, cause the enzyme on the test pieces to pollute the contrasting fluid,, also will cause the glucose in the contrasting fluid to consume along with the time gradually even this contaminant capacity is few, thereby when carrying out the affirmation of sensor-based system usefulness, produce the bad erroneous judgement of sensor-based system.
Summary of the invention
Because the problems referred to above, the present invention conceives a kind of contrasting fluid and relevant sensor-based system and method for testing that comprises alcohol regulator.According to the present invention, the contrasting fluid is lower than known contrasting fluid in the response intensity of sensor-based system, reduces the annoyance level that potential pollutant is verified and reacted among the contrasting fluid by this.Utilize the present invention, testing concentration comes lowly than actual concentrations in the measured contrasting fluid of qualified sensor-based system.According to the present invention, the contrasting fluid can have compared to the determinand of concentration known higher concentration again.Therefore, under the situation with same contaminant concentration, use contrasting fluid of the present invention, its pollutant causes the consume ratio to alleviate compared to known, thereby can effectively reduce the chance of sensor-based system usefulness erroneous judgement.
According to an embodiment, the invention provides a kind of contrasting fluid, in order to the decision effectiveness of electrochemical sensing system, this electrochemical sensing system is applicable to the concentration of measuring determinand in the humoral sample, this contrasting fluid comprises this determinand of concentration known; And alcohol regulator, wherein said contrasting fluid produces current signal in the qualified described electrochemical sensing system of usefulness, and the pairing measurement concentration of this current signal is less than this concentration known.
According to another embodiment, the invention provides a kind of as above-mentioned contrasting fluid, wherein said electrochemical sensing system also is applicable to the common contrasting fluid who contains this determinand but do not contain this alcohol regulator, when this common contrasting fluid and described contrasting fluid had the determinand of same concentrations, the current signal strength that described contrasting fluid produces in the qualified electrochemical sensing system of described usefulness was lower than the current signal strength that common contrasting fluid produces in this electrochemical sensing system.
According to another embodiment, the invention provides a kind of electrochemical sensing system again, in order to measure the concentration of determinand in the humoral sample, described electrochemical sensing system comprises aforesaid contrasting fluid, and this contrasting fluid is in order to determine this effectiveness of electrochemical sensing system.
Again according to another embodiment, the invention provides a kind of method that determines effectiveness of electrochemical sensing system, this electrochemical sensing system is used for measuring the concentration of humoral sample determinand, this electrochemical sensing system comprises galvanochemistry test piece, surveying instrument and contrasting fluid, this contrasting fluid comprises the described determinand and the alcohol regulator of concentration known, and described method comprises and connects described galvanochemistry test piece and surveying instrument; Described contrasting fluid is contacted with reaction reagent in the galvanochemistry test piece to produce a current signal, and corresponding one of this current signal is measured concentration; If drop in the described determinand normal concentration scope corresponding with described electrochemical sensing system with this measurement concentration, judge that so the usefulness of this electrochemical sensing system is qualified, otherwise, judge that then this electrochemical sensing system lost efficacy.
Description of drawings
Fig. 1 shows the response intensity comparison diagram after each contrasting fluid of embodiment of the invention 2A measures in identical qualified electrochemical sensing system;
Fig. 2 shows the response intensity comparison diagram after each contrasting fluid of embodiment of the invention 2B measures in identical qualified electrochemical sensing system;
Fig. 3 shows the response intensity comparison diagram after each contrasting fluid of embodiment of the invention 2C measures in identical qualified electrochemical sensing system; And
Fig. 4 shows the experimental data of the embodiment of the invention 3.
Embodiment
Indication electrochemical sensing system of the present invention comprises galvanochemistry test piece, surveying instrument and contrasting fluid, and it is applicable to the concentration of measuring determinand in the humoral sample.Can be about galvanochemistry test piece and surveying instrument with reference to Application No. 11/640,886, its content is incorporated this paper into for your guidance, but should be as limit.Be applicable to that determinand of the present invention is mainly the biochemical substances in the body fluid, comprises glucose, cholesterol, lactic acid or triglyceride etc.
Whether contrasting fluid of the present invention is normal in order to the usefulness of decision electrochemical sensing system.Contrasting fluid of the present invention comprises the determinand and the alcohol regulator of concentration known, wherein when the usefulness of electrochemical sensing system is qualified, the contrasting fluid will produce current signal in electrochemical sensing system, the pairing measurement concentration of this current signal is less than this concentration known.In other words, one of notion of the present invention is to utilize the measured value of determinand in the sensor-based system contrasting fluid lower than actual value, reduces the influence degree of pollutant to measured value.
Another notion of the present invention is that the concentration that improves determinand among the contrasting fluid makes it than known common contrasting fluid's height, and same contaminant reducing is to the influence degree of measured value.For example, have under the pollutant situation of equivalent common contrasting fluid and contrasting fluid of the present invention, when experiencing identical time loss and falling the determinand of same amount, contrasting fluid of the present invention is because original determinand content is higher, less with respect to the ratio that its contaminated and actual concentrations of known contrasting fluid descends, therefore the ratio that contrasting fluid's of the present invention measured value descends for known contrasting fluid is also with less.Therefore, contrasting fluid of the present invention will make the erroneous judgement of sensor-based system usefulness still less take place, and this application at the whole blood test macro will be more useful.
Alcohol regulator among the contrasting fluid of the present invention is preferably primary alcohol, polyvalent alcohol or secondary alcohol.Alcohol regulator preferably have suitable polarity and easily and aqueous vehicles dissolve each other, wherein said primary alcohol is preferably methyl alcohol, ethanol and propyl alcohol, the best is an ethanol, its concentration range is the ethanol that every liter of described contrasting fluid is contained 100ml to 500ml.Polyvalent alcohol is preferably glycerine (glycerol), polyglycol (polyethylene glycerol) and propylene glycol, wherein more preferably glycerine and polyglycol.The concentration range of glycerine is the glycerine that every liter of described contrasting fluid is contained 100ml to 500ml; The concentration range of polyglycol is the polyglycol that every liter of described contrasting fluid is contained 100g to 500g, and the preferred molecular weight of described polyglycol is between 1,000 to 10,000.Secondary alcohol is preferably isopropyl alcohol (isopropanol), 2-butanols (2-butyl alcohol), 2-amylalcohol (2-amyl alcohol), most preferably is isopropyl alcohol.The concentration range of isopropyl alcohol is the isopropyl alcohol that every liter of described contrasting fluid is contained 100ml to 500ml.According to another embodiment of the present invention, wherein alcohol regulator also can be the combination in any of above-mentioned all cpds.
Contrasting fluid of the present invention has general stability, does not have tangible contact toxicity immediately.Contrasting fluid's of the present invention composition also comprises solvent, buffering salt, signal medium thing and antiseptic except that above-mentioned determinand and alcohol regulator.Solvent is used to dissolve each constituent, and it is including but not limited to water.The buffering salt is including but not limited to phosphate, citrate etc.The signal medium thing can be the potassium ferricyanide or other suitable material.Antiseptic can be Sodium Benzoate or other suitable material.Below be the contrasting fluid's of the present invention preparation embodiment:
Embodiment 1A:
200 milligrams/deciliter of glucose (determinand)
The potassium ferricyanide 100 grams per liters
Sodium Benzoate 5 grams per liters
200 milliliters/liter of ethanol (alcohol regulator)
Embodiment 1B:
160 milligrams/deciliter of glucose (determinand)
The potassium ferricyanide 100 grams per liters
Sodium Benzoate 5 grams per liters
200 milliliters/liter of isopropyl alcohols (alcohol regulator)
Embodiment 1C:
200 milligrams/deciliter of glucose (determinand)
The potassium ferricyanide 100 grams per liters
Sodium Benzoate 5 grams per liters
200 milliliters/liter of glycerine (alcohol regulator)
Embodiment 1D:
200 milligrams/deciliter of glucose (determinand)
The potassium ferricyanide 100 grams per liters
Sodium Benzoate 5 grams per liters
Polyglycol (alcohol regulator) 250 grams per liters
The present invention determines the method for effectiveness of electrochemical sensing system, except that the contrasting fluid who uses with known different, similar with general system for detecting blood sugar or other similar electrochemical sensing system basically, its step comprises:
(1) connects galvanochemistry test piece and surveying instrument;
(2) contrasting fluid is contacted to produce current signal with reaction reagent in the galvanochemistry test piece.This current signal is through producing corresponding measurement concentration after the analysis of surveying instrument; With
(3) judge this measurement concentration.If this measurement concentration drops in the described determinand normal concentration scope corresponding with described electrochemical sensing system, judge that then the usefulness of this electrochemical sensing system is qualified, otherwise, judge that then this electrochemical sensing system lost efficacy.
The kind of the reaction reagent in the galvanochemistry test piece is relevant with determinand.For example, determinand is that the reaction reagent of the test piece of blood sugar has glucose oxidase (Glucose Oxidase is called for short GOD or GOX) or glucose dehydrogenase (Glucose Dehydrogenase).Determinand is that the reaction reagent of the test piece of lactic acid then contains lactic dehydrogenase (Lactate Dehydrogenase).Determinand is that the test piece of cholesterol then contains cholesterol esterase (Cholesterol esterase) and cholesterol oxidase (Cholesterol oxidase).Above-mentioned each test piece also can comprise the signal medium thing potassium ferricyanide (Potassium Ferricyanide), reach other composition such as citric acid (Citric acid) and potassium phosphate (Potassium Phosphate) or the like.
Embodiment 2A: glucose contrasting fluid of the present invention and known contrasting fluid's comparative example
Surveying instrument: PalmSens.
The galvanochemistry test piece: determinand is the test piece (GlucoSure Star) of glucose.
Common contrasting fluid (being known contrasting fluid) (CONTREX Plus):
The common contrasting fluid of-low value glucose (L1): contain 50 milligrams/deciliter of actual glucose concentration and an amount of damping fluid (citric acid and potassium phosphate).According to ISO 15197 specifications of qualitys, its normal concentration scope of measuring concentration is 110 milligrams/deciliter ± 20% (being 88 milligrams/minute rises between 132 milligrams/deciliter).
The common contrasting fluid of-high value glucose (L2): contain 160 milligrams/deciliter of actual glucose concentration and an amount of damping fluid (citric acid and potassium phosphate).According to ISO 15197 specifications of qualitys, its normal concentration scope of measuring concentration is 240 milligrams/deciliter ± 20% (being 192 milligrams/minute rises between 288 milligrams/deciliter).
Contrasting fluid of the present invention (A1): contain 160 milligrams/deciliter of actual glucose concentration; Alcohol regulator is glycerine 50wt% and other composition (as embodiment 1C).According to ISO 15197 specifications of qualitys, its normal concentration scope of measuring concentration is 110 milligrams/deciliter ± 20% (being 88 milligrams/minute rises between 132 milligrams/deciliter).
Contrasting fluid of the present invention (A2): contain 370 milligrams/deciliter of actual glucose concentration; Alcohol regulator is glycerine 50wt% and other composition (as embodiment 1C).According to ISO 15197 specifications of qualitys, its normal concentration scope of measuring concentration is 240 milligrams/deciliter ± 20% (being 192 milligrams/minute rises between 288 milligrams/deciliter).
Fig. 1 is the response intensity comparison diagram after each contrasting fluid of embodiment 2A measures in identical qualified electrochemical sensing system, and wherein L1 curve, L2 curve are represented common contrasting fluid of low value glucose and the common contrasting fluid of high value glucose respectively; The A1 curve then is glucose contrasting fluid of the present invention (A1), and 160 milligrams/deciliter of its glucose contents are identical with the known common contrasting fluid of high value glucose (L2).As shown in Figure 2, the value of reading of L1 and A1 is quite approaching.Briefly, in identical qualified electrochemical sensing system, the common contrasting fluid's of low value (L1) normal concentration scope is 88 milligrams/minute and rises between 132 milligrams/deciliter, and contrasting fluid A1 of the present invention is also in this scope.In other words, contrasting fluid A1 of the present invention reduces to the low sugar group with sugared group of effect that should produce of height, on behalf of contrasting fluid of the present invention, this reached the function that reduces response intensity, meaning is promptly according to the present invention, the measurement concentration of determinand in electrochemical sensing system is no longer apparently higher than actual concentrations, but lower than actual concentrations.
Embodiment 2B: cholesterol contrasting fluid of the present invention and known contrasting fluid's comparative example
Surveying instrument: PalmSens.
The galvanochemistry test piece: determinand is the test piece (cholSure) of cholesterol.
Common cholesterol contrasting fluid (L3) is (cholSure): contain 12.5 milligrams/deciliter of actual cholesterol concentrations and an amount of damping fluid (citric acid and potassium phosphate).
Cholesterol contrasting fluid of the present invention (A3): contain 12.5 milligrams/deciliter of actual cholesterol concentrations, 50% glycerine (alcohol regulator) and an amount of damping fluid (citric acid and potassium phosphate).
Embodiment 2C: lactic acid contrasting fluid of the present invention and known contrasting fluid's comparative example
Surveying instrument: PalmSens.
The galvanochemistry test piece: determinand is the general test piece (THE EDGE) of lactic acid.
Common lactic acid contrasting fluid (L4) (THE EDGE): contain 50 milligrams/deciliter of actual lactate concentrations and an amount of damping fluid (citric acid and potassium phosphate).
Lactic acid contrasting fluid of the present invention (A4): contain 50 milligrams/deciliter of actual lactate concentrations, 50% glycerine (alcohol regulator) and an amount of damping fluid (citric acid and potassium phosphate).
Fig. 2 and Fig. 3 are the response intensity comparison diagram after each contrasting fluid of embodiment 2B and 2C measures in identical qualified electrochemical sensing system, and wherein L3 and L4 curve are represented known cholesterol and the common contrasting fluid of lactic acid respectively; A3 and A4 curve then are respectively cholesterol of the present invention and lactic acid contrasting fluid.The L3 of Fig. 2 contains identical actual concentrations cholesterol respectively with A3.By putting d2 detection time as judgment standard, known cholesterol contrasting fluid is low for cholesterol contrasting fluid signal intensity ratio of the present invention.The L4 of Fig. 3 and A4 contain the lactic acid of identical actual concentrations respectively.By putting d3 detection time as judgment standard, the lactic acid contrasting fluid that lactic acid contrasting fluid signal intensity ratio of the present invention is known is low.
Embodiment 3: the present invention contains the glucose contrasting fluid of pollutant and known contrasting fluid's comparative example
As described above, the contrasting fluid is if polluted because of improper use, will cause including determinand and be consumed and detract, thereby produce erroneous judgement when confirming the usefulness of sensor-based system.Embodiment 3 is used for proof compared to known contrasting fluid, and contrasting fluid of the present invention has higher pollutant degree of admission, and sensor-based system usefulness erroneous judgement chance is relatively low.
With reference to the tabulation of figure 4, control group is known low value glucose contrasting fluid (CONTREX Plus), and containing the glucose actual concentrations before being polluted is 50 milligrams/deciliter.Surveying instrument is GlucoSure Star.The galvanochemistry test piece: determinand is the test piece (GlucoSure Star) of glucose.
According to aforementioned, the normal concentration scope that control group is measured concentration is 110 milligrams/deciliter ± 20% (being 88 milligrams/minute rises between 132 milligrams/deciliter).Experimental group then is glucose contrasting fluid of the present invention, contains the glucose actual concentrations before being polluted and be 160 milligrams/deciliter and an amount of isopropyl alcohol as alcohol regulator.Pollutant is example with the glucose oxidase.Day start in contaminated for these two groups, at the 15th day, the 30th day and the 60th day, use qualified surveying instrument and galvanochemistry test piece to measure, its result shows that the measurement concentration of experimental group is respectively 105 milligrams/deciliter, 99 milligrams/deciliter and 89 milligrams/deciliter, all drop on and assert in the normal scope of system effectiveness, show that contrasting fluid of the present invention does not cause erroneous judgement because of pollution.Yet the measurement concentration of control group is respectively 94 milligrams/deciliter, 77 milligrams/deciliter, and 44 milligrams/deciliter, wherein exceeds critical field with the 60th day measurement concentration on the 30th day, shows that known contrasting fluid causes erroneous judgement because of contaminated.
Same tabulation with reference to figure 4, two groups of contrasting fluids are polluted by glucose oxidase, consume 0.5 milligram/deciliter determinand every day, thereby the 15th day, the 30th day and the 60th day, contrasting fluid's failure values should be 7.5 milligrams/deciliter, 15 milligrams/deciliter and 30 milligrams/deciliter.To contain the glucose actual concentrations before being polluted is that benchmark calculates relative coefficient of losses, and the coefficient of losses of experimental group is 4.7% to 19.1%, and control group showed coefficient of losses up to 30%, 60% in the 30th day with the 60th day data.Hence one can see that, and contrasting fluid of the present invention is because of providing more determinand, and the coefficient of losses that the unit interval internal contamination is caused is low than the contrasting fluid of prior art, thereby can reduce when test macro usefulness and pollute the chance that causes erroneous judgement.
Although represented with reference to definite preferred embodiment of the present invention and described the present invention; yet it is not in order to restriction the present invention; the one of ordinary skilled in the art will be appreciated that; can be under the prerequisite that does not deviate from the aim of the present invention that limits by appended claims and scope the present invention be carried out modification on various forms and the details; therefore, protection scope of the present invention should be as the criterion with defining in the appended claims.
Claims (26)
1. contrasting fluid, in order to the decision effectiveness of electrochemical sensing system, this electrochemical sensing system is applicable to the concentration of measuring determinand in the humoral sample, this contrasting fluid comprises:
The described determinand of concentration known; And
Alcohol regulator, wherein said contrasting fluid produces current signal in the qualified described electrochemical sensing system of usefulness, and the pairing measurement concentration of this current signal is less than described concentration known.
2. contrasting fluid as claimed in claim 1, wherein said electrochemical sensing system is applicable to the common contrasting fluid who contains described determinand but do not contain described alcohol regulator, when common contrasting fluid and described contrasting fluid had the described determinand of same concentrations, the current signal strength that described contrasting fluid produces in the qualified electrochemical sensing system of usefulness was lower than the current signal strength that common contrasting fluid produces in the qualified electrochemical sensing system of described usefulness.
3. contrasting fluid as claimed in claim 1, wherein said determinand is glucose, cholesterol, lactic acid or triglyceride.
4. contrasting fluid as claimed in claim 1, wherein said alcohol regulator is selected from down group: primary alcohol, secondary alcohol, polyvalent alcohol, and their combination in any.
5. contrasting fluid as claimed in claim 1, wherein said alcohol regulator is an ethanol.
6. contrasting fluid as claimed in claim 5, wherein said concentration of ethanol scope is the ethanol that every liter of this contrasting fluid is contained 100ml to 500ml.
7. contrasting fluid as claimed in claim 1, wherein said alcohol regulator is a glycerine.
8. contrasting fluid as claimed in claim 7, the concentration range of wherein said glycerine is the glycerine that every liter of this contrasting fluid is contained 100ml to 500ml.
9. contrasting fluid as claimed in claim 1, wherein said alcohol regulator is a polyglycol.
10. contrasting fluid as claimed in claim 9, the concentration range of wherein said polyglycol is the polyglycol that every liter of this contrasting fluid is contained 100g to 500g.
11. contrasting fluid as claimed in claim 1, wherein said alcohol regulator is an isopropyl alcohol.
12. contrasting fluid as claimed in claim 11, the concentration range of wherein said isopropyl alcohol is the isopropyl alcohol that every liter of this contrasting fluid is contained 100ml to 500ml.
13. electrochemical sensing system, in order to measure the concentration of determinand in the humoral sample, described electrochemical sensing system comprises galvanochemistry test piece, surveying instrument and contrasting fluid as claimed in claim 1, and this contrasting fluid is in order to determine the usefulness of this electrochemical sensing system.
14. method that determines effectiveness of electrochemical sensing system, described electrochemical sensing system is used for measuring the concentration of humoral sample determinand, this electrochemical sensing system comprises galvanochemistry test piece, surveying instrument and contrasting fluid, this contrasting fluid comprises the described determinand and the alcohol regulator of concentration known, and this method comprises:
Connect described galvanochemistry test piece and surveying instrument;
Described contrasting fluid is contacted with reaction reagent in the galvanochemistry test piece to produce a current signal, and corresponding one of this current signal is measured concentration; With
If this measurement concentration drops in the described determinand normal concentration scope corresponding with described electrochemical sensing system, judge that so the usefulness of this electrochemical sensing system is qualified, otherwise, judge that then this electrochemical sensing system lost efficacy.
15. method as claimed in claim 14, when the usefulness of this electrochemical sensing system was qualified, this measured concentration less than this concentration known.
16. method as claimed in claim 14, wherein said electrochemical sensing system is applicable to the common contrasting fluid who contains described determinand but do not contain described alcohol regulator, when qualified and this common contrasting fluid and this contrasting fluid had the determinand of same concentrations when the usefulness of this electrochemical sensing system, the current signal strength that described contrasting fluid produces in described electrochemical sensing system was lower than the current signal strength that common contrasting fluid produces in described electrochemical sensing system.
17. method as claimed in claim 14, wherein said determinand are glucose, cholesterol, lactic acid or triglyceride.
18. method as claimed in claim 14, wherein said alcohol regulator is selected from down group: primary alcohol, secondary alcohol, polyvalent alcohol, and above-mentioned combination in any.
19. method as claimed in claim 14, wherein said alcohol regulator are ethanol.
20. contrasting fluid as claimed in claim 19, wherein said concentration of ethanol scope is the ethanol that every liter of this contrasting fluid is contained 100ml to 500ml.
21. contrasting fluid as claimed in claim 14, wherein said alcohol regulator is a glycerine.
22. contrasting fluid as claimed in claim 21, the concentration range of wherein said glycerine is the glycerine that every liter of this contrasting fluid is contained 100ml to 500ml.
23. contrasting fluid as claimed in claim 14, wherein said alcohol regulator is a polyglycol.
24. contrasting fluid as claimed in claim 23, the concentration range of wherein said polyglycol is the polyglycol that every liter of this contrasting fluid is contained 100g to 500g.
25. contrasting fluid as claimed in claim 14, wherein said alcohol regulator is an isopropyl alcohol.
26. contrasting fluid as claimed in claim 25, the concentration range of wherein said isopropyl alcohol is the isopropyl alcohol that every liter of this contrasting fluid is contained 100ml to 500ml.
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| US20090014339A1 (en) * | 2005-04-08 | 2009-01-15 | Beer Greg P | Oxidizable Species as an Internal Reference in Control Solutions for Biosensors |
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| US5723284A (en) * | 1996-04-01 | 1998-03-03 | Bayer Corporation | Control solution and method for testing the performance of an electrochemical device for determining the concentration of an analyte in blood |
| US7169273B2 (en) * | 2000-09-25 | 2007-01-30 | Asahi Kasei Kabushiki Kaisha | Enzyme electrode |
| CN1421700A (en) * | 2001-08-01 | 2003-06-04 | 生命扫描有限公司 | Method and apparatus for measuring concentration of analyte |
| US20040209371A1 (en) * | 2002-12-11 | 2004-10-21 | Conlon Dennis Robert | Multi-analyte reference solutions |
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